LOCUS       NM_004846                967 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E family
            member 2 (EIF4E2), transcript variant 1, mRNA.
ACCESSION   NM_004846
VERSION     NM_004846.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   Wang,F., Zhang,J., Lin,X., Yang,L., Zhou,Q., Mi,X., Li,Q., Wang,S.,
            Li,D., Liu,X.M. and Zhou,J.
  TITLE     METTL16 promotes translation and lung tumorigenesis by sequestering
            cytoplasmic eIF4E2
  JOURNAL   Cell Rep 42 (3), 112150 (2023)
   PUBMED   36840945
  REMARK    GeneRIF: METTL16 promotes translation and lung tumorigenesis by
            sequestering cytoplasmic eIF4E2.
REFERENCE   2  (bases 1 to 967)
  AUTHORS   Xu,Z., Choi,J.H., Dai,D.L., Luo,J., Ladak,R.J., Li,Q., Wang,Y.,
            Zhang,C., Wiebe,S., Liu,A.C.H., Ran,X., Yang,J., Naeli,P.,
            Garzia,A., Zhou,L., Mahmood,N., Deng,Q., Elaish,M., Lin,R.,
            Mahal,L.K., Hobman,T.C., Pelletier,J., Alain,T., Vidal,S.M.,
            Duchaine,T., Mazhab-Jafari,M.T., Mao,X., Jafarnejad,S.M. and
            Sonenberg,N.
  TITLE     SARS-CoV-2 impairs interferon production via NSP2-induced
            repression of mRNA translation
  JOURNAL   Proc Natl Acad Sci U S A 119 (32), e2204539119 (2022)
   PUBMED   35878012
REFERENCE   3  (bases 1 to 967)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 967)
  AUTHORS   Zinshteyn,B., Sinha,N.K., Enam,S.U., Koleske,B. and Green,R.
  TITLE     Translational repression of NMD targets by GIGYF2 and EIF4E2
  JOURNAL   PLoS Genet 17 (10), e1009813 (2021)
   PUBMED   34665823
  REMARK    GeneRIF: Translational repression of NMD targets by GIGYF2 and
            EIF4E2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 967)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   7  (bases 1 to 967)
  AUTHORS   Joshi,B., Cameron,A. and Jagus,R.
  TITLE     Characterization of mammalian eIF4E-family members
  JOURNAL   Eur J Biochem 271 (11), 2189-2203 (2004)
   PUBMED   15153109
REFERENCE   8  (bases 1 to 967)
  AUTHORS   Tee,A.R., Tee,J.A. and Blenis,J.
  TITLE     Characterizing the interaction of the mammalian eIF4E-related
            protein 4EHP with 4E-BP1
  JOURNAL   FEBS Lett 564 (1-2), 58-62 (2004)
   PUBMED   15094042
  REMARK    GeneRIF: 4EHP over-expression instigates a negative feedback loop
            that inhibits upstream signaling to 4E-BP1 and ribosomal protein S6
            kinase 1 (S6K1) whereas the 4E-BP1-binding-deficient mutant of
            4EHP(W95A) was unable to trigger this feedback loop
REFERENCE   9  (bases 1 to 967)
  AUTHORS   Tan,N.G., Ardley,H.C., Scott,G.B., Rose,S.A., Markham,A.F. and
            Robinson,P.A.
  TITLE     Human homologue of ariadne promotes the ubiquitylation of
            translation initiation factor 4E homologous protein, 4EHP
  JOURNAL   FEBS Lett 554 (3), 501-504 (2003)
   PUBMED   14623119
REFERENCE   10 (bases 1 to 967)
  AUTHORS   Rom,E., Kim,H.C., Gingras,A.C., Marcotrigiano,J., Favre,D.,
            Olsen,H., Burley,S.K. and Sonenberg,N.
  TITLE     Cloning and characterization of 4EHP, a novel mammalian
            eIF4E-related cap-binding protein
  JOURNAL   J Biol Chem 273 (21), 13104-13109 (1998)
   PUBMED   9582349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005874.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004846.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM423333.1, BC005874.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258416.8/ ENSP00000258416.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-967               BC005874.2         23-989
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..967
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /note="eukaryotic translation initiation factor 4E family
                     member 2"
                     /db_xref="GeneID:9470"
                     /db_xref="HGNC:HGNC:3293"
                     /db_xref="MIM:605895"
     exon            1..56
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..774
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /note="isoform A is encoded by transcript variant 1;
                     eIF4E-like cap-binding protein; eukaryotic translation
                     initiation factor 4E-like 3; eukaryotic translation
                     initiation factor 4E type 2; eIF-4E type 2; eIF4E-like
                     protein 4E-LP; mRNA cap-binding protein type 3; eukaryotic
                     translation initiation factor 4E homologous protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E type
                     2 isoform A"
                     /protein_id="NP_004837.1"
                     /db_xref="CCDS:CCDS2496.1"
                     /db_xref="GeneID:9470"
                     /db_xref="HGNC:HGNC:3293"
                     /db_xref="MIM:605895"
                     /translation="MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKR
                     KAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMV
                     RPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQF
                     MVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHT
                     DSIKMPGRLGPQRLLFQNLWKPRLNVP"
     exon            57..171
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     exon            172..306
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     exon            307..411
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     exon            412..564
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     exon            565..701
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     exon            702..967
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      949..954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="EIF4E2"
                     /gene_synonym="4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e"
                     /note="major polyA site"
ORIGIN      
        1 actccctgag gcagtggcga cagcggcggc gagaggatga acaacaagtt cgacgctttg
       61 aaagatgatg acagtgggga ccatgatcag aatgaagaaa acagcacaca gaaagatggt
      121 gagaaggaaa aaacggaacg agacaagaat cagagcagta gcaagagaaa ggctgttgtc
      181 cctggaccgg cagagcatcc cctgcagtac aactacactt tttggtactc caggagaacc
      241 cccggccgtc ccacgagctc acagagctat gaacagaata tcaaacagat tggcaccttt
      301 gcctctgtgg agcagttctg gaggttttat agccacatgg tacgtcctgg ggacctgaca
      361 ggccacagtg acttccatct cttcaaagaa ggaattaaac ccatgtggga ggatgatgca
      421 aataaaaatg gtggcaagtg gattattcgg ctgcggaagg gcttggcctc ccgttgctgg
      481 gagaatctca ttttggccat gctgggggaa cagttcatgg ttggggagga gatctgtggg
      541 gctgtggtgt ctgtccgctt tcaggaagac attatttcaa tatggaataa gactgccagt
      601 gaccaagcaa ccacagcccg aatccgggac acacttcggc gagtgcttaa cctacctccc
      661 aacaccatta tggaatacaa aactcacacc gacagcatca aaatgccagg caggctgggc
      721 ccccaaaggc tcctttttca aaacctctgg aagccgcggt tgaatgtgcc atgaccctct
      781 ccctctctgg atggcaccat cattgaagct ggcgtcatcg gagtctcttg ttctgttggc
      841 gtgctacctg gaagatcctt ctgtcctgga caagaggaat tggaagagca ttttatgttt
      901 taagaacagg ctgacacgca gcagctacaa caacagctga gatcacttaa taaatggtgc
      961 taaacta
//
