LOCUS       NM_001099408            1984 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E family
            member 1B (EIF4E1B), transcript variant 2, mRNA.
ACCESSION   NM_001099408 XM_927854 XM_940849
VERSION     NM_001099408.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Lorenzo-Orts,L., Strobl,M., Steinmetz,B., Leesch,F., Pribitzer,C.,
            Roehsner,J., Schutzbier,M., Durnberger,G. and Pauli,A.
  TITLE     eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs
  JOURNAL   EMBO Rep 25 (1), 404-427 (2024)
   PUBMED   38177902
  REMARK    GeneRIF: eIF4E1b is a non-canonical eIF4E protecting maternal
            dormant mRNAs.
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Joshi,B., Lee,K., Maeder,D.L. and Jagus,R.
  TITLE     Phylogenetic analysis of eIF4E-family members
  JOURNAL   BMC Evol Biol 5, 48 (2005)
   PUBMED   16191198
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091934.2, DA689940.1, AK094270.1, DR731203.1, DR008159.1 and
            BM709255.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099408.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.16017.1,
                                           SRR1660807.135458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318682.11/ ENSP00000323714.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC091934.2         32487-32493         c
            8-133               DA689940.1         1-126
            134-134             AC091934.2         32360-32360         c
            135-280             DA689940.1         128-273
            281-471             AK094270.1         1-191
            472-472             AC091934.2         21044-21044         c
            473-770             AK094270.1         193-490
            771-810             DR731203.1         1-40
            811-887             AK094270.1         531-607
            888-991             DR731203.1         118-221
            992-1002            DR008159.1         216-226
            1003-1380           BM709255.1         84-461
            1381-1981           AK094270.1         2224-2824
            1982-1984           AC091934.2         16524-16526         c
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..1984
                     /gene="EIF4E1B"
                     /note="eukaryotic translation initiation factor 4E family
                     member 1B"
                     /db_xref="GeneID:253314"
                     /db_xref="HGNC:HGNC:33179"
     exon            1..390
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            391..513
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            514..606
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..1320
                     /gene="EIF4E1B"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E type
                     1B"
                     /protein_id="NP_001092878.1"
                     /db_xref="CCDS:CCDS47345.1"
                     /db_xref="GeneID:253314"
                     /db_xref="HGNC:HGNC:33179"
                     /translation="MLAVEVSEAEGGIREWEEEEKEEEAAERTPTGEKSPNSPRTLLS
                     LRGKARTGGPMEVKLELHPLQNRWALWFFKNDRSRAWQDNLHLVTKVDTVEDFWALYS
                     HIQLASKLSSGCDYALFKDGIQPMWEDSRNKRGGRWLVSLAKQQRHIELDRLWLETLL
                     CLIGESFEEHSREVCGAVVNIRTKGDKIAVWTREAENQAGVLHVGRVYKERLGLSPKT
                     IIGYQAHADTATKSNSLAKNKFVV"
     exon            607..791
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            792..887
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            888..951
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1065
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1205
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1984
                     /gene="EIF4E1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E1B"
                     /note="hexamer: AATAAA"
     polyA_site      1947
                     /gene="EIF4E1B"
                     /note="major polyA site"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E1B"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="EIF4E1B"
                     /note="major polyA site"
ORIGIN      
        1 gtagtctgtt gggagttgag ggagggggac aacgcggcgt gtgaagagtg gggaagaaat
       61 cacgcgactg gatttggagt tctgctgggc tcgaatctca gctgtgcttt ttattaaccg
      121 tgggaccttg agctactcgg ctctcctttc tgaatgacag tttcctcctc tgtaaaacag
      181 gaatggttaa ttcaacgaat gtttactgag cgcttagtcc agtggtgcag gtttaaggct
      241 ggaggcagcg gaaaaggaaa acaaggttcc tggtctcggg aagcttacca tgggggtgtc
      301 tgtacgcgtg tgtgttcgtg cgctcagtgg tggaagacag gacagaaaat aaacggatca
      361 acatccaaag caacaaggtc attacagctt atggggaaac tgactcgatg aagctcaggc
      421 ctggccgcgg tcagggtaga atcaggacta gaacccaggc tgtgtggctg cagccctgac
      481 cctcaccatc caggtcaggc agagaacact caggtcttgg cccccatggt gtggggcttg
      541 gtcacagctg cttccccagc cccaggcctg cacgaagaag gcactcacta aatgcttgct
      601 gttgaggtga gtgaagctga gggtggaatc cgagagtggg aggaggagga gaaggaggag
      661 gaggcagcag agaggacgcc cacaggagaa aagtctccaa actctcccag gactttgctg
      721 tctctgagag ggaaggcccg gacggggggc cccatggaag tcaagctgga gctgcacccc
      781 ttgcagaaca ggtgggctct gtggttcttc aagaatgacc gcagccgggc ctggcaggac
      841 aacctgcacc tggtcaccaa ggtggacact gtggaggact tctgggcgct atacagtcac
      901 atccagctgg ccagcaagct ctcctctggc tgtgactacg ccctcttcaa ggatggcatc
      961 cagcccatgt gggaggacag caggaataaa cggggtggcc gctggctggt cagcctggcc
     1021 aagcagcagc gccacattga gctggaccgg ctgtggctgg agacgctgct gtgtctgatc
     1081 ggggagagct ttgaggaaca cagcagagag gtatgtgggg ccgtcgtcaa catccgcacc
     1141 aagggggaca agatcgctgt gtggacgagg gaggcggaaa accaggcggg cgtgctgcac
     1201 gttgggcgtg tatacaaaga gcgcctgggc ctctccccaa agaccatcat tgggtaccag
     1261 gcccatgcag acacagccac caagagcaac tccctagcca agaacaagtt tgtggtgtga
     1321 ggggggcctt ggcacccctc ctatgtaatg ggacagccgc cactgagcct cattactttg
     1381 ggggatgggg cgggactggg gatcagacag cctagttctt acctgtcctc aagtgaacag
     1441 gaatgcaaac actctttaac atgagttggg gcctgagcct taggggctag atgggggtag
     1501 tggtggcagt ctgaggacct agcttgtcct ggggccacag gacagcagca gggtggaaaa
     1561 aactcctgag ggtggggtga gtcatggcgg ggaaggaggg ctctatggta ggcggagaaa
     1621 cccatagtcc agcgtttact gtttccaccc aggaaggagg tgaggtggcc tgagagacag
     1681 actcttccat gggtggtggg ctcaagggca cagacattct ggagggtgaa cgccatcatt
     1741 tgtacagagg gatacgtggg ttgctgagga ctgagagagc cttgcaaggc cgctcccctt
     1801 ctccccagct gtgaccaggg ctgtctgggc cttgcctgcc tcagggccag actgaagtgg
     1861 aggtggaggg atgctgggct aggcctcacc aaggttctgg tagaagtggt ggaagtggat
     1921 aaacttgata ataaaagctt aagcatcttt ctgttcctgt tttaaataaa tacttctgaa
     1981 caaa
//
