LOCUS       NM_001391906            6397 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4 gamma 3
            (EIF4G3), transcript variant 19, mRNA.
ACCESSION   NM_001391906 XM_017002678
VERSION     NM_001391906.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6397)
  AUTHORS   Kang,J.Y., Wen,Z., Pan,D., Zhang,Y., Li,Q., Zhong,A., Yu,X.,
            Wu,Y.C., Chen,Y., Zhang,X., Kou,P.C., Geng,J., Wang,Y.Y., Hua,M.M.,
            Zong,R., Li,B., Shi,H.J., Li,D., Fu,X.D., Li,J., Nelson,D.L.,
            Guo,X., Zhou,Y., Gou,L.T., Huang,Y. and Liu,M.F.
  TITLE     LLPS of FXR1 drives spermiogenesis by activating translation of
            stored mRNAs
  JOURNAL   Science 377 (6607), eabj6647 (2022)
   PUBMED   35951695
REFERENCE   2  (bases 1 to 6397)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 6397)
  AUTHORS   Wang,Q., Wang,T., Hu,Y., Jiang,W., Lu,C., Zheng,W., Zhang,W.,
            Chen,Z. and Cao,H.
  TITLE     Circ-EIF4G3 promotes the development of gastric cancer by sponging
            miR-335
  JOURNAL   Pathol Res Pract 215 (9), 152507 (2019)
   PUBMED   31257089
  REMARK    GeneRIF: Our study demonstrates that circ-EIF4G3 promotes the
            proliferation, invasion and migration of gastric cancer via
            sponging miR-335.
            Erratum:[Pathol Res Pract. 2021 Jan;217:153163. doi:
            10.1016/j.prp.2020.153163.. PMID: 33272720]
REFERENCE   4  (bases 1 to 6397)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 6397)
  AUTHORS   Hashimoto,R., Ikeda,M., Yamashita,F., Ohi,K., Yamamori,H.,
            Yasuda,Y., Fujimoto,M., Fukunaga,M., Nemoto,K., Takahashi,T.,
            Tochigi,M., Onitsuka,T., Yamasue,H., Matsuo,K., Iidaka,T.,
            Iwata,N., Suzuki,M., Takeda,M., Kasai,K. and Ozaki,N.
  TITLE     Common variants at 1p36 are associated with superior frontal gyrus
            volume
  JOURNAL   Transl Psychiatry 4 (10), e472 (2014)
   PUBMED   25335168
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6397)
  AUTHORS   Waskiewicz,A.J., Johnson,J.C., Penn,B., Mahalingam,M., Kimball,S.R.
            and Cooper,J.A.
  TITLE     Phosphorylation of the cap-binding protein eukaryotic translation
            initiation factor 4E by protein kinase Mnk1 in vivo
  JOURNAL   Mol Cell Biol 19 (3), 1871-1880 (1999)
   PUBMED   10022874
REFERENCE   7  (bases 1 to 6397)
  AUTHORS   Pyronnet,S., Imataka,H., Gingras,A.C., Fukunaga,R., Hunter,T. and
            Sonenberg,N.
  TITLE     Human eukaryotic translation initiation factor 4G (eIF4G) recruits
            mnk1 to phosphorylate eIF4E
  JOURNAL   EMBO J 18 (1), 270-279 (1999)
   PUBMED   9878069
REFERENCE   8  (bases 1 to 6397)
  AUTHORS   Gingras,A.C., Raught,B. and Sonenberg,N.
  TITLE     eIF4 initiation factors: effectors of mRNA recruitment to ribosomes
            and regulators of translation
  JOURNAL   Annu Rev Biochem 68, 913-963 (1999)
   PUBMED   10872469
  REMARK    Review article
REFERENCE   9  (bases 1 to 6397)
  AUTHORS   Imataka,H., Gradi,A. and Sonenberg,N.
  TITLE     A newly identified N-terminal amino acid sequence of human eIF4G
            binds poly(A)-binding protein and functions in poly(A)-dependent
            translation
  JOURNAL   EMBO J 17 (24), 7480-7489 (1998)
   PUBMED   9857202
REFERENCE   10 (bases 1 to 6397)
  AUTHORS   Gradi,A., Imataka,H., Svitkin,Y.V., Rom,E., Raught,B., Morino,S.
            and Sonenberg,N.
  TITLE     A novel functional human eukaryotic translation initiation factor
            4G
  JOURNAL   Mol Cell Biol 18 (1), 334-342 (1998)
   PUBMED   9418880
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031005.2, AL627311.16,
            AL358392.19 and AL606477.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 14, 2021 this sequence version replaced XM_017002678.2.
            
            Summary: The protein encoded by this gene is thought to be part of
            the eIF4F protein complex, which is involved in mRNA cap
            recognition and transport of mRNAs to the ribosome. Interestingly,
            a microRNA (miR-520c-3p) has been found that negatively regulates
            synthesis of the encoded protein, and this leads to a global
            decrease in protein translation and cell proliferation. Therefore,
            this protein is a key component of the anti-tumor activity of
            miR-520c-3p. [provided by RefSeq, May 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602326.6/ ENSP00000473510.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL031005.2         4714-4889           c
            177-360             AL031005.2         4167-4350           c
            361-436             AL627311.16        119882-119957       c
            437-565             AL627311.16        81610-81738         c
            566-661             AL627311.16        33457-33552         c
            662-775             AL627311.16        31943-32056         c
            776-808             AL627311.16        28345-28377         c
            809-829             AL627311.16        13132-13152         c
            830-1009            AL627311.16        11792-11971         c
            1010-1124           AL627311.16        11078-11192         c
            1125-1222           AL627311.16        3746-3843           c
            1223-1345           AL358392.19        76459-76581         c
            1346-1454           AL358392.19        56988-57096         c
            1455-2294           AL358392.19        48476-49315         c
            2295-2383           AL358392.19        11868-11956         c
            2384-2630           AL358392.19        6682-6928           c
            2631-2764           AL358392.19        2353-2486           c
            2765-2884           AL606477.11        138463-138582       c
            2885-3055           AL606477.11        131147-131317       c
            3056-3253           AL606477.11        124269-124466       c
            3254-3400           AL606477.11        110062-110208       c
            3401-3637           AL606477.11        109422-109658       c
            3638-3742           AL606477.11        107174-107278       c
            3743-3875           AL606477.11        105331-105463       c
            3876-3970           AL606477.11        102349-102443       c
            3971-4064           AL606477.11        99924-100017        c
            4065-4182           AL606477.11        98506-98623         c
            4183-4403           AL606477.11        96204-96424         c
            4404-4519           AL606477.11        94361-94476         c
            4520-4692           AL606477.11        85802-85974         c
            4693-4818           AL606477.11        74093-74218         c
            4819-4900           AL606477.11        72563-72644         c
            4901-4999           AL606477.11        70046-70144         c
            5000-5146           AL606477.11        62338-62484         c
            5147-5228           AL606477.11        58104-58185         c
            5229-5375           AL606477.11        55684-55830         c
            5376-6397           AL606477.11        51425-52446         c
FEATURES             Location/Qualifiers
     source          1..6397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..6397
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /note="eukaryotic translation initiation factor 4 gamma 3"
                     /db_xref="GeneID:8672"
                     /db_xref="HGNC:HGNC:3298"
                     /db_xref="MIM:603929"
     exon            1..176
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            177..360
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            361..436
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            437..565
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            566..661
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     CDS             632..5557
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /note="isoform 14 is encoded by transcript variant 19;
                     eIF-4-gamma 3; eIF-4-gamma II"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4 gamma
                     3 isoform 14"
                     /protein_id="NP_001378835.1"
                     /db_xref="CCDS:CCDS90876.1"
                     /db_xref="GeneID:8672"
                     /db_xref="HGNC:HGNC:3298"
                     /db_xref="MIM:603929"
                     /translation="MNSQPQTRSPPSRTVPIHCTDNWKRRKVLEQTPVYRSLAGRGWI
                     KYCIFAAGPRPPHHQGGFRPIQFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQ
                     HIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDF
                     PNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGG
                     GSRNPTPPIGRPTSTPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEE
                     KPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARST
                     IAAPTSSALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDIC
                     KKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPP
                     EEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITVQRVL
                     EEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWK
                     KPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVE
                     ENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDR
                     EFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADF
                     GRQTPGGRGVPLLNVGSRRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPSQKRDSQ
                     ADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAI
                     DEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKK
                     QKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVK
                     LLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQ
                     DVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDE
                     GGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDA
                     LRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLTSRGSMGREKNDKPLPSATARP
                     NTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRESAKPEI
                     SAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVE
                     STLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAE
                     LVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREAD
                     LSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDK
                     ANDEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPIL
                     LKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKD
                     PAEQNGKGVALKSVTAFFTWLREAEEESEDN"
     exon            662..775
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            776..808
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            809..829
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1009
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1124
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1222
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1345
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1454
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..2294
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2383
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2630
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2764
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2884
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3055
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3253
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3400
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3637
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3742
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3875
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..3970
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4064
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4065..4182
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4403
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4519
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4520..4692
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4818
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4900
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            4901..4999
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5146
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5228
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            5229..5375
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..6397
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6370..6375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /note="hexamer: AATAAA"
     polyA_site      6397
                     /gene="EIF4G3"
                     /gene_synonym="eIF-4G 3; eIF4G 3; eIF4GII"
                     /note="major polyA site"
ORIGIN      
        1 agccgtcctg ccggactgct ggaggcggcc acagcgccat gttggatgct ctgctcgttg
       61 agtgaagaaa atccaccggc atcgcctgag ccccgctacc gagaagggcg ccgcttcctc
      121 cggggagggg gataaagatc ccccgccgcc ggcccatgag gatattgccg tgaaaggcac
      181 agcgactgca gcaggaaccg gacccggcac cggagcggcg gcggcggcgg cagcagcggt
      241 accgcctcct cacccggcgg cggcagcagc ggcggcggcg gcggcggcgg cggcggcggc
      301 ggcagcggtc ccccctcctc acccgaacat cagggccctc cagactcagg cgccccaaca
      361 aattcctaga ggacctgtgc aacaacctct tgaggatcga atcttcactc ccgctgtctc
      421 agcagtctac agcacggtaa cacaagtggc aagacagccg ggaaccccta ccccatcccc
      481 ttattcagca catgaaataa acaaggggca tccaaatctt gcggcaacgc ccccgggaca
      541 tgcatcgtcc cctggactct ctcaaacccc ttatccctct ggacagaatg caggtccaac
      601 cacgctggta taccctcaaa cccctcagac aatgaattca caacctcaaa cccgttctcc
      661 gcccagcaga acagtgccaa tacattgcac agacaactgg aagaggagga aggttttgga
      721 acagactccc gtttacaggt ccttggctgg aagaggctgg ataaaatact gcatttttgc
      781 agcggggcct cgacctcccc atcatcaggg aggattcaga cctatccagt ttttccagag
      841 gcctcaaata cagcctccta gagctaccat cccgaacagc agtccttcca ttcgtcctgg
      901 tgcacagaca cccactgcag tgtaccaggc taatcagcac atcatgatgg ttaaccatct
      961 gcccatgccg tacccagtgc cccaggggcc tcagtactgt ataccacagt accgtcatag
     1021 tggccctcct tatgttgggc ccccccaaca atatccagtt caaccaccgg ggccaggtcc
     1081 tttttatcct ggaccaggac ctggggactt ccccaatgct tatggaacgc ctttttaccc
     1141 aagtcagccg gtgtatcagt cagcacctat catagtgcct acgcagcaac agccgcctcc
     1201 agccaagaga gagaaaaaaa ctataagaat tcgggatcca aaccagggag gtaaagacat
     1261 aacagaggag attatgtctg gaggtggcag cagaaatcct actccaccca taggaagacc
     1321 cacgtccaca cctactcctc ctcagcagct gcccagccag gtccccgagc acagccctgt
     1381 ggtttatggg actgtggaga gcgctcatct tgctgccagc acccctgtca ctgcagctag
     1441 cgaccagaag caagaggaga agccaaaacc agatccagtg ttaaagtctc cttccccagt
     1501 ccttaggcta gtcctcagtg gagagaagaa agaacaagaa ggccagacat ctgaaactac
     1561 tgcaatagta tccatagcag agcttcctct gcctccatca cctaccactg tttcttctgt
     1621 tgctcgaagt acaattgcag cccccacctc ttctgctctt agtagccaac caatattcac
     1681 cactgctata gatgacagat gtgaactctc atccccaaga gaagacacaa ttcctatacc
     1741 cagcctcaca tcttgcacag aaacatcaga ccctttacca acaaatgaaa atgatgatga
     1801 tatatgcaag aaaccctgta gtgtagcacc taatgatatt ccactggttt ctagtactaa
     1861 cctaattaat gaaataaatg gagttagcga aaaattatca gccacggaga gcattgtgga
     1921 aatagtaaaa caggaagtat tgccattgac tcttgaattg gagattctcg aaaatccccc
     1981 agaagaaatg aaactggagt gtatcccagc tcccatcacc ccttccacag ttccttcctt
     2041 tcctccaact cctccaactc ctccagcttc tcctcctcac actccagtca ttgttcctgc
     2101 tgctgccact actgttagtt ctccgagtgc tgccatcaca gtccagagag tcctagagga
     2161 ggacgagagc ataagaactt gccttagtga agatgcaaaa gagattcaga acaaaataga
     2221 ggtagaagca gatgggcaaa cagaagagat tttggattct caaaacttaa attcaagaag
     2281 gagccctgtc ccagctcaaa tagctataac tgtaccaaag acatggaaga aaccaaaaga
     2341 tcggacccga accactgaag agatgttaga ggcagaattg gagcttaaag ctgaagagga
     2401 gctttccatt gacaaagtac ttgaatctga acaagataaa atgagccagg ggtttcatcc
     2461 tgaaagagac ccctctgacc taaaaaaagt gaaagctgtg gaagaaaatg gagaagaagc
     2521 tgagccagta cgtaatggtg ctgagagtgt ttctgagggt gaaggaatag atgctaattc
     2581 aggctccaca gatagttctg gtgatggggt tacatttcca tttaaaccag aatcctggaa
     2641 gcctactgat actgaaggta agaagcagta tgacagggag tttctgctgg acttccagtt
     2701 catgcctgcc tgtatacaaa aaccagaggg cctgcctcct atcagtgatg tggttcttga
     2761 caagatcaac caacccaaat tgccaatgcg aactctggat cctcgaattt tgcctcgagg
     2821 accagacttt acaccagcct ttgctgattt tggaaggcag acacctggtg gaagaggcgt
     2881 acctttgttg aatgttgggt cacgaagatc tcaacctggc caaagaagag aacccagaaa
     2941 gatcatcaca gtttctgtaa aagaagatgt acacctgaaa aaggcagaaa atgcctggaa
     3001 gccaagccaa aaacgagaca gccaagccga tgatcccgaa aacattaaaa cccaggagct
     3061 ttttagaaaa gttcgaagta tcttaaataa attgacacca cagatgttca atcaactgat
     3121 gaagcaagtg tcaggactta ctgttgacac agaggagcgg ctgaaaggag ttattgacct
     3181 ggtctttgag aaggctattg atgaacccag tttctctgtg gcttacgcaa acatgtgtcg
     3241 atgtctagta acgctgaaag tacccatggc agacaagcct ggtaacacag tgaatttccg
     3301 gaagctgcta ctgaaccgtt gccagaagga gtttgaaaaa gataaagcag atgatgatgt
     3361 ctttgagaag aagcagaaag aacttgaggc tgccagtgct ccagaggaga ggacaaggct
     3421 tcatgatgaa ctggaagaag ccaaggacaa agcccggcgg agatccattg gcaacatcaa
     3481 gtttattgga gaactcttta aactcaaaat gctgactgaa gccatcatgc atgactgtgt
     3541 ggtgaagctg ctaaagaacc atgatgaaga atccctggag tgcctgtgtc gcctgctcac
     3601 caccattggc aaagacttgg actttgaaaa agcaaagcca cgtatggacc agtactttaa
     3661 tcagatggag aaaattgtga aagaaagaaa aacctcatct aggattcggt tcatgcttca
     3721 agatgttata gacctaaggc tgtgcaattg ggtatctcga agagcagatc aagggcctaa
     3781 aactatcgaa cagattcaca aagaggctaa aatagaagaa caagaagagc aaaggaaggt
     3841 ccagcaactc atgaccaaag agaagagaag accaggtgtc cagagagtgg acgaaggtgg
     3901 gtggaacact gtacaagggg ccaagaacag tcgggtactg gacccctcaa aattcctaaa
     3961 aatcactaag cctacaattg atgaaaaaat tcagctggta cctaaagcac agctaggcag
     4021 ctggggaaaa ggcagcagtg gtggagcaaa ggcaagtgag actgatgcct tacggtcaag
     4081 tgcttccagt ttaaacagat tctctgccct gcaacctcca gcaccctcag ggtccacgcc
     4141 atccacgcct gtagagtttg attcccgaag gaccttaact agtcgtggaa gtatgggcag
     4201 ggagaagaat gacaagcccc ttccatctgc aacagctcgg ccaaatactt tcatgagggg
     4261 tggcagcagt aaagacctgc tagacaatca gtctcaagaa gagcagcgga gagagatgct
     4321 ggagaccgtg aagcagctca caggaggtgt ggatgtggag aggaacagca ctgaggctga
     4381 gcgaaataaa acaagggagt cagcaaaacc agaaatttca gcaatgtcag ctcatgacaa
     4441 ggctgcatta tcagaagagg aactggagag gaagtcgaaa tctatcattg atgaatttct
     4501 acacattaat gattttaagg aagccatgca gtgtgtggaa gagctgaatg cccagggcct
     4561 actacatgtt tttgtgagag tgggagtgga gtccaccctg gaaaggagcc agatcaccag
     4621 ggatcacatg ggccaattac tctatcagct ggtacagtca gaaaaactca gcaaacagga
     4681 ctttttcaaa ggtttttcag aaactttgga attggcagat gacatggcca ttgatattcc
     4741 ccatatttgg ttgtaccttg ctgaactggt gacccccatg ttaaaagaag gtggaatctc
     4801 catgagagaa cttaccatag aatttagcaa acctttactt cctgttggaa gagctggggt
     4861 cttgctatct gaaatattgc acctactatg caaacaaatg agccataaga aagtgggagc
     4921 cttatggagg gaggctgacc tcagctggaa ggacttttta ccagaaggag aagatgtaca
     4981 taattttctt ttggagcaga agttggactt catagagtct gacagtccct gttcctctga
     5041 agcactttca aagaaagaac tgtctgccga agagctgtat aagcgactcg agaaactcat
     5101 tattgaggac aaagcgaatg atgaacagat ctttgactgg gtagaggcta atctagacga
     5161 aatccagatg agttcaccta cattccttag agctttaatg actgctgttt gtaaagcagc
     5221 tattatagcc gactcttcta ccttcagagt ggacactgct gttatcaagc agagagtgcc
     5281 gatcttactc aagtacctag actcagatac agagaaggaa ctgcaagcac tttatgcact
     5341 acaagcatcg atagtaaaac ttgatcaacc tgccaatttg ctgcggatgt tttttgattg
     5401 tctatatgac gaggaggtga tctccgagga tgccttctac aaatgggaga gcagcaagga
     5461 ccctgcagag cagaatggga agggcgtggc tctgaaatct gtcacggcat tcttcacgtg
     5521 gctgcgggaa gcagaagagg agtctgagga taactaaaac ttcaaataca caaaatgaaa
     5581 caaaagaaac aatttaagta tttttttaaa aagtttcacg tcttcgccaa tcacagtgca
     5641 gcaaggccaa ttctcgcaga aacccccacg tgtgcacgag tgggagaggg gaaagagaaa
     5701 aaaaggtgat catggaggaa aaaggtactg gataaaagta aacttcaaac cttagggcgg
     5761 gagcactaaa accaaaatac atgtattatt tatagaaaat attttctgtt ttaatctttt
     5821 ctttttaaac aaggactcat acttaaaaaa atgtttagca aaaaaaaaaa aagttgagaa
     5881 cttttaattt attttaagga ctgcaaatgc cagtgtaatt ttttaatttg cagtttctgt
     5941 aaacaacttg tataatagaa aagcagagaa ataaatttcc ctccccttca agatgcacct
     6001 catgtttgtt ttaaggtata gcatttagtc cagatttgag aaagtttggg gtgaacaagg
     6061 taagaaagat tttttttttt ttggcatcaa atctttctgc ctgcctctca gcttgcttca
     6121 gaaaatttaa aaaatcacaa tagtaatcaa aacatacata acattgaaac agaaggaaat
     6181 gctgtggacc acagaactcc aagaattgtt taaaaaaaaa aaagtgctac cctgagaaaa
     6241 gtactcttaa tactcttgaa atctttagag caactttaag gcttgtaaat acatagaaca
     6301 aatatttaaa aaaacaaaaa gaaattgact cagtactatt tcttttcact ttgaaaatat
     6361 aaagaacaaa ataaagacaa acattgcaag tttaaaa
//
