LOCUS       NM_001144774            3965 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ELAV like RNA binding protein 4 (ELAVL4), transcript
            variant 2, mRNA.
ACCESSION   NM_001144774
VERSION     NM_001144774.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3965)
  AUTHORS   Li,S., Lv,J., Zhang,X., Zhang,Q., Li,Z., Lu,J., Huo,X., Guo,M.,
            Liu,X., Gao,R., Gong,J., Li,C., Li,W., Zhang,T., Wang,J., Chen,Z.
            and Du,X.
  TITLE     ELAVL4 promotes the tumorigenesis of small cell lung cancer by
            stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation
  JOURNAL   FASEB J 37 (10), e23170 (2023)
   PUBMED   37676718
  REMARK    GeneRIF: ELAVL4 promotes the tumorigenesis of small cell lung
            cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2
            activation.
REFERENCE   2  (bases 1 to 3965)
  AUTHORS   Silvestri,B., Mochi,M., Garone,M.G. and Rosa,A.
  TITLE     Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous
            System Diseases
  JOURNAL   Int J Mol Sci 23 (23), 14606 (2022)
   PUBMED   36498933
  REMARK    GeneRIF: Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in
            Nervous System Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3965)
  AUTHORS   van der Linden,R.J., Gerritsen,J.S., Liao,M., Widomska,J.,
            Pearse,R.V. 2nd, White,F.M., Franke,B., Young-Pearse,T.L. and
            Poelmans,G.
  TITLE     RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's
            disease-related molecular changes in human iPSC-derived neurons
  JOURNAL   Prog Neurobiol 217, 102316 (2022)
   PUBMED   35843356
  REMARK    GeneRIF: RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's
            disease-related molecular changes in human iPSC-derived neurons.
REFERENCE   4  (bases 1 to 3965)
  AUTHORS   Garone,M.G., Birsa,N., Rosito,M., Salaris,F., Mochi,M., de
            Turris,V., Nair,R.R., Cunningham,T.J., Fisher,E.M.C., Morlando,M.,
            Fratta,P. and Rosa,A.
  TITLE     ALS-related FUS mutations alter axon growth in motoneurons and
            affect HuD/ELAVL4 and FMRP activity
  JOURNAL   Commun Biol 4 (1), 1025 (2021)
   PUBMED   34471224
  REMARK    GeneRIF: ALS-related FUS mutations alter axon growth in motoneurons
            and affect HuD/ELAVL4 and FMRP activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3965)
  AUTHORS   Bowles,K.R., Silva,M.C., Whitney,K., Bertucci,T., Berlind,J.E.,
            Lai,J.D., Garza,J.C., Boles,N.C., Mahali,S., Strang,K.H.,
            Marsh,J.A., Chen,C., Pugh,D.A., Liu,Y., Gordon,R.E., Goderie,S.K.,
            Chowdhury,R., Lotz,S., Lane,K., Crary,J.F., Haggarty,S.J.,
            Karch,C.M., Ichida,J.K., Goate,A.M. and Temple,S.
  TITLE     ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss
            in MAPT mutation cerebral organoids
  JOURNAL   Cell 184 (17), 4547-4563 (2021)
   PUBMED   34314701
  REMARK    GeneRIF: ELAVL4, splicing, and glutamatergic dysfunction precede
            neuron loss in MAPT mutation cerebral organoids.
REFERENCE   6  (bases 1 to 3965)
  AUTHORS   Sekido,Y., Bader,S.A., Carbone,D.P., Johnson,B.E. and Minna,J.D.
  TITLE     Molecular analysis of the HuD gene encoding a paraneoplastic
            encephalomyelitis antigen in human lung cancer cell lines
  JOURNAL   Cancer Res 54 (18), 4988-4992 (1994)
   PUBMED   8069866
REFERENCE   7  (bases 1 to 3965)
  AUTHORS   Muresu,R., Baldini,A., Gress,T., Posner,J.B., Furneaux,H.M. and
            Siniscalco,M.
  TITLE     Mapping of the gene coding for a paraneoplastic encephalomyelitis
            antigen (HuD) to human chromosome site 1p34
  JOURNAL   Cytogenet Cell Genet 65 (3), 177-178 (1994)
   PUBMED   8222755
REFERENCE   8  (bases 1 to 3965)
  AUTHORS   Dalmau,J., Furneaux,H.M., Cordon-Cardo,C. and Posner,J.B.
  TITLE     The expression of the Hu (paraneoplastic encephalomyelitis/sensory
            neuronopathy) antigen in human normal and tumor tissues
  JOURNAL   Am J Pathol 141 (4), 881-886 (1992)
   PUBMED   1415481
REFERENCE   9  (bases 1 to 3965)
  AUTHORS   Szabo,A., Dalmau,J., Manley,G., Rosenfeld,M., Wong,E., Henson,J.,
            Posner,J.B. and Furneaux,H.M.
  TITLE     HuD, a paraneoplastic encephalomyelitis antigen, contains
            RNA-binding domains and is homologous to Elav and Sex-lethal
  JOURNAL   Cell 67 (2), 325-333 (1991)
   PUBMED   1655278
REFERENCE   10 (bases 1 to 3965)
  AUTHORS   Graus,F. and Ferrer,I.
  TITLE     Analysis of a neuronal antigen (Hu) expression in the developing
            rat brain detected by autoantibodies from patients with
            paraneoplastic encephalomyelitis
  JOURNAL   Neurosci Lett 112 (1), 14-18 (1990)
   PUBMED   2166930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK005107.1, AY033997.1, AL592182.6 and BC036071.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001144774.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036071.1, SRR1660807.78078.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371824.7/ ENSP00000360889.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CK005107.1         4-16
            14-956              AY033997.1         1-943
            957-1004            AL592182.6         33488-33535
            1005-1043           AL592182.6         35178-35216
            1044-3330           AL592182.6         38600-40886
            3331-3965           BC036071.1         3290-3924
FEATURES             Location/Qualifiers
     source          1..3965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33-p32.3"
     gene            1..3965
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /note="ELAV like RNA binding protein 4"
                     /db_xref="GeneID:1996"
                     /db_xref="HGNC:HGNC:3315"
                     /db_xref="MIM:168360"
     exon            1..279
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1371
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ELAV-like protein 4; paraneoplastic encephalomyelitis
                     antigen HuD; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D); ELAV like
                     neuron-specific RNA binding protein 4"
                     /codon_start=1
                     /product="ELAV-like protein 4 isoform 2"
                     /protein_id="NP_001138246.1"
                     /db_xref="CCDS:CCDS44140.1"
                     /db_xref="GeneID:1996"
                     /db_xref="HGNC:HGNC:3315"
                     /db_xref="MIM:168360"
                     /translation="MVMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGATTDDS
                     KTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEK
                     AINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIIT
                     SRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSS
                     QALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDGMTSLVGMNIP
                     GHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNY
                     DEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS"
     exon            280..520
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     exon            521..624
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     exon            625..778
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1004
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1043
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..3965
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /note="hexamer: AATAAA"
     polyA_site      3403
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
     regulatory      3945..3950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /note="hexamer: AATGAA"
     polyA_site      3965
                     /gene="ELAVL4"
                     /gene_synonym="HUD; PNEM"
                     /note="major polyA site"
ORIGIN      
        1 gagccaattt cagcaaggct ctgttcagtt gttcttatct acatcctaga atcgggggtt
       61 tcagctcact gctccttttc ttttttttct ttctctcccc cgcccacccc cccaaaaata
      121 attgatttgc tttacaatca tccacactgt gttttgtgga tctttaatta tatataacaa
      181 tagtagtcat tttaaatata tattctgaaa tctttgcaaa ttttaacaga agagtcgaag
      241 ctctgcgaga cccaatattt gccaataaga atggttatga taattagcac catggagcct
      301 caggtgtcaa atggtccgac atccaataca agcaatggac cctccagcaa caacagaaac
      361 tgtccttctc ccatgcaaac aggggcaacc acagatgaca gcaaaaccaa cctcatcgtc
      421 aactatttac cccagaatat gacccaagaa gaattcagga gtctcttcgg gagcattggt
      481 gaaatagaat cctgcaaact tgtgagagac aaaattacag gacagagttt agggtatgga
      541 tttgttaact atattgatcc aaaggatgca gagaaagcca tcaacacttt aaatggactc
      601 agactccaga ccaaaaccat aaaggtctca tatgcccgtc cgagctctgc ctcaatcagg
      661 gatgctaacc tctatgttag cggccttccc aaaaccatga cccagaagga actggagcaa
      721 cttttctcgc aatacggccg tatcatcacc tcacgaatcc tggttgatca agtcacagga
      781 gtgtccagag gggtgggatt catccgcttt gataagagga ttgaggcaga agaagccatc
      841 aaagggctga atggccagaa gcccagcggt gctacggaac cgattactgt gaagtttgcc
      901 aacaacccca gccagaagtc cagccaggcc ctgctctccc agctctacca gtcccccaac
      961 cggcgctacc caggtccact tcaccaccag gctcagaggt tcaggctgga caatttgctt
     1021 aatatggcct atggcgtaaa gaggttctcc ccaattacca ttgatggaat gacaagcctt
     1081 gtgggaatga acatccctgg tcacacagga actgggtggt gcatctttgt ctacaacctg
     1141 tcccccgatt ccgatgagag tgtcctctgg cagctctttg gcccctttgg agcagtgaac
     1201 aacgtaaagg tgattcgtga cttcaacacc aacaagtgca agggattcgg ctttgtcacc
     1261 atgaccaact atgatgaggc ggccatggcc atcgccagcc tcaacgggta ccgcctggga
     1321 gacagagtgt tgcaagtttc ctttaaaacc aacaaagccc acaagtcctg aatttcccat
     1381 tcttacttac taaaatatat atagaaatat atacgaacaa aacacacgcg cgcacacaca
     1441 cacatacacg aaagagagag aaacaaactt ttcaaggctt atattcaacc atggacttta
     1501 taagccagtg ttgcctaagt attaaaacat tggattatcc tgaggtgtac caggaaagga
     1561 ttttataatg cttagaaaaa aagaaaaaaa aaaaacaaaa aatacctttg atgcattgaa
     1621 tgttctttca tagctgtcgt tgttgaatat aatatacata gatagcgatg tgcagggatt
     1681 tttacccagc cagctaactt tactaccttc cttgaaggtg gatcttttta agatgaccat
     1741 tcgctcattt gaagaagaaa aacaaaaaac aaaaaaaata ataaaaataa aacaattttt
     1801 acaaagtaat gggattcaaa gaaaggaaaa aaagattttt cttttttgtc aaaatatcga
     1861 tccaatcaga ttggtaaaaa cccccacaca aattaaagag gaataataaa aattgcaaaa
     1921 ataaaaaaaa acttttgcaa atttttttat ttttccttct ttcttttata tcatgtgaac
     1981 taaaacagtc ttctgttagg ggatgggggc aagggggata cctgatgaca ttaacaattt
     2041 aataacatta acattgttgc caaagaggtg gtctctttgc tgaaaatggg tttcaagaaa
     2101 aatctatttt tataaaatat aaagaatttt tacaagagaa tctggatttg agaaaaaaat
     2161 attttgactg gctaatttag gggaaattga caactttgtc gcgttcatac tgcactggta
     2221 actttttaga gatcaagatg tgtgttttaa actggattcg tagactgttt tttgaaggat
     2281 gggctataaa cagatgatct tcatatcttt tcatagcatg taataataat taaaaaacaa
     2341 ttattaatta ctaggggaaa ggagtgttcg ttctacccag ggtaccacag ttccccacag
     2401 tcaaaaccca aaagcaagga gatgagttga aagacagttt ttctttaagt catcagtatg
     2461 ggatgtcagc agaacaaaaa ttaaaaagat taattttcct tttgatctaa aacttcctta
     2521 gtttgagcag taggtgctac aaaattattt acatatctta gtatcatagt taaatgtaat
     2581 gtgtttagga gaggaaaaca aaagatacat ttgctttaaa ttcattaaga aattttcaaa
     2641 ttcactttgt agcccatgct gatagaattg ggctgtgttg gtacatttga aacactgttt
     2701 atgttgcttg aaacacttat ttatttaatc gccgatgtga tgatgcctat ggccgagatc
     2761 aaatatagct agattggcta gactacttat ttgtttactt aaactatggg aagaagcata
     2821 ttattgtgtc attctgttgt gtgtgtatgt gtatatacaa tataaatata tatatataaa
     2881 gttatttttt ctttgggtta atttattata agttgtaaca cttggctagt tttgtttgta
     2941 tatgtcttaa aatgttttct tatgatattt aagtgacagt taaagaggta tcaaggtaac
     3001 ttgtgtagaa ctattctttg atatattgtc atgtttgttg tgaatatttt ttcttactgc
     3061 acagtagaaa aataaaaaca actgagtctt tattttaatg taactcagat tggggaaaac
     3121 aaaacagagc taagggaaca aaatgactga gggagcactc tcccacgtcc agtgcactga
     3181 tcattttagt atgtttgtgc tttgtacggt tatatattta aaacgaaaac aaaacaaaaa
     3241 aatacaaggg ttcatgctct tccctgggta atagaaacag ttactcgcta tgcataatct
     3301 agttgatagt taaatttgct attgcttttc ttgtcttgtt atataaaatc ttttcaatac
     3361 aagtttagtc ttaatggtaa taaaacgtta tggttattta taacttgtgc ttattttgtg
     3421 cattttttcc catgctgaac ccactaagtg catgtagaca ggactgttgt tttcacactg
     3481 aaaaggcaaa ctttgtagta gtcgttgtag tggtagacag ataacgaata ccaaggctgc
     3541 atcatagact cctcctttaa attttttttc tgtttttttt tcctcttttc ggttttggat
     3601 ataacaccag atttcagttc agagaacact cgttcaacat tcagggaaag ctttttacgt
     3661 cacctgctat gaatgaacgt agtttgctgg caaagttttg atgcatttgc taagcattag
     3721 tgggaaaggc atgccaaaat cttctctata atgtgttcaa tcttggggga aaaaaaaagg
     3781 aaaaaaaatc ttaggaccag gcagttgtat actttagtta ttaatgaatg acttcatgtt
     3841 aatcttgcta gtttagatga tttccaaggg aaagtattgt aaatgttttt ttttcataat
     3901 cttgttgtgt ttgaattatt tgtactttat ctgtccagac aataaatgaa agtgtgtaga
     3961 atgga
//
