LOCUS       NM_002212               1069 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 6 (EIF6),
            transcript variant 1, mRNA.
ACCESSION   NM_002212
VERSION     NM_002212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Huang,C.G., Zhou,X.Q., Zheng,A.F., Luo,X., Shen,J., Xiao,Z.G.,
            Yang,Z.H. and Dai,Q.
  TITLE     eIF6 Promotes Gastric Cancer Proliferation and Invasion by
            Regulating Cell Cycle
  JOURNAL   Dig Dis Sci 69 (9), 3249-3260 (2024)
   PUBMED   38987443
  REMARK    GeneRIF: eIF6 Promotes Gastric Cancer Proliferation and Invasion by
            Regulating Cell Cycle.
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Yi,D., Zhang,D., Zeng,Z., Zhang,S., Song,B., He,C., Li,M. and He,J.
  TITLE     Circular RNA eukaryotic translation initiation factor 6 facilitates
            TPC-1 cell proliferation and invasion through the
            microRNA-138-5p/lipase H axis
  JOURNAL   Funct Integr Genomics 23 (4), 313 (2023)
   PUBMED   37776372
  REMARK    GeneRIF: Circular RNA eukaryotic translation initiation factor 6
            facilitates TPC-1 cell proliferation and invasion through the
            microRNA-138-5p/lipase H axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Elliff,J., Biswas,A., Roshan,P., Kuppa,S., Patterson,A.,
            Mattice,J., Chinnaraj,M., Burd,R., Walker,S.E., Pozzi,N.,
            Antony,E., Bothner,B. and Origanti,S.
  TITLE     Dynamic states of eIF6 and SDS variants modulate interactions with
            uL14 of the 60S ribosomal subunit
  JOURNAL   Nucleic Acids Res 51 (4), 1803-1822 (2023)
   PUBMED   36651285
  REMARK    GeneRIF: Dynamic states of eIF6 and SDS variants modulate
            interactions with uL14 of the 60S ribosomal subunit.
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Scagliola,A., Miluzio,A., Mori,G., Ricciardi,S., Oliveto,S.,
            Manfrini,N. and Biffo,S.
  TITLE     Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma
            Growth: An In Vivo and In Vitro Study
  JOURNAL   Int J Mol Sci 23 (14), 7720 (2022)
   PUBMED   35887068
  REMARK    GeneRIF: Inhibition of eIF6 Activity Reduces Hepatocellular
            Carcinoma Growth: An In Vivo and In Vitro Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Keen,A.N., Payne,L.A., Mehta,V., Rice,A., Simpson,L.J., Pang,K.L.,
            Del Rio Hernandez,A., Reader,J.S. and Tzima,E.
  TITLE     Eukaryotic initiation factor 6 regulates mechanical responses in
            endothelial cells
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35024764
  REMARK    GeneRIF: Eukaryotic initiation factor 6 regulates mechanical
            responses in endothelial cells.
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Sanvito,F., Piatti,S., Villa,A., Bossi,M., Lucchini,G.,
            Marchisio,P.C. and Biffo,S.
  TITLE     The beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear
            matrix protein involved in 60S ribosomal subunit assembly
  JOURNAL   J Cell Biol 144 (5), 823-837 (1999)
   PUBMED   10085284
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Sanvito,F., Arrigo,G., Zuffardi,O., Agnelli,M., Marchisio,P.C. and
            Biffo,S.
  TITLE     Localization of p27 beta4 binding protein gene (ITGB4BP) to human
            chromosome region 20q11.2
  JOURNAL   Genomics 52 (1), 111-112 (1998)
   PUBMED   9740680
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Si,K., Chaudhuri,J., Chevesich,J. and Maitra,U.
  TITLE     Molecular cloning and functional expression of a human cDNA
            encoding translation initiation factor 6
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14285-14290 (1997)
   PUBMED   9405604
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Biffo,S., Sanvito,F., Costa,S., Preve,L., Pignatelli,R.,
            Spinardi,L. and Marchisio,P.C.
  TITLE     Isolation of a novel beta4 integrin-binding protein (p27(BBP))
            highly expressed in epithelial cells
  JOURNAL   J Biol Chem 272 (48), 30314-30321 (1997)
   PUBMED   9374518
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001119.2 and BM851166.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002212.3.
            
            Summary: Hemidesmosomes are structures which link the basal lamina
            to the intermediate filament cytoskeleton. An important functional
            component of hemidesmosomes is the integrin beta-4 subunit (ITGB4),
            a protein containing two fibronectin type III domains. The protein
            encoded by this gene binds to the fibronectin type III domains of
            ITGB4 and may help link ITGB4 to the intermediate filament
            cytoskeleton. The encoded protein, which is insoluble and found
            both in the nucleus and in the cytoplasm, can function as a
            translation initiation factor and prevent the association of the
            40S and 60S ribosomal subunits. Multiple non-protein coding
            transcript variants and variants encoding two different isoforms
            have been found for this gene. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1, 2, and 6 all encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.153922.1,
                                           SRR5189658.109685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374450.8/ ENSP00000363574.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1065              BC001119.2         18-1082
            1066-1069           BM851166.1         102-105
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..1069
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /note="eukaryotic translation initiation factor 6"
                     /db_xref="GeneID:3692"
                     /db_xref="HGNC:HGNC:6159"
                     /db_xref="MIM:602912"
     exon            1..47
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            48..159
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..790
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /EC_number="3.6.5.3"
                     /note="isoform a is encoded by transcript variant 1; B4
                     integrin interactor; p27 beta-4 integrin-binding protein;
                     eukaryotic translation initiation factor 3A"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 6
                     isoform a"
                     /protein_id="NP_002203.1"
                     /db_xref="CCDS:CCDS13249.1"
                     /db_xref="GeneID:3692"
                     /db_xref="HGNC:HGNC:6159"
                     /db_xref="MIM:602912"
                     /translation="MAVRASFENNCEIGCFAKLTNTYCLVAIGGSENFYSVFEGELSD
                     TIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDTVQIRRVEERLS
                     ALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGL
                     VHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVV
                     ESVFKLNEAQPSTIATSMRDSLIDSLT"
     exon            160..245
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            246..421
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            422..598
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            599..780
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1069
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /note="hexamer: ATTAAA"
     polyA_site      1069
                     /gene="EIF6"
                     /gene_synonym="b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP;
                     p27(BBP); p27BBP"
                     /note="major polyA site"
ORIGIN      
        1 agtccaaggt acagtcgccg cgtgcggagc ttgttactgg ttacttggcc tcatggcggt
       61 ccgagcttcg ttcgagaaca actgtgagat cggctgcttt gccaagctca ccaacaccta
      121 ctgtctggta gcgatcggag gctcagagaa cttctacagt gtgttcgagg gcgagctctc
      181 cgataccatc cccgtggtgc acgcgtctat cgccggctgc cgcatcatcg ggcgcatgtg
      241 tgtggggaac aggcacggtc tcctggtacc caacaatacc accgaccagg agctgcaaca
      301 cattcgcaac agcctcccag acacagtgca gattaggcgg gtggaggagc ggctctcagc
      361 cttgggcaat gtcaccacct gcaatgacta cgtggccttg gtccacccag acttggacag
      421 ggagacagaa gaaattctgg cagatgtgct caaggtggaa gtcttcagac agacagtggc
      481 cgaccaggtg ctagtaggaa gctactgtgt cttcagcaat cagggagggc tggtgcatcc
      541 caagacttca attgaagacc aggatgagct gtcctctctt cttcaagtcc cccttgtggc
      601 ggggactgtg aaccgaggca gtgaggtgat tgctgctggg atggtggtga atgactggtg
      661 tgccttctgt ggcctggaca caaccagcac agagctgtca gtggtggaga gtgtcttcaa
      721 gctgaatgaa gcccagccta gcaccattgc caccagcatg cgggattccc tcattgacag
      781 cctcacctga gtcaccttcc aagttgttcc atgggctcct ggctctggac tgtggccaac
      841 cttctccaca ttccgcccaa tctgtaccgg atgctggcag ggaggtggca gagagctcac
      901 tgggactgag gggctgggca cccaaccctt ttccacctgt gcttatcgcc tggatctatc
      961 attactgcaa aaacctgctc tgttgtgctg gctggcaggc cctgtggctg ctggctgagg
     1021 gttctgctgt cctgtgccac cccattaaag tgcagttccc tccgggcca
//
