LOCUS       NM_004096               7491 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E binding
            protein 2 (EIF4EBP2), mRNA.
ACCESSION   NM_004096
VERSION     NM_004096.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7491)
  AUTHORS   Shi,J.Y., Wen,R., Chen,J.Y., Feng,Y.Q., Zhang,Y.Y., Hou,S.J.,
            Xi,Y.J., Wang,J.F. and Zhang,Y.F.
  TITLE     Genetic evidence supporting potential causal roles of EIF4 family
            in breast cancer: a two-sample randomized Mendelian study
  JOURNAL   Sci Rep 14 (1), 20191 (2024)
   PUBMED   39215053
  REMARK    GeneRIF: Genetic evidence supporting potential causal roles of EIF4
            family in breast cancer: a two-sample randomized Mendelian study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7491)
  AUTHORS   Levy,T., Voeltzke,K., Hruby,L., Alasad,K., Bas,Z.,
            Snaebjornsson,M., Marciano,R., Scharov,K., Planque,M., Vriens,K.,
            Christen,S., Funk,C.M., Hassiepen,C., Kahler,A., Heider,B.,
            Picard,D., Lim,J.K.M., Stefanski,A., Bendrin,K., Vargas-Toscano,A.,
            Kahlert,U.D., Stuhler,K., Remke,M., Elkabets,M., Grunewald,T.G.P.,
            Reichert,A.S., Fendt,S.M., Schulze,A., Reifenberger,G., Rotblat,B.
            and Leprivier,G.
  TITLE     mTORC1 regulates cell survival under glucose starvation through
            4EBP1/2-mediated translational reprogramming of fatty acid
            metabolism
  JOURNAL   Nat Commun 15 (1), 4083 (2024)
   PUBMED   38744825
  REMARK    GeneRIF: mTORC1 regulates cell survival under glucose starvation
            through 4EBP1/2-mediated translational reprogramming of fatty acid
            metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7491)
  AUTHORS   Zeng,J., Lu,C., Huang,X. and Li,Y.
  TITLE     The human eIF4E:4E-BP2 complex structure for studying
            hyperphosphorylation
  JOURNAL   Phys Chem Chem Phys 26 (14), 10660-10672 (2024)
   PUBMED   38511550
  REMARK    GeneRIF: The human eIF4E:4E-BP2 complex structure for studying
            hyperphosphorylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7491)
  AUTHORS   Han,X., Yang,F., Zhang,Z., Hou,Z., Sun,Q., Su,T., Lv,W., Wang,Z.,
            Yuan,C., Zhang,G., Pi,X., Long,J. and Liu,H.
  TITLE     4EBP2-regulated protein translation has a critical role in high-fat
            diet-induced insulin resistance in hepatocytes
  JOURNAL   J Biol Chem 299 (11), 105315 (2023)
   PUBMED   37797700
  REMARK    GeneRIF: 4EBP2-regulated protein translation has a critical role in
            high-fat diet-induced insulin resistance in hepatocytes.
REFERENCE   5  (bases 1 to 7491)
  AUTHORS   Gingras,A.C. and Sonenberg,N.
  TITLE     Adenovirus infection inactivates the translational inhibitors
            4E-BP1 and 4E-BP2
  JOURNAL   Virology 237 (1), 182-186 (1997)
   PUBMED   9344920
REFERENCE   6  (bases 1 to 7491)
  AUTHORS   Lawrence,J.C. Jr., Fadden,P., Haystead,T.A. and Lin,T.A.
  TITLE     PHAS proteins as mediators of the actions of insulin, growth
            factors and cAMP on protein synthesis and cell proliferation
  JOURNAL   Adv Enzyme Regul 37, 239-267 (1997)
   PUBMED   9381973
  REMARK    Review article
REFERENCE   7  (bases 1 to 7491)
  AUTHORS   Tsukiyama-Kohara,K., Vidal,S.M., Gingras,A.C., Glover,T.W.,
            Hanash,S.M., Heng,H. and Sonenberg,N.
  TITLE     Tissue distribution, genomic structure, and chromosome mapping of
            mouse and human eukaryotic initiation factor 4E-binding proteins 1
            and 2
  JOURNAL   Genomics 38 (3), 353-363 (1996)
   PUBMED   8975712
REFERENCE   8  (bases 1 to 7491)
  AUTHORS   Lin,T.A. and Lawrence,J.C. Jr.
  TITLE     Control of the translational regulators PHAS-I and PHAS-II by
            insulin and cAMP in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 271 (47), 30199-30204 (1996)
   PUBMED   8939971
REFERENCE   9  (bases 1 to 7491)
  AUTHORS   Mader,S., Lee,H., Pause,A. and Sonenberg,N.
  TITLE     The translation initiation factor eIF-4E binds to a common motif
            shared by the translation factor eIF-4 gamma and the translational
            repressors 4E-binding proteins
  JOURNAL   Mol Cell Biol 15 (9), 4990-4997 (1995)
   PUBMED   7651417
REFERENCE   10 (bases 1 to 7491)
  AUTHORS   Pause,A., Belsham,G.J., Gingras,A.C., Donze,O., Lin,T.A.,
            Lawrence,J.C. Jr. and Sonenberg,N.
  TITLE     Insulin-dependent stimulation of protein synthesis by
            phosphorylation of a regulator of 5'-cap function
  JOURNAL   Nature 371 (6500), 762-767 (1994)
   PUBMED   7935836
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG717474.1, BC050633.1 and
            AC022532.13.
            
            On Nov 22, 2018 this sequence version replaced NM_004096.4.
            
            Summary: This gene encodes a member of the eukaryotic translation
            initiation factor 4E binding protein family. The gene products of
            this family bind eIF4E and inhibit translation initiation. However,
            insulin and other growth factors can release this inhibition via a
            phosphorylation-dependent disruption of their binding to eIF4E.
            Regulation of protein production through these gene products have
            been implicated in cell proliferation, cell differentiation and
            viral infection. [provided by RefSeq, Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.33657.1,
                                           SRR1803611.66710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373218.5/ ENSP00000362314.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BG717474.1         46-66
            22-2787             BC050633.1         1-2766
            2788-7491           AC022532.13        100777-105480       c
FEATURES             Location/Qualifiers
     source          1..7491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..7491
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 2"
                     /db_xref="GeneID:1979"
                     /db_xref="HGNC:HGNC:3289"
                     /db_xref="MIM:602224"
     exon            1..402
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..620
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /note="phosphorylated, heat and acid stable regulated by
                     insulin protein II; eIF4E-binding protein 2"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 2"
                     /protein_id="NP_004087.1"
                     /db_xref="CCDS:CCDS7303.1"
                     /db_xref="GeneID:1979"
                     /db_xref="HGNC:HGNC:3289"
                     /db_xref="MIM:602224"
                     /translation="MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFS
                     TTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIEDSKVEVNNLNNLN
                     NHDRKHAVGDDAQFEMDI"
     exon            403..588
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /inference="alignment:Splign:2.1.0"
     exon            589..7491
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2724
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /note="major polyA site"
     regulatory      2765..2770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /note="hexamer: ATTAAA"
     polyA_site      2803
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
     regulatory      7471..7476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
                     /note="hexamer: AGTAAA"
     polyA_site      7491
                     /gene="EIF4EBP2"
                     /gene_synonym="4EBP2; PHASII"
ORIGIN      
        1 gcttccggtc gtcgtcgtcg ccgctgctgc cgctgctgtt gctcctgagg ctgctggctg
       61 aggccggagg atcgagcggc ggcggcggcg gcggctgaga gggcggcggc gggagcggag
      121 cgggacgagg gaacgggagg aagcgagcga ggagcgcgca gagcgcgctt ttccgtccgc
      181 ctgaggagcc gaagcagccc cggccccgcc gccgccgcct gcccgccgga caaagccgag
      241 agcccgcgcc cacagccatg tcctcgtcag ccggcagcgg ccaccagccc agccagagcc
      301 gcgccatccc cacccgcacc gtggccatca gcgacgccgc gcagctacct catgactatt
      361 gcaccacgcc cggggggacg ctcttctcca ccacaccggg aggaactcga atcatttatg
      421 acagaaagtt tctgttggat cgtcgcaatt ctcccatggc tcagacccca ccctgccacc
      481 tgcccaatat cccaggagtc actagccctg gcaccttaat tgaagactcc aaagtagaag
      541 taaacaattt gaacaacttg aacaatcacg acaggaaaca tgcagttggg gatgatgctc
      601 agttcgagat ggacatctga ctctcctgca aggattagaa gaaaagcagc aacactgata
      661 cttgtgtgca cctgatttgg ccaataggat caacagtgaa aagacagaag aggcaatacc
      721 agcagtcccc attacagtct ccacctcccc gtcttcctct gggtgccaaa tgatgggaag
      781 atgagcttca tctgaccatt tcttctccct gtctcctgtt ccccttccca gttaaacagg
      841 ttagattgaa ggcccttgct gtatttctgt agagctaagc agcccttaga ggaaaacagt
      901 tcaactctga ctttcctagt tgttttttta ttgagagcca ccctcatacc ctgtaatttt
      961 gtcccaaatc aaatatcaac ctaccaacaa ctgcctggct gggaagtctg gggaagggat
     1021 acagagcttg gtgggcctaa caccattcat attccttacc ctctgtctct cctccctgta
     1081 tcccacctat ggttcagtgt tgcaagagtc tgggcttggg gtctttaaaa ccagcagggg
     1141 gaaatgataa aaagagagct gctttccctt ttaccttgag gtattcgtcc ctcgggacag
     1201 agcacagctt gtgcaactct ggtagcgtta ccctgtgaca ctgttttgag gtccacttcc
     1261 tttctttcct ctgggaggaa tgtcttctgt ctttggtatt atagttcatc ttcccattct
     1321 tttacttagt gcatttgtgc agatattttt aactctgtac atcagaagag agcccttggt
     1381 aaccagtttt gctcttcttc tgccactcct ccctgcttgc atctcgttgc tggcagagtc
     1441 ctcttgtact tcaagaaagc aaagtgattt tgtctgctcc tagagcaggt ccataccaag
     1501 taatagaggc actttagctt ccacttggtg ggtaaggcct gatcatagta ttctgtcaga
     1561 taatgcctaa gaatgaccgc tgaagaacgt tgacccattt gagtacccgg tctcagtcgt
     1621 catttttaag tccagtgagc attgtggtag ttgttcttag attgcagttt cttatgtttt
     1681 gagtttgaag ttgattttca gaatgttctt agaaaagaac tgcatttttt tcctttgtgg
     1741 atctgctttg tttggctgct gggatagata agcatgggct taaaaaatgt gttcctccca
     1801 gttttcttgc ctttcctgtt gtactctgaa tttctctccc tacctccctc actttcttcc
     1861 tctctccttc ctttccttcc tttttctcta ccaggccatt tttcaaattt acatcaaaga
     1921 tacctgaagt gttggtatct gagaatatct gtcactcctc ttatctgaga agtgaccttt
     1981 tatttttaag atgactacag acctattttt agatatgttt tcagtacaat tttgaacagc
     2041 aactttttaa ttaaacatct tccagtgtta ggaagttgag aaacgttcat aggcaagtct
     2101 gctgttctat gtcaccatct tttgtctccc ctagtccccc aggagctctt tcctttcccc
     2161 tctagttttg ggtgtgcatg tttggagttt gtagtgggtg gtttgtaaaa ctggaccatt
     2221 ctgccttgct atgggttgtt caagaaagcc tcattctttt ctgtgaccct ttcgcttttg
     2281 cattcaccct ccttcccacc tacctgtcct ggggctgttg agcagcataa taatcccggg
     2341 agaatgattc ccctcataga aagacaaaag catccatccc ctcatagtta agtagccact
     2401 ggtgtcctgg gaatttctgg ttggatttgg tgccctgaac ttttttatta agaaatcaga
     2461 tcccagggtg agagtaacag gccatttggc caagaaagaa acctgtttgt ttttcttttg
     2521 aactatgaaa agaccctgtt tgtgaatata ttttagaaag agaggaagga tgtctgcaga
     2581 actttgttct gttttctgcc acaaaaatgt gaatagttca gagtgaaaac cttttgtgat
     2641 ggttgatgtc tcaggaataa gctggatctc caatgttttg gggatgcttt gagtctcaaa
     2701 aaaaattgat aatcagaaaa gtaatttttg tttgtttgtt taatgtatcc ctgttctgtt
     2761 tttaattaaa ctccaagtct cattttacat attcttggaa aaacctaagt tgctctgtaa
     2821 tttacataag aagcatgctc aggacctctt tgtaccccgg ggagcctgat tctttgggaa
     2881 tgaagctttt cattcttcat acactggcct tggcatcctg tggaatttga cccaactagc
     2941 agctagtcag tctgtcagtg agcagaagag tgaactcttc ttgatcttta ttgctatgtg
     3001 tgaaaacttg gcttcctcac tgaacggtga ggaatggatt taaagcatga gctttagtag
     3061 tatcaagatg ccattttcct ttttcttgct gtcttgggga gcttctgcat gtgaccccct
     3121 aatcagaagg catgttttta gtatttcttg ggagtgtcag ctgtataatg cagcagctgt
     3181 tcaatccctt acccttctct gcaaggactt ccttacagct tggtgcagtt ctttcccaga
     3241 ggccaccact actagacagt ctttctttta tcttatggag ataaattggc atttaaaaaa
     3301 taatttcaca aggcatgaga taaactttca atagatgata cctttgtgtc atgcctcatg
     3361 gaattatttt tagaacaagc cagagtccat tgagtggttt acctctgcat gtttggaggg
     3421 aacctcacag atgaaaccct taatgaataa tgtgtccggg gttttttaga gagaaggagc
     3481 actcttaagt taccactttg agacagctct taacatctta gtgaccattt gtagttttct
     3541 ttttatgagg aacccatgct tctatacttg ggcggacaat cgagcttaat gagaagtgac
     3601 ttcccttcaa attccaacag cagacatgca ttgtcatgat tctgtcttct ttttagtgtg
     3661 gtttattgag ttcagcagtt ctcatattct gtttaaatag gtacagcatt ttcaagggca
     3721 cagatacaga gaagctggct ttctaggtat tgggcttcca agccaagagt tttgtccttc
     3781 cacctgtatt agttatctat tgctgtgtaa aaaattaccc taaatttagt atgttaaaat
     3841 agtaaacatt atctgtcagt ttctgtgggt taagaatttg ggagtagttt aacatgatgg
     3901 ttctggccca tggtatcatg aagttacagt caagattgaa caggggctgc agtcagctgg
     3961 agctggagaa accacttcca agttctctct ttgtggccgt tggcaggatg cctcagtttc
     4021 ttcccatgtg ggtctctgcg tagggcagca tgagtgtcct cacaccatga cacctggctt
     4081 ctccctgagc agctgattcc agagatcatg gggcagggcc aggagaaagc tgcagtgcct
     4141 tttaagacat agtcttggaa aggacacacc gtcacttctt atcctagttg ttagaagcaa
     4201 gccactaagt tcagcctgca ctcaaggaga gaggaattac acatacctct accccaatgg
     4261 agcagtagca aagaatttat ggacatatct taaaagcacc acaccccaac tggggatgaa
     4321 agtaggtcaa cagggaggta ggtttaatct agataagctg aaagatagat tgctatcaaa
     4381 aacagttctc caagatgtgc atagccaaac tgggatagaa ggcaaactcc ccaaagctac
     4441 ctgctggttt tgagaggggt ggtaagacat ggcaattccc aggagtagta gaaaataata
     4501 tgcctgacta ccaacagctc aagtatgctt atttgcacat cctagacttg gtgtctgtaa
     4561 gactcagtta ccacttttat tttcctgtag ctaggagtta gcaaaaggaa ctggggcctt
     4621 ccagccgagc cactaaacct gtcttatttg gaatggggat tgtccagcaa agggagcaaa
     4681 catgaattag atgttaagct attgagctga agaaaagaaa gcagttcaca tttaggtgaa
     4741 atagatgatg ttatcaggaa gccaggttcc caccagagtc ggtgcttggt acctggtctc
     4801 tccagtctca acagactcag gtcaggtctc tcacccagga agcaaccact caataaaata
     4861 gagaacatct gagaattaca aatgtctatg cttgattgct cctctaaatc cagtgcatag
     4921 gttaaccctg catgcccatt tcttcctggg cttcttgatg gcaatgtgtt cttaaataac
     4981 tggtcttgtg ttcatgctaa agacaaactt acatgaagtt tttcagttta agacattcta
     5041 gtgaatggct gctatgtgtt tctggcactc attcctaacc aagtctttag agatttcaga
     5101 tgaccttaaa gatgcaatat ctttttcttt ctttctttct ttcttttttt ctgagacaag
     5161 agttgcgccc tgtcgcccag gctggggtgc tggagtgcag tggtgcgatc tcagctcact
     5221 gcagcctctg cttcccaggt tcaagtgttt ctcctgcctc agccttccga gtagctggga
     5281 ttacaggcat gtaccactat gcctggctaa tttttatttc tatattttta gtagagatgg
     5341 ggtttcatca tgtttgccag gctggtctcg aactcctggc ctcaagtgat ccgcccacct
     5401 cagcctccca aagtgctggg attacaggcg cgagccaccg cgcctggcca aagatgcaaa
     5461 ttcttgtttg gatttatgct ctgcctcttc ccagcatttt cttatctgta gccctgcttg
     5521 cttgagagta tacttggata agaagtattg ctgttgaggg agctataaga aaaggattct
     5581 tcttccagaa gtaaagaact catctttaga gtacctttaa atgaattttg tttttctttc
     5641 ttattttgag gtggattggt cttctctttt tttgggtttc cagctcactg ggactctcag
     5701 accttacctt tccagctcaa acaccattag ttaaattcct tcattctcat tagaatgcag
     5761 cctgctgagt atgtgggttt cactgccgga gtccatcatt tagccagtat acatagagga
     5821 actgcttcga atcaaggcaa ctggtgaagg gcttagcatg ttggcagcaa tatcccagag
     5881 attgaatctg tttgcatttt cctcatctag gataacagct gcttgaagcc agggctctta
     5941 gccctttgca ttccccttga gcgaggaagc cacactgcct ttctgtgtct ggttcagagc
     6001 tcttccttct tggcatgttt tctggactac atgcacatgg gcagctatag attaatctgc
     6061 aaaacctagt cacttaccta cccataatat ctgggaaggt gtggtatttg ttttaaagaa
     6121 acattgtttc tttgggaggg cagtttctgt ctggactttg aggtggactt agttatccct
     6181 acagttcttt aactctcagc ttttaataaa agatgaaatc agatattgat gcagttgggt
     6241 cacaattctt tagaatgctt ctaccccagg gccgcttcct gttcctagtc atggttttcc
     6301 agtttagtag tggagtttct tgaggctaac ttacagaaat ttctaactga aaactttaag
     6361 agttattgat acttgttttt tcagtcagtc acttacatca cctagcctac tctctggaat
     6421 ttaaatttat ttctctaggc tggtcctgga agttgataac cttttggcaa agcttagatt
     6481 taggagaagg cttgagtccc tgttcagcgg gtctgtggat tctctttgct tatggctctc
     6541 tgcctgcagc cctggcagac catactgtat gtcatggata cccagtggaa atattactga
     6601 gatgaaacac atttccaagg gtatttaaac tctcactctg ccacctttct aagggtggga
     6661 ggctggcaga gatgctgcaa tgcttgataa tcatttggcc acactgaaat ttccaaaggg
     6721 agctcttgcc ggtgcttaaa accaaaactc ctggacactt agaaaattcc atgaatctag
     6781 cacaaaatat ccattcttgc ccaagtgtat cccctttctc tccagcttaa tctttttttt
     6841 tttttttttt ttaaagccca ggccaagggt acttttaact ggaaactggg gaggagggaa
     6901 gaacactagc agggagctaa gaggcaggtt gctgggtaag ccatcctgct cctacctggt
     6961 gcctgtatct acattgctga gtgctgtgcg ccagtgcctt tccttcatct gcagatggag
     7021 cccatctctt tccacctggg tgaggagacc ctctgctact ccaggggtaa accttaaaga
     7081 aggtgtcttg aagagcccag aggacactca cgtgctaagg tgtccatttt atgcatcttt
     7141 aaaatatttt atttaaaaaa aaaaatagcc ctgccctgtc ttagtgccac taacggccca
     7201 gttccatcca ttctgaatgg aaaagcggag actgccagca ctttccttgg tcttcccttt
     7261 gtctcccatg atgtgttgtt ccctcatccc tcccatccat ttcactgtgt gtggatggat
     7321 agcagagggt accacgcagt ccttgaggca gtcctgtgtg attccatgat cagttgtttt
     7381 tgtattttaa ctattcttcc aaaccagcag atgtttggaa attaaggaaa aaattaaatt
     7441 ctcatcaatg gttgctgtta tagttaaatc agtaaagatc ttgagtatca a
//
