LOCUS       NM_001099692            3908 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 5A like 1
            (EIF5AL1), mRNA.
ACCESSION   NM_001099692 XM_928947
VERSION     NM_001099692.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3908)
  AUTHORS   Wu,Y.Y., Wu,G.Q., Cai,N.L., Xu,Y.M. and Lau,A.T.Y.
  TITLE     Comparison of Human Eukaryotic Translation Initiation Factors 5A1
            and 5AL1: Identification of Amino Acid Residues Important for
            EIF5A1 Lysine 50 Hypusination and Its Protein Stability
  JOURNAL   Int J Mol Sci 24 (7), 6067 (2023)
   PUBMED   37047039
  REMARK    GeneRIF: Comparison of Human Eukaryotic Translation Initiation
            Factors 5A1 and 5AL1: Identification of Amino Acid Residues
            Important for EIF5A1 Lysine 50 Hypusination and Its Protein
            Stability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3908)
  AUTHORS   Zhou,B. and Guo,R.
  TITLE     Integrative analysis of significant RNA-binding proteins in
            colorectal cancer metastasis
  JOURNAL   J Cell Biochem 119 (12), 9730-9741 (2018)
   PUBMED   30132996
  REMARK    GeneRIF: EIF5AL1 expression is associated with colorectal cancer
            metastasis.
REFERENCE   3  (bases 1 to 3908)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   4  (bases 1 to 3908)
  AUTHORS   Clement,P.M., Johansson,H.E., Wolff,E.C. and Park,M.H.
  TITLE     Differential expression of eIF5A-1 and eIF5A-2 in human cancer
            cells
  JOURNAL   FEBS J 273 (6), 1102-1114 (2006)
   PUBMED   16519677
REFERENCE   5  (bases 1 to 3908)
  AUTHORS   Facchiano,A.M., Stiuso,P., Chiusano,M.L., Caraglia,M., Giuberti,G.,
            Marra,M., Abbruzzese,A. and Colonna,G.
  TITLE     Homology modelling of the human eukaryotic initiation factor 5A
            (eIF-5A)
  JOURNAL   Protein Eng 14 (11), 881-890 (2001)
   PUBMED   11742107
REFERENCE   6  (bases 1 to 3908)
  AUTHORS   Koettnitz,K., Wohl,T., Kappel,B., Lottspeich,F., Hauber,J. and
            Bevec,D.
  TITLE     Identification of a new member of the human eIF-5A gene family
  JOURNAL   Gene 159 (2), 283-284 (1995)
   PUBMED   7622067
REFERENCE   7  (bases 1 to 3908)
  AUTHORS   Steinkasserer,A., Jones,T., Sheer,D., Koettnitz,K., Hauber,J. and
            Bevec,D.
  TITLE     The eukaryotic cofactor for the human immunodeficiency virus type 1
            (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three
            eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2
  JOURNAL   Genomics 25 (3), 749-752 (1995)
   PUBMED   7759117
REFERENCE   8  (bases 1 to 3908)
  AUTHORS   Koettnitz,K., Kappel,B., Baumruker,T., Hauber,J. and Bevec,D.
  TITLE     The genomic structure encoding human initiation factor eIF-5A
  JOURNAL   Gene 144 (2), 249-252 (1994)
   PUBMED   7545941
REFERENCE   9  (bases 1 to 3908)
  AUTHORS   Smit-McBride,Z., Dever,T.E., Hershey,J.W. and Merrick,W.C.
  TITLE     Sequence determination and cDNA cloning of eukaryotic initiation
            factor 4D, the hypusine-containing protein
  JOURNAL   J Biol Chem 264 (3), 1578-1583 (1989)
   PUBMED   2492279
REFERENCE   10 (bases 1 to 3908)
  AUTHORS   Park,M.H., Liu,T.Y., Neece,S.H. and Swiggard,W.J.
  TITLE     Eukaryotic initiation factor 4D. Purification from human red blood
            cells and the sequence of amino acids around its single hypusine
            residue
  JOURNAL   J Biol Chem 261 (31), 14515-14519 (1986)
   PUBMED   3095320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133481.14.
            
            On Jun 16, 2020 this sequence version replaced NM_001099692.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC070048.1, BX400276.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520547.4/ ENSP00000430706.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3908              AL133481.14        162062-165969
FEATURES             Location/Qualifiers
     source          1..3908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..3908
                     /gene="EIF5AL1"
                     /gene_synonym="bA342M3.3; eIF-4D; eIF-5A; eIF-5A-1;
                     eIF-5A1; EIF5A; EIF5AP1"
                     /note="eukaryotic translation initiation factor 5A like 1"
                     /db_xref="GeneID:143244"
                     /db_xref="HGNC:HGNC:17419"
     exon            1..3908
                     /gene="EIF5AL1"
                     /gene_synonym="bA342M3.3; eIF-4D; eIF-5A; eIF-5A-1;
                     eIF-5A1; EIF5A; EIF5AP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..582
                     /gene="EIF5AL1"
                     /gene_synonym="bA342M3.3; eIF-4D; eIF-5A; eIF-5A-1;
                     eIF-5A1; EIF5A; EIF5AP1"
                     /note="eukaryotic translation initiation factor 5A
                     pseudogene 1; Rev-binding factor; Eukaryotic translation
                     initiation factor 5A-1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     5A-1-like"
                     /protein_id="NP_001093162.1"
                     /db_xref="CCDS:CCDS53546.1"
                     /db_xref="GeneID:143244"
                     /db_xref="HGNC:HGNC:17419"
                     /translation="MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGWPCKIVEMS
                     ASKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLL
                     QDSGEVPEDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK"
ORIGIN      
        1 ggtagaggcg gcggcggcgg cggcggcggc gggctcggag gcagcggttg ggctcgcggc
       61 gagcggacgg ggtcgagtca gtgccgtttg cgccagttgg aatcgaagcc tcttaaaatg
      121 gcagatgatt tggacttcga gacaggagat gcaggggcct cagccacctt cccaatgcag
      181 tgctcagcat tacgtaagaa tggctttgtg gtgctcaaag gctggccatg taagatcgtg
      241 gagatgtctg cttcgaagac tggcaagcac ggccacgcca aggtccatct ggttggtatt
      301 gacatcttta ctgggaagaa atatgaagat atctgcccgt caactcataa tatggatgtc
      361 cccaacatca aaaggaatga cttccagctg attggcatcc aggatgggta cctatcactg
      421 ctccaggaca gcggggaggt accagaggac cttcgtctcc ctgagggaga ccttggcaag
      481 gagattgagc agaagtacga ctgtggagaa gagatcctga tcacggtgct gtctgccatg
      541 acagaggagg cagctgttgc aatcaaggcc atggcaaaat aactggctcc caaggtggca
      601 gtggtggcag cagtgatcct ccgaacctgc agaggccccc tcccccagcc tggcctggct
      661 ctggcctggt cctaggttgg actcctccta cacaatttat ttgacgtttt attttggttt
      721 tccccacccc ctcaatctgt cagggagccc ctgcccttca cctagctccc ttggccagga
      781 gcgagcgaag ccatggcctt ggtgaagctg ccctcctctt ctcccctcac actacagccc
      841 tggtggggga gaagggggtg ggtgctgctt gtggtttagt cttttttttt tttttaaatt
      901 caatctggaa tcagaaagcg gtggattctg gcaaatggtc cttgtgccct ccccactcat
      961 ccttggtctg gtcccctgtt gcccatagcc ctttaccctg agcaccaccc aacagactgg
     1021 ggaccagccc cctcgcctgc ctgtgtctct ccccaaaccc ctttagatgg ggagggaaga
     1081 agaggagagg ggaggggacc tgccccctcc tcaggcatct gggaagggcc tgcccccatg
     1141 ggctttaccc ttccctgcgg gctctctccc cgacacattt gttaaaatca aacctgaata
     1201 aaactacaag tttaatatga aaaaaaaaaa aaaagaaaga aagacgtgta aaatgccaag
     1261 aactctagga aacagggaca aaaacacttc aaagagaaag ttcatgcact tgtttctgac
     1321 cacccagggc acccttcagc acacgctgtc tggagtggcc tgaagcaagg agtgtcttgt
     1381 gaggtgcaga ggatgcaatg ggagcagggt cctgtcccca ccctaaagga gttcacagtt
     1441 taacgcaaat gagaagccag tgaggacatc actactcctg ctgtgaactt gggaactaga
     1501 aacacaaaac ctgagtctgg agggaagcta aggaagcatt ctgctctgga gtagacatga
     1561 gtgcgtgtga agcttctgat ctcccatgag agcaatgggg acatggggca gaatctaaaa
     1621 cccatgactg aaagcaccaa attgctaaaa tggcaataaa gagacatgag gccaagatgg
     1681 agaagaagga acccaggacg agggtcagcc tcacatttgg ggctcatttc cctcagtttc
     1741 ctcactgaat ttcagaaggg actaactgag atgcaaagaa gcagagcagc ttttgcacca
     1801 tgtggaggac tagatggaaa acaagtagac tgagggtctg ctagtgaagg tgacccctac
     1861 tgaagtccac tggctttggt tgggacccag aagagtcaca cgccaggaat agaggtggac
     1921 aggaaacacc ctgacttttg tagggactga acctcactga taacctcaat tgcggatggt
     1981 atggagggtg tctaggtgtg ctaggacccc tgcccattcc ccagaaatag actcccatct
     2041 tttctacagc aagataacgt gctagtaggc ctcaattcat tgctaaatat ttttaacgag
     2101 tgtcttacat ttagccaaaa agactagtca tgtggcagga aaaatacaat gtcatatgac
     2161 caaaagctaa aagactgtga aaatgaatcc agaggtgacc caagcattga atttaacaat
     2221 gccagtacct ggacctccgc ttgcccctaa aacattacaa tcaagaatgt aggaagggaa
     2281 aggaaacacg aagattaatc aagcaggaag gacaagctca gttttgcacc cactgaattt
     2341 gccacaaata ttgtggaaaa tattctcggg gacattgcag ttgtctactt tggttggcac
     2401 atggttcata caacagtgtt tgtgtcagtg aacatcttac tcttcctcgg cagtctttct
     2461 ttgcccagag atttcgcaat gactgttgac cttcatcatc accttttgga ctttggcttg
     2521 cactttagct tctgtagatc tccatgatgt aaagaagtat tttaggtcca ttttaattcc
     2581 tgcaaaggat aaaatccttc tatttgtgtg catataagtg gacctgagcc cttggttagg
     2641 gtgtagagag gagaagggga gaaacctgag ggccagaagc tgttctttcc cttaaaaggg
     2701 caaactcatt tccacactat ggggactctg acagatagca taccttcctg tctatggcta
     2761 ttggacctgc aggctttccc ctgtaaatcc gtgttctgtc attgacattt tgtgactgta
     2821 agacagactt gagataagac atctagaaaa caataattga acaatgatgt gaatatattt
     2881 cacacaactg aactgtacat ttcaacaagg ttaagatggt aattatcacg ttatacattt
     2941 tttaccgcag gttaaaatgt ttcacaggtt gaaaggaaag caactacctt cagttctctg
     3001 agttcaagaa tttgtaacat ttcaccccct gctccttcct gatcttctgt ggagcatctt
     3061 ttttccatcc atgctctact cagagcccac tttcccttcc ctgacaccag cttcactgag
     3121 gctggttgga acctaacaca aaacattctc agtaatgact gaattcccac aaagaattcc
     3181 atatagactg catatgagtt gaatcttcta agacatgaaa tatttgttct cttcttggct
     3241 aatatgcaat gcaaatcctg ttgcagatgt acgtcatata cctctgaaat tcctgatgta
     3301 ttcaatgaaa taacatcttt aaagttctgt gtagaatgtt ttttttctga tttcttcaca
     3361 tacgatagaa aaaaaaaccc aaaaaaacat gtactaggat ttcaatagaa gcaatgggtg
     3421 atctaaaaag atgaaagagc aaccgcatgc gccctacagc taccgctaga ttttatgggg
     3481 aaagcagctg gcccagtttg cagctaggag aaatgtcaaa cacatgaaga aatgagaagc
     3541 aaagaaaaac catgaggcat gaacatttca tggcaatcac gatgtcctgg tttgtgagat
     3601 aatgggatag aggagtagaa aacaaggaga aagatgagaa ggtacaaagt ggttcaagtc
     3661 aaacagctca actgaacttt tcttaatgga atatttaaaa agtggtacat taaaaaactt
     3721 cccccagttc acatcaaaaa ttctctcttc aggactaagt tgggtagaga ctgttcaatg
     3781 tgcctagata tcttcagaac ttatatattt tctgttttct acgtatgttg aagggcagtg
     3841 ccaaatgatg tgtaattatc taggttgtaa aaataaaaca tactccccct tcccttgagg
     3901 ataaaaaa
//
