LOCUS       NM_001418               3794 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4 gamma 2
            (EIF4G2), transcript variant 1, mRNA.
ACCESSION   NM_001418
VERSION     NM_001418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3794)
  AUTHORS   Shen,Y., Zhang,Y., Wang,Q., Jiang,B., Jiang,X. and Luo,B.
  TITLE     MicroRNA-877-5p promotes osteoblast differentiation by targeting
            EIF4G2 expression
  JOURNAL   J Orthop Surg Res 19 (1), 134 (2024)
   PUBMED   38342889
  REMARK    GeneRIF: MicroRNA-877-5p promotes osteoblast differentiation by
            targeting EIF4G2 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3794)
  AUTHORS   Meril,S., Bahlsen,M., Eisenstein,M., Savidor,A., Levin,Y.,
            Bialik,S., Pietrokovski,S. and Kimchi,A.
  TITLE     Loss-of-function cancer-linked mutations in the EIF4G2
            non-canonical translation initiation factor
  JOURNAL   Life Sci Alliance 7 (3), e202302338 (2023)
   PUBMED   38129098
  REMARK    GeneRIF: Loss-of-function cancer-linked mutations in the EIF4G2
            non-canonical translation initiation factor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3794)
  AUTHORS   Jia,Z., Wang,Y., Gao,J., Zheng,M., Wang,P. and Zu,G.
  TITLE     miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION
            AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY
            TARGETING EIF4G2
  JOURNAL   Shock 60 (4), 594-602 (2023)
   PUBMED   37646610
  REMARK    GeneRIF: miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL
            PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER
            ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
REFERENCE   4  (bases 1 to 3794)
  AUTHORS   Alard,A., Katsara,O., Rios-Fuller,T., Parra,C., Ozerdem,U.,
            Ernlund,A. and Schneider,R.J.
  TITLE     Breast cancer cell mesenchymal transition and metastasis directed
            by DAP5/eIF3d-mediated selective mRNA translation
  JOURNAL   Cell Rep 42 (6), 112646 (2023)
   PUBMED   37314929
  REMARK    GeneRIF: Breast cancer cell mesenchymal transition and metastasis
            directed by DAP5/eIF3d-mediated selective mRNA translation.
REFERENCE   5  (bases 1 to 3794)
  AUTHORS   Takahashi,K., Maruyama,M., Tokuzawa,Y., Murakami,M., Oda,Y.,
            Yoshikane,N., Makabe,K.W., Ichisaka,T. and Yamanaka,S.
  TITLE     Evolutionarily conserved non-AUG translation initiation in
            NAT1/p97/DAP5 (EIF4G2)
  JOURNAL   Genomics 85 (3), 360-371 (2005)
   PUBMED   15718103
  REMARK    GeneRIF: Exclusive use of a GUG translation initiation codon is
            conserved in human, chicken, Xenopus, and zebrafish.
REFERENCE   6  (bases 1 to 3794)
  AUTHORS   Pyronnet,S., Imataka,H., Gingras,A.C., Fukunaga,R., Hunter,T. and
            Sonenberg,N.
  TITLE     Human eukaryotic translation initiation factor 4G (eIF4G) recruits
            mnk1 to phosphorylate eIF4E
  JOURNAL   EMBO J 18 (1), 270-279 (1999)
   PUBMED   9878069
REFERENCE   7  (bases 1 to 3794)
  AUTHORS   Imataka,H. and Sonenberg,N.
  TITLE     Human eukaryotic translation initiation factor 4G (eIF4G) possesses
            two separate and independent binding sites for eIF4A
  JOURNAL   Mol Cell Biol 17 (12), 6940-6947 (1997)
   PUBMED   9372926
REFERENCE   8  (bases 1 to 3794)
  AUTHORS   Levy-Strumpf,N., Deiss,L.P., Berissi,H. and Kimchi,A.
  TITLE     DAP-5, a novel homolog of eukaryotic translation initiation factor
            4G isolated as a putative modulator of gamma interferon-induced
            programmed cell death
  JOURNAL   Mol Cell Biol 17 (3), 1615-1625 (1997)
   PUBMED   9032289
REFERENCE   9  (bases 1 to 3794)
  AUTHORS   Imataka,H., Olsen,H.S. and Sonenberg,N.
  TITLE     A new translational regulator with homology to eukaryotic
            translation initiation factor 4G
  JOURNAL   EMBO J 16 (4), 817-825 (1997)
   PUBMED   9049310
  REMARK    GeneRIF: translation starts exclusively at a non-AUG translation
            initiation codon (GUG).
REFERENCE   10 (bases 1 to 3794)
  AUTHORS   Shaughnessy,J.D. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     cDNA cloning, expression analysis, and chromosomal localization of
            a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G
  JOURNAL   Genomics 39 (2), 192-197 (1997)
   PUBMED   9027506
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK223548.1 and DB272352.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001418.3.
            
            Summary: Translation initiation is mediated by specific recognition
            of the cap structure by eukaryotic translation initiation factor 4F
            (eIF4F), which is a cap binding protein complex that consists of
            three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this
            gene shares similarity with the C-terminal region of eIF4G that
            contains the binding sites for eIF4A and eIF3; eIF4G, in addition,
            contains a binding site for eIF4E at the N-terminus. Unlike eIF4G,
            which supports cap-dependent and independent translation, this gene
            product functions as a general repressor of translation by forming
            translationally inactive complexes. In vitro and in vivo studies
            indicate that translation of this mRNA initiates exclusively at a
            non-AUG (GUG) codon. Alternatively spliced transcript variants
            encoding different isoforms of this gene have been described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.280558.1, BC043149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000339995.11/ ENSP00000340281.6
            non-AUG initiation codon :: PMID: 9049310, 15718103
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1879              AK223548.1         31-1909
            1880-2419           DB272352.1         11-550
            2420-3794           AK223548.1         2450-3824
FEATURES             Location/Qualifiers
     source          1..3794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3794
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /note="eukaryotic translation initiation factor 4 gamma 2"
                     /db_xref="GeneID:1982"
                     /db_xref="HGNC:HGNC:3297"
                     /db_xref="MIM:602325"
     exon            1..222
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            223..349
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..3032
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (GUG) translation initiation codon; eIF-4-gamma 2;
                     eukaryotic translation initiation factor 4G-like 1;
                     death-associated protein 5; aging-associated protein 1;
                     DAP-5; eIF4G 2; eIF-4G 2"
                     /codon_start=1
                     /transl_except=(pos:309..311,aa:Met)
                     /product="eukaryotic translation initiation factor 4 gamma
                     2 isoform 1"
                     /protein_id="NP_001409.3"
                     /db_xref="CCDS:CCDS31428.1"
                     /db_xref="GeneID:1982"
                     /db_xref="HGNC:HGNC:3297"
                     /db_xref="MIM:602325"
                     /translation="MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPG
                     QNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLN
                     VGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQS
                     TTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELG
                     KLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQ
                     YFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDL
                     GVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQD
                     RFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQL
                     QGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQT
                     PPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVN
                     GVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLN
                     VLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLA
                     KLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQ
                     IKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPS
                     KEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFY
                     DMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD"
     exon            350..415
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            416..556
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            557..659
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            660..791
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            792..858
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1010
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1121
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1205
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1304
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1446
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1607
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1721
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1847
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1952
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2168
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2427
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2632
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2844
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2966
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3794
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3774..3779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /note="hexamer: AATAAA"
     polyA_site      3794
                     /gene="EIF4G2"
                     /gene_synonym="AAG1; DAP5; NAT1; P97"
                     /note="major polyA site"
ORIGIN      
        1 gccagcagtg agtcggagct ctatggaggt ggcagcgggt accgagtggc ggctgcagca
       61 gcgactcctc tgagctgagt ttgaggccgt ccccgactcc ttcctccccc ttccctcccc
      121 cttttttttg ttttccgttc ccctttcccc tcccttccct atccccgacg accggatcct
      181 gaggaggcag ctgcggtggc agctgctgag ttctcggtga aggtatttca tttctcctgt
      241 cccctcccct ccccacccca tctattaata ttattctttt gaagattctt cgttgtcaag
      301 ccgccaaagt ggagagtgcg attgcagaag ggggtgcttc tcgtttcagt gcttcttcgg
      361 gcggaggagg aagtaggggt gcacctcagc actatcccaa gactgctggc aacagcgagt
      421 tcctggggaa aaccccaggg caaaacgctc agaaatggat tcctgcacga agcactagac
      481 gagatgacaa ctccgcagca aacaactccg caaacgaaaa agaacgacat gatgcaatct
      541 tcaggaaagt aagaggcata ctaaataagc ttactcctga aaagtttgac aagctatgcc
      601 ttgagctcct caatgtgggt gtagagtcta aactcatcct taaaggggtc atactgctga
      661 ttgtggacaa agccctagaa gagccaaagt atagctcact gtatgctcag ctatgtctgc
      721 gattggcaga agatgcacca aactttgatg gcccagcagc agagggtcaa ccaggacaga
      781 agcaaagcac cacattcaga cgcctcctaa tttccaaatt acaagatgaa tttgaaaacc
      841 gaactagaaa tgttgatgtc tatgataagc gtgaaaatcc cctcctcccc gaggaggagg
      901 aacagagagc cattgctaag atcaagatgt tgggaaacat caaattcatt ggagagcttg
      961 gcaagcttga tcttattcac gaatctatcc ttcataagtg catcaaaaca cttttggaaa
     1021 agaagaagag agtccaactc aaagatatgg gagaggattt ggagtgcctc tgtcagataa
     1081 tgaggacagt gggacctaga ttagaccatg aacgagccaa gtccttaatg gatcagtact
     1141 ttgcccgaat gtgctccttg atgttaagta aggaattgcc agcaaggatt cgtttcctgc
     1201 tgcaggatac cgtagagttg cgagaacacc attgggttcc tcgcaaggct tttcttgaca
     1261 atggaccaaa gacgatcaat caaattcgtc aagatgcagt aaaagatcta ggggtgttta
     1321 ttcctgctcc tatggctcaa gggatgagaa gtgacttctt tctggaggga ccgttcatgc
     1381 cacccaggat gaaaatggat agggacccac ttggaggact tgctgatatg tttggacaaa
     1441 tgccaggtag cggaattggt actggtccag gagttatcca ggatagattt tcacccacca
     1501 tgggacgtca tcgttcaaat caactcttca atggccatgg gggacacatc atgcctccca
     1561 cacaatcgca gtttggagag atgggaggca agtttatgaa aagccagggg ctaagccagc
     1621 tctaccataa ccagagtcag ggactcttat cccagctgca aggacagtcg aaggatatgc
     1681 cacctcggtt ttctaagaaa ggacagctta atgcagatga gattagcctg aggcctgctc
     1741 agtcgttcct aatgaataaa aatcaagtgc caaagcttca gccccagata actatgattc
     1801 ctcctagtgc acaaccacca cgcactcaaa caccacctct gggacagaca cctcagcttg
     1861 gtctcaaaac taatccaccg cttatccagg aaaagcctgc caagaccagc aaaaagccac
     1921 caccgtcaaa ggaagaactc cttaaactaa ctgaaactgt tgtgactgaa tatctaaata
     1981 gtggaaatgc aaatgaggct gtcaatggtg taagagaaat gagggctcct aaacactttc
     2041 ttcctgagat gttaagcaaa gtaatcatcc tgtcactaga tagaagcgat gaagataaag
     2101 aaaaagcaag ttctttgatc agtttactca aacaggaagg gatagccaca agtgacaact
     2161 tcatgcaggc tttcctgaat gtattggacc agtgtcccaa actggaggtt gacatccctt
     2221 tggtgaaatc ctatttagca cagtttgcag ctcgtgccat catttcagag ctggtgagca
     2281 tttcagaact agctcaacca ctagaaagtg gcacccattt tcctctcttc ctactttgtc
     2341 ttcagcagtt agctaaatta caagatcgag aatggttaac agaacttttt caacaaagca
     2401 aggtcaatat gcagaaaatg ctcccagaaa ttgatcagaa taaggaccgc atgttggaga
     2461 ttttggaagg aaagggactg agtttcttat tcccactcct caaattggag aaggaactgt
     2521 tgaagcaaat aaagttggat ccatcccctc aaaccatata taaatggatt aaagataaca
     2581 tctctcccaa acttcatgta gataaaggat ttgtgaacat cttaatgact agcttcttac
     2641 agtacatttc tagtgaagta aaccccccca gcgatgaaac agattcatcc tctgctcctt
     2701 ccaaagaaca gttagagcag gaaaaacaac tactactatc tttcaagcca gtaatgcaga
     2761 aatttcttca tgatcacgtt gatctacaag tcagtgccct gtatgctctc caggtgcact
     2821 gctataacag caacttccca aaaggcatgt tacttcgctt ttttgtgcac ttctatgaca
     2881 tggaaattat tgaagaagaa gctttcttgg cttggaaaga agatataacc caagagtttc
     2941 cgggaaaagg caaggctttg ttccaggtga atcagtggct aacctggtta gaaactgctg
     3001 aagaagaaga atcagaggaa gaagctgact aaagaaccag ccaaagcctt aaattgtgca
     3061 aaacatactg ttgctatgat gtaactgcat ttgacctaac cactgcgaaa attcattccg
     3121 ctgtaatgtt ttcacaatat ttaaagcaga agcacgtcag ttaggatttc cttctgcata
     3181 aggttttttt gtagtgtaat gtcttaatca tagtctacca tcaaatattt taggagtatc
     3241 tttaatgttt agatagtata ttagcagcat gcaataatta catcataagt tctcaagcag
     3301 aggcagtcta ttgcaaggac cttctttgct gccagttatc ataggctgtt ttaagttaga
     3361 aaactgaata gcaacactga atactgtaga aatgcacttt gctcagtaat acttgagttg
     3421 ttgcaatatt tgattatcca tttggttgtt acagaaaaat tcttaactgt aattgatggt
     3481 tgttgccgta atagtatatt gcctgtattt ctacctctag taatgggctt tatgtgctag
     3541 attttaatat ccttgagcct gggcaagtgc acaagtcttt ttaaaagaaa catggtttac
     3601 ttgcacaaaa ctgatcagtt ttgagagatc gttaatgccc ttgaagtggt ttttgtgggt
     3661 gtgaaacaaa tggtgagaat ttgaattggt ccctcctatt atagtattga aattaagtct
     3721 acttaattta tcaagtcatg ttcatgccct gattttatat acttgtatct atcaataaac
     3781 attgtgatac ttga
//
