LOCUS       NM_019843               3647 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E nuclear
            import factor 1 (EIF4ENIF1), transcript variant 1, mRNA.
ACCESSION   NM_019843
VERSION     NM_019843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3647)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3647)
  AUTHORS   Ding,Y., Chen,S., Jin,J., Sun,Y., Chu,C., Kee,K., Xin,M. and Li,L.
  TITLE     POI-associated EIF4ENIF1 mutations exhibit impaired translation
            regulation abilities
  JOURNAL   Gene 917, 148456 (2024)
   PUBMED   38604507
  REMARK    GeneRIF: POI-associated EIF4ENIF1 mutations exhibit impaired
            translation regulation abilities.
REFERENCE   3  (bases 1 to 3647)
  AUTHORS   Zuberek,J., Warzecha,M., Dobrowolski,M. and Modrak-Wojcik,A.
  TITLE     An intramolecular disulphide bond in human 4E-T affects its binding
            to eIF4E1a protein
  JOURNAL   Eur Biophys J 52 (6-7), 497-510 (2023)
   PUBMED   37798395
  REMARK    GeneRIF: An intramolecular disulphide bond in human 4E-T affects
            its binding to eIF4E1a protein.
REFERENCE   4  (bases 1 to 3647)
  AUTHORS   Shang,L., Ren,S., Yang,X., Zhang,F., Jin,L., Zhang,X. and Wu,Y.
  TITLE     EIF4ENIF1 variants in two patients with non-syndromic premature
            ovarian insufficiency
  JOURNAL   Eur J Med Genet 65 (10), 104597 (2022)
   PUBMED   36030004
  REMARK    GeneRIF: EIF4ENIF1 variants in two patients with non-syndromic
            premature ovarian insufficiency.
REFERENCE   5  (bases 1 to 3647)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3647)
  AUTHORS   Andrei,M.A., Ingelfinger,D., Heintzmann,R., Achsel,T.,
            Rivera-Pomar,R. and Luhrmann,R.
  TITLE     A role for eIF4E and eIF4E-transporter in targeting mRNPs to
            mammalian processing bodies
  JOURNAL   RNA 11 (5), 717-727 (2005)
   PUBMED   15840819
  REMARK    GeneRIF: human P bodies contain the cap-binding protein eIF4E and
            the related factor eIF4E-transporter (eIF4E-T), suggesting novel
            roles for these proteins in targeting mRNAs for 5' --> 3'
            degradation
REFERENCE   7  (bases 1 to 3647)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 3647)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 3647)
  AUTHORS   Warner,D.R., Roberts,E.A., Greene,R.M. and Pisano,M.M.
  TITLE     Identification of novel Smad binding proteins
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1185-1190 (2003)
   PUBMED   14651998
REFERENCE   10 (bases 1 to 3647)
  AUTHORS   Dostie,J., Ferraiuolo,M., Pause,A., Adam,S.A. and Sonenberg,N.
  TITLE     A novel shuttling protein, 4E-T, mediates the nuclear import of the
            mRNA 5' cap-binding protein, eIF4E
  JOURNAL   EMBO J 19 (12), 3142-3156 (2000)
   PUBMED   10856257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314636.1 and BC032941.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019843.3.
            
            Summary: The protein encoded by this gene is a nucleocytoplasmic
            shuttle protein for the translation initiation factor eIF4E. This
            shuttle protein interacts with the importin alpha-beta complex to
            mediate nuclear import of eIF4E. It is predominantly cytoplasmic;
            its own nuclear import is regulated by a nuclear localization
            signal and nuclear export signals. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.156767.1,
                                           SRR1660805.188778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330125.10/ ENSP00000328103.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AK314636.1         47-154
            109-3134            AK314636.1         156-3181
            3135-3647           BC032941.1         2600-3112
FEATURES             Location/Qualifiers
     source          1..3647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..3647
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /note="eukaryotic translation initiation factor 4E nuclear
                     import factor 1"
                     /db_xref="GeneID:56478"
                     /db_xref="HGNC:HGNC:16687"
                     /db_xref="MIM:607445"
     exon            1..149
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            150..272
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3134
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /note="isoform a is encoded by transcript variant 1;
                     2610509L04Rik; eukaryotic translation initiation factor 4E
                     transporter; eIF4E transporter; 4E-transporter"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E
                     transporter isoform a"
                     /protein_id="NP_062817.2"
                     /db_xref="CCDS:CCDS13898.1"
                     /db_xref="GeneID:56478"
                     /db_xref="HGNC:HGNC:16687"
                     /db_xref="MIM:607445"
                     /translation="MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHS
                     KQRPSCLSEKYDSDGVWDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPR
                     ERVKEDDLDVVLSPQRRSFGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRI
                     ISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEE
                     PEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDE
                     VEVILAQEPAADQEVPRDAVLPEQSPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSA
                     SRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQNSGNYFAPIPLEDHA
                     ENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSVEEVEAGLKGLKVDQQ
                     VKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQPKVSRNLE
                     SHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTTSLLGQRAPSPP
                     LSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPMSPITAQMSQLELQQ
                     AALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSP
                     APAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLS
                     SSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKEQDYRPKATGRKTPTLASP
                     VPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVHPQHLPSLLQTGVLPPG
                     MDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPGSGS
                     HAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFGSDVLQQPLPSMP
                     AKVISVDELEYRQ"
     exon            273..346
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            347..474
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            475..761
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            762..963
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1139
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1275
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1455
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1688
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1760
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1944
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2024
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2164
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2249
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2382
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2727
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2892
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3647
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3615..3620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /note="hexamer: ATTAAA"
     polyA_site      3647
                     /gene="EIF4ENIF1"
                     /gene_synonym="4E-T; Clast4"
                     /note="major polyA site"
ORIGIN      
        1 agttacggcg gctgaagaga gacagcccaa gccggtcggg gtgggggcgc gagagcgaag
       61 gctgcgggga gcggcgctgg gaccggtgcg ggcagcgggg aggggagcgg cggccgaggc
      121 aaagggccgc cgagcggcgg aggcaccgag tgcagagcat tgtagaccaa ggagccatgg
      181 ataggagaag tatgggtgaa acagaaagtg gagatgcttt ccttgacctg aagaagcctc
      241 ctgcctccaa atgcccccat cgctatacaa aagaagaact cttggatata aaagaactcc
      301 cccattccaa acagaggcct tcatgccttt ctgaaaaata tgacagtgat ggtgtctggg
      361 accctgagaa gtggcatgcc tctctctacc cagcttcagg gcggagctca ccagtggaaa
      421 gtctgaagaa agagttggat acagaccggc cttccctggt gcgcaggata gtagatccac
      481 gagagcgtgt gaaagaagat gacttagatg ttgttctcag ccctcagaga cggagctttg
      541 gagggggctg ccacgtgaca gccgctgtta gctcccggcg ctcaggaagt ccattagaga
      601 aagatagtga tgggcttcgt ctgcttggtg gacgtaggat tggcagtggg aggataatct
      661 ctgcccggac ctttgagaag gatcaccgtc ttagcgataa ggacctgcgg gacttgagag
      721 acagagaccg agagagggac ttcaaggaca agcgtttcag gagagagttt ggagatagta
      781 agcgtgtctt tggtgagcgt agaagaaatg attcttacac agaagaagaa ccagagtggt
      841 tctctgctgg acccacaagt cagtctgaaa ccatcgaact gactggcttt gatgataaga
      901 tactagaaga agatcacaaa gggagaaaaa gaacaaggcg acggacagcc tctgtgaagg
      961 aaggtatagt agagtgcaat ggaggagtgg ccgaagagga tgaagtggag gtcatccttg
     1021 cacaggagcc tgcggctgat caggaagtgc caagggatgc tgtcttgcct gagcagtccc
     1081 caggagactt tgactttaat gagttcttta accttgataa ggtgccatgc ttggcttcga
     1141 tgatagaaga tgttttggga gaagggtcag tctctgccag tcggttcagt aggtggttct
     1201 ctaacccgag cagatcagga agccgatcca gcagtcttgg gtcaacacca catgaagagc
     1261 tagagagact tgcaggtctg gagcaagcca tcctctctcc tggacagaac tcggggaatt
     1321 actttgctcc tataccattg gaagaccatg ctgaaaataa agtggatatt ttagaaatgc
     1381 tacagaaagc caaagtggat ttgaaacctc ttctttccag cctttctgca aataaagaaa
     1441 aacttaaaga aagctcacat tcaggggttg tgctttcagt ggaggaggta gaagcaggtc
     1501 tgaagggctt gaaggttgac cagcaagtga agaattcaac tcccttcatg gcagaacacc
     1561 tagaagagac cttgagtgcc gtaaccaaca atcgacaact gaagaaagac ggagacatga
     1621 ctgcgttcaa caagctagtg agcacaatga aggcaagtgg gactttgcct tctcagccca
     1681 aagtcagccg aaaccttgaa agccatttga tgtcccctgc tgagattcca ggccagcctg
     1741 tccctaagaa catcctgcag gaacttctgg gtcaaccagt tcagagacct gcttcttcca
     1801 atcttctgag tggccttatg gggagcttgg agcctacaac atctttactg ggccaaagag
     1861 caccctctcc tcccttgtca caggtgtttc aaactcgagc agcctcagct gactaccttc
     1921 gcccaagaat accatcacca attggtttca caccaggacc acagcagcta ctcggagatc
     1981 cattccaagg catgcgcaaa cccatgagcc ccatcacagc ccagatgagc cagctggagt
     2041 tgcaacaggc agctttagaa gggctggcct tgccacatga ccttgctgta caggcagcaa
     2101 acttctacca gcctggtttt ggcaaaccac aggtggacag aaccagagat ggattcagaa
     2161 acaggcaaca gcgagtgacc aagtcaccag cacccgtgca tcgagggaat tcctcttccc
     2221 ctgcccctgc tgcctccatc acaagcatgc tttctccttc ctttacccct acctcagtga
     2281 ttcgtaagat gtacgagagc aaagagaaaa gcaaggagga gccagcatct ggaaaagcag
     2341 ctcttggtga cagtaaagag gatactcaga aggccagtga agaaaacctc ctgtcatcca
     2401 gctctgtacc cagtgccgat cgagactctt ctcccactac aaattccaaa ctgtcagcat
     2461 tacagaggtc ttcgtgttcc accccactgt cccaggccaa ccgttacacc aaagaacaag
     2521 attatcgacc taaagcaact gggagaaaaa cacccacctt ggcatcccca gttcctacaa
     2581 caccttttct ccgccctgtc caccaagttc cccttgtccc ccatgtccct atggttaggc
     2641 ctgctcacca gcttcaccca gggttggtac agaggatgct ggcccaggga gtacatccac
     2701 agcatcttcc aagtttgctc caaactggtg tgcttcctcc tgggatggac ttgagtcatt
     2761 tacagggaat atctggcccc atcctgggtc agccctttta ccctttacct gctgctagtc
     2821 accctctctt aaaccctcgt cctggaacac ctctgcatct ggcaatggtg caacagcagc
     2881 tacagcgctc agttctgcat cctccaggct ctggttccca tgcagcagct gtcagcgttc
     2941 agacaacccc tcagaacgtg cccagccggt caggcctgcc ccacatgcac tcccagctgg
     3001 agcatcgccc cagccagagg agcagctccc ctgtgggcct tgccaaatgg tttggctcag
     3061 atgtgctaca gcaacccctg ccctccatgc ccgccaaagt tatcagtgta gatgaattgg
     3121 aataccgaca gtgagcaggg caggcagact caactaagcc cggacctgtg gtggcacact
     3181 gggcaggacc ctgcttcatc tcgggttggt ttatgggctt ttactttgga gcactctgtg
     3241 tgaagctgtt tggtggaacc catgcatctg gtgtggtccg cattatgatg gaaggatctt
     3301 aaccagtcga gtggagtgta cattgtctga atacaggatg cacaatgttg tcaatcctgg
     3361 aaatggtctt tcttttttgt aagatatgtg aatgaagtgt tggtgtcctc accaagaggt
     3421 ggcacctaag ggttctgagg aaataaatgt atagaccctt atgtacagac ctgtgtataa
     3481 acaacttttg tatatacata taggatagct tttttgaact atacagctgt acataaaagt
     3541 agctgatatt agttaggcct gtgtcaacag tttggatttt tttcacttgt acatttggga
     3601 ttttcttttg gttgattaaa attgcatatg ctaagtgtgt gaatgaa
//
