LOCUS       NM_001416               1758 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 4A1 (EIF4A1),
            transcript variant 1, mRNA.
ACCESSION   NM_001416
VERSION     NM_001416.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Shi,J.Y., Wen,R., Chen,J.Y., Feng,Y.Q., Zhang,Y.Y., Hou,S.J.,
            Xi,Y.J., Wang,J.F. and Zhang,Y.F.
  TITLE     Genetic evidence supporting potential causal roles of EIF4 family
            in breast cancer: a two-sample randomized Mendelian study
  JOURNAL   Sci Rep 14 (1), 20191 (2024)
   PUBMED   39215053
  REMARK    GeneRIF: Genetic evidence supporting potential causal roles of EIF4
            family in breast cancer: a two-sample randomized Mendelian study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Jiao,D., Sun,H., Zhao,X., Chen,Y., Lv,Z., Shi,Q., Li,Y., Wang,C.
            and Gao,K.
  TITLE     mTORC1/S6K1 signaling promotes sustained oncogenic translation
            through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in
            cancer cells
  JOURNAL   Elife 12, 92236 (2024)
   PUBMED   38738857
  REMARK    GeneRIF: mTORC1/S6K1 signaling promotes sustained oncogenic
            translation through modulating CRL3[IBTK]-mediated ubiquitination
            of eIF4A1 in cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1758)
  AUTHORS   Schmidt,T., Dabrowska,A., Waldron,J.A., Hodge,K., Koulouras,G.,
            Gabrielsen,M., Munro,J., Tack,D.C., Harris,G., McGhee,E., Scott,D.,
            Carlin,L.M., Huang,D., Le Quesne,J., Zanivan,S., Wilczynska,A. and
            Bushell,M.
  TITLE     eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to
            activate localised eIF4A1-unwinding through eIF4A1-multimerisation
            to facilitate translation
  JOURNAL   Nucleic Acids Res 51 (4), 1859-1879 (2023)
   PUBMED   36727461
  REMARK    GeneRIF: eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences
            to activate localised eIF4A1-unwinding through
            eIF4A1-multimerisation to facilitate translation.
REFERENCE   4  (bases 1 to 1758)
  AUTHORS   Steinmann,S.M., Sanchez-Martin,A., Tanzer,E., Cigliano,A.,
            Pes,G.M., Simile,M.M., Desaubry,L., Marin,J.J.G., Evert,M. and
            Calvisi,D.F.
  TITLE     eIF4A1 Is a Prognostic Marker and Actionable Target in Human
            Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 24 (3), 2055 (2023)
   PUBMED   36768380
  REMARK    GeneRIF: eIF4A1 Is a Prognostic Marker and Actionable Target in
            Human Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1758)
  AUTHORS   Gonzalez-Ortiz,A., Pulido-Capiz,A., Castaneda-Sanchez,C.Y.,
            Ibarra-Lopez,E., Galindo-Hernandez,O., Calderon-Fernandez,M.A.,
            Lopez-Cossio,L.Y., Diaz-Molina,R., Chimal-Vega,B.,
            Serafin-Higuera,N., Cordova-Guerrero,I. and Garcia-Gonzalez,V.
  TITLE     eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a
            Triple-Negative Breast Cancer Cell Model
  JOURNAL   Cells 11 (24), 4069 (2022)
   PUBMED   36552834
  REMARK    GeneRIF: eIF4A/PDCD4 Pathway, a Factor for Doxorubicin
            Chemoresistance in a Triple-Negative Breast Cancer Cell Model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1758)
  AUTHORS   Imataka,H. and Sonenberg,N.
  TITLE     Human eukaryotic translation initiation factor 4G (eIF4G) possesses
            two separate and independent binding sites for eIF4A
  JOURNAL   Mol Cell Biol 17 (12), 6940-6947 (1997)
   PUBMED   9372926
REFERENCE   7  (bases 1 to 1758)
  AUTHORS   Kukimoto,I., Watanabe,S., Taniguchi,K., Ogata,T., Yoshiike,K. and
            Kanda,T.
  TITLE     Characterization of the cloned promoter of the human initiation
            factor 4AI gene
  JOURNAL   Biochem Biophys Res Commun 233 (3), 844-847 (1997)
   PUBMED   9168945
REFERENCE   8  (bases 1 to 1758)
  AUTHORS   Kim,N.S., Kato,T., Abe,N. and Kato,S.
  TITLE     Nucleotide sequence of human cDNA encoding eukaryotic initiation
            factor 4AI
  JOURNAL   Nucleic Acids Res 21 (8), 2012 (1993)
   PUBMED   8493113
REFERENCE   9  (bases 1 to 1758)
  AUTHORS   Yoder-Hill,J., Pause,A., Sonenberg,N. and Merrick,W.C.
  TITLE     The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges
            with eIF-4A
  JOURNAL   J Biol Chem 268 (8), 5566-5573 (1993)
   PUBMED   8449919
REFERENCE   10 (bases 1 to 1758)
  AUTHORS   Reddy,N.S., Roth,W.W., Bragg,P.W. and Wahba,A.J.
  TITLE     Isolation and mapping of a gene for protein synthesis initiation
            factor 4A and its expression during differentiation of murine
            erythroleukemia cells
  JOURNAL   Gene 70 (2), 231-243 (1988)
   PUBMED   3215517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG284868.1, AC016876.10 and AA446856.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001416.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.25858.1,
                                           SRR3476690.81751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293831.13/ ENSP00000293831.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BG284868.1         133-146
            15-40               AC016876.10        21509-21534         c
            41-89               AC016876.10        20065-20113         c
            90-222              AC016876.10        19695-19827         c
            223-362             AC016876.10        19115-19254         c
            363-531             AC016876.10        17681-17849         c
            532-641             AC016876.10        17208-17317         c
            642-785             AC016876.10        16886-17029         c
            786-923             AC016876.10        16667-16804         c
            924-1013            AC016876.10        16457-16546         c
            1014-1093           AC016876.10        16129-16208         c
            1094-1727           AC016876.10        15398-16031         c
            1728-1758           AA446856.1         18-48               c
FEATURES             Location/Qualifiers
     source          1..1758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1758
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /note="eukaryotic translation initiation factor 4A1"
                     /db_xref="GeneID:1973"
                     /db_xref="HGNC:HGNC:3282"
                     /db_xref="MIM:602641"
     exon            1..40
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1238
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 4A; eukaryotic
                     initiation factor 4A-I; eukaryotic initiation factor 4AI;
                     ATP-dependent RNA helicase eIF4A-1"
                     /codon_start=1
                     /product="eukaryotic initiation factor 4A-I isoform 1"
                     /protein_id="NP_001407.1"
                     /db_xref="CCDS:CCDS11113.1"
                     /db_xref="GeneID:1973"
                     /db_xref="HGNC:HGNC:3282"
                     /db_xref="MIM:602641"
                     /translation="MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLL
                     RGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQ
                     ALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPG
                     RVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPS
                     DVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAV
                     IFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLAR
                     GIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYN
                     TSIEEMPLNVADLI"
     exon            41..89
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            90..222
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            223..362
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            363..531
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            532..641
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            642..785
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            786..923
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1013
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1093
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1758
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
     regulatory      1736..1741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /note="hexamer: AATAAA"
     polyA_site      1758
                     /gene="EIF4A1"
                     /gene_synonym="DDX2A; EIF-4A; eIF-4A-I; EIF4A; eIF4A-I"
                     /note="major polyA site"
ORIGIN      
        1 cctagtttct aaggatcatg tctgcgagcc aggattcccg atccagagac aatggccccg
       61 atgggatgga gcccgaaggc gtcatcgaga gtaactggaa tgagattgtt gacagctttg
      121 atgacatgaa cctctcggag tcccttctcc gtggcatcta cgcgtatggt tttgagaagc
      181 cctctgccat ccagcagcga gccattctac cttgtatcaa gggttatgat gtgattgctc
      241 aagcccaatc tgggactggg aaaacggcca catttgccat atcgattctg cagcagattg
      301 aattagatct aaaagccacc caggccttgg tcctagcacc cactcgagaa ttggctcagc
      361 agatacagaa ggtggtcatg gcactaggag actacatggg cgcctcctgt cacgcctgta
      421 tcgggggcac caacgtgcgt gctgaggtgc agaaactgca gatggaagct ccccacatca
      481 tcgtgggtac ccctggccgt gtgtttgata tgcttaaccg gagatacctg tcccccaaat
      541 acatcaagat gtttgtactg gatgaagctg acgaaatgtt aagccgtgga ttcaaggacc
      601 agatctatga catattccaa aagctcaaca gcaacaccca ggtagttttg ctgtcagcca
      661 caatgccttc tgatgtgctt gaggtgacca agaagttcat gagggacccc attcggattc
      721 ttgtcaagaa ggaagagttg accctggagg gtatccgcca gttctacatc aacgtggaac
      781 gagaggagtg gaagctggac acactatgtg acttgtatga aaccctgacc atcacccagg
      841 cagtcatctt catcaacacc cggaggaagg tggactggct caccgagaag atgcatgctc
      901 gagatttcac tgtatccgcc atgcatggag atatggacca aaaggaacga gacgtgatta
      961 tgagggagtt tcgttctggc tctagcagag ttttgattac cactgacctg ctggccagag
     1021 gcattgatgt gcagcaggtt tctttagtca tcaactatga ccttcccacc aacagggaaa
     1081 actatatcca cagaatcggt cgaggtggac ggtttggccg taaaggtgtg gctattaaca
     1141 tggtgacaga agaagacaag aggactcttc gagacattga gaccttctac aacacctcca
     1201 ttgaggaaat gcccctcaat gttgctgacc tcatctgagg ggctgtcctg ccacccagcc
     1261 ccagccaggg ctcaatctct gggggctgag gagcagcagg aggggggagg gaagggagcc
     1321 aagggatgga catcttgtca ttttttttct ttgaataaat gtcacttttt gaggcaaaag
     1381 aaggaaccgt gaacatttta gacacccttt tctttggggt aggctcttgc cccaggcgcc
     1441 ggctcttctc ccaaaaaaaa aaaaaaaaca ctaatccatt tccctaacct agtaacctcc
     1501 agatcccaga ggctctcctc acctcagctg agctcctttg aaagtgattc aagggactat
     1561 gtcactcagc ctcatttgct ggaccaaatc tggagggaga acccctaaaa cccctaagtg
     1621 aggttgccca gggggttgtc cccaggtggg gggaagcagg ggagagaaaa tggtagccat
     1681 ttttacattg ttttgtatag tatttattga ttcaggaaac aaacacaaaa ttctgaataa
     1741 aatgacttgg aaactgcc
//
