LOCUS       NM_001968               2427 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4E (EIF4E),
            transcript variant 1, mRNA.
ACCESSION   NM_001968
VERSION     NM_001968.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2427)
  AUTHORS   Valcikova,B., Vadovicova,N., Smolkova,K., Zacpalova,M., Krejci,P.,
            Lee,S., Rauch,J., Kolch,W., von Kriegsheim,A., Dorotikova,A.,
            Andrysik,Z., Vichova,R., Vacek,O., Soucek,K. and Uldrijan,S.
  TITLE     eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS
            mutations
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2321305121 (2024)
   PUBMED   39436655
  REMARK    GeneRIF: eIF4F controls ERK MAPK signaling in melanomas with BRAF
            and NRAS mutations.
REFERENCE   2  (bases 1 to 2427)
  AUTHORS   Gomaa,A., Maacha,S., Peng,D., Soutto,M., Genoula,M., Bhat,N.,
            Cao,L., Zhu,S., Castells,A., Chen,Z., Zaika,A., McDonald,O.G. and
            El-Rifai,W.
  TITLE     SOX9 is regulated by AURKA in response to Helicobacter pylori
            infection via EIF4E-mediated cap-dependent translation
  JOURNAL   Cancer Lett 593, 216939 (2024)
   PUBMED   38729556
REFERENCE   3  (bases 1 to 2427)
  AUTHORS   Yang,G., Smibert,C.A., Kaplan,D.R. and Miller,F.D.
  TITLE     An eIF4E1/4E-T complex determines the genesis of neurons from
            precursors by translationally repressing a proneurogenic
            transcription program
  JOURNAL   Neuron 84 (4), 723-739 (2014)
   PUBMED   25456498
  REMARK    GeneRIF: neural precursors are transcriptionally primed to generate
            neurons, but an eIF4E/4E-T complex sequesters and represses
            translation of proneurogenic proteins to determine appropriate
            neurogenesis.
REFERENCE   4  (bases 1 to 2427)
  AUTHORS   Feoktistova,K., Tuvshintogs,E., Do,A. and Fraser,C.S.
  TITLE     Human eIF4E promotes mRNA restructuring by stimulating eIF4A
            helicase activity
  JOURNAL   Proc Natl Acad Sci U S A 110 (33), 13339-13344 (2013)
   PUBMED   23901100
  REMARK    GeneRIF: Human eIF4E promotes mRNA restructuring by stimulating
            eIF4A helicase activity.
REFERENCE   5  (bases 1 to 2427)
  AUTHORS   Xu,X., Vatsyayan,J., Gao,C., Bakkenist,C.J. and Hu,J.
  TITLE     Sumoylation of eIF4E activates mRNA translation
  JOURNAL   EMBO Rep 11 (4), 299-304 (2010)
   PUBMED   20224576
  REMARK    GeneRIF: The findings suggest further that eIF4E sumoylation is a
            new fundamental regulatory mechanism of protein synthesis and might
            be important in promoting human cancers.
REFERENCE   6  (bases 1 to 2427)
  AUTHORS   Brown,C.J., McNae,I., Fischer,P.M. and Walkinshaw,M.D.
  TITLE     Crystallographic and mass spectrometric characterisation of eIF4E
            with N7-alkylated cap derivatives
  JOURNAL   J Mol Biol 372 (1), 7-15 (2007)
   PUBMED   17631896
  REMARK    GeneRIF: Crystallographic and mass spectrometric characterisation
            of eIF4E with N7-alkylated cap derivatives.
            Review article
REFERENCE   7  (bases 1 to 2427)
  AUTHORS   Tomoo,K., Shen,X., Okabe,K., Nozoe,Y., Fukuhara,S., Morino,S.,
            Ishida,T., Taniguchi,T., Hasegawa,H., Terashima,A., Sasaki,M.,
            Katsuya,Y., Kitamura,K., Miyoshi,H., Ishikawa,M. and Miura,K.
  TITLE     Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)-
            and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate
            (m(7)GpppA)-bound human full-length eukaryotic initiation factor
            4E: biological importance of the C-terminal flexible region
  JOURNAL   Biochem J 362 (Pt 3), 539-544 (2002)
   PUBMED   11879179
  REMARK    GeneRIF: The crystal structures of the full-length human eukaryotic
            initiation factor (eIF) 4E complexed with two mRNA cap analogues
REFERENCE   8  (bases 1 to 2427)
  AUTHORS   Lejbkowicz,F., Goyer,C., Darveau,A., Neron,S., Lemieux,R. and
            Sonenberg,N.
  TITLE     A fraction of the mRNA 5' cap-binding protein, eukaryotic
            initiation factor 4E, localizes to the nucleus
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9612-9616 (1992)
   PUBMED   1384058
REFERENCE   9  (bases 1 to 2427)
  AUTHORS   Ueda,H., Iyo,H., Doi,M., Inoue,M., Ishida,T., Morioka,H.,
            Tanaka,T., Nishikawa,S. and Uesugi,S.
  TITLE     Combination of Trp and Glu residues for recognition of mRNA cap
            structure. Analysis of m7G base recognition site of human cap
            binding protein (IF-4E) by site-directed mutagenesis
  JOURNAL   FEBS Lett 280 (2), 207-210 (1991)
   PUBMED   1672854
REFERENCE   10 (bases 1 to 2427)
  AUTHORS   Rychlik,W., Domier,L.L., Gardner,P.R., Hellmann,G.M. and
            Rhoads,R.E.
  TITLE     Amino acid sequence of the mRNA cap-binding protein from human
            tissues
  JOURNAL   Proc Natl Acad Sci U S A 84 (4), 945-949 (1987)
   PUBMED   3469651
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1148. doi:
            10.1073/pnas.89.3.1148a.. PMID: 1736299]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019131.7, M15353.1 and
            AC093836.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_001968.4.
            
            Summary: The protein encoded by this gene is a component of the
            eukaryotic translation initiation factor 4F complex, which
            recognizes the 7-methylguanosine cap structure at the 5' end of
            messenger RNAs. The encoded protein aids in translation initiation
            by recruiting ribosomes to the 5'-cap structure. Association of
            this protein with the 4F complex is the rate-limiting step in
            translation initiation. This gene acts as a proto-oncogene, and its
            expression and activation is associated with transformation and
            tumorigenesis. Several pseudogenes of this gene are found on other
            chromosomes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.21376.1,
                                           SRR11853558.18858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450253.7/ ENSP00000389624.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC019131.7         12401-12403         c
            4-867               M15353.1           1-864
            868-2427            AC093836.3         72851-74410         c
FEATURES             Location/Qualifiers
     source          1..2427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2427
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="eukaryotic translation initiation factor 4E"
                     /db_xref="GeneID:1977"
                     /db_xref="HGNC:HGNC:3287"
                     /db_xref="MIM:133440"
     exon            1..39
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..675
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="isoform 1 is encoded by transcript variant 1; mRNA
                     cap-binding protein; eIF-4F 25 kDa subunit; eukaryotic
                     translation initiation factor 4E-like 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4E
                     isoform 1"
                     /protein_id="NP_001959.1"
                     /db_xref="CCDS:CCDS34031.1"
                     /db_xref="GeneID:1977"
                     /db_xref="HGNC:HGNC:3287"
                     /db_xref="MIM:133440"
                     /translation="MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWA
                     LWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMW
                     EDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKG
                     DKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV"
     exon            40..146
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     exon            147..242
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     exon            243..306
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     exon            307..420
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     exon            421..560
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     exon            561..2427
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1613..1618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="hexamer: AATAAA"
     polyA_site      1647
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="major polyA site"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="major polyA site"
     regulatory      2108..2113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="hexamer: AATAAA"
     polyA_site      2427
                     /gene="EIF4E"
                     /gene_synonym="AUTS19; CBP; eIF-4E; EIF4E1; EIF4EL1;
                     EIF4F"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgatcag atcgatctaa gatggcgact gtcgaaccgg aaaccacccc tactcctaat
       61 cccccgacta cagaagagga gaaaacggaa tctaatcagg aggttgctaa cccagaacac
      121 tatattaaac atcccctaca gaacagatgg gcactctggt tttttaaaaa tgataaaagc
      181 aaaacttggc aagcaaacct gcggctgatc tccaagtttg atactgttga agacttttgg
      241 gctctgtaca accatatcca gttgtctagt aatttaatgc ctggctgtga ctactcactt
      301 tttaaggatg gtattgagcc tatgtgggaa gatgagaaaa acaaacgggg aggacgatgg
      361 ctaattacat tgaacaaaca gcagagacga agtgacctcg atcgcttttg gctagagaca
      421 cttctgtgcc ttattggaga atcttttgat gactacagtg atgatgtatg tggcgctgtt
      481 gttaatgtta gagctaaagg tgataagata gcaatatgga ctactgaatg tgaaaacaga
      541 gaagctgtta cacatatagg gagggtatac aaggaaaggt taggacttcc tccaaagata
      601 gtgattggtt atcagtccca cgcagacaca gctactaaga gcggctccac cactaaaaat
      661 aggtttgttg tttaagaaga caccttctga gtattctcat aggagactgc gtcaagcaat
      721 cgagatttgg gagctgaacc aaagcctctt caaaaagcag agtggactgc atttaaattt
      781 gatttccatc ttaatgttac tcagatataa gagaagtctc attcgccttt gtcttgtact
      841 tctgtgttca tttttttttt tttttttggc tagagtttcc actatcccaa tcaaagaatt
      901 acagtacaca tccccagaat ccataaatgt gttcctggcc cactctgtaa tagttcagta
      961 gaattaccat taattacata cagattttac ctatccacaa tagtcagaaa acaacttggc
     1021 atttctatac tttacaggaa aaaaaattct gttgttccat tttatgcaga agcatatttt
     1081 gctggtttga aagattatga tgcatacagt tttctagcaa ttttctttgt ttctttttac
     1141 agcattgtct ttgctgtact cttgctgatg gctgctagat tttaatttat ttgtttccct
     1201 acttgataat attagtgatt ctgatttcag tttttcattt gttttgcttt tgtttttttc
     1261 ctcatgtaac attggtgaag gatccaggaa tatgacacaa aggtggaata aacattaatt
     1321 ttgtgcattc tttggtaatt ttttttgttt tttgtaacta caaagctttg ctacaaattt
     1381 atgcatttca ttcaaatcag tgatctatgt ttgtgtgatt tcctaaacat aattgtggat
     1441 tataaaaaat gtaacatcat aattacattc ctaactagaa ttagtatgtc tgtttttgta
     1501 tctttatgct gtattttaac actttgtatt acttaggtta ttttgctttg gttaaaaatg
     1561 gctcaagtag aaaagcagtc ccattcatat taagacagtg tacaaaactg taaataaaat
     1621 gtgtacagtg aattgtcttt tagacaacta gatttgtcct tttatttctc catctttata
     1681 gaaggaattt gtacttctta ttgcaaggca gtctctatat tatgtcttct tttgtggtgt
     1741 cttccatgtg aacagcataa gtttggagca ctagtttgat tattatgttt attacaattt
     1801 ttaataaatt gaataggtag tatcatatat atggaattaa attgatgtgg ctatctttgt
     1861 ttttttataa agtaaggcac agtcattcag tcttaggtaa ataatgtact ctcttaatat
     1921 gttaatactc atgagaattg ggatctgatg catcaccatt tgattggtag caacagtggt
     1981 tgtaaaactt ggttgctgaa ttgagttgtt tctatgttaa gtgtcaaaat gatagtgtag
     2041 ggaaagtaca ggtggtgggg acatatgcat taagaatctt gttagtgttg caatctaaat
     2101 agaatggaat aaacaggtgt taagacatat ttatagtggt aaattgttgt agtatggtat
     2161 tctgtaaact tgaaaacttg atctactctt tgtaggtatc atttgaaagc aaacttgaaa
     2221 atgttttgta catagtacat acttgtatag tcctgtgaga tgaagtatgg ctatcagacc
     2281 aaaggataag ccaaactgta ggtagcagaa tggaaattat tattttgaga ggaaaatttg
     2341 tctttgaatg gtgattatga cttaatcatt ttaaaactga taaacttgac aaaaaccctg
     2401 tatgaaataa acatgaaatt aatagca
//
