LOCUS       NM_016091               2669 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit L
            (EIF3L), transcript variant 1, mRNA.
ACCESSION   NM_016091
VERSION     NM_016091.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Herrmannova,A., Prilepskaja,T., Wagner,S., Sikrova,D., Zeman,J.,
            Poncova,K. and Valasek,L.S.
  TITLE     Adapted formaldehyde gradient cross-linking protocol implicates
            human eIF3d and eIF3c, k and l subunits in the 43S and 48S
            pre-initiation complex assembly, respectively
  JOURNAL   Nucleic Acids Res 48 (4), 1969-1984 (2020)
   PUBMED   31863585
  REMARK    GeneRIF: Whereas the eIF3c knockdown reduces it, downregulation of
            eIF3k or eIF3l increases mRNA recruitment, suggesting that the
            latter subunits possess a regulatory potential. Altogether this
            study provides new insights into the role of human eIF3 in the
            initial assembly steps of the translational machinery
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Hinnebusch,A.G.
  TITLE     eIF3: a versatile scaffold for translation initiation complexes
  JOURNAL   Trends Biochem Sci 31 (10), 553-562 (2006)
   PUBMED   16920360
  REMARK    Review article
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Yuan,X., Zhao,J., Zentgraf,H., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Multiple interactions between RNA polymerase I, TIF-IA and TAF(I)
            subunits regulate preinitiation complex assembly at the ribosomal
            gene promoter
  JOURNAL   EMBO Rep 3 (11), 1082-1087 (2002)
   PUBMED   12393749
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   Morris-Desbois,C., Rety,S., Ferro,M., Garin,J. and Jalinot,P.
  TITLE     The human protein HSPC021 interacts with Int-6 and is associated
            with eukaryotic translation initiation factor 3
  JOURNAL   J Biol Chem 276 (49), 45988-45995 (2001)
   PUBMED   11590142
REFERENCE   10 (bases 1 to 2669)
  AUTHORS   Seither,P., Iben,S., Thiry,M. and Grummt,I.
  TITLE     PAF67, a novel protein that is associated with the
            initiation-competent form of RNA polymerase I
  JOURNAL   Biol Chem 382 (8), 1163-1170 (2001)
   PUBMED   11592397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA051005.1, BC029265.1 and AL022311.5.
            
            On Nov 23, 2018 this sequence version replaced NM_016091.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222529.1, SRR1660807.236876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652021.1/ ENSP00000499067.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA051005.1         48-60
            14-1176             BC029265.1         1-1163
            1177-1177           AL022311.5         6183-6183
            1178-1891           BC029265.1         1165-1878
            1892-2669           AL022311.5         17071-17848
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2669
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="eukaryotic translation initiation factor 3 subunit
                     L"
                     /db_xref="GeneID:51386"
                     /db_xref="HGNC:HGNC:18138"
                     /db_xref="MIM:619197"
     exon            1..64
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1726
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="isoform 1 is encoded by transcript variant 1; eIEF
                     associated protein HSPC021; eukaryotic translation
                     initiation factor 3 subunit 6-interacting protein;
                     eukaryotic translation initiation factor 3 subunit
                     E-interacting protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit L isoform 1"
                     /protein_id="NP_057175.1"
                     /db_xref="CCDS:CCDS13960.1"
                     /db_xref="GeneID:51386"
                     /db_xref="HGNC:HGNC:18138"
                     /db_xref="MIM:619197"
                     /translation="MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQT
                     YQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKL
                     TERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNY
                     CNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSN
                     PKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVG
                     LLRLHSLLGDYYQAIKVLENIELNKKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIR
                     VFANILLYIQRTKSMFQRTTYKYEMINKQNEQMHALLAIALTMYPMRIDESIHLQLRE
                     KYGDKMLRMQKGDPQVYEELFSYSCPKFLSPVVPNYDNVHPNYHKEPFLQQLKVFSDE
                     VQQQAQLSTIRSFLKLYTTMPVAKLAGFLDLTEQEFRIQLLVFKHKMKNLVWTSGISA
                     LDGEFQSASEVDFYIDKDMIHIADTKVARRYGDFFIRQIHKFEELNRTLKKMGQRP"
     exon            65..113
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            114..324
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            325..404
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            405..466
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            467..536
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            537..610
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            611..782
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            783..937
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1108
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1606
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1687
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..2669
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1871..1876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="hexamer: AGTAAA"
     polyA_site      1893
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="major polyA site"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
                     /note="hexamer: CATAAA"
     polyA_site      2669
                     /gene="EIF3L"
                     /gene_synonym="EIF3EIP; EIF3S11; EIF3S6IP; HSPC021;
                     HSPC025; MSTP005"
ORIGIN      
        1 ctttccggcg gtgctcgcaa gcgaggcagc catgtcttat cccgctgatg attatgagtc
       61 tgaggcggct tatgacccct acgcttatcc cagcgactat gatatgcaca caggagatcc
      121 aaagcaggac cttgcttatg aacgtcagta tgaacagcaa acctatcagg tgatccctga
      181 ggtgatcaaa aacttcatcc agtatttcca caaaactgtc tcagatttga ttgaccagaa
      241 agtgtatgag ctacaggcca gtcgtgtctc cagtgatgtc attgaccaga aggtgtatga
      301 gatccaggac atctatgaga acagctggac caagctgact gaaagattct tcaagaatac
      361 accttggccc gaggctgaag ccattgctcc acaggttggc aatgatgctg tcttcctgat
      421 tttatacaaa gaattatact acaggcacat atatgccaaa gtcagtgggg gaccttcctt
      481 ggagcagagg tttgaatcct attacaacta ctgcaatctc ttcaactaca ttcttaatgc
      541 cgatggtcct gctccccttg aactacccaa ccagtggctc tgggatatta tcgatgagtt
      601 catctaccag tttcagtcat tcagtcagta ccgctgtaag actgccaaga agtcagagga
      661 ggagattgac tttcttcgtt ccaatcccaa aatctggaat gttcatagtg tcctcaatgt
      721 ccttcattcc ctggtagaca aatccaacat caaccgacag ttggaggtat acacaagcgg
      781 aggtgaccct gagagtgtgg ctggggagta tgggcggcac tccctctaca aaatgcttgg
      841 ttacttcagc ctggtcgggc ttctccgcct gcactccctg ttaggagatt actaccaggc
      901 catcaaggtg ctggagaaca tcgaactgaa caagaagagt atgtattccc gtgtgccaga
      961 gtgccaggtc accacatact attatgttgg gtttgcatat ttgatgatgc gtcgttacca
     1021 ggatgccatc cgggtcttcg ccaacatcct cctctacatc cagaggacca agagcatgtt
     1081 ccagaggacc acgtacaagt atgagatgat taacaagcag aatgagcaga tgcatgcgct
     1141 gctggccatt gccctcacga tgtaccccat gcgtattgat gagagcattc acctccagct
     1201 gcgggagaaa tatggggaca agatgttgcg catgcagaaa ggtgacccac aagtctatga
     1261 agaacttttc agttactcct gccccaagtt cctgtcgcct gtagtgccca actatgataa
     1321 tgtgcacccc aactaccaca aagagccctt cctgcagcag ctgaaggtgt tttctgatga
     1381 agtacagcag caggcccagc tttcaaccat ccgcagcttc ctgaagctct acaccaccat
     1441 gcctgtggcc aagctggctg gcttcctgga cctcacagag caggagttcc ggatccagct
     1501 tcttgtcttc aaacacaaga tgaagaacct cgtgtggacc agcggtatct cagccctgga
     1561 tggtgaattt cagtcagcct cagaggttga cttctacatt gataaggaca tgatccacat
     1621 cgcggacacc aaggtcgcca ggcgttatgg ggatttcttc atccgtcaga tccacaaatt
     1681 tgaggagctt aatcgaaccc tgaagaagat gggacagaga ccttgatgat attcacacac
     1741 attcaggaac ctgttttgat gtattatagg caggaagtgt ttttgctacc gtgaaacctt
     1801 tacctagatc agccatcagc ctgtcaactc agttaacaag ttaaggaccg aagtgtttca
     1861 agtggatctc agtaaaggat ctttggagcc agatttgtcg tctcattatt gtaggagaga
     1921 atttgtgggt tgtggcagta atacatttcc catgtgtcct gatgctttca ggatacatca
     1981 gttgttagtg tttaaattga gttattttta ttttgtgctt ttgagatgga gtctcactct
     2041 gtctcccagg ctggagtgca gtagcgtgat ctcagttcgt tgcatcctcc gctgcccagg
     2101 ttcaagcagt tctgcctcag ccttccaagt agctgggatt acaggcgtgt gccaccacac
     2161 tcagctaatt tttgtattct cagtagagat gggttttacc atgttggcca ggctggtctc
     2221 gaactcctgg cctcaagtga ttcgcctgcc ttggcctccc aaaatgtgct aggattacag
     2281 gcatgagcca ccacgccccg cctaaattca aaatcttttt gttttttttt agacggagtc
     2341 tcactctgtc gcccaggttg gagtgtactg gcgcgatctc ggctcactgc aagctccacc
     2401 tcccaggttc ctgccattct cctgcctcag cctcccaagt agctgggact acaggcaccc
     2461 gccaccatgc ccggccaatt ttttgtattt tttagtagag atggggtttc accgtgttag
     2521 ccaggatggt ctcagatttc ctgacctcgt gatctgccca tctctgcctc ctaaagtact
     2581 gggattacag gcgtgagcca ccgtgcccag ccctaaattg aattcttaaa tccctcttgt
     2641 tcataaagca gtatatttgg tttacagga
//
