LOCUS       NM_020390               5534 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 5A2 (EIF5A2),
            mRNA.
ACCESSION   NM_020390
VERSION     NM_020390.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5534)
  AUTHORS   Lou,D., Jia,Q., Zhang,H., Wang,J., Liu,L., Liu,Z., Jia,X., Wang,J.
            and Shan,C.
  TITLE     MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration
            Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma
  JOURNAL   Biochem Genet 62 (3), 1603-1616 (2024)
   PUBMED   37656330
  REMARK    GeneRIF: MiR-5189-3p Suppresses cell Proliferation, Invasion and
            Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell
            Carcinoma.
REFERENCE   2  (bases 1 to 5534)
  AUTHORS   Zhao,L., Huang,J., Liu,W., Su,X., Zhao,B., Wang,X. and He,X.
  TITLE     Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian
            cancer by elevating EIF5A2 expression
  JOURNAL   J Cancer Res Clin Oncol 150 (4), 179 (2024)
   PUBMED   38584230
  REMARK    GeneRIF: Long non-coding RNA RAD51-AS1 promotes the tumorigenesis
            of ovarian cancer by elevating EIF5A2 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5534)
  AUTHORS   Yang,J., Xiang,H., Cheng,M., Jiang,X., Chen,Y., Zheng,L., Yan,S.,
            Zhang,S., Zhang,C., Chen,W. and Chen,D.
  TITLE     microRNA-15a-5p suppresses hypoxia-induced tumor growth and
            chemoresistance in bladder cancer by binding to eIF5A2
  JOURNAL   Neoplasma 71 (1), 60-69 (2024)
   PUBMED   38506035
  REMARK    GeneRIF: microRNA-15a-5p suppresses hypoxia-induced tumor growth
            and chemoresistance in bladder cancer by binding to eIF5A2.
REFERENCE   4  (bases 1 to 5534)
  AUTHORS   Yang,J., Jiang,X., Chen,Y. and Teng,L.
  TITLE     EIF5A2 Promotes Doxorubicin Resistance in Bladder Cancer Cells
            through the TGF-beta Signaling Pathway
  JOURNAL   Discov Med 35 (179), 1167-1176 (2023)
   PUBMED   38058082
  REMARK    GeneRIF: EIF5A2 Promotes Doxorubicin Resistance in Bladder Cancer
            Cells through the TGF-beta Signaling Pathway.
REFERENCE   5  (bases 1 to 5534)
  AUTHORS   Wu,R., Zhong,Q., Liu,H. and Liu,S.
  TITLE     MicroRNA-577/EIF5A2 axis suppressed the proliferation of
            DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-beta
            signaling pathway
  JOURNAL   Chem Biol Drug Des 102 (4), 815-827 (2023)
   PUBMED   37500510
  REMARK    GeneRIF: MicroRNA-577/EIF5A2 axis suppressed the proliferation of
            DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-beta
            signaling pathway.
REFERENCE   6  (bases 1 to 5534)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 5534)
  AUTHORS   Guan,X.Y., Fung,J.M., Ma,N.F., Lau,S.H., Tai,L.S., Xie,D.,
            Zhang,Y., Hu,L., Wu,Q.L., Fang,Y. and Sham,J.S.
  TITLE     Oncogenic role of eIF-5A2 in the development of ovarian cancer
  JOURNAL   Cancer Res 64 (12), 4197-4200 (2004)
   PUBMED   15205331
  REMARK    GeneRIF: eIF-5A2 overexpression was significantly associated with
            the advanced stage of ovarian cancer.
REFERENCE   8  (bases 1 to 5534)
  AUTHORS   Clement,P.M., Henderson,C.A., Jenkins,Z.A., Smit-McBride,Z.,
            Wolff,E.C., Hershey,J.W., Park,M.H. and Johansson,H.E.
  TITLE     Identification and characterization of eukaryotic initiation factor
            5A-2
  JOURNAL   Eur J Biochem 270 (21), 4254-4263 (2003)
   PUBMED   14622290
  REMARK    GeneRIF: role in eukaryotic cell survival similar to that of the
            ubiquitous eIF5A-1
REFERENCE   9  (bases 1 to 5534)
  AUTHORS   Guan,X.Y., Sham,J.S., Tang,T.C., Fang,Y., Huo,K.K. and Yang,J.M.
  TITLE     Isolation of a novel candidate oncogene within a frequently
            amplified region at 3q26 in ovarian cancer
  JOURNAL   Cancer Res 61 (9), 3806-3809 (2001)
   PUBMED   11325856
REFERENCE   10 (bases 1 to 5534)
  AUTHORS   Jenkins,Z.A., Haag,P.G. and Johansson,H.E.
  TITLE     Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved
            vertebrate variant of eukaryotic translation initiation factor 5A
            with tissue-specific expression
  JOURNAL   Genomics 71 (1), 101-109 (2001)
   PUBMED   11161802
  REMARK    GeneRIF: Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A)
            stimulates ribosomal peptidyltransferase activity, transport of
            HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys
            50. Human EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and
            eIF5AII.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY205261.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020390.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY205261.1, AY205260.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295822.7/ ENSP00000295822.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5534              AY205261.1         1-5534
FEATURES             Location/Qualifiers
     source          1..5534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..5534
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="eukaryotic translation initiation factor 5A2"
                     /db_xref="GeneID:56648"
                     /db_xref="HGNC:HGNC:3301"
                     /db_xref="MIM:605782"
     exon            1..95
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            96..295
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..592
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="eIF-5A-2; eukaryotic initiation factor 5A"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 5A-2"
                     /protein_id="NP_065123.1"
                     /db_xref="CCDS:CCDS3214.1"
                     /db_xref="GeneID:56648"
                     /db_xref="HGNC:HGNC:3301"
                     /db_xref="MIM:605782"
                     /translation="MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMS
                     TSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLL
                     TETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK"
     exon            296..400
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            401..532
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     exon            533..5534
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      588..593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="hexamer: AATAAA"
     polyA_site      612
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="major polyA site"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="hexamer: ATTAAA"
     polyA_site      1953
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="major polyA site"
     regulatory      3608..3613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="major polyA site"
     regulatory      4535..4540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="hexamer: ATTAAA"
     polyA_site      4553
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="major polyA site"
     regulatory      5511..5516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
                     /note="hexamer: AATAAA"
     polyA_site      5534
                     /gene="EIF5A2"
                     /gene_synonym="EIF-5A2; eIF5AII"
ORIGIN      
        1 ggaactgccg cggccgccac cgccgctgcc ggcgccgctg ctgtagggga ccagcgcggg
       61 tgcgcagacg aaaggcgctc tttgccagct gaaagttccc acggaaaaac taccatctcc
      121 cctgcccacc atggcagacg aaattgattt cactactgga gatgccgggg cttccagcac
      181 ttaccctatg cagtgctcgg ccttgcgcaa aaacggcttc gtggtgctca aaggacgacc
      241 atgcaaaata gtggagatgt caacttccaa aactggaaag catggtcatg ccaaggttca
      301 ccttgttgga attgatattt tcacgggcaa aaaatatgaa gatatttgtc cttctactca
      361 caacatggat gttccaaata ttaagagaaa tgattatcaa ctgatatgca ttcaagatgg
      421 ttacctttcc ctgctgacag aaactggtga agttcgtgag gatcttaaac tgccagaagg
      481 tgaactaggc aaagaaatag agggaaaata caatgcaggt gaagatgtac aggtgtctgt
      541 catgtgtgca atgagtgaag aatatgctgt agccataaaa ccctgcaaat aaacggaaac
      601 atcaggcatg aacactgttt atgtctgaat caactgcaga tctaatttgg ttctaagttg
      661 tcaccaaagc tatagccttc ataagcaacc tcatttcttt ttttaattgt tttcagattg
      721 tgctgggtta gttttgcaag caattgataa tttttaaaaa attatcaata tgtataattt
      781 tttttgaatt ttgtagatat gtttcctata atattcctgt ggttttcagt atgtcagtcc
      841 aagaaacaaa caagatagct tcagcagatg tgatttgtct gagcaaatca ttcctgtgtt
      901 ttagttagat gataaaccag ggttttaaat caaacaatgt agcataaagt ggtattgaag
      961 taccatattt aagttgaact gctctgcatt aattacagat ttaatataaa atgaactgat
     1021 tatatattgg aattgttgca ctttcagcct gtgtagggca aacacaaatc cttaaacaaa
     1081 aatcatgtta tcaaaaactg tcagttattt tggtggccac atgcaaccat gtgattactt
     1141 tggtcatact atttaccaaa ttgttggcaa acttgatgta accttatatg gtggttttag
     1201 tcccttctta tggttggcag aagggcactg aactgttggg tgaaagttag ttagcaagta
     1261 agattataag gaagacacaa aagacagtgg caaagagggt tgattaaatc tataagtttt
     1321 tatgtgagga ctttgtaagt cagcataaaa atgaaaagtt gtttctcagt tgtttttgct
     1381 tttaactttg cccccaacgt ttaaagggag tgatctgctt tacatgatac tatgcaatgc
     1441 ttgttttcca actatgttga ataaatagta atatttatca gtaaatactc ctttccaact
     1501 tccttttttt tttttttttt tttgagactg agtctcactc catcagccag gctggagtgc
     1561 agtggtgcaa tctcggctca ctgcaacctc tgcctcccga gttcaagcaa ttctcctgcc
     1621 tcagcctccc aagtagctgg gactacaggt gcatgccacc acgcccagct acttttttgt
     1681 gtattttagt agagatgggg tttcaccatg ttgtctaggc tggtcttgaa ctcctgacct
     1741 caggtgatcc acctgcctca gcctcccaaa gtgctgggat tacaggcatg agccaccaca
     1801 cccagcccct ttccaaccat ttctaagtag attttttgac attaatgtat ttattaaaca
     1861 aaaactgaga attccttaaa ttgatttgga atttttgtta attttatgtc ctttttttcc
     1921 taaagtgaat taaagtgaat catggaagca gcattacttt atatgaatat tattatttaa
     1981 gttaagttat tttaagtata tgcatttttt ctgattgttg tgtgacttaa ttcagttgct
     2041 ggtgtgaact ataactagca aataattcta taaactgaat tattttaaaa ggtattttag
     2101 gtgacaccac tgcatttcta tttcatcttt tgagtcatat gtatattatt tccagaattt
     2161 tagacattat tacagggttt gtgaggacct ttgactcagt gacaatcatc atattggagc
     2221 aaaacataga acaaaatcac tatctcagaa ataccttaat tctctaagac tggctcttag
     2281 acctctccca tcatgccttg acctctaaaa agccctttgt tcctatcttc taaaggaaag
     2341 tatatcatat atgatgatgt aactgatcta atcagtgact ggaaatagca ttagtaacag
     2401 aagatcccaa gttttagttg cttaatttgt acacactttt aaatattgtc ttagcctcgg
     2461 caaaccaatt tggggaagaa gcaagatact ttaagagaaa tacaaaggaa atttctaaag
     2521 cacaagaaat agtgaggtag tagttagtcg tctttcctac aacattttag cttttgccca
     2581 tctaaagcac aattaaaatt aggctacatt ctttccagta ttctatttaa gtacctacta
     2641 catactgctc tagtttctta gtactctgta atgtgtatct taattgctac tggttggcat
     2701 tgtaactcat aggaattcca gaaaattatt aatccgtgct gcttgcagtt cattcatatg
     2761 gcccctctta accatgctgg tgttatgatt cagtattaac tctcaattag catgcccctg
     2821 ttcttcctaa cttgtaaaat ttcacataaa tatattttca attgtgtaca aattaagggt
     2881 gtacaaatta taataatgca tctctatctt catactttga atggcaaacg ctatttatgc
     2941 ataaatattt tcattttaag taatatatga agtgtaaata ctcgatatat aagtatagat
     3001 tttaaagata tgggacttta ttttcacata agtcaataga tgtttctcta gaacaaaata
     3061 tttagtaaag ctttataaat tatattaaaa ggaagcgggg aacatgtatt ttttaacata
     3121 gaacagaagt gacttcattc tttttagaca tcagaaatgt taaagttgat tcccaatatt
     3181 tgttgtactt ttttgtagca aatgttaaaa atcacgagtt accatgtata gaatgtggac
     3241 tgtcatgttg atatcattgt acagtgataa gccattttta tctgtataca tttcaccaat
     3301 ttattaacag gttgaatatt tgtttctttt tagaacattt tatttatact gtgaagactt
     3361 tgttatacct tatttgctac aacatagatc atatcattgc tactttgact tagcatttgc
     3421 atcataaaca taattatgat gtttttttca tgctcccttc caggggctca gtcacttgaa
     3481 gaaactgttg ctaaccaagc tcttgactct gtttccctta atgatacaag tctctgtacc
     3541 agcgctttat gttaattacc aaaactctcc tgcatcagag catgatatct ataataggag
     3601 atactgcaat aaaatgatta ggctgtaaaa tttggagaca caatttttca ttacaatgca
     3661 atttgcatgt gcacatgtgc gcacataact ttatatgtta gttctttttt ccaaactccc
     3721 aactcttaaa agtattgtag tctgttggtg cctcaactgt tggtaacttt ttttttttaa
     3781 atttacaact ttccacaact tgtttttgta ctttaaggtt tctcaattag aatatttcta
     3841 gttgagctgt aatttgaatg cattgttctc agggctattt gtgctaaaag ctgaaatttc
     3901 attattttaa agctaattgc ctgaaaatat attggcagaa ttttcccaaa ttgtaataac
     3961 tgtgatacat gcatataaaa aaatccttaa tgtcaacaca cttaaactac atgctaaata
     4021 gtcaagaaaa aaatggaaac agtagcatcc atactggaat cttgccatat ttttttcatt
     4081 ttagaataga ttttggcagt ctcatcttag aatcctatcc ttaggataca tctgaaagca
     4141 ttcctttggc atggacccca gagatagttt tggagccagg cattgatgta gaggttcacc
     4201 aaacatattt agggataata gataaattca taatgctttt ttgggtacac tgaaatgttt
     4261 acatactgaa ttctgtaata tgaactagga acgcatttac tatgagaaaa tatggctctt
     4321 aagcagtgta agagtgaaaa tataagcata tttccattaa cagtatattg tactgatcag
     4381 cagctctcat tttaacatca gttaggcata atatttcata gttttcaagc cttttttttc
     4441 tgctaacatt cagacaagta acaggcaaca aagatttaag aaaaatttat ggtggaaaac
     4501 cttaaaaatt gagacaattc aatctattta atctattaaa ttttttctct gaattgggta
     4561 tatggcatca ttatttgatt ttagcaggga acatttggat ttagcttatg aaacacagat
     4621 gttctatggg aacatggctt gaagccaata tgtaatttaa tgtttttcca ttaaacaaac
     4681 atctgaacac caacttagct accaagtgag gtcaagtgcc tgaaaagtac tgtatacatc
     4741 taataagcat gttttcctta tgtaaaagat gcactttatg gcaatgcata ccaggctttc
     4801 acctgctaga aacatacttg ttgccaactt tgccatctac cactattctc ctccttagaa
     4861 caggtagaaa cctattttac aaaaaaaaaa aaaaaaaaaa aaagacaggt tattgtattt
     4921 atatgaagtc cctaaaactg tttcttggta ttgatagact taagtttatc ttagttcaag
     4981 attgcacttt ttaaaaaact ctggactatt ttcagcaatg accgaacagc ttgtcacaca
     5041 tcatagttgt gatctttttt gaggagttat ttattgtggt taatatctac tataaataag
     5101 cattcttgtg cttgttacaa agcataatgc aaattactag ttctatacta gtataatgaa
     5161 aatgactagt tctatactgt tatgtacttt tgtcttcctc cccaaaaagg aaacagttta
     5221 gcattgtcta aattcagtgg cactttttta gtaatacatt tttttttctt agatacagga
     5281 gaactattgc ttttacctgc agaaactcaa atgttttcgc taaaacttta aaattctaaa
     5341 atacgtagta tgggtattac taattgtaca ttttacattt caaaaatagt taaaattcaa
     5401 atgttaagtc tttgacttaa aaaaccttta aatatagata ataccttaac aattataact
     5461 ttgtgatatt attaaaatat atttgtctgt taacttcatc agttgtatta aataaaaata
     5521 gttaacagct tgca
//
