LOCUS       NM_014740               2524 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3),
            transcript variant 1, mRNA.
ACCESSION   NM_014740
VERSION     NM_014740.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Li,J., Xin,Y., Zhang,S., Li,Y., Jiang,M., Zhang,S., Yang,L.,
            Yang,J., Cao,P. and Lu,J.
  TITLE     EIF4A3 is stabilized by the long noncoding RNA BC200 to regulate
            gene expression during Epstein-Barr virus infection
  JOURNAL   J Med Virol 96 (10), e29955 (2024)
   PUBMED   39370864
  REMARK    GeneRIF: EIF4A3 is stabilized by the long noncoding RNA BC200 to
            regulate gene expression during Epstein-Barr virus infection.
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Zhou,Q., Cai,B., Liu,K. and Chen,H.
  TITLE     EIF4A3-Induced Upregulation of hsa_circ_0049396 Attenuates the
            Tumorigenesis of Nasopharyngeal Carcinoma by Regulating the
            Hippo-YAP Pathway
  JOURNAL   DNA Cell Biol 43 (10), 510-519 (2024)
   PUBMED   39133108
  REMARK    GeneRIF: EIF4A3-Induced Upregulation of hsa_circ_0049396 Attenuates
            the Tumorigenesis of Nasopharyngeal Carcinoma by Regulating the
            Hippo-YAP Pathway.
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Jiang,X., Peng,M., Liu,Q., Peng,Q., Oyang,L., Li,S., Xu,X.,
            Shen,M., Wang,J., Li,H., Wu,N., Tan,S., Lin,J., Xia,L., Tang,Y.,
            Luo,X., Liao,Q. and Zhou,Y.
  TITLE     Circular RNA hsa_circ_0000467 promotes colorectal cancer
            progression by promoting eIF4A3-mediated c-Myc translation
  JOURNAL   Mol Cancer 23 (1), 151 (2024)
   PUBMED   39085875
  REMARK    GeneRIF: Circular RNA hsa_circ_0000467 promotes colorectal cancer
            progression by promoting eIF4A3-mediated c-Myc translation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Cao,C., Wu,X., Li,Z., Xie,Y., Xu,S., Guo,J. and Sun,W.
  TITLE     EIF4A3-Bound hsa_circ_0006847 Exerts a Tumor-Suppressive Role in
            Gastric Cancer
  JOURNAL   DNA Cell Biol 43 (5), 232-244 (2024)
   PUBMED   38513058
  REMARK    GeneRIF: EIF4A3-Bound hsa_circ_0006847 Exerts a Tumor-Suppressive
            Role in Gastric Cancer.
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Yuan,L.X., Luo,M., Liu,R.Y., Wang,H.X., Ju,L.L., Wang,F., Cao,Y.L.,
            Wang,Z.C. and Chen,L.
  TITLE     Hsa_circ_0005397 promotes hepatocellular carcinoma progression
            through EIF4A3
  JOURNAL   BMC Cancer 24 (1), 239 (2024)
   PUBMED   38383334
  REMARK    GeneRIF: Hsa_circ_0005397 promotes hepatocellular carcinoma
            progression through EIF4A3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Palacios,I.M., Gatfield,D., St Johnston,D. and Izaurralde,E.
  TITLE     An eIF4AIII-containing complex required for mRNA localization and
            nonsense-mediated mRNA decay
  JOURNAL   Nature 427 (6976), 753-757 (2004)
   PUBMED   14973490
  REMARK    GeneRIF: identification of eIF4AIII and Barentsz as components of a
            conserved protein complex that is essential for mRNA localization
            in flies and nonsense-mediated mRNA decay in mammals
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Chan,C.C., Dostie,J., Diem,M.D., Feng,W., Mann,M., Rappsilber,J.
            and Dreyfuss,G.
  TITLE     eIF4A3 is a novel component of the exon junction complex
  JOURNAL   RNA 10 (2), 200-209 (2004)
   PUBMED   14730019
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Holzmann,K., Gerner,C., Poltl,A., Schafer,R., Obrist,P.,
            Ensinger,C., Grimm,R. and Sauermann,G.
  TITLE     A human common nuclear matrix protein homologous to eukaryotic
            translation initiation factor 4A
  JOURNAL   Biochem Biophys Res Commun 267 (1), 339-344 (2000)
   PUBMED   10623621
  REMARK    GeneRIF: NMP 265, a common part of the nuclear matrix, is located
            in the nucleus via an N-terminal amino acid sequence.
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Li,Q., Imataka,H., Morino,S., Rogers,G.W. Jr., Richter-Cook,N.J.,
            Merrick,W.C. and Sonenberg,N.
  TITLE     Eukaryotic translation initiation factor 4AIII (eIF4AIII) is
            functionally distinct from eIF4AI and eIF4AII
  JOURNAL   Mol Cell Biol 19 (11), 7336-7346 (1999)
   PUBMED   10523622
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA667983.1, BC004386.1 and
            AC087741.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 24, 2018 this sequence version replaced NM_014740.3.
            
            Summary: This gene encodes a member of the DEAD box protein family.
            DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure, such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. The protein encoded by this gene is a
            nuclear matrix protein. Its amino acid sequence is highly similar
            to the amino acid sequences of the translation initiation factors
            eIF4AI and eIF4AII, two other members of the DEAD box protein
            family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.12526.1,
                                           SRR14038193.3358645.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649764.2/ ENSP00000497641.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               DA667983.1         56-561
            507-1638            BC004386.1         493-1624
            1639-2524           AC087741.18        74919-75804
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2524
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /note="eukaryotic translation initiation factor 4A3"
                     /db_xref="GeneID:9775"
                     /db_xref="HGNC:HGNC:18683"
                     /db_xref="MIM:608546"
     exon            1..336
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1403
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 48; eukaryotic
                     initiation factor 4A-like NUK-34; nuclear matrix protein
                     265; ATP-dependent RNA helicase DDX48; ATP-dependent RNA
                     helicase eIF4A-3; eukaryotic initiation factor 4A-III; NMP
                     265; DEAD box protein 48"
                     /codon_start=1
                     /product="eukaryotic initiation factor 4A-III isoform 1"
                     /protein_id="NP_055555.1"
                     /db_xref="CCDS:CCDS11767.1"
                     /db_xref="GeneID:9775"
                     /db_xref="HGNC:HGNC:18683"
                     /db_xref="MIM:608546"
                     /translation="MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMG
                     LREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDI
                     QVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVV
                     AGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLIS
                     ATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLT
                     ITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLIST
                     DVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDI
                     EQYYSTQIDEMPMNVADLI"
     exon            337..409
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            410..476
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            477..539
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            540..672
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            673..753
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            754..895
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1034
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1150
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1258
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1386
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..2524
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /note="hexamer: ATTAAA"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /note="hexamer: CATAAA"
     polyA_site      1643
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /note="major polyA site"
     polyA_site      1675
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
                     /note="hexamer: ATTAAA"
     polyA_site      2524
                     /gene="EIF4A3"
                     /gene_synonym="DDX48; eIF-4A-III; eIF4A-III; eIF4AIII;
                     Fal1; MUK34; NMP265; NUK34; RCPS"
ORIGIN      
        1 acagcgaggt cggcagcggc acagcgaggt cggcagcggc acagcgaggt cggcagcggc
       61 acagcgaggt cggcagcggc agcgaggtcg gcagcggcac agcgaggtcg gcagcggcag
      121 cgaggtcggc agcggcgcgc gctgtgctct tccgcggact ctgaatcatg gcgaccacgg
      181 ccacgatggc gacctcgggc tcggcgcgaa agcggctgct caaagaggaa gacatgacta
      241 aagtggaatt cgagaccagc gaggaggtgg atgtgacccc cacgttcgac accatgggcc
      301 tgcgggagga cctgctgcgg ggcatctacg cttacggttt tgaaaaacca tcagcaatcc
      361 agcaacgagc aatcaagcag atcatcaaag ggagagatgt catcgcacag tctcagtccg
      421 gcacaggaaa aacagccacc ttcagtatct cagtcctcca gtgtttggat attcaggttc
      481 gtgaaactca agctttgatc ttggctccca caagagagtt ggctgtgcag atccagaagg
      541 ggctgcttgc tctcggtgac tacatgaatg tccagtgcca tgcctgcatt ggaggcacca
      601 atgttggcga ggacatcagg aagctggatt acggacagca tgttgtcgcg ggcactccag
      661 ggcgtgtttt tgatatgatt cgtcgcagaa gcctaaggac acgtgctatc aaaatgttgg
      721 ttttggatga agctgatgaa atgttgaata aaggtttcaa agagcagatt tacgatgtat
      781 acaggtacct gcctccagcc acacaggtgg ttctcatcag tgccacgctg ccacacgaga
      841 ttctggagat gaccaacaag ttcatgaccg acccaatccg catcttggtg aaacgtgatg
      901 aattgactct ggaaggcatc aagcaatttt tcgtggcagt ggagagggaa gagtggaaat
      961 ttgacactct gtgtgacctc tacgacacac tgaccatcac tcaggcggtc atcttctgca
     1021 acaccaaaag aaaggtggac tggctgacgg agaaaatgag ggaagccaac ttcactgtat
     1081 cctcaatgca tggagacatg ccccagaaag agcgggagtc catcatgaag gagttccggt
     1141 cgggcgccag ccgagtgctt atttctacag atgtctgggc cagggggttg gatgtccctc
     1201 aggtgtccct catcattaac tatgatctcc ctaataacag agaattgtac atacacagaa
     1261 ttgggagatc aggtcgatac ggccggaagg gtgtggccat taactttgta aagaatgacg
     1321 acatccgcat cctcagagat atcgagcagt actattccac tcagattgat gagatgccga
     1381 tgaacgttgc tgatcttatc tgaagcagca gatcagtggg atgagggaga ctgttcacct
     1441 gctgtgtact cctgtttgga agtatttaga tccagattct acttaatggg gtttatatgg
     1501 actttcttct cataaatggc ctgccgtctc ccttcctttg aagaggatat ggggattctg
     1561 ctctcttttc ttatttacat gtaaataata cattgttcta agtctttttc attaaaaatt
     1621 taaaactttt cccataaact ctatacttct aaggtgccac caccttctct agtaacttac
     1681 tgtgtagtct tgggtcattt cactcacttt tctttttttc ttttcttttt cttttttttt
     1741 tttgagacag tctccctctg ttgcccaggc aggagcgcag tggcgtgatc tcctctcacc
     1801 gcaagctcca cttcctgggt tcatgccatt ctcctacctc agcctcccac gtagctggga
     1861 gtacaggcgg ccgccaccat gccaggctaa tttttttgta ttttcagtag agacggggtt
     1921 tcaccgtgtt agccaagatg gtctcgatct cctgacctcg tgatccaccc acctcggcct
     1981 cccaaagtgc tgggattaca ggcgtgagcc actgcacccg gcccatttca ctcacttttc
     2041 taatcttttt ttttggaaag agtttcatcg ttgatgagtt ttgctctgct gcccaggctg
     2101 aagagcagtg gcaccatcac aactcattgc agccacaacc tcctgggctc aagcgatcct
     2161 ctcacctcac cctcctgagt agctgggact acaggtgcat gccagcacat ctggctaata
     2221 tttaaatttt ttgtagagac agggtctcac tttgtggcct aggctggtct gtcactcatg
     2281 ggtttaagtg attctcccat cttggcctta caaagtgctg ggataacagg tgtgagccac
     2341 catgcctggc ctcatttttc taattttttt tttttgttgt ttttttgaga gcccaggatc
     2401 tccctgtcgc ccaggcagga gtatagtggc aggatcatga cttaccacaa tgttgacaaa
     2461 ctaaaacaga taattatctg tttaaatatt taaattatta aagtatttaa gttatctgtt
     2521 gaaa
//
