LOCUS       NM_001417               3856 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4B (EIF4B),
            transcript variant 2, mRNA.
ACCESSION   NM_001417
VERSION     NM_001417.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Quintas,A., Harvey,R.F., Horvilleur,E., Garland,G.D., Schmidt,T.,
            Kalmar,L., Dezi,V., Marini,A., Fulton,A.M., Poyry,T.A.A.,
            Cole,C.H., Turner,M., Sawarkar,R., Chapman,M.A., Bushell,M. and
            Willis,A.E.
  TITLE     Eukaryotic initiation factor 4B is a multi-functional RNA binding
            protein that regulates histone mRNAs
  JOURNAL   Nucleic Acids Res 52 (19), 12039-12054 (2024)
   PUBMED   39225047
  REMARK    GeneRIF: Eukaryotic initiation factor 4B is a multi-functional RNA
            binding protein that regulates histone mRNAs.
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Shi,J.Y., Wen,R., Chen,J.Y., Feng,Y.Q., Zhang,Y.Y., Hou,S.J.,
            Xi,Y.J., Wang,J.F. and Zhang,Y.F.
  TITLE     Genetic evidence supporting potential causal roles of EIF4 family
            in breast cancer: a two-sample randomized Mendelian study
  JOURNAL   Sci Rep 14 (1), 20191 (2024)
   PUBMED   39215053
  REMARK    GeneRIF: Genetic evidence supporting potential causal roles of EIF4
            family in breast cancer: a two-sample randomized Mendelian study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3856)
  AUTHORS   Mondal,S., Rousseau,S., Talenton,V., Thiam,C.A.B., Aznauryan,M. and
            Mackereth,C.D.
  TITLE     Backbone resonance assignments of the C-terminal region of human
            translation initiation factor eIF4B
  JOURNAL   Biomol NMR Assign 17 (2), 199-203 (2023)
   PUBMED   37368134
  REMARK    GeneRIF: Backbone resonance assignments of the C-terminal region of
            human translation initiation factor eIF4B.
REFERENCE   4  (bases 1 to 3856)
  AUTHORS   Alexander,M.S. and Velinov,M.
  TITLE     DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and
            Molecular Basis
  JOURNAL   Genes (Basel) 14 (10), 1940 (2023)
   PUBMED   37895289
  REMARK    GeneRIF: DOCK3-Associated Neurodevelopmental Disorder-Clinical
            Features and Molecular Basis.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3856)
  AUTHORS   Cao,Y., Chen,Z., Qin,Z., Qian,K., Liu,T. and Zhang,Y.
  TITLE     CDKN2AIP-induced cell senescence and apoptosis of testicular
            seminoma are associated with CARM1 and eIF4beta
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (5), 604-614 (2022)
   PUBMED   35593475
  REMARK    GeneRIF: CDKN2AIP-induced cell senescence and apoptosis of
            testicular seminoma are associated with CARM1 and eIF4beta.
REFERENCE   6  (bases 1 to 3856)
  AUTHORS   Methot,N., Song,M.S. and Sonenberg,N.
  TITLE     A region rich in aspartic acid, arginine, tyrosine, and glycine
            (DRYG) mediates eukaryotic initiation factor 4B (eIF4B)
            self-association and interaction with eIF3
  JOURNAL   Mol Cell Biol 16 (10), 5328-5334 (1996)
   PUBMED   8816444
REFERENCE   7  (bases 1 to 3856)
  AUTHORS   Naranda,T., Strong,W.B., Menaya,J., Fabbri,B.J. and Hershey,J.W.
  TITLE     Two structural domains of initiation factor eIF-4B are involved in
            binding to RNA
  JOURNAL   J Biol Chem 269 (20), 14465-14472 (1994)
   PUBMED   8182051
REFERENCE   8  (bases 1 to 3856)
  AUTHORS   Methot,N., Pause,A., Hershey,J.W. and Sonenberg,N.
  TITLE     The translation initiation factor eIF-4B contains an RNA-binding
            region that is distinct and independent from its ribonucleoprotein
            consensus sequence
  JOURNAL   Mol Cell Biol 14 (4), 2307-2316 (1994)
   PUBMED   8139536
REFERENCE   9  (bases 1 to 3856)
  AUTHORS   Milburn,S.C., Hershey,J.W., Davies,M.V., Kelleher,K. and
            Kaufman,R.J.
  TITLE     Cloning and expression of eukaryotic initiation factor 4B cDNA:
            sequence determination identifies a common RNA recognition motif
  JOURNAL   EMBO J 9 (9), 2783-2790 (1990)
   PUBMED   2390971
REFERENCE   10 (bases 1 to 3856)
  AUTHORS   Howe,J.G. and Hershey,J.W.
  TITLE     Translational initiation factor and ribosome association with the
            cytoskeletal framework fraction from HeLa cells
  JOURNAL   Cell 37 (1), 85-93 (1984)
   PUBMED   6722878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC068888.35.
            
            On Jun 2, 2019 this sequence version replaced NM_001417.6.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.19838.1,
                                           SRR1803614.213627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262056.14/ ENSP00000262056.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC068888.35        60912-60952         c
            42-179              AC068888.35        50798-50935         c
            180-388             AC068888.35        48402-48610         c
            389-505             AC068888.35        47382-47498         c
            506-560             AC068888.35        45548-45602         c
            561-695             AC068888.35        44781-44915         c
            696-833             AC068888.35        39489-39626         c
            834-1007            AC068888.35        39220-39393         c
            1008-1236           AC068888.35        33374-33602         c
            1237-1334           AC068888.35        32699-32796         c
            1335-1548           AC068888.35        29786-29999         c
            1549-1604           AC068888.35        28997-29052         c
            1605-1710           AC068888.35        28065-28170         c
            1711-1783           AC068888.35        27706-27778         c
            1784-3856           AC068888.35        25193-27265         c
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..3856
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /note="eukaryotic translation initiation factor 4B"
                     /db_xref="GeneID:1975"
                     /db_xref="HGNC:HGNC:3285"
                     /db_xref="MIM:603928"
     exon            1..41
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1864
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 4B
                     isoform 2"
                     /protein_id="NP_001408.2"
                     /db_xref="CCDS:CCDS41788.1"
                     /db_xref="GeneID:1975"
                     /db_xref="HGNC:HGNC:3285"
                     /db_xref="MIM:603928"
                     /translation="MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADET
                     DDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGN
                     LPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEES
                     LGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDD
                     SFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGS
                     GRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKL
                     NLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLD
                     EPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENET
                     LNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSG
                     GGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKK
                     DQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE"
     exon            42..179
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            180..388
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            389..505
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            506..560
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            561..695
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            696..833
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1007
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1236
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1334
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1548
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1604
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1710
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1783
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..3856
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2005
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /note="major polyA site"
     regulatory      3827..3832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /note="hexamer: AATAAA"
     polyA_site      3856
                     /gene="EIF4B"
                     /gene_synonym="EIF-4B; PRO1843"
                     /note="major polyA site"
ORIGIN      
        1 cttttgcgtt ctctttccct ctcccaacat ggcggcctca gcaaaaaaga agaataagaa
       61 ggggaagact atctccctaa cagactttct ggctgaggat gggggtactg gtggaggaag
      121 cacctatgtt tccaaaccag tcagctgggc tgatgaaacg gatgacctgg aaggagatgt
      181 ttcgaccact tggcacagta acgatgacga tgtgtatagg gcgcctccaa ttgaccgttc
      241 catccttccc actgctccac gggctgctcg ggaacccaat atcgaccgga gccgtcttcc
      301 caaatcgcca ccctacactg cttttctagg aaacctaccc tatgatgtta cagaagagtc
      361 aattaaggaa ttctttcgag gattaaatat cagtgcagtg cgtttaccac gtgaacccag
      421 caatccagag aggttgaaag gttttggtta tgctgaattt gaggacctgg attccctgct
      481 cagtgccctg agtctcaatg aagagtctct aggtaacagg agaattcgag tggacgttgc
      541 tgatcaagca caggataaag acagggatga tcgttctttt ggccgtgata gaaatcggga
      601 ttctgacaaa acagatacag actggagggc tcgtcctgct acagacagct ttgatgacta
      661 cccacctaga agaggtgatg atagctttgg agacaagtat cgagatcgtt atgattcaga
      721 ccggtatcgg gatgggtatc gggatgggta tcgggatggc ccacgccggg atatggatcg
      781 atatggtggc cgggatcgct atgatgaccg aggcagcaga gactatgata gaggctatga
      841 ttcccggata ggcagtggca gaagagcatt tggcagtggg tatcgcaggg atgatgacta
      901 cagaggaggc ggggaccgct atgaagaccg atatgacaga cgggatgatc ggtcgtggag
      961 ctccagagat gattactctc gggatgatta taggcgtgat gatagaggtc ccccccaaag
     1021 acccaaactg aatctaaagc ctcggagtac tcctaaggaa gatgattcct ctgctagtac
     1081 ctcccagtcc actcgagctg cttctatctt tggaggggca aagcctgttg acacagctgc
     1141 tagagaaaga gaagtagaag aacggctaca gaaggaacaa gagaagttgc agcgtcagct
     1201 ggatgagcca aaactagaac gacggcctcg ggagagacac ccaagctggc gaagtgaaga
     1261 aactcaggaa cgggaacggt cgaggacagg aagtgagtca tcacaaactg ggacctccac
     1321 cacatctagc agaaatgcac gaaggagaga gagtgagaag tctctagaaa atgaaacact
     1381 caataaggag gaagattgcc actctccaac ttctaaacct cccaaacctg atcagcccct
     1441 aaaggtaatg ccagcccctc caccaaagga gaatgcttgg gtgaagcgaa gttctaaccc
     1501 tcctgctcga tctcagagct cagacacaga gcagcagtcc cctacaagtg gtgggggaaa
     1561 agtagctcca gctcaaccat ctgaggaagg accaggaagg aaagatgaaa ataaagtaga
     1621 tgggatgaat gccccaaaag gccaaactgg gaactctagc cgtggtccag gcgacggagg
     1681 gaacagagac cactggaagg agtcagatag gaaagatggc aaaaaggatc aagactccag
     1741 atctgcacct gagccaaaga aacctgagga aaatccagct tccaagttca gttctgcaag
     1801 caagtatgct gctctctctg ttgatggtga agatgaaaat gagggagaag attatgccga
     1861 atagacctct acatcctgtg cttttctcct agtttctctc caccctggaa cattcgagag
     1921 caaatcaaaa cctctatcca gacaagacaa aataaaactc accatctcct gaagaccttt
     1981 cttacctttt tttaaaaaca aaaaatgaaa ttattttgca tgctgctgca gcctttaaag
     2041 tattgaagta actggagaat tgccaataca gccagagaga aagggactac agctttttag
     2101 aggaaaagtt gtggtgcgtt atgtcaccat gcagttgcca gtgtgattag tgcctagggg
     2161 tctccattta gcagaaatgg taatgacagt gatataatgc ctggaacctg gttgggcagt
     2221 aggggaggga ggtagaagga aaagtgtgag atttctacct tttagttttt atcctattgt
     2281 ggcatatatg aattctcaaa cattatctga ataaattttc cactcttgga aaggtagatt
     2341 tagcctcaag ttgttctagt ctccaggagg ctgccagccc ctcctcttat ttaattctga
     2401 gttttggggg ccagcctaga gggaattcct tttttttttt taacccccca ggggggtagt
     2461 tgggagtgag actataggcc ataaagaatg ggactgcatt ggaccaaaat aaatgggaaa
     2521 atcgtggttt gaaaagaagc ttttgggaag tgatgagtca ttttgcacca ggtaataggg
     2581 gaaaattgtg tgacctccag caaacacatg aatggttatt tcctggagcc ggaagcactt
     2641 gggggtcgtg gtaattccca gtgttttctg tgtcctagtt ttaccctttc taaacactgt
     2701 cctttttgaa agttttgaat atatccacat tctattgaaa ccttgaaact aaaaatttag
     2761 actcttatca tcatcttaag ttcttcatgc tactcttaac ctcccaaaaa gcagtatcta
     2821 agtcacatac atgatgtctt gggcattttc tcagccatgg agaactctga aaggaagaat
     2881 cgctgctttt ctcaagcaaa tcggtttctt gatgtctttt ggttctcctt gcctgctcct
     2941 gatgcttgga ccccttttat tgatcagagt gctctagaat aatggatggt cttggatgat
     3001 ggataaatag ggacagggac agttaaattg ggagcctttc ttacaacctt gatgggattt
     3061 ttccccccaa gtttccttct ccactgaaat gccacactaa tgcttgttgg attcatgagg
     3121 tggccagacc aatgtgttgt tttgttgttg tttttttaag cttcccttga gagaataaat
     3181 ggtaatggag agaactattt aacaaggtcc tggtttctct tgcaacacag tagctaaact
     3241 tgcctgcttt tatatgcatt tttgtaggga tcagcttggt agacagtatt agcggagaaa
     3301 caccttgatc ttggtttgca agcccttctc ccatcagtcc tagattaggc cctgttcagc
     3361 catgcagggg tgttggttta tgcgtgctgc agcagtgggc ataatgaata taatttaccc
     3421 agtggacaaa ggtgtgtacc aagtgaattt aaataattgg tgtggattgg ccagtagcta
     3481 agaagtgggc ttttaaagag tattgaagat tgaaagggtt tttctttctt ttttaaaaaa
     3541 gaaaaacaaa ctattgattg tagataatga aaagctaggg tttgccctct tcatgtctac
     3601 tctccttcca aatagttata tccaaaactg tttttccctc tcccctacct tgtcccccct
     3661 attaaaatag aaacagggat tgattaatgt cccgctcctg aatacatgta aaatttgtac
     3721 aaaaatatct tctatgaaaa tgatttgtaa tctgtagact tattacctgg gagatgtctt
     3781 gatgtaaaat cccatccttt gggttgtggg ttttttgttt tctccaaata aatctgatct
     3841 ttaaagttca ttgtaa
//
