LOCUS       NM_001420               4742 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens ELAV like RNA binding protein 3 (ELAVL3), transcript
            variant 1, mRNA.
ACCESSION   NM_001420
VERSION     NM_001420.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4742)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4742)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4742)
  AUTHORS   Cai,R., Zhao,F., Zhou,H., Wang,Z., Lin,D., Huang,L., Xie,W.,
            Chen,J., Zhou,L., Zhang,N. and Huang,C.
  TITLE     A tumor-associated autoantibody panel for the detection of
            non-small cell lung cancer
  JOURNAL   Front Oncol 12, 1056572 (2022)
   PUBMED   36531074
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4742)
  AUTHORS   Diaz-Garcia,S., Ko,V.I., Vazquez-Sanchez,S., Chia,R.,
            Arogundade,O.A., Rodriguez,M.J., Traynor,B.J., Cleveland,D. and
            Ravits,J.
  TITLE     Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic
            and familial amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 142 (6), 985-1001 (2021)
   PUBMED   34618203
  REMARK    GeneRIF: Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in
            sporadic and familial amyotrophic lateral sclerosis.
REFERENCE   5  (bases 1 to 4742)
  AUTHORS   Lu,Y.L., Liu,Y., McCoy,M.J. and Yoo,A.S.
  TITLE     MiR-124 synergism with ELAVL3 enhances target gene expression to
            promote neuronal maturity
  JOURNAL   Proc Natl Acad Sci U S A 118 (22) (2021)
   PUBMED   34031238
  REMARK    GeneRIF: MiR-124 synergism with ELAVL3 enhances target gene
            expression to promote neuronal maturity.
REFERENCE   6  (bases 1 to 4742)
  AUTHORS   Park,S., Myszka,D.G., Yu,M., Littler,S.J. and Laird-Offringa,I.A.
  TITLE     HuD RNA recognition motifs play distinct roles in the formation of
            a stable complex with AU-rich RNA
  JOURNAL   Mol Cell Biol 20 (13), 4765-4772 (2000)
   PUBMED   10848602
  REMARK    Erratum:[Mol Cell Biol. 2004 Aug;24(15):6888]
REFERENCE   7  (bases 1 to 4742)
  AUTHORS   King,P.H.
  TITLE     RNA-binding analyses of HuC and HuD with the VEGF and c-myc
            3'-untranslated regions using a novel ELISA-based assay
  JOURNAL   Nucleic Acids Res 28 (7), E20 (2000)
   PUBMED   10710437
REFERENCE   8  (bases 1 to 4742)
  AUTHORS   Sakai,K., Kitagawa,Y. and Hirose,G.
  TITLE     Analysis of the RNA recognition motifs of human neuronal ELAV-like
            proteins in binding to a cytokine mRNA
  JOURNAL   Biochem Biophys Res Commun 256 (2), 263-268 (1999)
   PUBMED   10079173
REFERENCE   9  (bases 1 to 4742)
  AUTHORS   Van Tine,B.A., Knops,J.F., Butler,A., Deloukas,P., Shaw,G.M. and
            King,P.H.
  TITLE     Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence
            in situ hybridization utilizing a novel tyramide labeling technique
  JOURNAL   Genomics 53 (3), 296-299 (1998)
   PUBMED   9799595
REFERENCE   10 (bases 1 to 4742)
  AUTHORS   Sakai,K., Gofuku,M., Kitagawa,Y., Ogasawara,T., Hirose,G.,
            Yamazaki,M., Koh,C.S., Yanagisawa,N. and Steinman,L.
  TITLE     A hippocampal protein associated with paraneoplastic neurologic
            syndrome and small cell lung carcinoma
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1200-1208 (1994)
   PUBMED   7511893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008481.9, BI117592.1,
            BC014144.2, L26405.1, AL512714.1 and AI199100.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001420.3.
            
            Summary: A member of the ELAVL protein family, ELAV-like 3 is a
            neural-specific RNA-binding protein which contains three RNP-type
            RNA recognition motifs. The observation that ELAVL3 is one of
            several Hu antigens (neuronal-specific RNA-binding proteins)
            recognized by the anti-Hu serum antibody present in sera from
            patients with paraneoplastic encephalomyelitis and sensory
            neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two
            alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.28665.1,
                                           SRR3476690.447031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359227.8/ ENSP00000352162.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC008481.9         64989-65046         c
            59-65               BI117592.1         2-8
            66-1569             BC014144.2         1-1504
            1570-2234           L26405.1           1254-1918
            2235-3233           AL512714.1         27-1025
            3234-3593           AL512714.1         1027-1386
            3594-4573           AL512714.1         1389-2368
            4574-4604           AL512714.1         2370-2400
            4605-4740           AI199100.1         1-136               c
            4741-4742           AC008481.9         35326-35327         c
FEATURES             Location/Qualifiers
     source          1..4742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4742
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /note="ELAV like RNA binding protein 3"
                     /db_xref="GeneID:1995"
                     /db_xref="HGNC:HGNC:3314"
                     /db_xref="MIM:603458"
     exon            1..447
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1542
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /note="isoform 1 is encoded by transcript variant 1; Hu
                     antigen C; ELAV like neuron-specific RNA binding protein
                     3; paraneoplastic limbic encephalitis antigen 21;
                     paraneoplastic cerebellar degeneration-associated antigen;
                     ELAV-like protein 3; hu-antigen C; ELAV (embryonic lethal,
                     abnormal vision, Drosophila)-like 3 (Hu antigen C)"
                     /codon_start=1
                     /product="ELAV-like protein 3 isoform 1"
                     /protein_id="NP_001411.2"
                     /db_xref="CCDS:CCDS32912.1"
                     /db_xref="GeneID:1995"
                     /db_xref="HGNC:HGNC:3314"
                     /db_xref="MIM:603458"
                     /translation="MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN
                     YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNG
                     LKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQ
                     VTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHL
                     YQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLS
                     GGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTN
                     YDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA"
     exon            448..667
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     exon            668..771
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     exon            772..925
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1151
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1190
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..4742
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /note="hexamer: AACAAA"
     polyA_site      3491
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /note="major polyA site"
     regulatory      4722..4727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /note="hexamer: AATAAA"
     polyA_site      4742
                     /gene="ELAVL3"
                     /gene_synonym="HUC; HUCL; PLE21"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgga gcgcgcagcg cgggccggag ggagggaggg agggtgggcg aggggagagg
       61 acttgaacac acgggaccgg acaggaccga ccgaggggcg gcggcgaaag gcagagcgcc
      121 gcgatctctg tcgggaagcg caacctcccc gggccccgcg gggccgcgca gggggcgtcc
      181 tcaaccccgc gcccgctccc tctttccatc ccctgccgcc cgcaggccac cccggggccc
      241 ggccatccgc gcgcgcatcc ccgggttcgg gcccgtccct ggccctcgag ggagccgccg
      301 ccttcatcgc cacatctgca gcggccgcac cagaggccgc ccgggcggga ccccagcgtg
      361 agcatcgggc gcccccctag gagtgcacca cccccggagc ccccctcaac acggaccgcg
      421 cccgccgggc acacaagaat ggtcactcag atactggggg ccatggagtc tcaggtgggg
      481 gggggcccgg ccggcccggc cctgcccaac gggccactcc ttggtacaaa tggagccact
      541 gacgacagca agaccaacct catcgtcaac tacctgcccc agaacatgac ccaggatgag
      601 ttcaagagtc tcttcggcag cattggcgac atcgagtcct gcaagttggt tcgggacaag
      661 atcacagggc agagccttgg ctacgggttt gtgaactatt ctgaccccaa tgatgcagac
      721 aaagccatca acaccctcaa cggcctcaaa ttacagacga agaccatcaa ggtgtcctat
      781 gccagaccca gttcagcatc catccgggat gctaacctgt acgtcagcgg gctccccaag
      841 accatgagcc agaaagagat ggagcagctc ttctcccagt acggccgcat catcacgtcc
      901 cgcatcctgg tggaccaggt cacaggtgtc tctcggggtg tgggattcat ccgctttgac
      961 aagaggattg aggccgaaga ggctatcaaa ggactgaatg ggcagaagcc gctgggcgca
     1021 gctgagccca tcacagtcaa gttcgcgaac aacccaagtc agaagacggg gcaggcgctg
     1081 ctcacccacc tctaccagtc atccgcccgg cgctacgcag gccccctaca ccatcagacc
     1141 cagcgtttcc ggctggacaa tttgctcaac atggcctacg gcgtcaagag tcccctgtcg
     1201 ctcatcgcca ggttctcgcc gatcgccatc gatggtatga gcggcctggc gggcgtgggc
     1261 ctgtcggggg gcgcggcggg cgccggctgg tgcatcttcg tgtacaacct gtcaccggag
     1321 gcagacgaga gcgtgctgtg gcagctgttc gggccttttg gggcagtcac caacgtcaag
     1381 gtcatccgtg atttcaccac caacaagtgc aagggtttcg gcttcgtgac catgaccaac
     1441 tatgacgagg cggccatggc catcgccagc ctgaacggct atcgcctggg cgagcgcgtg
     1501 ctgcaggtct ccttcaagac cagcaaacag cacaaggcgt gagcccaccc cgcctgccct
     1561 cccaccccct ccccgggcag cagagagaga gagagagaaa gagagagaga gagagagaag
     1621 gggcccaaga gagacagcac aggcagcccc acggacgacg cgagggcccc acgtccctgc
     1681 ggaagccaca gggtgagcac tctggggtgg gagggtctgc agggaattgg gggggtgccc
     1741 ggggatcccc cgccccatcc tcctgccccc accccaggct gggctgttca ctctctcgtc
     1801 ttggtttggt tcatggtgaa ggtttttgtt tcttttttcg gctaaaaaga atgcagagat
     1861 gtgcccccac ccccaccctc gaccaccccc gatgggatgg cttggggggc tccagggggt
     1921 gccctcccag acccccttgc ccaggcctcc ccagcaccta ggtggggcct ggggtaggag
     1981 gaacaggttt aaaaatcccc aaaaaagcga accgtgagga ggggtgtggg cacccccggc
     2041 ccagtgcccc ctggtggaat gcgggggagc aggcagtggg gctggaagca gaaacaaaat
     2101 gaaaaaaaaa ggggggtggg aggggaagaa aaactctatt tttgtaaaaa gggaaaaaga
     2161 cctcgtggag aatttttact ggggattctt gaacttgaaa aaaaaaaaca caaaaaaaga
     2221 caaaaaaaaa aaaagaaaat attttggcag gttatgttta ccaactgggg cgggggtggg
     2281 gggggcccag ggagcagggc ttaggggcta gcagcccacg gggccacaca gagaaacaac
     2341 cacgcagaca gtcacaccac ggggacacac ggacagacgc agacggacac agcgacatgc
     2401 cccagacacg ttaagggact ggttggccaa actcagacac gtggacaggg atagacagaa
     2461 agagacagaa gctggggcta cgtccatgtg gacacagacc acagatgtgg gcacacgaat
     2521 ccatccacct gtccacgtgc acacgtgaat gtagcgatag atatttggac atcaaatttg
     2581 gacaccaggt cacggagaaa cacaaacacc acccaggaac acgcagacat atgcccatag
     2641 catcccacag gcccaggcag gaggtcccac cccagaccct gccccagacg ctccctcacc
     2701 ctctcggccc cctcgccctg gcccccaggt tctctgcaga gatctctcct ggacccccag
     2761 cggtctcctt ggcgcccacg aacacaggcg tgcacacgca gcgcacatgc attgagacac
     2821 acgatacctc gttccacctt ggcgtcacgg tgggctggag gcagcccccc cccccacaac
     2881 acttgaggcc aaaggacacc cctgtccccg gggctcagcc tccccctggg ccgaggcctt
     2941 ggcccacaca gctgagggag aggcccagcc ctgagcctcc cccaccagga ctgggcctcc
     3001 ccggcagcaa gaccccggca ctccccgcca ggcccagggt ggggtggatg ggcccaaagg
     3061 cccagcccca cactcctttc ccgtccactt gtcacctacc tatccccttt cggtttgttg
     3121 ggtttttcgt ctttccagat tgcagtggac acagcccccg atctcgagcc ccggcccccg
     3181 gcttctgtct ggacattgca tcgccctagt tttctttctt taaaaaaaaa aaattccaac
     3241 agaagccaca ggccggagcc cctgggagcc ctcgcaccgc tccccacccc actcagcggc
     3301 cccatcggaa ctgagaattg caaaaccccc gactttagct atagttaagt tgccttcccc
     3361 cggtgtcccc acgtttggtg tctggctatg gcgcccccat ctgactgtcc agctctctct
     3421 cccccacccc tcccggtgtt gttattaaac gtctgtggag cttctgctgc aaggaacaaa
     3481 aaagaaaaaa atcaaaaaag cgacaaaaaa acacaaacag aagaggaaaa aaaagcaaca
     3541 aaaaaagaaa acacacagaa gagatttaaa aaaaaaaaag gaaaaaaaaa aaagacataa
     3601 actggcacca gttaactttc ttgtactttt ttgctgaatt tagcttcttg tagttttaac
     3661 ttattgctat gttaactatt tattctcctc gttgccctgt aaggacatcc gtgtatattt
     3721 ctgttacttc atccggtttg caagttaaag gaacgacaat gttctctttg tttctttaag
     3781 ttttgccgag acatggttat gcctaattta tttataaaag gggaagtgga atcattaaag
     3841 taataataat tattaataac agtaatggta gccgagtggc acgcgggggc gtgtgctctg
     3901 cgggacagtc cccacggcca gcgacgtcca ggtcaccaat gggattcttt ttgctcttgt
     3961 cttgagaatt ttttcagtcc tatttagctg gtgaaatccc tagcttgttc ttgatacacg
     4021 aacctattta ttctcgtggt tttaagtcct ccctgccctc tctcctctcc cctgcagcag
     4081 ggcagggacc cctctcccct gctgtctctt ggggctctct cccctccgcc ctctgcattc
     4141 gggaacacgc acgtccgcgt gggaagcttg cagcagggcg tccgagcaat aagggctggg
     4201 tttgtccccc accctggggg gggccaggct ccagagaggg ggcacctccc cacacacccc
     4261 ccccccaccg aggcctaggc ccctgccacc cccaagactg ggaggggact tctttttcta
     4321 aaacacaaaa ctcagcccag ccaggccccc tccctggagg ccagcccctc cccgcagggg
     4381 gccaggccgg ggctcccagg cgagggggac ttggggcttc cacgtccctg gggggcaggg
     4441 gccaggccag gggggagggg gctcagcccc tccacccctc ccttcatcct gttatttatt
     4501 cggaaggttt caaatcacga cagagtccat gttggaggtg ataaaaaact gtaaaaaaaa
     4561 aaaaaaaaaa aaagacaaaa caaaagacaa aaaaaaaaaa aaaacccaac aagaacactt
     4621 cgcgttgcgt ttagactatt tattaccggg atcacaggcc tggccgcggt aacagacttt
     4681 tacatggaat tgtttaatta tttgtacttt tcatgccaga aaataaaagt tcagaatctt
     4741 aa
//
