LOCUS       NM_004432               3983 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ELAV like RNA binding protein 2 (ELAVL2), transcript
            variant 1, mRNA.
ACCESSION   NM_004432
VERSION     NM_004432.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Yuan,S.G., Zheng,K., Chen,M. and Zhang,Z.
  TITLE     Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein
            Interaction Network in Rheumatoid Arthritis and Construction of
            Molecular Subtypes in Peripheral Blood
  JOURNAL   Altern Ther Health Med 30 (1), 134-141 (2024)
   PUBMED   37773661
  REMARK    GeneRIF: Analysis of Enrichment Pathway, Hub Gene, and
            Protein-Protein Interaction Network in Rheumatoid Arthritis and
            Construction of Molecular Subtypes in Peripheral Blood.
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Nekoeian,S., Ferdowsian,S., Asgari,Y. and Azizi,Z.
  TITLE     Identification of Hub Genes Associated with Resistance to
            Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene
            Co-expression Network Analysis
  JOURNAL   Mol Biotechnol 65 (11), 1913-1922 (2023)
   PUBMED   36877306
  REMARK    GeneRIF: Identification of Hub Genes Associated with Resistance to
            Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene
            Co-expression Network Analysis.
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3983)
  AUTHORS   Xie,Y., Wu,H., Hu,W., Zhang,H., Li,A., Zhang,Z., Ren,S. and
            Zhang,X.
  TITLE     Identification of Hub Genes of Lung Adenocarcinoma Based on
            Weighted Gene Co-Expression Network in Chinese Population
  JOURNAL   Pathol Oncol Res 28, 1610455 (2022)
   PUBMED   36032660
  REMARK    GeneRIF: Identification of Hub Genes of Lung Adenocarcinoma Based
            on Weighted Gene Co-Expression Network in Chinese Population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3983)
  AUTHORS   Li,X., Dong,L., Yu,H., Zhang,Y. and Wang,S.
  TITLE     Bioinformatic Analysis Identified Hub Genes Associated with
            Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood
            Mononuclear Cells
  JOURNAL   Genes (Basel) 12 (12), 1888 (2021)
   PUBMED   34946837
  REMARK    GeneRIF: Bioinformatic Analysis Identified Hub Genes Associated
            with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood
            Mononuclear Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3983)
  AUTHORS   Han,J., Knops,J.F., Longshore,J.W. and King,P.H.
  TITLE     Localization of human elav-like neuronal protein 1 (Hel-N1) on
            chromosome 9p21 by chromosome microdissection polymerase chain
            reaction and fluorescence in situ hybridization
  JOURNAL   Genomics 36 (1), 189-191 (1996)
   PUBMED   8812435
REFERENCE   7  (bases 1 to 3983)
  AUTHORS   Gao,F.B. and Keene,J.D.
  TITLE     Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP
            structures and are implicated in neuronal differentiation
  JOURNAL   J Cell Sci 109 (Pt 3), 579-589 (1996)
   PUBMED   8907704
REFERENCE   8  (bases 1 to 3983)
  AUTHORS   King,P.H.
  TITLE     Hel-N2: a novel isoform of Hel-N1 which is conserved in rat neural
            tissue and produced in early embryogenesis
  JOURNAL   Gene 151 (1-2), 261-265 (1994)
   PUBMED   7828887
REFERENCE   9  (bases 1 to 3983)
  AUTHORS   Gao,F.B., Carson,C.C., Levine,T. and Keene,J.D.
  TITLE     Selection of a subset of mRNAs from combinatorial 3' untranslated
            region libraries using neuronal RNA-binding protein Hel-N1
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11207-11211 (1994)
   PUBMED   7972035
REFERENCE   10 (bases 1 to 3983)
  AUTHORS   King,P.H., Levine,T.D., Fremeau,R.T. Jr. and Keene,J.D.
  TITLE     Mammalian homologs of Drosophila ELAV localized to a neuronal
            subset can bind in vitro to the 3' UTR of mRNA encoding the Id
            transcriptional repressor
  JOURNAL   J Neurosci 14 (4), 1943-1952 (1994)
   PUBMED   8158249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161628.9 and AL445623.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004432.4.
            
            Summary: In humans, the ELAV like RNA binding protein gene family
            has four members (ELAVL1-4). ELAVL RNA binding proteins recognize
            AU-rich elements in the 3' UTRs of gene transcripts and thereby
            regulate gene expression post-transcriptionally. The protein
            encoded by this gene binds to several 3' UTRs, including its own
            and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and,
            like ELAVL3 and ELAVL4, is expressed specifically in neurons and
            primarily localizes to the cytoplasm. This protein also forms a
            cytosolic complex with the normally nuclear-localized ELAVL1
            protein. Alternative splicing of this gene results in multiple
            transcript variants encoding distinct protein isoforms. [provided
            by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (1) encodes isoform (a). Variants
            1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.138910.1,
                                           SRR1660805.45795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397312.7/ ENSP00000380479.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AL161628.9         176041-176475       c
            436-679             AL161628.9         112241-112484       c
            680-783             AL161628.9         81257-81360         c
            784-937             AL445623.2         180745-180898       c
            938-1163            AL445623.2         177206-177431       c
            1164-1202           AL445623.2         169275-169313       c
            1203-3983           AL445623.2         165931-168711       c
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..3983
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /note="ELAV like RNA binding protein 2"
                     /db_xref="GeneID:1993"
                     /db_xref="HGNC:HGNC:3313"
                     /db_xref="MIM:601673"
     exon            1..435
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     exon            436..679
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1530
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /note="isoform a is encoded by transcript variant 1;
                     ELAV-like protein 2; nervous system-specific RNA-binding
                     protein Hel-N1; hu-antigen B; ELAV (embryonic lethal,
                     abnormal vision, Drosophila)-like 2 (Hu antigen B); ELAV
                     like neuron-specific RNA binding protein 2"
                     /codon_start=1
                     /product="ELAV-like protein 2 isoform a"
                     /protein_id="NP_004423.2"
                     /db_xref="CCDS:CCDS6515.1"
                     /db_xref="GeneID:1993"
                     /db_xref="HGNC:HGNC:3313"
                     /db_xref="MIM:601673"
                     /translation="METQLSNGPTCNNTANGPTTINNNCSSPVDSGNTEDSKTNLIVN
                     YLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNG
                     LRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQ
                     VTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQL
                     YQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGHPGTGW
                     CIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAI
                     ASLNGYRLGDRVLQVSFKTNKTHKA"
     exon            680..783
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     exon            784..937
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1163
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1202
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..3983
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3966..3971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /note="hexamer: AACAAA"
     polyA_site      3983
                     /gene="ELAVL2"
                     /gene_synonym="HEL-N1; HELN1; HUB"
                     /note="major polyA site"
ORIGIN      
        1 aagacgtcct cccccctatt tctgttctta gttagagatg cagcagctta ctcctgtagc
       61 gacctactaa aaagcaacaa ggagaaagac atcgtctttt tgaaaaaacg ttctttcgtc
      121 tcttttcttt gttccttggt ttgtttttct tgcccctttt tgtttagttg aacggcaata
      181 ggagggtagt ctctccgtct ttttaaactc ttttttaagt ttcccctccc ctttcatatt
      241 ttttttcgcc atttctttta gcattggact ttggggtcga aagcgtttct ttttatttgc
      301 ttcttttaag ccgagcacag tttaggtttc gtgctgtctt aagagaacta tccagcagct
      361 tcttgctcat ccttattggg agaactgcac cgttacttta aaaacacaca tacacaaaaa
      421 ccttaaggga gaaagcaggt aattgctgcc atggaaacac aactgtctaa tgggccaact
      481 tgcaataaca cagccaatgg tccaaccacc ataaacaaca actgttcgtc accagttgac
      541 tctgggaaca cagaagacag caagaccaac ttaatagtca actaccttcc tcagaacatg
      601 acacaggagg aactaaagag tctctttggg agcattggtg aaatagagtc ctgtaagctt
      661 gtaagagaca aaataacagg gcagagcttg ggatatggct ttgtgaacta cattgacccc
      721 aaggatgcag agaaagctat caacaccctg aatggattga gacttcaaac caaaacaata
      781 aaagtttcct atgctcgccc aagttcagct tctatcagag atgcaaattt atatgtcagc
      841 ggacttccaa aaacaatgac ccagaaggag ttggaacagc ttttttcaca atatggacgc
      901 attattactt ctcgtattct tgtcgaccag gtcactggca tatcaagggg tgtagggttt
      961 attcgatttg acaagcgaat tgaggcagaa gaagctatca aaggcctaaa tggccagaaa
     1021 cctcccggtg ccacggagcc aatcactgta aagtttgcta ataacccaag ccaaaaaacc
     1081 aatcaggcca tcctttccca gctgtaccag tctccaaaca gaaggtatcc aggaccgcta
     1141 gctcagcagg cacagcgttt taggttggac aatctgctca atatggctta tggagtaaag
     1201 aggttttctc caatgaccat tgacggaatg accagtttgg ctggaattaa tatccctggg
     1261 caccctggaa cagggtggtg tatatttgtg tacaacctgg ctcctgacgc agatgagagt
     1321 atcctgtggc aaatgtttgg gccttttgga gctgtcacca atgtgaaggt catccgtgac
     1381 tttaacacca ataaatgcaa aggttttgga tttgtgacta tgacaaacta tgatgaggct
     1441 gccatggcga tagctagcct caatggatac cgtctgggag acagagtact gcaggtctcc
     1501 tttaagacaa acaaaacgca caaagcctaa tgagctcttg tcctcagtcc atttatatat
     1561 gaaaactata caacaaaggc aagttaagag aaactttata cattagtaaa tgtctttgta
     1621 agtcagtgtt gagatgggga taaaatgact acttagcatc ctaagaaata tgtgagattt
     1681 tttattgcta gtatttgaat taaaacttct taaatatctt ttatgtttga atatggacaa
     1741 gaggtacagg gtttttacct gtcacattgc attctattgc cttctttgaa gaaggtggac
     1801 cttttaaagt gtttcagcta agggaagaca tttcttttct ttttacataa ctgccttgaa
     1861 cctgtgagta aatattgagg ctttgtgttg taattcttca gttggttgtg tctttttttt
     1921 cccccctttt tttccttttt ctgattagct ttgtgtttgg tttacattta aagcattgct
     1981 gttatgtctg tttaagaaaa gtattttgaa gtttacattt ttatttatga agtttaaaac
     2041 agtatttatt ttgtaattat gatttgggtt ggggaagggg gggctacatt ataaacgctt
     2101 attgtaagaa tactggagaa cttttcgtaa agcagtacct tgccaaagag ataagagcct
     2161 ctttgatgtg ggtttaaaaa aagcatctat ttttataaaa aagaaaattt ggagaaactt
     2221 tttactggtc ctggaacaaa tattttgact tgaatacttt gagaaatctc ttcatatgac
     2281 acctagtgag cttttaaaat ttaccaggaa atttgcagcg gttggaaaat ttagaaagat
     2341 ttatggtgta gaaaatactt ttgagatctt tgtatgaaag gagtagaatc aatgggggga
     2401 aacactgctg gtttcatttt tgtaatcacc agtggagcgt ctgatcatcc tggttattat
     2461 gtgataggtg gctcacattg atttgtgatt ttgaaacaaa taaaaaaaat ttacaaaaga
     2521 atatataaga gcaggcaaga aatttaaatt accgagagat gggggaaaaa atctgttctt
     2581 cctaaagaaa tcccttcaga tagagctcat ggtgtttagt gatgtacttg cagtattgtt
     2641 tgaagaattg ttttgtctta aggaaaaaag acgttgcaca tgatttgtac tgcagcaaat
     2701 cagcaaaagt gatctgagtt ggatatattt gaaggtattt tgaaagttac gttcaaggct
     2761 aacacctgag ctttgtgtaa tgtaaataag accttgtgtt tatgaacctt tcagctaatt
     2821 taattttttt tcccttacat gccaagtgat gttcaggttt tgaatgtttt tgtatcagtt
     2881 ttttcctttg taaatggcat taacattgtt acttgaggtc ttgcttaatc acttttgttg
     2941 tcctgaggac ttgaatttac agtgcatcag atttgttgca aattttgtct gtagatagtc
     3001 tagcttcagc tgtttatggt gatgctacat tttggtttat aaatatgttt gtggtataaa
     3061 aaaatgagta taaccatagg ttttgaacaa atttccttac atttttcata caaaaatcat
     3121 aaatatctgt atgctattga aatttaactt tgtatgatgc ttaaaaacca ctatttgggg
     3181 aaataataaa ataagtcttt accatgtatg aaagaaattt taaaaaatac aaaatatttt
     3241 ctgattagca tctagcttat aataaatttt caaaaaagct gaaggcaaaa atgccttcat
     3301 caggatgcac tgagaactat atagttacgt cctgcttttt gtataaactg agatgctcac
     3361 atgcttcccc ttagaacagg caatgtgcta tgcataacat agttgtacat tatctttgcg
     3421 gttgctttga gttttatttt ttattattta aaattgtagt tataaaattt ttcagtatag
     3481 tacagtacat atactgtgag gcgcgtgcta aagtgaataa gcgagttttc atgctgaccc
     3541 actcaatgct attcagaaat caattggctt agcactttct catatcctta ggtgcattta
     3601 gattgccaga gttaaccttc tgcgtttaaa aaaagaaaaa cactaaaaaa taaaatacat
     3661 gtatatactt aaaaaaaaat aataaggttt ccctcaaggg aaaacagcag ctacatgctt
     3721 ctttcctata ctactgtagc aaaccaaggc attgatgaga gggcatgcaa attgtgcttc
     3781 actttacagt gttttatcag agcacttaat aaaatgtaag gctggtattt atttgaagtt
     3841 gtacagtatg acttaattca catctgttgg aatagaaaat atattctgtt gagtatttaa
     3901 gaggctgtac atgttttctt ttgtgtttgg attctttgta ctttttcatg ttcagtacat
     3961 caataaacaa agttgaaggg aaa
//
