LOCUS       NM_018127               3767 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens elaC ribonuclease Z 2 (ELAC2), transcript variant 1,
            mRNA.
ACCESSION   NM_018127
VERSION     NM_018127.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3767)
  AUTHORS   Blinka,S., Mishra,R. and Hsieh,A.C.
  TITLE     ELAC2 is a functional prostate cancer risk allele
  JOURNAL   Trends Mol Med 29 (8), 586-588 (2023)
   PUBMED   37353407
  REMARK    GeneRIF: ELAC2 is a functional prostate cancer risk allele.
REFERENCE   2  (bases 1 to 3767)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3767)
  AUTHORS   Zahiri,Z. and Zahiri,F.
  TITLE     A Study of Ser217Leu and Ala541Thr Polymorphism in the Men
            Afflicted with Prostate Cancer and in the Men being Suspicious of
            Prostate Cancer
  JOURNAL   Asian Pac J Cancer Prev 21 (6), 1551-1557 (2020)
   PUBMED   32592348
  REMARK    GeneRIF: A Study of Ser217Leu and Ala541Thr Polymorphism in the Men
            Afflicted with Prostate Cancer and in the Men being Suspicious of
            Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3767)
  AUTHORS   Saoura,M., Powell,C.A., Kopajtich,R., Alahmad,A., Al-Balool,H.H.,
            Albash,B., Alfadhel,M., Alston,C.L., Bertini,E., Bonnen,P.E.,
            Bratkovic,D., Carrozzo,R., Donati,M.A., Di Nottia,M., Ghezzi,D.,
            Goldstein,A., Haan,E., Horvath,R., Hughes,J., Invernizzi,F.,
            Lamantea,E., Lucas,B., Pinnock,K.G., Pujantell,M., Rahman,S.,
            Rebelo-Guiomar,P., Santra,S., Verrigni,D., McFarland,R.,
            Prokisch,H., Taylor,R.W., Levinger,L. and Minczuk,M.
  TITLE     Mutations in ELAC2 associated with hypertrophic cardiomyopathy
            impair mitochondrial tRNA 3'-end processing
  JOURNAL   Hum Mutat 40 (10), 1731-1748 (2019)
   PUBMED   31045291
  REMARK    GeneRIF: Our study thus broadly confirms the correlation of ELAC2
            variants with severe infantile-onset forms of HCM and mitochondrial
            respiratory chain dysfunction.
REFERENCE   5  (bases 1 to 3767)
  AUTHORS   Noda,D., Itoh,S., Watanabe,Y., Inamitsu,M., Dennler,S., Itoh,F.,
            Koike,S., Danielpour,D., ten Dijke,P. and Kato,M.
  TITLE     ELAC2, a putative prostate cancer susceptibility gene product,
            potentiates TGF-beta/Smad-induced growth arrest of prostate cells
  JOURNAL   Oncogene 25 (41), 5591-5600 (2006)
   PUBMED   16636667
  REMARK    GeneRIF: candidate prostate cancer susceptibility gene ELAC2
            potentiates TGF-beta/Smad-induced transcriptional responses
REFERENCE   6  (bases 1 to 3767)
  AUTHORS   Takaku,H., Minagawa,A., Takagi,M. and Nashimoto,M.
  TITLE     A candidate prostate cancer susceptibility gene encodes tRNA 3'
            processing endoribonuclease
  JOURNAL   Nucleic Acids Res 31 (9), 2272-2278 (2003)
   PUBMED   12711671
REFERENCE   7  (bases 1 to 3767)
  AUTHORS   Vesprini,D., Nam,R.K., Trachtenberg,J., Jewett,M.A.,
            Tavtigian,S.V., Emami,M., Ho,M., Toi,A. and Narod,S.A.
  TITLE     HPC2 variants and screen-detected prostate cancer
  JOURNAL   Am J Hum Genet 68 (4), 912-917 (2001)
   PUBMED   11254449
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3767)
  AUTHORS   Xu,J., Zheng,S.L., Carpten,J.D., Nupponen,N.N., Robbins,C.M.,
            Mestre,J., Moses,T.Y., Faith,D.A., Kelly,B.D., Isaacs,S.D.,
            Wiley,K.E., Ewing,C.M., Bujnovszky,P., Chang,B., Bailey-Wilson,J.,
            Bleecker,E.R., Walsh,P.C., Trent,J.M., Meyers,D.A. and Isaacs,W.B.
  TITLE     Evaluation of linkage and association of HPC2/ELAC2 in patients
            with familial or sporadic prostate cancer
  JOURNAL   Am J Hum Genet 68 (4), 901-911 (2001)
   PUBMED   11254448
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3767)
  AUTHORS   Tavtigian,S.V., Simard,J., Teng,D.H., Abtin,V., Baumgard,M.,
            Beck,A., Camp,N.J., Carillo,A.R., Chen,Y., Dayananth,P.,
            Desrochers,M., Dumont,M., Farnham,J.M., Frank,D., Frye,C.,
            Ghaffari,S., Gupte,J.S., Hu,R., Iliev,D., Janecki,T., Kort,E.N.,
            Laity,K.E., Leavitt,A., Leblanc,G., McArthur-Morrison,J.,
            Pederson,A., Penn,B., Peterson,K.T., Reid,J.E., Richards,S.,
            Schroeder,M., Smith,R., Snyder,S.C., Swedlund,B., Swensen,J.,
            Thomas,A., Tranchant,M., Woodland,A.M., Labrie,F., Skolnick,M.H.,
            Neuhausen,S., Rommens,J. and Cannon-Albright,L.A.
  TITLE     A candidate prostate cancer susceptibility gene at chromosome 17p
  JOURNAL   Nat Genet 27 (2), 172-180 (2001)
   PUBMED   11175785
  REMARK    GeneRIF: ELAC2 harbors mutations (including a frameshift and a
            nonconservative missense change) that segregate with prostate
            cancer in two Utah pedigrees
REFERENCE   10 (bases 1 to 3767)
  AUTHORS   Rebbeck,T.R., Walker,A.H., Zeigler-Johnson,C., Weisburg,S.,
            Martin,A.M., Nathanson,K.L., Wein,A.J. and Malkowicz,S.B.
  TITLE     Association of HPC2/ELAC2 genotypes and prostate cancer
  JOURNAL   Am J Hum Genet 67 (4), 1014-1019 (2000)
   PUBMED   10986046
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC394013.1, AF304370.1,
            AC005277.1 and AA706335.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018127.6.
            
            Summary: The protein encoded by this gene has a C-terminal domain
            with tRNA 3' processing endoribonuclease activity, which catalyzes
            the removal of the 3' trailer from precursor tRNAs. The protein
            also interacts with activated Smad family member 2 (Smad2) and its
            nuclear partner forkhead box H1 (also known as FAST-1), and reduced
            expression can suppress transforming growth factor-beta induced
            growth arrest. Mutations in this gene result in an increased risk
            of prostate cancer. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF304370.1, BC004158.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338034.9/ ENSP00000337445.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                DC394013.1         35-114
            81-2988             AF304370.1         1-2908
            2989-3481           AC005277.1         104119-104611
            3482-3767           AA706335.1         11-296              c
FEATURES             Location/Qualifiers
     source          1..3767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3767
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /note="elaC ribonuclease Z 2"
                     /db_xref="GeneID:60528"
                     /db_xref="HGNC:HGNC:14198"
                     /db_xref="MIM:605367"
     exon            1..325
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2561
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /EC_number="3.1.26.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tRNase Z (long form); zinc phosphodiesterase ELAC protein
                     2; ribonuclease Z 2; tRNase Z 2; tRNA 3 endonuclease 2;
                     putative prostate cancer susceptibility protein
                     HPC2/ELAC2; RNase Z 2; elaC homolog protein 2; heredity
                     prostate cancer protein 2; elaC homolog 2; elaC-like
                     protein 2"
                     /codon_start=1
                     /product="zinc phosphodiesterase ELAC protein 2 isoform 1"
                     /protein_id="NP_060597.4"
                     /db_xref="CCDS:CCDS11164.1"
                     /db_xref="GeneID:60528"
                     /db_xref="HGNC:HGNC:14198"
                     /db_xref="MIM:605367"
                     /translation="MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTRE
                     KRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEGVQRLMQEHKLKV
                     ARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKG
                     IELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPLSRLSPERSSDSESN
                     ENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLPVGTAAIAPIIA
                     AVKDGKSITHEGREILAEELCTPPDPGAAFVVVECPDESFIQPICENATFQRYQGKAD
                     APVALVVHMAPASVLVDSRYQQWMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLI
                     HPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEA
                     LQLPNFQQSVQEYRRSAQDGPAPAEKRSQYPEIIFLGTGSAIPMKIRNVSATLVNISP
                     DTSLLLDCGEGTFGQLCRHYGDQVDRVLGTLAAVFVSHLHADHHTGLPSILLQRERAL
                     ASLGKPLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISSPAVERL
                     ISSLLRTCDLEEFQTCLVRHCKHAFGCALVHTSGWKVVYSGDTMPCEALVRMGKDATL
                     LIHEATLEDGLEEEAVEKTHSTTSQAISVGMRMNAEFIMLNHFSQRYAKVPLFSPNFS
                     EKVGVAFDHMKVCFGDFPTMPKLIPPLKALFAGDIEEMEERREKRELRQVRAALLSRE
                     LAGGLEDGEPQQKRAHTEEPQAKKVRAQ"
     exon            326..376
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..447
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..512
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..570
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..639
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..759
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..818
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..877
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..950
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1063
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1159
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1298
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1384
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1503
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1600
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1739
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1778
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1888
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1988
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2109
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2188
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2333
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..3767
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /note="hexamer: AATAAA"
     polyA_site      2988
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /note="major polyA site"
     regulatory      3744..3749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
                     /note="hexamer: AATAAA"
     polyA_site      3767
                     /gene="ELAC2"
                     /gene_synonym="COXPD17; ELC2; HPC2"
ORIGIN      
        1 atgcggagcg gctaggtggt gcacgggaaa cgcgggcgta ggtgaccggc ggctttctca
       61 gttttggtgg agacgggcgc atgtgggcgc tttgctcgct gctgcggtcc gcggccggac
      121 gcaccatgtc gcagggacgc accatatcgc aggcacccgc ccgccgcgag cggccgcgca
      181 aggacccgct gcggcacctg cgcacgcgag agaagcgcgg accgtcgggg tgctccggcg
      241 gcccaaacac cgtgtacctg caggtggtgg cagcgggtag ccgggactcg ggcgccgcgc
      301 tctacgtctt ctccgagttc aaccggtatc tcttcaactg tggagaaggc gttcagagac
      361 tcatgcagga gcacaagtta aaggttgctc gcctggacaa catattcctg acacgaatgc
      421 actggtctaa tgttgggggc ttaagtggaa tgattcttac tttaaaggaa accgggcttc
      481 caaagtgtgt actttctgga cctccacaac tggaaaaata cctcgaagca atcaaaatat
      541 tttctggtcc attgaaagga atagaactgg ctgtgcggcc ccactctgcc ccagaatacg
      601 aggatgaaac catgacagtt taccagatcc ccatacacag tgaacagagg aggggaaagc
      661 accaaccatg gcagagtcca gaaaggcctc tcagcaggct cagtccagag cgatcttcag
      721 actccgagtc gaatgaaaat gagccacacc ttccacatgg tgttagccag agaagagggg
      781 tcagggactc ttccctggtc gtagctttca tctgtaagct tcacttaaag agaggaaact
      841 tcttggtgct caaagcaaag gagatgggcc tcccagttgg gacagctgcc atcgctccca
      901 tcattgctgc tgtcaaggac gggaaaagca tcactcatga aggaagagag attttggctg
      961 aagagctgtg tactcctcca gatcctggtg ctgcttttgt ggtggtagaa tgtccagatg
     1021 aaagcttcat tcaacccatc tgtgagaatg ccacctttca gaggtaccaa ggaaaggcag
     1081 atgcccccgt ggccttggtg gttcacatgg ccccagcatc tgtgcttgtg gacagcaggt
     1141 accagcagtg gatggagagg tttgggcctg acacccagca cttggtcctg aatgagaact
     1201 gtgcctcagt tcacaacctt cgcagccaca agattcaaac ccagctcaac ctcatccacc
     1261 cggacatctt ccccctgctc accagtttcc gctgtaagaa ggagggcccc accctcagtg
     1321 tgcccatggt tcagggtgaa tgcctcctca agtaccagct ccgtcccagg agggagtggc
     1381 agagggatgc cattattact tgcaatcctg aggaattcat agttgaggcg ctgcagcttc
     1441 ccaacttcca gcagagcgtg caggagtaca ggaggagtgc gcaggacggc ccagccccag
     1501 cagagaaaag aagtcagtac ccagaaatca tcttccttgg aacagggtct gccatcccga
     1561 tgaagattcg aaatgtcagt gccacacttg tcaacataag ccccgacacg tctctgctac
     1621 tggactgtgg tgagggcaca tttgggcagc tgtgccgtca ttacggagac caggtggaca
     1681 gggtcctggg caccctggct gctgtgtttg tgtcccacct gcacgcagat caccacacgg
     1741 gcttgccaag tatcttgctg cagagagaac gcgccttggc atctttggga aagccgcttc
     1801 accctttgct ggtggttgcc cccaaccagc tcaaagcctg gctccagcag taccacaacc
     1861 agtgccagga ggtcctgcac cacatcagta tgattcctgc caaatgcctt caggaagggg
     1921 ctgagatctc cagtcctgca gtggaaagat tgatcagttc gctgttgcga acatgtgatt
     1981 tggaagagtt tcagacctgt ctggtgcggc actgcaagca tgcgtttggc tgtgcgctgg
     2041 tgcacacctc tggctggaaa gtggtctatt ccggggacac catgccctgc gaggctctgg
     2101 tccggatggg gaaagatgcc accctcctga tacatgaagc caccctggaa gatggtttgg
     2161 aagaggaagc agtggaaaag acacacagca caacgtccca agccatcagc gtggggatgc
     2221 ggatgaacgc ggagttcatt atgctgaacc acttcagcca gcgctatgcc aaggtccccc
     2281 tcttcagccc caacttcagc gagaaagtgg gagttgcctt tgaccacatg aaggtctgct
     2341 ttggagactt tccaacaatg cccaagctga ttcccccact gaaagccctg tttgctggcg
     2401 acatcgagga gatggaggag cgcagggaga agcgggagct gcggcaggtg cgggcggccc
     2461 tcctgtccag ggagctggca ggcggcctgg aggatgggga gcctcagcag aagcgggccc
     2521 acacagagga gccacaggcc aagaaggtca gagcccagtg aagatctggg agaccctgaa
     2581 ctcagaaggc tgtgtgtctt ctgccccacg cacgcacccg tatctgccct ccttgctggt
     2641 agaagctgaa gagcacggtc ccccaggagg cagctcagga taggtggtat ggagctgtgc
     2701 cgaggcttgg gctcccacat aagcactagt ctatagatgc ctcttaggac tggtgcctgg
     2761 cacagccgcg ggccaggagg ctgccacacg gaagcaagca gatgaactaa tttcatttca
     2821 aggcagtttt taaagaagtc ttggaaacag acggcggcac ctttcctcta atccagcaaa
     2881 gtgattccct gcacaccaga gacaagcaga gtaacaggat cagtgggtct aagtgtccga
     2941 gacttaacga aaatagtatt tcagctgcaa taaagattga gtttgcaatt gtgagttctt
     3001 ttgcttcctc ctgctgctgc tacagagcag ggtctgctgt gcaccacctt ggagaaggct
     3061 ctctgtgctg tagtgtggca gctgcctggt acccgggtgg cttggaagaa gtcagctccc
     3121 gtcgtagtga gcacctctgg aacctgtcct cagagagcca cccttattcg ccaagtcttt
     3181 ttgacaactc gagctgtgcc agctcacagc agggcgtgct ttctctatca atcaatcaat
     3241 caatcaatca aatcaatcag tgagagcctg gctgggctgg tgtcattggt cagggaaatg
     3301 caagtcttct ggtggttctg ggtaaaagtg gagacaatag atttgctgtg ttgttgcttc
     3361 catactgaga ggagtgagga tcactttgcc ctcgaaggtt ttgagaaatg gcacacgggg
     3421 ctggtttcca ttgtcctcct tgcgggattt acagacgtgg attagtgctc gacaaatgga
     3481 gagcattttc caaggaagta agtaagtaaa gtaagtaagt aagtaagtaa gttgaatcta
     3541 gtatttattg tgtatattcc ctacccagga gaatgtaaaa agaagagctt taaaaactca
     3601 aaagacaagc aagcgagaga tcagccaggg acctggcttt acacaggtgg tgaccttcag
     3661 gctccatccc ggtgtgcatt tgagattgac ggccatgtcc ccgcaggttt attaaagcaa
     3721 gaacagatgc caagctcagg gataataaat ctattttaat aacgtta
//
