LOCUS       NM_001969               5710 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 5 (EIF5),
            transcript variant 1, mRNA.
ACCESSION   NM_001969
VERSION     NM_001969.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5710)
  AUTHORS   Cai,S.X., Chen,W.S., Zeng,W., Cheng,X.F., Lin,M.B. and Wang,J.S.
  TITLE     Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis
  JOURNAL   Curr Med Sci 41 (4), 764-769 (2021)
   PUBMED   34403101
  REMARK    GeneRIF: Roles of HDAC2, eIF5, and eIF6 in Lung Cancer
            Tumorigenesis.
REFERENCE   2  (bases 1 to 5710)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5710)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5710)
  AUTHORS   Lin,K.Y., Nag,N., Pestova,T.V. and Marintchev,A.
  TITLE     Human eIF5 and eIF1A Compete for Binding to eIF5B
  JOURNAL   Biochemistry 57 (40), 5910-5920 (2018)
   PUBMED   30211544
REFERENCE   5  (bases 1 to 5710)
  AUTHORS   Tang,L., Morris,J., Wan,J., Moore,C., Fujita,Y., Gillaspie,S.,
            Aube,E., Nanda,J., Marques,M., Jangal,M., Anderson,A., Cox,C.,
            Hiraishi,H., Dong,L., Saito,H., Singh,C.R., Witcher,M.,
            Topisirovic,I., Qian,S.B. and Asano,K.
  TITLE     Competition between translation initiation factor eIF5 and its
            mimic protein 5MP determines non-AUG initiation rate genome-wide
  JOURNAL   Nucleic Acids Res 45 (20), 11941-11953 (2017)
   PUBMED   28981728
  REMARK    GeneRIF: Data show that eIF5-mimic protein (5MP) represses non-AUG
            translation by competing with translation initiation factor 5
            (eIF5) for the Met-tRNAi-binding factor eIF2.
REFERENCE   6  (bases 1 to 5710)
  AUTHORS   Das,S. and Maitra,U.
  TITLE     Mutational analysis of mammalian translation initiation factor 5
            (eIF5): role of interaction between the beta subunit of eIF2 and
            eIF5 in eIF5 function in vitro and in vivo
  JOURNAL   Mol Cell Biol 20 (11), 3942-3950 (2000)
   PUBMED   10805737
REFERENCE   7  (bases 1 to 5710)
  AUTHORS   Pestova,T.V., Lomakin,I.B., Lee,J.H., Choi,S.K., Dever,T.E. and
            Hellen,C.U.
  TITLE     The joining of ribosomal subunits in eukaryotes requires eIF5B
  JOURNAL   Nature 403 (6767), 332-335 (2000)
   PUBMED   10659855
REFERENCE   8  (bases 1 to 5710)
  AUTHORS   Bandyopadhyay,A. and Maitra,U.
  TITLE     Cloning and characterization of the p42 subunit of mammalian
            translation initiation factor 3 (eIF3): demonstration that eIF3
            interacts with eIF5 in mammalian cells
  JOURNAL   Nucleic Acids Res 27 (5), 1331-1337 (1999)
   PUBMED   9973622
REFERENCE   9  (bases 1 to 5710)
  AUTHORS   Das,S., Maiti,T., Das,K. and Maitra,U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 5
            (eIF5) with the beta-subunit of eIF2
  JOURNAL   J Biol Chem 272 (50), 31712-31718 (1997)
   PUBMED   9395514
REFERENCE   10 (bases 1 to 5710)
  AUTHORS   Si,K., Das,K. and Maitra,U.
  TITLE     Characterization of multiple mRNAs that encode mammalian
            translation initiation factor 5 (eIF-5)
  JOURNAL   J Biol Chem 271 (28), 16934-16938 (1996)
   PUBMED   8663286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138976.5.
            
            On Nov 23, 2018 this sequence version replaced NM_001969.4.
            
            Summary: Eukaryotic translation initiation factor-5 (EIF5)
            interacts with the 40S initiation complex to promote hydrolysis of
            bound GTP with concomitant joining of the 60S ribosomal subunit to
            the 40S initiation complex. The resulting functional 80S ribosomal
            initiation complex is then active in peptidyl transfer and chain
            elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied
            by OMIM, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.83710.1,
                                           SRR1660803.200837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216554.8/ ENSP00000216554.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL138976.5         146763-146786
            25-233              AL138976.5         146915-147123
            234-513             AL138976.5         148179-148458
            514-595             AL138976.5         148562-148643
            596-768             AL138976.5         149203-149375
            769-880             AL138976.5         149642-149753
            881-1026            AL138976.5         150853-150998
            1027-1185           AL138976.5         151261-151419
            1186-1347           AL138976.5         151698-151859
            1348-1512           AL138976.5         152165-152329
            1513-1647           AL138976.5         152953-153087
            1648-5710           AL138976.5         153489-157551
FEATURES             Location/Qualifiers
     source          1..5710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.32"
     gene            1..5710
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="eukaryotic translation initiation factor 5"
                     /db_xref="GeneID:1983"
                     /db_xref="HGNC:HGNC:3299"
                     /db_xref="MIM:601710"
     exon            1..24
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            25..233
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            234..513
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1737
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 5"
                     /protein_id="NP_001960.2"
                     /db_xref="CCDS:CCDS9980.1"
                     /db_xref="GeneID:1983"
                     /db_xref="HGNC:HGNC:3299"
                     /db_xref="MIM:601710"
                     /translation="MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAK
                     ALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPEC
                     ENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEK
                     KNRKGKDKENGSVSSSETPPPPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDE
                     ISDHAKVLTLSDDLERTIEERVNILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMG
                     PLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIP
                     HILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGG
                     EEEDEDENIEVVYSKAASVPKVETVKSDNKDDDIDIDAI"
     exon            514..595
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            596..768
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            769..880
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1026
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1185
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1347
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1512
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1647
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..5710
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="hexamer: AATAAA"
     polyA_site      2045
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="major polyA site"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="hexamer: ATTAAA"
     polyA_site      3856
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="major polyA site"
     regulatory      3884..3889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="hexamer: AACAAG"
     polyA_site      3913
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
     regulatory      5684..5689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
                     /note="hexamer: AATAAA"
     polyA_site      5710
                     /gene="EIF5"
                     /gene_synonym="EIF-5; EIF-5A"
ORIGIN      
        1 agtcagagcg agaacattcc agaggtcgcc cagctccggc gctgacgggt gtggaccgcg
       61 gacgtcgctg ggacagcccc tccccgctgc tcggcggcgg cacctggccc ggccgctcct
      121 cgctgcgctt cgcctccgcc tcctcggact cggactcggg tttatatcgc gcctcacttc
      181 atcccagtcc cgggcgagca gcgttgggtt tatgtcttta tttgacgaaa acgagctgtt
      241 gcgcagccat tggtacctgt attggggaaa catagcatac aagcaagaag cttacagcct
      301 cagtggcgaa aattttttca tgtcagagac cgagaactct tgcagtcgtt tatgtcatcc
      361 cttcttctcc agacagaaga taccaaaaag ttgcaatcaa agatctcttc atcttattga
      421 taaagccact aataagccaa aatgtctgtc aatgtcaacc gcagcgtgtc agaccagttc
      481 tatcgctaca agatgccccg tctgattgcc aaggttgagg gcaaaggcaa tggaatcaag
      541 acagttatag tcaacatggt tgacgttgca aaggcgctta atcggcctcc aacgtatccc
      601 accaaatatt ttggttgtga gctgggagca cagacccagt ttgatgttaa gaatgaccgt
      661 tacattgtca atggatctca tgaggcgaat aagctgcaag acatgttgga tggattcatt
      721 aaaaaatttg ttctctgtcc tgaatgtgag aatcctgaaa cagatttgca tgtcaatcca
      781 aagaagcaaa caataggtaa ttcttgtaaa gcctgtggct atcgaggcat gcttgacaca
      841 catcataaac tctgcacatt cattctcaaa aacccacctg agaatagtga cagtggtaca
      901 ggaaagaaag aaaaagaaaa gaaaaacaga aagggcaaag acaaggaaaa tggctccgta
      961 tccagcagtg agacaccacc accaccacca ccaccaaatg aaattaatcc tcctccacat
     1021 acaatggaag aagaggagga tgatgactgg ggagaagata caactgagga agctcaaagg
     1081 cgtcgaatgg atgaaatcag tgaccatgca aaagttctga cactcagtga tgatttggaa
     1141 agaacaattg aggagagggt caatatcctc tttgattttg ttaagaaaaa gaaagaagag
     1201 ggtgttattg attcatctga caaagaaatc gttgctgaag cagaaagact ggatgtaaaa
     1261 gccatgggcc ctcttgttct aactgaagtt ctttttaatg agaagattag agaacagatt
     1321 aagaaataca ggcgccattt cctacgattt tgtcacaaca acaaaaaagc ccaacggtac
     1381 cttcttcatg gtttggagtg tgtggtagca atgcatcaag ctcagcttat ctccaagatt
     1441 ccacatatct tgaaggagat gtacgatgca gaccttttag aagaagaggt catcatcagc
     1501 tggtcggaaa aggcctctaa gaaatatgtc tccaaagaac ttgccaaaga gattcgtgtc
     1561 aaagcagaac catttataaa atggttgaag gaggcagagg aagaatcttc tggtggcgaa
     1621 gaagaagatg aagatgagaa cattgaggtg gtgtattcga aggctgccag tgtaccgaaa
     1681 gttgagactg taaagtcaga caacaaggat gacgacatcg atattgatgc catttaaagg
     1741 gatggatgca acctagctta acagtataat gctgcaaatt ttcctccatt atcagccaga
     1801 agtgcaacat gtatgtgcaa aagctaaaat ggcttaacat catgctacac tttacactaa
     1861 aaatctatta ctgtgagtgg tctgttatta agcccaatga gacatctagg gagtccatac
     1921 acatcagtga gcagatgtag tttgcttatt tatagcatgt ttctttttga aaaactagtg
     1981 gtggacacat ttggatcaca tttatacagt tataaaaata aaggtttgat tttggtcgtt
     2041 cttcagatgt ttggctctga atgacttaag ctgaagtaac tggctcctta ctttaaatgt
     2101 tctgccatca tttcacctga tgagcattct tggagcctgc cagatattgt taggtcctgg
     2161 ggctgcaaag aggtcctcaa caggatgtaa agcaaactta attgtaatta atttattcag
     2221 cccattaaga aagtactaaa gttttatctc tgtagttcct caaattggca tctggtaatg
     2281 tacattgtga ggtagactga taatgaaatg acagtgtaac atcttaacca agaagtaaat
     2341 atgacctcag tgtcctataa ataatgtaag agcaggattt gaaacttgga gagctgtttt
     2401 ctcatttcat gtacacttgc cccaaattgt ctttgaagtc gtgtgcattg cacgttggat
     2461 gagccaggga aattattaca ttaacaagca ttttgtgtgt acgtagtagt tactttgtac
     2521 tgagagaact tgctttgggg tgcaattaat aaactgattt tatttgggag aaacaaggaa
     2581 gggtgcactt aactagcaac ctaagcatga tttttcagct tttgccctta gggtttaaat
     2641 tacaattcca aaatgttaga catactgtat tttttcgttc agtgtggctt taattttccc
     2701 ctcttgcagt ttgttctgta atgcctttta catttggaca catagtttat gctttttaga
     2761 ttttggttgc tttcttgcca aaataagtgt taactgtgtt tcaaacttga ttttctttcc
     2821 tttttctttt ttttttcttc cagaatgtct tatttaaaaa gaaagctaaa agcatacttc
     2881 taagtcagag cctctatttt ggtgtaagac ttgggatatt ttttacttca cattgaatat
     2941 agccaggcac ccaagaagtc tgatggccac ctgagtgcag gtgacaagga cctgacagag
     3001 cccatgcagg gctttagatt tggacacaca agagttgata acttcctcat gaactccttg
     3061 cctgatctaa actcatatta tgggttctga ctgtttgagt aatcatcttc aaggttaaac
     3121 ctcttggcag ttaccctttt cacaaagtgc acagtgggaa tcgagaatcg atagggttaa
     3181 ttttggagca gtggcttata ccattcacct ctgttttttt gtgattattt cacagataat
     3241 gagaccttaa taacaaatag gcgtaaaaaa attttcacat tgaaatgata gaaacatttg
     3301 atgtaataaa acttggttgg cttgatattt taaggaattg aaacctagca atcttattgg
     3361 agagacaaga attggtctcc agctgccttt gatcaagatt cgggtgcaag tggagcagga
     3421 gccatatacc tggagggaat gtgctttgtc acaccaaaga ggattttttt ttcttcaaac
     3481 ttgtatgttg cctaggtttc aaattctttg ccgcaaggct gatctgcttt cattaactgg
     3541 aattctgtag gagatactgg tgacctaagc taagttgcac tcagcatact cagtgtcaag
     3601 ctaatgaggt tctattataa aggttctact tttaatctga gggaaaacat gttcagggct
     3661 tctagaacac taaaaaattt ggcttaaacc agtgttcagt ctggtgccaa acttcgaatg
     3721 gaatacaaat tcacataatc tgaactttgt tcacaggtta tcctaataga gtaattcttc
     3781 actttgctct attgaactgt cttaaggatt tgtttaaaca gctaagttac ttgattaaaa
     3841 taatgataaa attgtatttt gtctttgctt taatattaaa gttaacaagt tttcatttta
     3901 taatgagatc aaagcattgg aatctgccct gttttgtagc cgttgctttg gatttgtgtt
     3961 ggatgtatcc tgcagttaca cttgccagcc ccactcacaa aagttgttca tttcattggg
     4021 tcactggctt tatttgctag tcttgtctgt gaactgagca tctgcctcag ttttattact
     4081 tgaaatcttg gcaggtgctt aatagggaac atacatacag ctatgtaact gtgaataatt
     4141 gtatatatct ctagttaaga atgagggaat ggggaggttt gctttctaaa caagtgcatt
     4201 ctgaaattga cttaaaaatt tttagtgtgg gtcctaaagt ttagagatgg gcaaggaggt
     4261 ctctaatcca ccgcttcccg cttgagaagg gaggggtatc aaaattgagc cccaagctgt
     4321 ttgttccagt gtaccaagca ctgactttat gcctttggcc tggagatggc agaagtgaaa
     4381 gctggccatc tgcaaaaagc agataagtga gtttgaacct tttgcatttt gttagctcag
     4441 tcagtcctca tcgtggtcct gaggcatagg tactgttgta ccaaggtcac ttatctaaca
     4501 aaataaccct tcatgtattt taaatttatt tgacaagtct gcagacaatc cttatctaac
     4561 cagctatttt cttaattgct acagcttgac ctaccagtat tccggagtaa ccagcaaatg
     4621 caaagttgac cttgttcctg catcatcttt ttgatggttc aaatttcagc ctccctgact
     4681 actacaaagc cagagcagtc ttagtaccag aaacagtgtt gcactttcgt tgcatgtgct
     4741 gtgtgacccc aaggggacag ggagtcactt tggtcatctc tgtccccagt acagatcttg
     4801 attcatagtg acattccata agtggggtga cagcaaatga cttgcaggta gtctcattgt
     4861 aggtttgtgc accagagtga ccctgtgagc ctttgttaat aggttgggag ctcagggtgt
     4921 ttatgtccac ctgtctggtc tagccaaaca gtttttttct gggaatcaaa tttctgtggt
     4981 ttttatggcc agaaatttta aggacttgtg tgtgctggga tatgagaata gaagctacag
     5041 agttcttttc ttgggaccta gactgggagg tgcaatgtca ggacctccag gtgaatggta
     5101 ggatctgagt tgaccctgca gttcggttat gcagtcaatt atttcttttt aagaggagga
     5161 ggattcactt gggtgttggg atcaaatttg gattctgtcc caggccttac tgtaaaacta
     5221 ggggattgcc tttccatatc tgctgggggt ggagaccctt atgtgcagca ctcaatccca
     5281 ctggaagcct aatgctgcag tcagaagcaa tgcctggctg gggcagtagg ggaaattcca
     5341 cccaattttg ctatgagcct aaaacctctt taaaaacggt cagttaacta aaaaataaaa
     5401 atcaagtctt taggagagta gaaaacacaa ttaactaaaa agcagggaca tctgaaagag
     5461 acgtattaag ttaacatttt taaaaatcca aatgaaagta aatggaataa atgtatcagg
     5521 taaaggacaa gttgtaagct tggattttta ggtctagcaa tacactgttt acaagagcat
     5581 cacctaaaat gtgacaaaag atgttgaaag gatgaaaaaa ggtatagtag acatacacta
     5641 accaaaaatg tagctctttg aatctcagaa aaaagtagat tttaataaag tgtgaaagtt
     5701 gtcaatcaaa
//
