LOCUS       NM_001370332            3986 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens E74 like ETS transcription factor 1 (ELF1), transcript
            variant 6, mRNA.
ACCESSION   NM_001370332 XM_011534950
VERSION     NM_001370332.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3986)
  AUTHORS   Zhu,P., Dou,C., Song,Z., Bi,X., Wu,X. and Miao,Y.
  TITLE     ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and
            motility in early pregnancy
  JOURNAL   Am J Reprod Immunol 90 (3), e13758 (2023)
   PUBMED   37641376
  REMARK    GeneRIF: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation
            and motility in early pregnancy.
REFERENCE   2  (bases 1 to 3986)
  AUTHORS   Zhao,L., Wu,X., Zhang,Z., Fang,L., Yang,B. and Li,Y.
  TITLE     ELF1 suppresses autophagy to reduce cisplatin resistance via the
            miR-152-3p/NCAM1/ERK axis in lung cancer cells
  JOURNAL   Cancer Sci 114 (6), 2650-2663 (2023)
   PUBMED   36846943
  REMARK    GeneRIF: ELF1 suppresses autophagy to reduce cisplatin resistance
            via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
REFERENCE   3  (bases 1 to 3986)
  AUTHORS   Han,D., Li,X. and Cheng,Y.
  TITLE     Transcription Factor ELF1 Modulates Cisplatin Sensitivity in
            Prostate Cancer by Targeting MEIS Homeobox 2
  JOURNAL   Chem Res Toxicol 36 (3), 360-368 (2023)
   PUBMED   36763086
  REMARK    GeneRIF: Transcription Factor ELF1 Modulates Cisplatin Sensitivity
            in Prostate Cancer by Targeting MEIS Homeobox 2.
REFERENCE   4  (bases 1 to 3986)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3986)
  AUTHORS   Hu,M., Li,H., Xie,H., Fan,M., Wang,J., Zhang,N., Ma,J. and Che,S.
  TITLE     ELF1 Transcription Factor Enhances the Progression of Glioma via
            ATF5 promoter
  JOURNAL   ACS Chem Neurosci 12 (7), 1252-1261 (2021)
   PUBMED   33720698
  REMARK    GeneRIF: ELF1 Transcription Factor Enhances the Progression of
            Glioma via ATF5 promoter.
REFERENCE   6  (bases 1 to 3986)
  AUTHORS   Oettgen,P., Akbarali,Y., Boltax,J., Best,J., Kunsch,C. and
            Libermann,T.A.
  TITLE     Characterization of NERF, a novel transcription factor related to
            the Ets factor ELF-1
  JOURNAL   Mol Cell Biol 16 (9), 5091-5106 (1996)
   PUBMED   8756667
REFERENCE   7  (bases 1 to 3986)
  AUTHORS   John,S., Reeves,R.B., Lin,J.X., Child,R., Leiden,J.M.,
            Thompson,C.B. and Leonard,W.J.
  TITLE     Regulation of cell-type-specific interleukin-2 receptor alpha-chain
            gene expression: potential role of physical interactions between
            Elf-1, HMG-I(Y), and NF-kappa B family proteins
  JOURNAL   Mol Cell Biol 15 (3), 1786-1796 (1995)
   PUBMED   7862168
REFERENCE   8  (bases 1 to 3986)
  AUTHORS   Wang,C.Y., Petryniak,B., Thompson,C.B., Kaelin,W.G. and Leiden,J.M.
  TITLE     Regulation of the Ets-related transcription factor Elf-1 by binding
            to the retinoblastoma protein
  JOURNAL   Science 260 (5112), 1330-1335 (1993)
   PUBMED   8493578
REFERENCE   9  (bases 1 to 3986)
  AUTHORS   Leiden,J.M., Wang,C.Y., Petryniak,B., Markovitz,D.M., Nabel,G.J.
            and Thompson,C.B.
  TITLE     A novel Ets-related transcription factor, Elf-1, binds to human
            immunodeficiency virus type 2 regulatory elements that are required
            for inducible trans activation in T cells
  JOURNAL   J Virol 66 (10), 5890-5897 (1992)
   PUBMED   1527846
REFERENCE   10 (bases 1 to 3986)
  AUTHORS   Thompson,C.B., Wang,C.Y., Ho,I.C., Bohjanen,P.R., Petryniak,B.,
            June,C.H., Miesfeldt,S., Zhang,L., Nabel,G.J., Karpinski,B. et al.
  TITLE     cis-acting sequences required for inducible interleukin-2 enhancer
            function bind a novel Ets-related protein, Elf-1
  JOURNAL   Mol Cell Biol 12 (3), 1043-1053 (1992)
   PUBMED   1545787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157877.11.
            
            On May 7, 2019 this sequence version replaced XM_011534950.1.
            
            Summary: This gene encodes an E26 transformation-specific related
            transcription factor. The encoded protein is primarily expressed in
            lymphoid cells and acts as both an enhancer and a repressor to
            regulate transcription of various genes. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC030507.2, SRR1803613.247909.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL157877.11        123931-124019       c
            90-280              AL157877.11        118862-119052       c
            281-397             AL157877.11        117781-117897       c
            398-697             AL157877.11        86686-86985         c
            698-878             AL157877.11        63539-63719         c
            879-986             AL157877.11        56032-56139         c
            987-1154            AL157877.11        54509-54676         c
            1155-1238           AL157877.11        48545-48628         c
            1239-1431           AL157877.11        47655-47847         c
            1432-1881           AL157877.11        45624-46073         c
            1882-3986           AL157877.11        36627-38731         c
FEATURES             Location/Qualifiers
     source          1..3986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..3986
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="E74 like ETS transcription factor 1"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
     exon            1..89
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..280
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..397
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..697
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             626..2485
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="isoform a is encoded by transcript variant 6;
                     ets-related transcription factor Elf-1; E74-like factor 1
                     (ets domain transcription factor)"
                     /codon_start=1
                     /product="ETS-related transcription factor Elf-1 isoform
                     a"
                     /protein_id="NP_001357261.1"
                     /db_xref="CCDS:CCDS9374.1"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
                     /translation="MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADI
                     LNSYAGLACVEEPNDMITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAA
                     EALLNMDSPGPMLDEKRINNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKY
                     ADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALL
                     QDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGI
                     LAKVEGQRLVYQFKEMPKDLIYINDEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSS
                     PGVKGGATTVLKPGNSKAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPV
                     QAVPEGEAARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQTVPLTT
                     VIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLGPAQVQQVL
                     TSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPGTVITSVIKTQETKTLT
                     QEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSNGFTSQVAMKQNELLEPNSF"
     exon            698..878
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..986
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1154
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1238
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1431
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1881
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..3986
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3657..3662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="hexamer: AATAAT"
     polyA_site      3688
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="major polyA site"
     regulatory      3860..3865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="hexamer: AATAAA"
     polyA_site      3882
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="major polyA site"
     regulatory      3966..3971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /note="hexamer: AATAAA"
     polyA_site      3986
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
ORIGIN      
        1 aatctacagg agccatttta acagctaaaa cttgtcggat tgctttttat tttcaagctc
       61 aaaagacgat agagaaagaa tacttgaagg tattaacatc atcctcattg tcagagccct
      121 cttgccttct atagtttgta tgaagattgg tttaacaatt tttatattaa aagctatcaa
      181 agtgatatat gcacaccatt caaaatttaa ttcataggtc tataatgaaa aggagcctgc
      241 ctcctctgcc ccttctgact ctcagtcctg ctgtccaaag gatcagatat ctgccgatga
      301 tgacttctaa cccattcaga atctttctat ggtatattgc cctggggtgt aaaatcctcc
      361 aggaccctaa acagatggac agttgatgca tttcagggcc aagaagcttg agagaagaaa
      421 aatttcagaa aaattgtctc aatttgacta gaatatcaat gaaccaggaa aactgaagca
      481 ccttccctaa agaaaacttg ggtatacaat tactccacag acagagctga gggtttttta
      541 cccaaatcag tcactggatt ttgctgcctg atacgtgaat cttcttggaa tttttctcat
      601 gtggatctaa ggggaatgct ttattatggc tgctgttgtc caacagaacg acctagtatt
      661 tgaatttgct agtaacgtca tggaggatga acgacagctt ggtgatccag ctatttttcc
      721 tgccgtaatt gtggaacatg ttcctggtgc tgatattctc aatagttatg ccggtctagc
      781 ctgtgtggaa gagcccaatg acatgattac tgagagttca ctggatgttg ctgaagaaga
      841 aatcatagac gatgatgatg atgacatcac ccttacagtt gaagcttctt gtcatgacgg
      901 ggatgaaaca attgaaacta ttgaggctgc tgaggcactc ctcaatatgg attcccctgg
      961 ccctatgctg gatgaaaaac gaataaataa taatatattt agttcacctg aagatgacat
     1021 ggttgttgcc ccagtcaccc atgtgtccgt cacattagat gggattcctg aagtgatgga
     1081 aacacagcag gtgcaagaaa aatatgcaga ctcaccggga gcctcatcac cagaacagcc
     1141 taagaggaaa aaaggaagaa aaactaaacc accacgacca gattccccag ccactacgcc
     1201 aaatatatct gtgaagaaga aaaacaaaga tggaaaggga aacacaattt atctttggga
     1261 gtttttactg gcactgctcc aggacaaggc tacttgtcct aaatacatca agtggaccca
     1321 gcgagagaaa ggcattttta aattggtgga ttctaaagca gtgtccaggt tgtgggggaa
     1381 gcacaaaaac aaacctgata tgaattatga gaccatggga agagcactca ggtactatta
     1441 ccaaaggggt attctggcaa aagtggaagg tcagcgcttg gtgtatcagt ttaaagaaat
     1501 gccaaaagat cttatatata taaatgatga ggatccaagt tccagcatag agtcttcaga
     1561 tccatcgcta tcttcatcag ccacttcaaa taggaatcaa accagccggt cgagagtatc
     1621 ttcaagtcca ggggtaaaag gaggagccac tacagttcta aaaccaggga attctaaagc
     1681 tgcaaaaccc aaagatcctg tggaagttgc acaaccatca gaagttttga ggacagtgca
     1741 gcccacgcag tctccatatc ctacccagct cttccggact gttcatgtag tacagccagt
     1801 acaggctgtc ccagagggag aagcagctag aaccagtacc atgcaggatg aaacattaaa
     1861 ttcttccgtt cagagtatta ggactataca ggctccaacc caagttccag tggttgtgtc
     1921 tcctaggaat cagcagttgc atacagtaac actccaaaca gtgccactca caacagttat
     1981 agccagcaca gatccatcag caggtactgg atctcagaag tttattttac aagccattcc
     2041 atcatcacag cccatgacag tactgaaaga aaatgtcatg ctgcagtcac aaaaggcggg
     2101 ctctcctcct tcaattgtct tgggccctgc ccaggttcag caggtcctta ctagcaatgt
     2161 tcagaccatt tgcaatggaa ccgtcagtgt ggcttcctct ccatccttca gtgctactgc
     2221 acctgtggtg accttttctc ctcgcagttc acagctggtt gctcacccac ctggcactgt
     2281 aatcacttca gttatcaaaa ctcaagaaac aaaaactctt acacaggaag tagagaaaaa
     2341 ggaatctgaa gatcatttga aagagaacac tgagaaaacg gagcagcagc cacagcctta
     2401 tgtgatggta gtgtccagtt ccaatggatt tacttctcag gtagctatga aacaaaacga
     2461 actgctggaa cccaactctt tttagttaat ataccaaagc ttatgaataa ttgtttgtta
     2521 attgaacatt ttcaattata tgcagactga ctgattctaa gataaattct aaggaggttt
     2581 ctaattttgt aattgttaaa aatagagtta attttgactt tgttagatga gggaggaaaa
     2641 ctcaactgtt tctctttgtt atctaaatgt ttcagaattc aatcgtgaag gaacaggcat
     2701 tttacactat gaagacattc ttttgagatt tttatttcag ttgctatatc ataagcattt
     2761 ttaaagtttc ttttctaatt ttacattgta ttagattttc tgattctttt gtaaatacag
     2821 aacttaaata gaaggcaaca ggaaatttat ataggaacta ttttcattcc acttgtgtaa
     2881 gttaagtctt gactctttca aatgcaaaaa acctatttta tgctttgtta aaattatggt
     2941 gtcacttaga ttgactttag ttgactgcac tatataatat agaactatga atatgtagaa
     3001 taacatgaaa aattggaggt gctggtggta tggctgaccc tgtttcagaa gcaggatagt
     3061 ataaaagcat cagcctaaga atggcactcc cactaactag ctatgtaatc ttgacctctt
     3121 tgggctttag ttcctctcat aaaaggaaga gatgtattgg attagactag atgatcacca
     3181 ctttctcttc tagttctaat ttttttaatt ctaataccta tattttcaag ttatgtcaat
     3241 taaatcatta tcaggttatt tcctaatgta agaatagcta aaatgttgca gagaaataag
     3301 tgacccaaca aaatttattc atctgttatg ggtaagatct gccataaatt cttcctaaat
     3361 aatttgttta ctaactcttt aggccactgt gctttgcggt ccattagtaa acttgtgttg
     3421 ctaagtgcta aacagaatac tgctattttg agagagtcaa gactctttct taagggccaa
     3481 gaaagcaact tgagccttgg gctaatctgg ctgagtagtc agttataaaa gcataattgc
     3541 tttatatttt ggatcatttt ttactggggg cggacttggg gggggttgca tacaaagata
     3601 acatatatat ccaactttct gaaatgaaat gtttttagat tactttttca actgtaaata
     3661 atgtacattt aatgtcacaa gaaaaaaatg tcttctgcaa attttctagt ataacagaaa
     3721 tttttgtaga tgaaaaaaat cattatgttt agaggtctaa tgctatgttt tcatattaca
     3781 gagtgaattt gtatttaaac aaaaatttaa attttggaat cctctaaaca tttttgtatc
     3841 tttaattggt ttattattaa ataaatcata taaaaattct cagtgtctgt tttcaggcaa
     3901 aagtttctta aagaataagt gtgcagagaa tattactaga acatcagcat tacttaatgt
     3961 ttataaataa atttcattag tcagaa
//
