LOCUS       NM_018696               2211 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens elaC ribonuclease Z 1 (ELAC1), mRNA.
ACCESSION   NM_018696
VERSION     NM_018696.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2211)
  AUTHORS   Seki,M., Komuro,A., Ishikawa,T., Takahashi,M. and Nashimoto,M.
  TITLE     Genes for tRNA recycling are upregulated in response to infection
            with Theiler's mouse encephalitis virus
  JOURNAL   Biochem Biophys Res Commun 587, 63-68 (2022)
   PUBMED   34864548
  REMARK    GeneRIF: Genes for tRNA recycling are upregulated in response to
            infection with Theiler's mouse encephalitis virus.
REFERENCE   2  (bases 1 to 2211)
  AUTHORS   Seki,M., Komuro,A., Takahashi,M. and Nashimoto,M.
  TITLE     Transcription from the proximal promoter of ELAC1, a gene for tRNA
            repair, is upregulated by interferons
  JOURNAL   Biochem Biophys Res Commun 585, 162-168 (2021)
   PUBMED   34808499
  REMARK    GeneRIF: Transcription from the proximal promoter of ELAC1, a gene
            for tRNA repair, is upregulated by interferons.
REFERENCE   3  (bases 1 to 2211)
  AUTHORS   Yip,M.C.J., Savickas,S., Gygi,S.P. and Shao,S.
  TITLE     ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality
            Control
  JOURNAL   Cell Rep 30 (7), 2106-2114 (2020)
   PUBMED   32075755
  REMARK    GeneRIF: ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated
            Quality Control.
REFERENCE   4  (bases 1 to 2211)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   5  (bases 1 to 2211)
  AUTHORS   Brzezniak,L.K., Bijata,M., Szczesny,R.J. and Stepien,P.P.
  TITLE     Involvement of human ELAC2 gene product in 3' end processing of
            mitochondrial tRNAs
  JOURNAL   RNA Biol 8 (4), 616-626 (2011)
   PUBMED   21593607
REFERENCE   6  (bases 1 to 2211)
  AUTHORS   Rossmanith,W.
  TITLE     Localization of human RNase Z isoforms: dual nuclear/mitochondrial
            targeting of the ELAC2 gene product by alternative translation
            initiation
  JOURNAL   PLoS One 6 (4), e19152 (2011)
   PUBMED   21559454
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2211)
  AUTHORS   Takahashi,M., Takaku,H. and Nashimoto,M.
  TITLE     Regulation of the human tRNase ZS gene expression
  JOURNAL   FEBS Lett 582 (17), 2532-2536 (2008)
   PUBMED   18573253
  REMARK    GeneRIF: Human tRNase ZS gene expression appears to be
            post-transcriptionally regulated.
REFERENCE   8  (bases 1 to 2211)
  AUTHORS   Takaku,H., Minagawa,A., Takagi,M. and Nashimoto,M.
  TITLE     A candidate prostate cancer susceptibility gene encodes tRNA 3'
            processing endoribonuclease
  JOURNAL   Nucleic Acids Res 31 (9), 2272-2278 (2003)
   PUBMED   12711671
REFERENCE   9  (bases 1 to 2211)
  AUTHORS   Yanaihara,N., Kohno,T., Takakura,S., Takei,K., Otsuka,A.,
            Sunaga,N., Takahashi,M., Yamazaki,M., Tashiro,H., Fukuzumi,Y.,
            Fujimori,Y., Hagiwara,K., Tanaka,T. and Yokota,J.
  TITLE     Physical and transcriptional map of a 311-kb segment of chromosome
            18q21, a candidate lung tumor suppressor locus
  JOURNAL   Genomics 72 (2), 169-179 (2001)
   PUBMED   11401430
REFERENCE   10 (bases 1 to 2211)
  AUTHORS   Tavtigian,S.V., Simard,J., Teng,D.H., Abtin,V., Baumgard,M.,
            Beck,A., Camp,N.J., Carillo,A.R., Chen,Y., Dayananth,P.,
            Desrochers,M., Dumont,M., Farnham,J.M., Frank,D., Frye,C.,
            Ghaffari,S., Gupte,J.S., Hu,R., Iliev,D., Janecki,T., Kort,E.N.,
            Laity,K.E., Leavitt,A., Leblanc,G., McArthur-Morrison,J.,
            Pederson,A., Penn,B., Peterson,K.T., Reid,J.E., Richards,S.,
            Schroeder,M., Smith,R., Snyder,S.C., Swedlund,B., Swensen,J.,
            Thomas,A., Tranchant,M., Woodland,A.M., Labrie,F., Skolnick,M.H.,
            Neuhausen,S., Rommens,J. and Cannon-Albright,L.A.
  TITLE     A candidate prostate cancer susceptibility gene at chromosome 17p
  JOURNAL   Nat Genet 27 (2), 172-180 (2001)
   PUBMED   11175785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI870985.1, AF308695.1 and AC087687.5.
            
            On Nov 23, 2018 this sequence version replaced NM_018696.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.912620.1,
                                           SRR1803611.251653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269466.8/ ENSP00000269466.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AI870985.1         25-264
            241-2210            AF308695.1         248-2217
            2211-2211           AC087687.5         110272-110272
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..2211
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /note="elaC ribonuclease Z 1"
                     /db_xref="GeneID:55520"
                     /db_xref="HGNC:HGNC:14197"
                     /db_xref="MIM:608079"
     exon            1..75
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /inference="alignment:Splign:2.1.0"
     exon            76..240
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1175
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /EC_number="3.1.26.11"
                     /note="tRNA Z (short form); tRNase ZS; tRNA 3' processing
                     endoribonuclease; RNase Z 1; tRNase Z 1; RNaseZ(S);
                     deleted in Ma29; ribonuclease Z 1; tRNA 3 endonuclease 1;
                     elaC homolog protein 1; elaC homolog 1"
                     /codon_start=1
                     /product="zinc phosphodiesterase ELAC protein 1"
                     /protein_id="NP_061166.1"
                     /db_xref="CCDS:CCDS11949.1"
                     /db_xref="GeneID:55520"
                     /db_xref="HGNC:HGNC:14197"
                     /db_xref="MIM:608079"
                     /translation="MSMDVTFLGTGAAYPSPTRGASAVVLRCEGECWLFDCGEGTQTQ
                     LMKSQLKAGRITKIFITHLHGDHFFGLPGLLCTISLQSGSMVSKQPIEIYGPVGLRDF
                     IWRTMELSHTELVFHYVVHELVPTADQCPAEELKEFAHVNRADSPPKEEQGRTILLDS
                     EENSYLLFDDEQFVVKAFRLFHRIPSFGFSVVEKKRPGKLNAQKLKDLGVPPGPAYGK
                     LKNGISVVLENGVTISPQDVLKKPIVGRKICILGDCSGVVGDGGVKLCFEADLLIHEA
                     TLDDAQMDKAKEHGHSTPQMAATFAKLCRAKRLVLTHFSQRYKPVALAREGETDGIAE
                     LKKQAESVLDLQEVTLAEDFMVISIPIKK"
     exon            241..708
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /inference="alignment:Splign:2.1.0"
     exon            709..2211
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2189..2194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /note="hexamer: AATAAA"
     polyA_site      2211
                     /gene="ELAC1"
                     /gene_synonym="D29"
                     /note="major polyA site"
ORIGIN      
        1 gtagccccgc ggacagctgg gccagggtgc gggcctgcgc ctccctcggc tcctggcgcg
       61 ggcctcgggg agaggggtgg aagatgtcta tggatgtgac attcctgggg acgggtgcag
      121 catacccatc tccaacccgg ggtgcctctg ctgtggtcct tcggtgtgaa ggcgagtgct
      181 ggctctttga ctgtggggag ggaacacaga cacagcttat gaaaagccaa cttaaagcag
      241 ggagaattac caagatcttc atcacacacc ttcatggaga ccatttcttt ggccttcctg
      301 ggctcctctg cacaatcagc ctgcagagtg gctccatggt gtccaaacag cctattgaaa
      361 tctatggccc tgtagggctt cgggacttta tctggcgaac catggaactc tctcacacgg
      421 agctggtctt ccattatgtg gttcatgaac tggttcctac agcagatcaa tgtcctgcag
      481 aagaactaaa agaatttgcg catgtgaata gagcagacag tcctcccaaa gaggaacaag
      541 gaagaactat cctgttagac tcagaagaaa actcatacct tctgtttgat gatgaacaat
      601 ttgttgtaaa agcatttcgc ctctttcaca gaattccctc atttgggttt tcagtcgtgg
      661 aaaagaaacg cccaggtaaa ctcaatgcac agaaacttaa agaccttggt gttccaccag
      721 gtcctgccta tgggaagctg aaaaatggaa tttctgttgt tctggaaaat ggggttacaa
      781 tttctcccca agatgtctta aaaaagccta ttgttggaag aaaaatctgc atattgggtg
      841 actgctctgg ggttgtgggt gatggaggag taaaactgtg ctttgaagca gacctgttga
      901 tccacgaagc aaccctggat gatgcccaga tggacaaagc aaaggagcat ggccacagca
      961 caccacagat ggcagcaaca tttgcaaagt tgtgccgtgc aaagaggctg gttctgactc
     1021 acttcagtca gaggtacaaa ccagttgcct tggccagaga aggagaaaca gatggcattg
     1081 cagaactaaa aaagcaagct gaatcagtgt tagatctcca agaagtgact ctagcagaag
     1141 attttatggt gataagcatt ccaatcaaga aatgaaacca gtgttcctga gtgcacactg
     1201 acatgtctgt gaatatgtta ctgaacctat agtccagttt ttttatttct tgttttagtc
     1261 tgaaattatt tgggccctaa taatcctaaa aagaatggag ctgcattgat gaattggctc
     1321 agtatttaaa gggagcaaac tttttgataa taaatctttt taagagaaaa aaaacccagc
     1381 atcctttttg aagtccagat ttgtcaaaat gatagactat tcagttatac atcttatttt
     1441 gtgctactac cacagatagc caatattcca tgcagtcctg ggcttagctt ctgcccagct
     1501 ttattgctgc tattggcaaa gagcacagga ctcagccctc gtggctaaaa atggtatttt
     1561 ggcagtttgt attgaatctg tttgtgttat taacagaaga gggagaaatg tcatgagacg
     1621 ttggacaggc aggattgatg atagcatgac catagctttg ctggaatact gaatgcaggg
     1681 tttggctagg tgtttatttt aacattttat taaactttct atttgggtct taacccatgg
     1741 ttctcagctg gggtgacact gctcctctag aagcaggttt gaaattatgg gtatgttttc
     1801 ttgtcacagt gactgagtac ggtggtggta gtggtggtac tactactact ggtatttagt
     1861 cagcagggat aagggatgtt agctgtcctg caaagttttg gtcagtcata tacaataaag
     1921 aatcatctca ccccgaaatg caaattgcag gcccattgag atacacagca agttagttta
     1981 tactcttgat gtgaatatag tttaccaaaa ttagtgacat aatgagtgga attactaggt
     2041 aagtcaaatc ctaaagagtg aatgtgttag aattgcagtg tcataccaaa taacattcaa
     2101 aagaaatgag ccattaagtg aagcttatga acctggaggt aaaaaatgct tatctgttaa
     2161 actgaggttt cattgacgtg tccctattaa taaacgttat ttgccccaca a
//
