LOCUS       NM_003732                693 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E binding
            protein 3 (EIF4EBP3), mRNA.
ACCESSION   NM_003732
VERSION     NM_003732.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Zhai,S., Lin,S., Lin,Z., Xu,J., Ji,T., Chen,K., Wu,K., Liu,H.,
            Ying,H., Fei,W., Wang,J., Fu,G., Wang,Y., Hu,X. and Cai,X.
  TITLE     eIF4EBP3 was downregulated by methylation and acted as a tumor
            suppressor by targeting eIF4E/beta-catenin in gastric cancer
  JOURNAL   Gastric Cancer 23 (3), 483-496 (2020)
   PUBMED   31853750
  REMARK    GeneRIF: eIF4EBP3 was downregulated by methylation and acted as a
            tumor suppressor by targeting eIF4E/beta-catenin in gastric cancer.
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Lv,K.T., Liu,Z., Feng,J., Zhao,W., Hao,T., Ding,W.Y., Chu,J.P. and
            Gao,L.J.
  TITLE     MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis
            through Targeting the eIF4EBP3 Gene in Human Cervical Squamous
            Carcinoma Cells
  JOURNAL   Int J Med Sci 15 (2), 142-152 (2018)
   PUBMED   29333098
  REMARK    GeneRIF: Role of the eIF4EBP3 gene in miR-22-3p-mediated cervical
            squamous carcinoma cell growth
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Tsukumo,Y., Alain,T., Fonseca,B.D., Nadon,R. and Sonenberg,N.
  TITLE     Translation control during prolonged mTORC1 inhibition mediated by
            4E-BP3
  JOURNAL   Nat Commun 7, 11776 (2016)
   PUBMED   27319316
  REMARK    GeneRIF: The data reveal that 4E-BP3 expression is controlled by
            the transcription factor TFE3 through a cis-regulatory element in
            the EIF4EBP3 gene promoter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Poulin,F., Brueschke,A. and Sonenberg,N.
  TITLE     Gene fusion and overlapping reading frames in the mammalian genes
            for 4E-BP3 and MASK
  JOURNAL   J Biol Chem 278 (52), 52290-52297 (2003)
   PUBMED   14557257
  REMARK    GeneRIF: there are overlapping reading frames in the mouse and
            human genes for 4E-BP3 and MASK
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Ferguson,G., Mothe-Satney,I. and Lawrence,J.C. Jr.
  TITLE     Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated
            dissociation from eIF4E
  JOURNAL   J Biol Chem 278 (48), 47459-47465 (2003)
   PUBMED   14507920
  REMARK    GeneRIF: PHAS-II, but not PHAS-III, contributes to the control of
            protein synthesis by insulin
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Kleijn,M., Scheper,G.C., Wilson,M.L., Tee,A.R. and Proud,C.G.
  TITLE     Localisation and regulation of the eIF4E-binding protein 4E-BP3
  JOURNAL   FEBS Lett 532 (3), 319-323 (2002)
   PUBMED   12482586
  REMARK    GeneRIF: 4E-BP3 is associated with eIF4E in the cell nucleus and
            cytoplasm
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Tee,A.R. and Proud,C.G.
  TITLE     Caspase cleavage of initiation factor 4E-binding protein 1 yields a
            dominant inhibitor of cap-dependent translation and reveals a novel
            regulatory motif
  JOURNAL   Mol Cell Biol 22 (6), 1674-1683 (2002)
   PUBMED   11865047
REFERENCE   10 (bases 1 to 693)
  AUTHORS   Poulin,F., Gingras,A.C., Olsen,H., Chevalier,S. and Sonenberg,N.
  TITLE     4E-BP3, a new member of the eukaryotic initiation factor 4E-binding
            protein family
  JOURNAL   J Biol Chem 273 (22), 14002-14007 (1998)
   PUBMED   9593750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011399.6, AF038869.1 and
            BC010881.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003732.2.
            
            Summary: This gene encodes a member of the EIF4EBP family, which
            consists of proteins that bind to eukaryotic translation initiation
            factor 4E and regulate its assembly into EIF4F, the multi-subunit
            translation initiation factor that recognizes the mRNA cap
            structure. Read-through transcription from the neighboring upstream
            gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that
            encodes a protein comprised of the MASK protein sequence for the
            majority of the protein and a different C-terminus due to an
            alternate reading frame for the EIF4EBP3 segments. [provided by
            RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF038869.1, SRR1163657.37210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310331.3/ ENSP00000308472.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC011399.6         18226-18229         c
            5-432               AF038869.1         1-428
            433-693             BC010881.1         425-685
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..693
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 3"
                     /db_xref="GeneID:8637"
                     /db_xref="HGNC:HGNC:3290"
                     /db_xref="MIM:603483"
     exon            1..179
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..379
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /note="eukaryotic initiation factor 4E-binding protein 3;
                     eIF4E-binding protein 3"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 3"
                     /protein_id="NP_003723.1"
                     /db_xref="CCDS:CCDS4226.1"
                     /db_xref="GeneID:8637"
                     /db_xref="HGNC:HGNC:3290"
                     /db_xref="MIM:603483"
                     /translation="MSTSTSCPIPGGRDQLPDCYSTTPGGTLYATTPGGTRIIYDRKF
                     LLECKNSPIARTPPCCLPQIPGVTTPPTAPLSKLEELKEQETEEEIPDDAQFEMDI"
     exon            180..350
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..693
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      676..681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /note="hexamer: AGTAAA"
     polyA_site      693
                     /gene="EIF4EBP3"
                     /gene_synonym="4E-BP3; 4EBP3"
                     /note="major polyA site"
ORIGIN      
        1 gagtccgcct cagactcaga gctgcgctcc tcgacctcaa cgccaggcgg ttactttgct
       61 gctcctcccg ctcgctatgt caacgtccac tagctgcccg attcccgggg gccgggacca
      121 gctgcccgac tgctacagca ccacgccggg gggcacgcta tacgccacta cccccggagg
      181 caccaggatc atctacgacc gaaagttcct gctggagtgc aagaactcac ccattgcccg
      241 gacacccccc tgctgcctcc ctcagattcc cggggtcaca actcctccaa cagcccctct
      301 ctccaagctg gaggagctga aggagcagga gacagaggaa gagatacccg atgacgcaca
      361 atttgaaatg gacatctaat ccagtgcaga tgacctggca tgtggagtta cagagggatc
      421 cctcatgcca ctgctgccac cacctcttcc tggggcatcc aaaggccagc tggcctcatc
      481 taatctggaa gggagtgact tgttagttcc aggcctcctt tagttctgag gcagctagac
      541 cagggatagg agtgggcaac ttgccaagcc cttaactcta cttcctcttc agtctgtggt
      601 actcctccta accctaaacc ctctatgctc aggggctgga actggggaat ggagtaagtc
      661 accttctgac tgcttagtaa acattcaaag aaa
//
