LOCUS       NM_004095                827 bp    mRNA    linear   PRI 22-MAR-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E binding
            protein 1 (EIF4EBP1), mRNA.
ACCESSION   NM_004095
VERSION     NM_004095.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 827)
  AUTHORS   Wu,X., Mi,T., Jin,L., Ren,C., Wang,J., Zhang,Z., Liu,J., Wang,Z.,
            Guo,P. and He,D.
  TITLE     Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated
            macrophages and tumor cells in MRTK
  JOURNAL   Eur J Pharmacol 978, 176787 (2024)
   PUBMED   38944176
  REMARK    GeneRIF: Tumoral EIF4EBP1 regulates the crosstalk between
            tumor-associated macrophages and tumor cells in MRTK.
REFERENCE   2  (bases 1 to 827)
  AUTHORS   Al-Lamki,R.S., Tolkovsky,A.M., Alawwami,M., Lu,W., Field,S.F.,
            Wang,J., Pober,J.S. and Bradley,J.R.
  TITLE     Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma
            Proliferation via Phosphorylated 4E Binding Protein-1 and
            Mitochondrial Gene Translation
  JOURNAL   Am J Pathol 194 (7), 1374-1387 (2024)
   PUBMED   38537932
  REMARK    GeneRIF: Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal
            Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and
            Mitochondrial Gene Translation.
REFERENCE   3  (bases 1 to 827)
  AUTHORS   Levy,T., Voeltzke,K., Hruby,L., Alasad,K., Bas,Z.,
            Snaebjornsson,M., Marciano,R., Scharov,K., Planque,M., Vriens,K.,
            Christen,S., Funk,C.M., Hassiepen,C., Kahler,A., Heider,B.,
            Picard,D., Lim,J.K.M., Stefanski,A., Bendrin,K., Vargas-Toscano,A.,
            Kahlert,U.D., Stuhler,K., Remke,M., Elkabets,M., Grunewald,T.G.P.,
            Reichert,A.S., Fendt,S.M., Schulze,A., Reifenberger,G., Rotblat,B.
            and Leprivier,G.
  TITLE     mTORC1 regulates cell survival under glucose starvation through
            4EBP1/2-mediated translational reprogramming of fatty acid
            metabolism
  JOURNAL   Nat Commun 15 (1), 4083 (2024)
   PUBMED   38744825
  REMARK    GeneRIF: mTORC1 regulates cell survival under glucose starvation
            through 4EBP1/2-mediated translational reprogramming of fatty acid
            metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 827)
  AUTHORS   Nagaraj,S., Stankiewicz-Drogon,A., Darzynkiewicz,E., Wojda,U. and
            Grzela,R.
  TITLE     miR-483-5p orchestrates the initiation of protein synthesis by
            facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1
            levels
  JOURNAL   Sci Rep 14 (1), 4237 (2024)
   PUBMED   38378793
  REMARK    GeneRIF: miR-483-5p orchestrates the initiation of protein
            synthesis by facilitating the decrease in phosphorylated
            Ser209eIF4E and 4E-BP1 levels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 827)
  AUTHORS   Lorenzo-Orts,L., Strobl,M., Steinmetz,B., Leesch,F., Pribitzer,C.,
            Roehsner,J., Schutzbier,M., Durnberger,G. and Pauli,A.
  TITLE     eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs
  JOURNAL   EMBO Rep 25 (1), 404-427 (2024)
   PUBMED   38177902
REFERENCE   6  (bases 1 to 827)
  AUTHORS   Feigenblum,D. and Schneider,R.J.
  TITLE     Cap-binding protein (eukaryotic initiation factor 4E) and
            4E-inactivating protein BP-1 independently regulate cap-dependent
            translation
  JOURNAL   Mol Cell Biol 16 (10), 5450-5457 (1996)
   PUBMED   8816458
REFERENCE   7  (bases 1 to 827)
  AUTHORS   Haghighat,A., Mader,S., Pause,A. and Sonenberg,N.
  TITLE     Repression of cap-dependent translation by 4E-binding protein 1:
            competition with p220 for binding to eukaryotic initiation
            factor-4E
  JOURNAL   EMBO J 14 (22), 5701-5709 (1995)
   PUBMED   8521827
REFERENCE   8  (bases 1 to 827)
  AUTHORS   Mader,S., Lee,H., Pause,A. and Sonenberg,N.
  TITLE     The translation initiation factor eIF-4E binds to a common motif
            shared by the translation factor eIF-4 gamma and the translational
            repressors 4E-binding proteins
  JOURNAL   Mol Cell Biol 15 (9), 4990-4997 (1995)
   PUBMED   7651417
REFERENCE   9  (bases 1 to 827)
  AUTHORS   Pause,A., Belsham,G.J., Gingras,A.C., Donze,O., Lin,T.A.,
            Lawrence,J.C. Jr. and Sonenberg,N.
  TITLE     Insulin-dependent stimulation of protein synthesis by
            phosphorylation of a regulator of 5'-cap function
  JOURNAL   Nature 371 (6500), 762-767 (1994)
   PUBMED   7935836
REFERENCE   10 (bases 1 to 827)
  AUTHORS   Haystead,T.A., Haystead,C.M., Hu,C., Lin,T.A. and Lawrence,J.C. Jr.
  TITLE     Phosphorylation of PHAS-I by mitogen-activated protein (MAP)
            kinase. Identification of a site phosphorylated by MAP kinase in
            vitro and in response to insulin in rat adipocytes
  JOURNAL   J Biol Chem 269 (37), 23185-23191 (1994)
   PUBMED   8083223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC004459.1 and AB044548.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004095.3.
            
            Summary: This gene encodes one member of a family of translation
            repressor proteins. The protein directly interacts with eukaryotic
            translation initiation factor 4E (eIF4E), which is a limiting
            component of the multisubunit complex that recruits 40S ribosomal
            subunits to the 5' end of mRNAs. Interaction of this protein with
            eIF4E inhibits complex assembly and represses translation. This
            protein is phosphorylated in response to various signals including
            UV irradiation and insulin signaling, resulting in its dissociation
            from eIF4E and activation of mRNA translation. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE739835.1, AB044548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338825.5/ ENSP00000340691.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-820               BC004459.1         25-844
            821-827             AB044548.1         826-832
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..827
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /note="eukaryotic translation initiation factor 4E binding
                     protein 1"
                     /db_xref="GeneID:1978"
                     /db_xref="HGNC:HGNC:3288"
                     /db_xref="MIM:602223"
     exon            1..185
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..397
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /note="eIF4E-binding protein 1; phosphorylated heat- and
                     acid-stable protein regulated by insulin 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor
                     4E-binding protein 1"
                     /protein_id="NP_004086.1"
                     /db_xref="CCDS:CCDS6100.1"
                     /db_xref="GeneID:1978"
                     /db_xref="HGNC:HGNC:3288"
                     /db_xref="MIM:602223"
                     /translation="MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFS
                     TTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSP
                     EDKRAGGEESQFEMDI"
     exon            186..365
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            366..827
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      797..802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /note="hexamer: AATAAA"
     polyA_site      827
                     /gene="EIF4EBP1"
                     /gene_synonym="4E-BP1; 4EBP1; BP-1; PHAS-I"
                     /note="major polyA site"
ORIGIN      
        1 agggcagcga gaggttcgcg ggtgcagcgc acaggagacc atgtccgggg gcagcagctg
       61 cagccagacc ccaagccggg ccatccccgc cactcgccgg gtggtgctcg gcgacggcgt
      121 gcagctcccg cccggggact acagcacgac ccccggcggc acgctcttca gcaccacccc
      181 gggaggtacc aggatcatct atgaccggaa attcctgatg gagtgtcgga actcacctgt
      241 gaccaaaaca cccccaaggg atctgcccac cattccgggg gtcaccagcc cttccagtga
      301 tgagcccccc atggaagcca gccagagcca cctgcgcaat agcccagaag ataagcgggc
      361 gggcggtgaa gagtcacagt ttgagatgga catttaaagc accagccatc gtgtggagca
      421 ctaccaaggg gcccctcagg gccttcctgg gaggagtccc accagccagg ccttatgaaa
      481 gtgatcatac tgggcaggcg ttggcgtggg gtcggacacc ccagcccttt ctccctcact
      541 cagggcacct gccccctcct cttcgtgaac accagcagat acctccttgt gcctccactg
      601 atgcaggagc tgccacccca aggggagtga cccctgccag cacaccctgc agccaagggc
      661 caggaagtgg acaagaacga acccttcctt ccgaatgatc agcagttcca gcccctcgct
      721 gctgggggcg caaccacccc ttccttaggt tgatgtgctt gggaaagctc cctccccctc
      781 cttccccaag agaggaaata aaagccacct tcgccctagg gccaaga
//
