LOCUS       NM_020775               6880 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens endosome-lysosome associated apoptosis and autophagy
            regulator 1 (ELAPOR1), transcript variant 1, mRNA.
ACCESSION   NM_020775
VERSION     NM_020775.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6880)
  AUTHORS   Cho,C.J., Park,D. and Mills,J.C.
  TITLE     ELAPOR1 is a secretory granule maturation-promoting factor that is
            lost during paligenosis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 322 (1), G49-G65 (2022)
   PUBMED   34816763
  REMARK    GeneRIF: ELAPOR1 is a secretory granule maturation-promoting factor
            that is lost during paligenosis.
REFERENCE   2  (bases 1 to 6880)
  AUTHORS   Stinnesbeck,M., Kristiansen,A., Ellinger,J., Hauser,S., Egevad,L.,
            Tolkach,Y. and Kristiansen,G.
  TITLE     Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer
  JOURNAL   APMIS 129 (4), 204-212 (2021)
   PUBMED   33455017
  REMARK    GeneRIF: Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate
            cancer.
REFERENCE   3  (bases 1 to 6880)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    GeneRIF: Inceptor counteracts insulin signalling in beta-cells to
            control glycaemia.
            Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z. PMID: 33712809]
REFERENCE   4  (bases 1 to 6880)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6880)
  AUTHORS   Meseure,D., Drak Alsibai,K., Vacher,S., Hatem,R., Nicolas,A.,
            Callens,C., Lerebours,F. and Bieche,I.
  TITLE     Altered Expression of Three EGFR Posttranslational Regulators MDGI,
            MIG6, and EIG121 in Invasive Breast Carcinomas
  JOURNAL   Anal Cell Pathol (Amst) 2020, 9268236 (2020)
   PUBMED   32377505
  REMARK    GeneRIF: Altered Expression of Three EGFR Posttranslational
            Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6880)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 6880)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 6880)
  AUTHORS   Deng,L., Broaddus,R.R., McCampbell,A., Shipley,G.L., Loose,D.S.,
            Stancel,G.M., Pickar,J.H. and Davies,P.J.
  TITLE     Identification of a novel estrogen-regulated gene, EIG121, induced
            by hormone replacement therapy and differentially expressed in type
            I and type II endometrial cancer
  JOURNAL   Clin Cancer Res 11 (23), 8258-8264 (2005)
   PUBMED   16322283
  REMARK    GeneRIF: Down-regulation of KIAA1324 protein is associated with
            endometrial cancer
REFERENCE   9  (bases 1 to 6880)
  AUTHORS   Bauer,M., Aust,G. and Schumacher,U.
  TITLE     Different transcriptional expression of KIAA1324 and its splicing
            variants in human carcinoma cell lines with different metastatic
            capacity
  JOURNAL   Oncol Rep 11 (3), 677-680 (2004)
   PUBMED   14767521
REFERENCE   10 (bases 1 to 6880)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL138933.18 and AL356389.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_020775.4.
            
            Summary: Expression of this gene is induced by estrogen and the
            encoded protein has been characterized as a transmembrane protein.
            The encoded protein has been found in to correlate with survival in
            certain carcinomas (PMID: 21102415) and may be important for
            cellular response to stress (PMID: 21072319). Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.110792.1,
                                           SRR1803615.237380.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369939.8/ ENSP00000358955.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AL138933.18        6337-6558
            223-343             AL356389.20        10258-10378
            344-536             AL356389.20        12863-13055
            537-684             AL356389.20        20230-20377
            685-765             AL356389.20        20852-20932
            766-871             AL356389.20        21838-21943
            872-1021            AL356389.20        22052-22201
            1022-1110           AL356389.20        33409-33497
            1111-1288           AL356389.20        36541-36718
            1289-1417           AL356389.20        37430-37558
            1418-1508           AL356389.20        37956-38046
            1509-1614           AL356389.20        39730-39835
            1615-1752           AL356389.20        40090-40227
            1753-2016           AL356389.20        40975-41238
            2017-2190           AL356389.20        42785-42958
            2191-2371           AL356389.20        45838-46018
            2372-2468           AL356389.20        46343-46439
            2469-2570           AL356389.20        46937-47038
            2571-2697           AL356389.20        48218-48344
            2698-2876           AL356389.20        48423-48601
            2877-3042           AL356389.20        49099-49264
            3043-6880           AL356389.20        51308-55145
FEATURES             Location/Qualifiers
     source          1..6880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..6880
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /note="endosome-lysosome associated apoptosis and
                     autophagy regulator 1"
                     /db_xref="GeneID:57535"
                     /db_xref="HGNC:HGNC:29618"
                     /db_xref="MIM:611298"
     exon            1..222
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..3111
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /note="isoform 1 is encoded by transcript variant 1;
                     maba1; estrogen-induced gene 121 protein"
                     /codon_start=1
                     /product="endosome/lysosome-associated apoptosis and
                     autophagy regulator 1 isoform 1"
                     /protein_id="NP_065826.3"
                     /db_xref="CCDS:CCDS794.1"
                     /db_xref="GeneID:57535"
                     /db_xref="HGNC:HGNC:29618"
                     /db_xref="MIM:611298"
                     /translation="MAEPGHSHHLSARVRGRTERRIPRLWRLLLWAGTAFQVTQGTGP
                     ELHACKESEYHYEYTACDSTGSRWRVAVPHTPGLCTSLPDPIKGTECSFSCNAGEFLD
                     MKDQSCKPCAEGRYSLGTGIRFDEWDELPHGFASLSANMELDDSAAESTGNCTSSKWV
                     PRGDYIASNTDECTATLMYAVNLKQSGTVNFEYYYPDSSIIFEFFVQNDQCQPNADDS
                     RWMKTTEKGWEFHSVELNRGNNVLYWRTTAFSVWTKVPKPVLVRNIAITGVAYTSECF
                     PCKPGTYADKQGSSFCKLCPANSYSNKGETSCHQCDPDKYSEKGSSSCNVRPACTDKD
                     YFYTHTACDANGETQLMYKWAKPKICSEDLEGAVKLPASGVKTHCPPCNPGFFKTNNS
                     TCQPCPYGSYSNGSDCTRCPAGTEPAVGFEYKWWNTLPTNMETTVLSGINFEYKGMTG
                     WEVAGDHIYTAAGASDNDFMILTLVVPGFRPPQSVMADTENKEVARITFVFETLCSVN
                     CELYFMVGVNSRTNTPVETWKGSKGKQSYTYIIEENTTTSFTWAFQRTTFHEASRKYT
                     NDVAKIYSINVTNVMNGVASYCRPCALEASDVGSSCTSCPAGYYIDRDSGTCHSCPTN
                     TILKAHQPYGVQACVPCGPGTKNNKIHSLCYNDCTFSRNTPTRTFNYNFSALANTVTL
                     AGGPSFTSKGLKYFHHFTLSLCGNQGRKMSVCTDNVTDLRIPEGESGFSKSITAYVCQ
                     AVIIPPEVTGYKAGVSSQPVSLADRLIGVTTDMTLDGITSPAELFHLESLGIPDVIFF
                     YRSNDVTQSCSSGRSTTIRVRCSPQKTVPGSLLLPGTCSDGTCDGCNFHFLWESAAAC
                     PLCSVADYHAIVSSCVAGIQKTTYVWREPKLCSGGISLPEQRVTICKTIDFWLKVGIS
                     AGTCTAILLTVLTCYFWKKNQKLEYKYSKLVMNATLKDCDLPAADSCAIMEGEDVEDD
                     LIFTSKKSLFGKIKSFTSKRTPDGFDSVPLKTSSGGLDMDL"
     exon            223..343
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            344..536
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            537..684
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            685..765
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            766..871
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1021
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1110
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1288
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1417
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1508
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1614
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1752
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..2016
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2190
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2371
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2468
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2570
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2697
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2876
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3042
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..6880
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /note="hexamer: AATATA"
     polyA_site      3328
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /note="major polyA site"
     regulatory      6684..6689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /note="hexamer: ATTAAA"
     polyA_site      6716
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
     regulatory      6861..6866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
                     /note="hexamer: AATAAA"
     polyA_site      6880
                     /gene="ELAPOR1"
                     /gene_synonym="EIG121; KIAA1324"
ORIGIN      
        1 cgccttctgc cagcagaagc agcagccgca gcacctgagc cgctactgcc gctcactcag
       61 gacaacgcta tggctgagcc tgggcacagc caccatctct ccgccagagt caggggaaga
      121 actgagaggc gcataccccg gctgtggcgg ctgctgctct gggctgggac cgccttccag
      181 gtgacccagg gaacgggacc ggagcttcat gcctgcaaag agtctgagta ccactatgag
      241 tacacggcgt gtgacagcac gggttccagg tggagggtcg ccgtgccgca taccccgggc
      301 ctgtgcacca gcctgcctga ccccatcaag ggcaccgagt gctccttctc ctgcaacgcc
      361 ggggagtttc tggatatgaa ggaccagtca tgtaagccat gcgctgaggg ccgctactcc
      421 ctcggcacag gcattcggtt tgatgagtgg gatgagctgc cccatggctt tgccagcctc
      481 tcagccaaca tggagctgga tgacagtgct gctgagtcca ccgggaactg tacttcgtcc
      541 aagtgggttc cccggggcga ctacatcgcc tccaacacgg acgaatgcac agccacactg
      601 atgtacgccg tcaacctgaa gcaatctggc accgttaact tcgaatacta ctatccagac
      661 tccagcatca tctttgagtt tttcgttcag aatgaccagt gccagcccaa tgcagatgac
      721 tccaggtgga tgaagaccac agagaaagga tgggaattcc acagtgtgga gctaaatcga
      781 ggcaataatg tcctctattg gagaaccaca gccttctcag tatggaccaa agtacccaag
      841 cctgtgctgg tgagaaacat tgccataaca ggggtggcct acacttcaga atgcttcccc
      901 tgcaaacctg gcacgtatgc agacaagcag ggctcctctt tctgcaaact ttgcccagcc
      961 aactcttatt caaataaagg agaaacttct tgccaccagt gtgaccctga caaatactca
     1021 gagaaaggat cttcttcctg taacgtgcgc ccagcttgca cagacaaaga ttatttctac
     1081 acacacacgg cctgcgatgc caacggagag acacaactca tgtacaaatg ggccaagccg
     1141 aaaatctgta gcgaggacct tgagggggca gtgaagctgc ctgcctctgg tgtgaagacc
     1201 cactgcccac cctgcaaccc aggcttcttc aaaaccaaca acagcacctg ccagccctgc
     1261 ccatatggtt cctactccaa tggctcagac tgtacccgct gccctgcagg gactgaacct
     1321 gctgtgggat ttgaatacaa atggtggaac acgctgccca caaacatgga aacgaccgtt
     1381 ctcagtggga tcaacttcga gtacaagggc atgacaggct gggaggtggc tggtgatcac
     1441 atttacacag ctgctggagc ctcagacaat gacttcatga ttctcactct ggttgtgcca
     1501 ggatttagac ctccgcagtc ggtgatggca gacacagaga ataaagaggt ggccagaatc
     1561 acatttgtct ttgagaccct ctgttctgtg aactgtgagc tctacttcat ggtgggtgtg
     1621 aattctagga ccaacactcc tgtggagacg tggaaaggtt ccaaaggcaa acagtcctat
     1681 acctacatca ttgaggagaa cactaccacg agcttcacct gggccttcca gaggaccact
     1741 tttcatgagg caagcaggaa gtacaccaat gacgttgcca agatctactc catcaatgtc
     1801 accaatgtta tgaatggtgt ggcctcctac tgccgtccct gtgccctaga agcctctgat
     1861 gtgggctcct cctgcacctc ttgtcctgct ggttactata ttgaccgaga ttcaggaacc
     1921 tgccactcct gccccactaa cacaattctg aaagcccacc agccttatgg tgtccaggcc
     1981 tgtgtgccct gtggtccagg gaccaagaac aacaagatcc actctctgtg ctacaacgat
     2041 tgcaccttct cacgcaacac tccgaccagg actttcaact acaacttctc cgctttggca
     2101 aacactgtca ctcttgctgg agggccaagc ttcacttcca aagggctgaa atacttccat
     2161 cactttaccc tcagtctctg tggaaaccag ggtaggaaaa tgtctgtgtg caccgacaat
     2221 gtcactgacc tccggattcc tgagggtgag tcagggttct ccaaatctat cacagcctac
     2281 gtctgccagg cagtcatcat ccccccagag gtgacaggct acaaggccgg ggtttcctca
     2341 cagcctgtca gccttgctga tcgacttatt ggggtgacaa cagatatgac tctggatgga
     2401 atcacctccc cagctgaact tttccacctg gagtccttgg gaataccgga cgtgatcttc
     2461 ttttataggt ccaatgatgt gacccagtcc tgcagttctg ggagatcaac caccatccgc
     2521 gtcaggtgca gtccacagaa aactgtccct ggaagtttgc tgctgccagg aacgtgctcg
     2581 gatgggacct gtgatggctg caacttccac ttcctgtggg agagcgcggc tgcttgcccg
     2641 ctctgctcag tggctgacta ccatgctatc gtcagcagct gtgtggctgg gatccagaag
     2701 actacttacg tgtggcgaga acccaagcta tgctctggtg gcatttctct gcctgagcag
     2761 agagtcacca tctgcaaaac catagatttc tggctgaaag tgggcatctc tgcaggcacc
     2821 tgtactgcca tcctgctcac cgtcttgacc tgctactttt ggaaaaagaa tcaaaaacta
     2881 gagtacaagt actccaagct ggtgatgaat gctactctca aggactgtga cctgccagca
     2941 gctgacagct gcgccatcat ggaaggcgag gatgtagagg acgacctcat ctttaccagc
     3001 aagaagtcac tctttgggaa gatcaaatca tttacctcca agaggactcc tgatggattt
     3061 gactcagtgc cgctgaagac atcctcagga ggcctagaca tggacctgtg agaggcactg
     3121 cctgcctcac ctgcctcctc accttgcata gcacctttgc aagcctgcgg cgatttgggt
     3181 gccagcatcc tgcaacaccc actgctggaa atctcttcat tgtggcctta tcagatgttt
     3241 gaatttcaga tcttttttta tagagtaccc aaaccctcct ttctgcttgc ctcaaacctg
     3301 ccaaatatac ccacactttg tttgtaaatt atgcccttgc ttgtatcttg tttcccaaaa
     3361 tggcccatcc gccagagcca tagcttcgtc tgctcataat tcttatagct ttggaatgaa
     3421 aatatttcta tcttcttaag tatagaaact atttcctctg tcctctaact taagggcaga
     3481 aacagctggg agttttcctc gcatgccctc agctcatgat ctcttcagga gagaggctgg
     3541 gtgaggaggg tgtcggggtt ccctggtgga taatcttcat agcagcctgg atccatttcc
     3601 cctggataac cagctcaaag ggagtgaaaa tggtagtctg agggcaaggg gagcaaggcc
     3661 tgggtaagaa aagccttgaa aagcataaaa agaggccggg cgcggtggct cacgcctgta
     3721 atcccagcac tttgggaggc cgaggcgggc agatcatgag gtcgggagat tgagaccatc
     3781 ctggctaaca cggtgaaacc ccgtctctac taaaaataca aaaaattagc cgggcgtggt
     3841 ggcgggtgcc tgtagtccca gctactcggg aggctgaggc gggagaatag cgtgaacctg
     3901 gaaggcggag cttgcagtga gccgagatcg cgccactgca ctccatccag cctgggtgac
     3961 agagtgagac tctgcctcaa aaaaaaaaaa aaaaaaaaag aaaagcacaa agagaggcaa
     4021 caaggaatgt ttttgttttt gagacaggct ctcactctgt cacctaggct ggagtgcagt
     4081 ggcataatca ctgttcagtg cagcctcaag ctcttgggct caagctatcc tcccatctca
     4141 acctctcaag tagctaggac tacaagtgtg caccaccagg ctcactaatt tttatatttt
     4201 ttgtagacac agggtttcac catgttgccc aggctggtct ccaactcctg ggctcaagtg
     4261 atctgtccgc ctcagcctcc caaactgctg ggattacagg cataagccac tgcactcagc
     4321 cttttatttg ttttttaaac cacgtagctc attgccttct cttaagtaaa tgatagatat
     4381 tctcactgaa gccaaaggaa taagttcatc aagaaaatgc ccaaagccct ggtggataca
     4441 tcctccctat ctttttttta aaccttccac tatcactcta tgacactgaa aagaaccagg
     4501 taagccccaa acccagatgt tccagcctta tcctctgttg ggtttaccca cagacatagc
     4561 aaaccctgtc agtgaggaaa attccccatc cttgagtgcc cccgtcctag aagtttgggc
     4621 catattatgg aacaggggtc tcttatttga aaagagcaca aggaggccaa gattttaatg
     4681 gggcacttta ggggatacag cccacaatgg catgggcctg aggtggccgt gatgtctgct
     4741 tctaagctta acgcatctgc tcaggcacag aataaacgtc taggctggcc aaaaaaggaa
     4801 ctgaatccca ggcccatacg ccagcaccag aatcaaacca gtcttcaagg aaggaaggct
     4861 aggagagttt aacaagattt tcactgggcc cagcatggtg gctcacacct gtaatcccaa
     4921 ggcagaatgg tggcttgagc tcaggagttc aagaccagcc tgggcaacac agtgagaccc
     4981 tgtctctaaa aaatttaaaa ataaacaagg tgttcaccaa gctgggatac ttctcactat
     5041 taagccccta tctttctctt tttttcattc tcaattgctt tgtgtgataa aaaactaaag
     5101 agacttctgg tccaatttct ggcaacatcc cttctgaaag gtgagtagag tgggtgtctt
     5161 ctatgcccat tttccccaat tttacacaaa ctattatcaa tgaactttta agtacctaga
     5221 atgggtaaaa ccagagcaag actttaaatt accttcttct ttcttctact ggcagttctg
     5281 cctccatcac tatcaggcta gggtgacctt cccttggtca agccccaatt gcccatgatt
     5341 tgtgcctgtg ccctttctcc agtgaccatt tggtgaccag atggtagata tagaaagggg
     5401 atggcatttg caagtgacta gtctgccaca aaatgctcat ctgattagcc actgctgccc
     5461 tggcaatggc tttgtaagag tcaatgagaa ctagagccag gctgtggtcc ctggccatca
     5521 acagtgttgg tgacggcagg gagtcccttt ggtttaataa atccagtttt tctttgggta
     5581 tccaaattct cccctccttt tgtaggagtc aggctctcag aacctgtgtc catgttggaa
     5641 cttcccccag tgtggatgca gatacgcagc tcctgagctc cagcctaaag tcttctgtag
     5701 cctcagcaat acttgggcac ctgctgtctc actgaatagc tttcttttgt gacaaaggcc
     5761 acagacagcc cttagactat tccggaaaca gtaggaaaaa ttacatatgt ctttgacttc
     5821 tttattctga ctccactgat tttagccata atactttaag gagctacttt ttactacccc
     5881 ttaccgtgct gacttctgca ggtctgccct gtgacctgtc aggaactcct gagttacgct
     5941 actggggtca cctgttgctc ccctagcaag ttaggcatgt catatatttt taacagcttt
     6001 attgagatat aattcacata ttacacaatt cacctttaaa acatacgatt caatggtttt
     6061 cagcaaactc acagagttgt ccgcccactt gagagcaaac acatgttcaa ttttcttttc
     6121 cttttttttt ttgagacaga gtcagctttg ttgcccaggc tggagtgcag tgccatgatc
     6181 ttggctcact gcagcctccc catcctgggt tcaagtgatc cttctgcttc agcctcccca
     6241 gtagctggga ttacaagcat gcgccaccac gcctagctaa tttttgtgtt tttagtagag
     6301 atggggtttc accatgttgg ccaggctggt ctcaaactcc tggactcaag tgatccaccc
     6361 acctcggcct cccaaagtgc tgggattaca ggtgtaagcc accgtgcctg gcctacatgt
     6421 tcaattttct atgaacaaag gctttagtcc ttgacccagg gctaaagtgg tctgtccaag
     6481 ctgttgttgg tagagggagt atgataaaat gtttaaatct catttggtta ccttgagtcc
     6541 tggaacatgc agtaactgtc atgctataga catcatctgt atttggctgg gaatacaaat
     6601 gaagattgtg gtgtattcaa gcagtagggt ttttgctttt gtttttgttt tagtgccaac
     6661 aaaacttttt tttgtctgac tacattaaag ataagactga ctatatttat acaacagaaa
     6721 ctttgtaata gattttttca gctttgtgaa atcgaatttt ttttcatcag ggctggttgg
     6781 atttcctttt taccctgtaa tccaagcgtt aatagtttgt tagaagatgg gttattgcat
     6841 gtcacttttt ttttttgtaa aataaaaaca taccttacaa
//
