LOCUS       NM_001419               6054 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens ELAV like RNA binding protein 1 (ELAVL1), mRNA.
ACCESSION   NM_001419
VERSION     NM_001419.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6054)
  AUTHORS   Cai,Z., Zhai,X., Xu,J., Hong,T., Yang,K., Min,S., Du,J., Cai,Z.,
            Wang,Z., Shen,M., Wang,D. and Shen,Y.
  TITLE     ELAVL1 regulates PD-L1 mRNA stability to disrupt the infiltration
            of CD4-positive T cells in prostate cancer
  JOURNAL   Neoplasia 57, 101049 (2024)
   PUBMED   39265220
  REMARK    GeneRIF: ELAVL1 regulates PD-L1 mRNA stability to disrupt the
            infiltration of CD4-positive T cells in prostate cancer.
REFERENCE   2  (bases 1 to 6054)
  AUTHORS   Cui,Y., Wen,H., Tang,J., Chen,J., Zhou,J., Hou,M., Rong,X., Lan,Y.
            and Wu,Q.
  TITLE     ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells
            through the HMGB3/beta-catenin axis
  JOURNAL   Mol Med 30 (1), 172 (2024)
   PUBMED   39390359
  REMARK    GeneRIF: ELAVL1 regulates glycolysis in nasopharyngeal carcinoma
            cells through the HMGB3/beta-catenin axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6054)
  AUTHORS   Adamoski,D., M Dos Reis,L., Mafra,A.C.P., Correa-da-Silva,F.,
            Moraes-Vieira,P.M.M., Berindan-Neagoe,I., Calin,G.A. and
            Dias,S.M.G.
  TITLE     HuR controls glutaminase RNA metabolism
  JOURNAL   Nat Commun 15 (1), 5620 (2024)
   PUBMED   38965208
  REMARK    GeneRIF: HuR controls glutaminase RNA metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6054)
  AUTHORS   Long,J., Zhao,W., Xiang,Y., Wang,Y., Xiang,W., Liu,X., Jiang,M.,
            Song,Y. and Hu,J.
  TITLE     STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding
            protein HuR to inhibit IL-1beta-induced IL-8 production
  JOURNAL   Int Immunopharmacol 133, 112065 (2024)
   PUBMED   38608448
  REMARK    GeneRIF: STAT3 promotes cytoplasmic-nuclear translocation of
            RNA-binding protein HuR to inhibit IL-1beta-induced IL-8
            production.
REFERENCE   5  (bases 1 to 6054)
  AUTHORS   Liu,C., Lin,Y., Wang,Y., Lin,S., Zhou,J., Tang,H., Yi,X., Ma,Z.,
            Xia,T., Jiang,B., Tian,F., Ju,Z., Liu,B., Gu,X., Yang,Z. and
            Wang,W.
  TITLE     HuR promotes triglyceride synthesis and intestinal fat absorption
  JOURNAL   Cell Rep 43 (5), 114238 (2024)
   PUBMED   38748875
  REMARK    GeneRIF: HuR promotes triglyceride synthesis and intestinal fat
            absorption.
REFERENCE   6  (bases 1 to 6054)
  AUTHORS   Blaxall,B.C., Pellett,A.C., Wu,S.C., Pende,A. and Port,J.D.
  TITLE     Purification and characterization of beta-adrenergic receptor
            mRNA-binding proteins
  JOURNAL   J Biol Chem 275 (6), 4290-4297 (2000)
   PUBMED   10660597
REFERENCE   7  (bases 1 to 6054)
  AUTHORS   Wang,W., Furneaux,H., Cheng,H., Caldwell,M.C., Hutter,D., Liu,Y.,
            Holbrook,N. and Gorospe,M.
  TITLE     HuR regulates p21 mRNA stabilization by UV light
  JOURNAL   Mol Cell Biol 20 (3), 760-769 (2000)
   PUBMED   10629032
REFERENCE   8  (bases 1 to 6054)
  AUTHORS   Sakai,K., Kitagawa,Y. and Hirose,G.
  TITLE     Analysis of the RNA recognition motifs of human neuronal ELAV-like
            proteins in binding to a cytokine mRNA
  JOURNAL   Biochem Biophys Res Commun 256 (2), 263-268 (1999)
   PUBMED   10079173
REFERENCE   9  (bases 1 to 6054)
  AUTHORS   Ma,W.J. and Furneaux,H.
  TITLE     Localization of the human HuR gene to chromosome 19p13.2
  JOURNAL   Hum Genet 99 (1), 32-33 (1997)
   PUBMED   9003489
REFERENCE   10 (bases 1 to 6054)
  AUTHORS   Ma,W.J., Cheng,S., Campbell,C., Wright,A. and Furneaux,H.
  TITLE     Cloning and characterization of HuR, a ubiquitously expressed
            Elav-like protein
  JOURNAL   J Biol Chem 271 (14), 8144-8151 (1996)
   PUBMED   8626503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU542524.1, BC003376.2,
            W37464.1, AI375368.1, AL713686.1, AW139417.1, BM696191.1 and
            BM664469.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001419.2.
            
            Summary: The protein encoded by this gene is a member of the ELAVL
            family of RNA-binding proteins that contain several RNA recognition
            motifs, and selectively bind AU-rich elements (AREs) found in the
            3' untranslated regions of mRNAs. AREs signal degradation of mRNAs
            as a means to regulate gene expression, thus by binding AREs, the
            ELAVL family of proteins play a role in stabilizing ARE-containing
            mRNAs. This gene has been implicated in a variety of biological
            processes and has been linked to a number of diseases, including
            cancer. It is highly expressed in many cancers, and could be
            potentially useful in cancer diagnosis, prognosis, and therapy.
            [provided by RefSeq, Sep 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.172621.1, BC003376.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407627.7/ ENSP00000385269.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               BU542524.1         5-136
            133-2354            BC003376.2         100-2321
            2355-2459           W37464.1           238-342
            2460-2878           AI375368.1         65-483
            2879-5072           AL713686.1         268-2461
            5073-5343           AW139417.1         9-279               c
            5344-5813           BM696191.1         1-470
            5814-6054           BM664469.1         18-258              c
FEATURES             Location/Qualifiers
     source          1..6054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6054
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /note="ELAV like RNA binding protein 1"
                     /db_xref="GeneID:1994"
                     /db_xref="HGNC:HGNC:3312"
                     /db_xref="MIM:603466"
     exon            1..147
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /inference="alignment:Splign:2.1.0"
     exon            148..335
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1144
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /note="Hu antigen R; embryonic lethal, abnormal vision,
                     drosophila, homolog-like 1; hu-antigen R; Human antigen R;
                     ELAV (embryonic lethal, abnormal vision, Drosophila)-like
                     1 (Hu antigen R)"
                     /codon_start=1
                     /product="ELAV-like protein 1"
                     /protein_id="NP_001410.2"
                     /db_xref="CCDS:CCDS12193.1"
                     /db_xref="GeneID:1994"
                     /db_xref="HGNC:HGNC:3312"
                     /db_xref="MIM:603466"
                     /translation="MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIG
                     EVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEV
                     IKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEA
                     EEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRF
                     RFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVI
                     RDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK"
     exon            336..439
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /inference="alignment:Splign:2.1.0"
     exon            440..593
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /inference="alignment:Splign:2.1.0"
     exon            594..819
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /inference="alignment:Splign:2.1.0"
     exon            820..6054
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2328..2333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /note="hexamer: ATTAAA"
     polyA_site      2354
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /note="major polyA site"
     regulatory      5401..5406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /note="hexamer: AATAAA"
     polyA_site      5440
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
     regulatory      6030..6035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
                     /note="hexamer: AATAAA"
     polyA_site      6054
                     /gene="ELAVL1"
                     /gene_synonym="ELAV1; Hua; HUR; MelG"
ORIGIN      
        1 gtgcgcgctg aggaggagcc gctgccgccg tcgccgtcgc cgccaccgcc gccaccgcta
       61 ccgaggccga gcggagccgt tagcgccgcg ccgccgccgc ctcccgcccg ccccggagca
      121 gccccgggcc cgcccgcccg catccagatt tttgaaaaat acaatgtcta atggttatga
      181 agaccacatg gccgaagact gcaggggtga catcgggaga acgaatttga tcgtcaacta
      241 cctccctcag aacatgaccc aggatgagtt acgaagcctg ttcagcagca ttggtgaagt
      301 tgaatctgca aaacttattc gggataaagt agcaggacac agcttgggct atggctttgt
      361 gaactacgtg accgcgaagg atgcagagag agcgatcaac acgctgaacg gcttgaggct
      421 ccagtcaaaa accattaagg tgtcgtatgc tcgcccgagc tcagaggtga tcaaagacgc
      481 caacttgtac atcagcgggc tcccgcggac catgacccag aaggacgtag aagacatgtt
      541 ctctcggttt gggcggatca tcaactcgcg ggtcctcgtg gatcagacta caggtttgtc
      601 cagaggggtt gcgtttatcc ggtttgacaa acggtcggag gcagaagagg caattaccag
      661 tttcaatggt cataaacccc caggttcctc tgagcccatc acagtgaagt ttgcagccaa
      721 ccccaaccag aacaaaaacg tggcactcct ctcgcagctg taccactcgc cagcgcgacg
      781 gttcggaggc cccgttcacc accaggcgca gagattcagg ttctccccca tgggcgtcga
      841 tcacatgagc gggctctctg gcgtcaacgt gccaggaaac gcctcctccg gctggtgcat
      901 tttcatctac aacctggggc aggatgccga cgaggggatc ctctggcaga tgtttgggcc
      961 gtttggtgcc gtcaccaatg tgaaagtgat ccgcgacttc aacaccaaca agtgcaaagg
     1021 gtttggcttt gtgaccatga caaactatga agaagccgcg atggccatag ccagcctgaa
     1081 cggctaccgc ctgggggaca aaatcttaca ggtttccttc aaaaccaaca agtcccacaa
     1141 ataactcgct catgcttttt tttgtacgga atagataatt aagagtgaag gagttgaaac
     1201 ttttcttgtt agtgtacaac tcattttgcg ccaattttca caagtgtttg tctttgtctg
     1261 aatgagaagt gagaaggttt ttatactctg ggatgcaacc gacatgttca aatgtttgaa
     1321 atcccacaat gttagaccaa tcttaagttt cgtaagttat ttcctttaag atatatatta
     1381 aacagaaatc taagtagaac tgcattgact aaccagtccc tctggatggt ggtgaacctg
     1441 aagcatgctt taacctctaa gactgtctaa cacgcgtttc attcaatgtc tccacagact
     1501 gggtagcaaa aaaatcacct tttagtttta gtttttaatc taaagatgtt agacagatgc
     1561 tgagtgtgcg ttttctcaac cgcttcaaca ttgtaagcga tgtatgcttt ggttgacagg
     1621 aagttccttt tccaggcagg tcccgttgcc acctcctgct cactcagtcc cgggctctgc
     1681 cgagtggtcc tgggaatggc ggcgggcccg tccagcgtgg gccaccactg gggccggggg
     1741 ccacgggctg catgctgggc gggccctcca gagaaggaca caaacgtgtt tcgtaagccc
     1801 aggcaccaat gggaatggac caaagagttt cagggaaact ccagtatatt ccagagtcag
     1861 atctaagctc caggcacgcc tgaagatgtg ttgctactct gacatcccga gtttctgtcc
     1921 acacattgca tgcacagcgc cccacacatt ggatactgtt gttcacgata atttctcccg
     1981 ttttccagag catttaacat agcttggagg cgtaaaatgg ctctgtattt taataacaca
     2041 gaaacatttg agcattgtat ttctcgcatc ccttctcgtg agcgcttaga cctttttcta
     2101 ttttagtcgg attttgtttt ggaattttgc ttttgtatga acactcagca gaaaagtact
     2161 tacttcttgc cagttatcta ttaaccaaaa cctttgattt gtagttttaa agattaaccc
     2221 tcaaagttct cttcataact gccttgacat tttgggttgt tctgttctgt taattttctt
     2281 ttgctttttt gtgttttttg tttgttttta cttttgcatt taagaccatt aaatttgatt
     2341 ttgttttgct cgaattttgt tttgtttttt attttacctt ttctttcttt ttggctaggg
     2401 aaggtgcagg tggcccagca ttcagggagg agtcgtaaga tcttaagaaa ccaatccttg
     2461 cctcaagcaa aagcatttct gaatctgtga cgcaagaatg tgcagttaca ggctggtggc
     2521 ttttaaacca ggagcccgga ggaagggtga aagagaaagc ctgtgaaata ggcagggcca
     2581 gatcacccaa aactcctcag gactgggatc tggcgtttat aaataactag tttacagaga
     2641 gaatcacaaa caggataact tagtaccagc agtttttaac cttgacgtga gactaaaacg
     2701 tgaccgtagg ctgtttttta gttattgctc tcatgagatg atggctgtat ttatctgttt
     2761 atttatacct atttatgtat ttatttattg aagtgtgaaa ttgagcaata ggcaggcacc
     2821 accgtcccca gagcaggtca gcgtctcgag aggcccctgg acaattgagg atgcccatcc
     2881 cctccccttt ccctgatctt ttactgaggg gctgtgtgcg cgatccttgc aaattgatga
     2941 tgttgccatc cgtacccagg ctgtgtctca taaaagtcgg cctggtgcca gagaggacct
     3001 cctttctccc acagaatccc agatcctcag gaaaagccaa aaccgaggcc cattgcccgg
     3061 attcgacaca aaagagggtc cctgctctgt tgcccgagag cagtctgcat cctgggacca
     3121 gaatgctttc ctggaaaaag aagcctttca ggtttccctg ggccagcatc ttctgatgga
     3181 aggtgggagc caacaccctt ctgatggaag gtgggagcca acacccttct gatggaaggt
     3241 gggagccaac acccttctga tggaaggtgg gagccaacac ccttctgatg gaaggtggga
     3301 gccaacaccc ttctgatgga aggcgggatt cccgcttctg aaactccccc tggagtctca
     3361 ctcccacaca tgcccatagc tagcattcaa cagagaactc tgtcttaagc ttcaactgtg
     3421 aaaatgatga cgggcttgta gcacctcagc ttctttcctc gccccctttt atctgaatcc
     3481 tatcaattat tctgatgctg ggacaggtga gaagaaactg tgaagtatat gagcctttga
     3541 aagttccctg aagtttctca gttcaggaac attctcattg tatgtggtct ccgctgtttg
     3601 aacagccttc tagctaaaaa attccaaagc ctttatttgg gagtcttagc ttgcaagctt
     3661 gtggaaggat ttagcttaac aactgtcact cctgaaaagc aatctctgtt ccatcaaggt
     3721 tctagttgct ggccctgtgt cctcaaagtt cattacatct tatcaaggcc tgtttgcaaa
     3781 ggggagatcc cttttcttaa aaaaggctca acccaaaaga aaccatttct taaaaaattt
     3841 tacatagatc agttgtattt ctatttagca aaaatgagtg ctctgctttt atttgggaat
     3901 ttcgatgaaa aagcgttcag agtagataat gttcatttat caaaaatctg gtttgggaaa
     3961 taccaaagag gctttgattg aattcccttt tgacccgtgt gtaacttcct ctggtagtta
     4021 gaccccaggc agctccgaat ttgtgaacct gcttcctgat gaattctccc ttgttccccc
     4081 ttggctctgc cattatttcg ttttcagtgt aatttgccaa gccgcagttt tctgtgctgg
     4141 ctgtgcctct agtcgcagct ctgtgactga ttccctcccg ggtgctgagt cccctccccg
     4201 gccaccatcc tgcgtgaata tcctgaaatt catgggcttc ctcgggggcc cgcccgcagg
     4261 tggtgctggg tgggttccgc caccttctcc tggaaggtga gccttttcct ggccaagggc
     4321 agctgcctta acctctgaga gtctgcgctt ggccttagtc ctggagaccc agcctccagg
     4381 gactgaaccg tgctgctgtt gggagccaag accggccctt tggagccggc agcccagggg
     4441 tccctgctgg atcagagaaa tagaagcacc cgaagacggt tagtggcaat tccttgaccc
     4501 ggtttgcttc caaatgaagg ccatttgtcc accaggcatt gaaaagacat gacttaccca
     4561 gtccggcatc ggacttgaaa aatcgaaatt gacatcactc agctgttaca tttcacatcc
     4621 gattcagccc ccttttattt ccatgtgctt ttcgcagcct tcctgtgttg gatgaaagag
     4681 aataagaatt cagctgacag gaggcctcta tcctgtccct ccaccccacc ctccacctca
     4741 atcccctccc atcttcccca gacctacctc acctactagg acctgaggca gctccttagc
     4801 agagacccct ggggtttagc tgactctggg ggtcaggggt tcctgtcccc aaacttcgca
     4861 agacagccct gaagtcacaa gtgctttctt ttaagtggca ttggcaattg gcgtgtaatg
     4921 atggcagtag aatctgaatc tcggatccca ggcagggttc acatttccaa acctttttga
     4981 tttcccctga cctctaatgg ctggatccta tttttctaca acctttcagt gacatcgttc
     5041 aggtttcttt cttggccatt taaaaaaaca aatttttttt ttctcacttg taagtcaccg
     5101 ccagtaccta agttaggcta acggagactt tgacaggact ggatttttct tccaccagaa
     5161 gagaagcctt ttccgttggt ttggggccac ctctttgacc atgaccatgt gatgttccgt
     5221 ttacagtgac ttgctttggg ggaggggagg ctctcttaac cgattcccat gttgtacagt
     5281 agatggttag accttttgta tattagtgtg ttttaagtta ttgatttgtt ttatataaaa
     5341 taatttattt ttcaggtgcc atttttcatt ttaactttgt ttttacatgg gtttgttttc
     5401 aataaagtct gacactggtg tccaaaagtc aacaataaaa tgaatcccat tgtgttcttt
     5461 tgaagatgcc tatgtaactt ttaagctttt taaattattt tcagaaaaaa aaaaagaaaa
     5521 gcccttatca gttttccatc agcccattgc ctttttattt ttttttttta atccttgtga
     5581 ataaatgttc tttagtgttt taggaggaaa aagcaaacct agattttgat aacccagaag
     5641 acttcagatt aataaagaag ctttgaaaga agaccatttt tcaaaatttt agtgaagtgt
     5701 gaatattttt tgtcaatggc tttctcaaag agaatgaaac ttttgcacca ttttcagagt
     5761 ttttatagag atgccaaatt gatatattta catgtaatgg aaacatgaaa aagttttatt
     5821 aaacaattgt tcatagctgt gtagacattt taattcagtt tccaaagctc tcaaaaaatc
     5881 gtatttttga agtacggagt gatgcggttt ggggcgtggc ttacagttcc aacgactcaa
     5941 ttgtcccgat actcagttct ttctacaggt atcaggttcg tgttaaacgc tgtatgttaa
     6001 ctatgactgg aattctgtga tattttggta ataaatgaag tgggatcatt gcga
//
