LOCUS       NM_001970               1264 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 5A (EIF5A),
            transcript variant B, mRNA.
ACCESSION   NM_001970 XM_001724572
VERSION     NM_001970.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Guo,K. and Zhou,J.
  TITLE     Insights into eukaryotic translation initiation factor 5A: Its role
            and mechanisms in protein synthesis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119849 (2024)
   PUBMED   39303786
  REMARK    GeneRIF: Insights into eukaryotic translation initiation factor 5A:
            Its role and mechanisms in protein synthesis.
            Review article
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Chen,X., Zhang,Y., Chen,S., Yang,Y., Sun,G. and Pan,P.
  TITLE     Construction of a nomogram for predicting HNSCC distant metastasis
            and identification of EIF5A as a hub gene
  JOURNAL   Sci Rep 14 (1), 13367 (2024)
   PUBMED   38862693
  REMARK    GeneRIF: Construction of a nomogram for predicting HNSCC distant
            metastasis and identification of EIF5A as a hub gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Liao,R., Chen,X., Cao,Q., Bai,L., Ma,C., Dai,Z. and Dong,C.
  TITLE     AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A
            hypusination-TCF4 axis
  JOURNAL   Breast Cancer Res 26 (1), 70 (2024)
   PUBMED   38654332
  REMARK    GeneRIF: AMD1 promotes breast cancer aggressiveness via a
            spermidine-eIF5A hypusination-TCF4 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Xiong,H., Ye,J., Luo,Q., Li,W., Xu,N. and Yang,H.
  TITLE     Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte
            wasting in cancer cachexia
  JOURNAL   Cell Signal 112, 110901 (2023)
   PUBMED   37743008
  REMARK    GeneRIF: Exosomal EIF5A derived from Lewis lung carcinoma induced
            adipocyte wasting in cancer cachexia.
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Zeng,J., Ye,Z., Shi,S., Liang,Y., Meng,Q., Zhang,Q. and Le,A.D.
  TITLE     Targeted inhibition of eIF5Ahpu suppresses tumor growth and
            polarization of M2-like tumor-associated macrophages in oral cancer
  JOURNAL   Cell Death Dis 14 (8), 579 (2023)
   PUBMED   37653021
  REMARK    GeneRIF: Targeted inhibition of eIF5A[hpu] suppresses tumor growth
            and polarization of M2-like tumor-associated macrophages in oral
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1264)
  AUTHORS   Koettnitz,K., Kappel,B., Baumruker,T., Hauber,J. and Bevec,D.
  TITLE     The genomic structure encoding human initiation factor eIF-5A
  JOURNAL   Gene 144 (2), 249-252 (1994)
   PUBMED   7545941
REFERENCE   7  (bases 1 to 1264)
  AUTHORS   Park,M.H., Wolff,E.C., Smit-McBride,Z., Hershey,J.W. and Folk,J.E.
  TITLE     Comparison of the activities of variant forms of eIF-4D. The
            requirement for hypusine or deoxyhypusine
  JOURNAL   J Biol Chem 266 (13), 7988-7994 (1991)
   PUBMED   1850732
REFERENCE   8  (bases 1 to 1264)
  AUTHORS   Chung,S.I., Park,M.H., Folk,J.E. and Lewis,M.S.
  TITLE     Eukaryotic initiation factor 5A: the molecular form of the
            hypusine-containing protein from human erythrocytes
  JOURNAL   Biochim Biophys Acta 1076 (3), 448-451 (1991)
   PUBMED   1900436
REFERENCE   9  (bases 1 to 1264)
  AUTHORS   Smit-McBride,Z., Dever,T.E., Hershey,J.W. and Merrick,W.C.
  TITLE     Sequence determination and cDNA cloning of eukaryotic initiation
            factor 4D, the hypusine-containing protein
  JOURNAL   J Biol Chem 264 (3), 1578-1583 (1989)
   PUBMED   2492279
REFERENCE   10 (bases 1 to 1264)
  AUTHORS   Park,M.H., Liu,T.Y., Neece,S.H. and Swiggard,W.J.
  TITLE     Eukaryotic initiation factor 4D. Purification from human red blood
            cells and the sequence of amino acids around its single hypusine
            residue
  JOURNAL   J Biol Chem 261 (31), 14515-14519 (1986)
   PUBMED   3095320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB111036.1, AY129320.1 and AC026954.14.
            
            On Nov 23, 2018 this sequence version replaced NM_001970.4.
            
            Transcript Variant: This variant (B) contains an alternate in-frame
            exon in the 5' coding region and uses a downstream start codon
            compared to variant A. The encoded isoform (B) has a shorter
            N-terminus compared to isoform A. Variants B, C, and D encode the
            same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.531995.1,
                                           SRR1163657.220063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336458.13/ ENSP00000336776.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               CB111036.1         92-209
            119-623             AY129320.1         198-702
            624-1264            AC026954.14        33309-33949
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1264
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /note="eukaryotic translation initiation factor 5A"
                     /db_xref="GeneID:1984"
                     /db_xref="HGNC:HGNC:3300"
                     /db_xref="MIM:600187"
     exon            1..125
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /inference="alignment:Splign:2.1.0"
     exon            126..311
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..611
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /note="isoform B is encoded by transcript variant B;
                     eukaryotic translation initiation factor 5A-1; rev-binding
                     factor; eukaryotic initiation factor 5A"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 5A-1
                     isoform B"
                     /protein_id="NP_001961.1"
                     /db_xref="CCDS:CCDS11099.1"
                     /db_xref="GeneID:1984"
                     /db_xref="HGNC:HGNC:3300"
                     /db_xref="MIM:600187"
                     /translation="MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMS
                     TSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLL
                     QDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK"
     exon            312..416
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /inference="alignment:Splign:2.1.0"
     exon            417..548
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /inference="alignment:Splign:2.1.0"
     exon            549..622
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /inference="alignment:Splign:2.1.0"
     exon            623..1264
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /note="hexamer: AATAAA"
     polyA_site      1264
                     /gene="EIF5A"
                     /gene_synonym="eIF-4D; EIF-5A; EIF5A1; eIF5AI; FABAS"
                     /note="major polyA site"
ORIGIN      
        1 gtactaagac ccgtgtgcag cagcggcggc ggcggtagag gcggcggcgg cggcggcagc
       61 gggctcggag gcagcggttg ggctcgcggc gagcggacgg ggtcgagtca gtgcgttcgc
      121 gcgagttgga atcgaagcct cttaaaatgg cagatgactt ggacttcgag acaggagatg
      181 caggggcctc agccaccttc ccaatgcagt gctcagcatt acgtaagaat ggctttgtgg
      241 tgctcaaagg ccggccatgt aagatcgtcg agatgtctac ttcgaagact ggcaagcacg
      301 gccacgccaa ggtccatctg gttggtattg acatctttac tgggaagaaa tatgaagata
      361 tctgcccgtc aactcataat atggatgtcc ccaacatcaa aaggaatgac ttccagctga
      421 ttggcatcca ggatgggtac ctatcactgc tccaggacag cggggaggta cgagaggacc
      481 ttcgtctccc tgagggagac cttggcaagg agattgagca gaagtacgac tgtggagaag
      541 agatcctgat cacggtgctg tctgccatga cagaggaggc agctgttgca atcaaggcca
      601 tggcaaaata actggctccc agggtggcgg tggtggcagc agtgatcctc tgaacctgca
      661 gaggccccct ccccgagcct ggcctggctc tggcccggtc ctaagctgga ctcctcctac
      721 acaatttatt tgacgtttta ttttggtttt ccccaccccc tcaatctgtc ggggagcccc
      781 tgcccttcac ctagctccct tggccaggag cgagcgaagc tgtggccttg gtgaagctgc
      841 cctcctcttc tcccctcaca ctacagccct ggtgggggag aagggggtgg gtgctgcttg
      901 tggtttagtc tttttttttt tttttttttt aattcaatct ggaatcagaa agcggtggat
      961 tctggcaaat ggtccttgtg ccctccccac tcatccctgg tctggtcccc tgttgcctat
     1021 agccctttac cctgagcacc accccaacag actggggacc agccccctcg cctgcctgtg
     1081 tctctcccca aaccccttta gatggggagg gaagaggagg agaggggagg ggacctgccc
     1141 cctcctcagg catctgggag ggccctgccc ccatgggctt tacccttccc tgcgggctct
     1201 ctccccgaca catttgttaa aatcaaacct gaataaaact acaagtttaa tatgaagccc
     1261 ccaa
//
