LOCUS       NM_013234                772 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit K
            (EIF3K), transcript variant 1, mRNA.
ACCESSION   NM_013234
VERSION     NM_013234.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 772)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 772)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 772)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 772)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 772)
  AUTHORS   Herrmannova,A., Prilepskaja,T., Wagner,S., Sikrova,D., Zeman,J.,
            Poncova,K. and Valasek,L.S.
  TITLE     Adapted formaldehyde gradient cross-linking protocol implicates
            human eIF3d and eIF3c, k and l subunits in the 43S and 48S
            pre-initiation complex assembly, respectively
  JOURNAL   Nucleic Acids Res 48 (4), 1969-1984 (2020)
   PUBMED   31863585
  REMARK    GeneRIF: Whereas the eIF3c knockdown reduces it, downregulation of
            eIF3k or eIF3l increases mRNA recruitment, suggesting that the
            latter subunits possess a regulatory potential. Altogether this
            study provides new insights into the role of human eIF3 in the
            initial assembly steps of the translational machinery
REFERENCE   6  (bases 1 to 772)
  AUTHORS   Shen,X., Yang,Y., Liu,W., Sun,M., Jiang,J., Zong,H. and Gu,J.
  TITLE     Identification of the p28 subunit of eukaryotic initiation factor
            3(eIF3k) as a new interaction partner of cyclin D3
  JOURNAL   FEBS Lett 573 (1-3), 139-146 (2004)
   PUBMED   15327989
  REMARK    GeneRIF: cyclin D3 specifically interacted with eIF3k through its
            C-terminal domain; eIF3k distributed both in nucleus and cytoplasm
            and colocalized with cyclin D3
REFERENCE   7  (bases 1 to 772)
  AUTHORS   Wei,Z., Zhang,P., Zhou,Z., Cheng,Z., Wan,M. and Gong,W.
  TITLE     Crystal structure of human eIF3k, the first structure of eIF3
            subunits
  JOURNAL   J Biol Chem 279 (33), 34983-34990 (2004)
   PUBMED   15180986
  REMARK    GeneRIF: eIF3k has three putative protein-binding surfaces and has
            potential RNA binding activity
REFERENCE   8  (bases 1 to 772)
  AUTHORS   Mayeur,G.L., Fraser,C.S., Peiretti,F., Block,K.L. and Hershey,J.W.
  TITLE     Characterization of eIF3k: a newly discovered subunit of mammalian
            translation initiation factor elF3
  JOURNAL   Eur J Biochem 270 (20), 4133-4139 (2003)
   PUBMED   14519125
REFERENCE   9  (bases 1 to 772)
  AUTHORS   Sampath,P., Mazumder,B., Seshadri,V. and Fox,P.L.
  TITLE     Transcript-selective translational silencing by gamma interferon is
            directed by a novel structural element in the ceruloplasmin mRNA 3'
            untranslated region
  JOURNAL   Mol Cell Biol 23 (5), 1509-1519 (2003)
   PUBMED   12588972
REFERENCE   10 (bases 1 to 772)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG943109.1 and BC001031.2.
            
            On May 17, 2019 this sequence version replaced NM_013234.3.
            
            Summary: The 700-kD eukaryotic translation initiation factor-3
            (eIF3) is the largest eIF and contains at least 12 subunits,
            including EIF2S12. eIF3 plays an essential role in translation by
            binding directly to the 40S ribosomal subunit and promoting
            formation of the 40S preinitiation complex (Mayeur et al., 2003
            [PubMed 14519125]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.149550.1,
                                           DRR138527.532196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248342.9/ ENSP00000248342.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BG943109.1         116-137
            23-772              BC001031.2         1-750
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..772
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /note="eukaryotic translation initiation factor 3 subunit
                     K"
                     /db_xref="GeneID:27335"
                     /db_xref="HGNC:HGNC:24656"
                     /db_xref="MIM:609596"
     exon            1..140
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..738
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 3, subunit 12;
                     muscle specific; eIF-3 p28; muscle-specific gene M9
                     protein"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit K isoform 1"
                     /protein_id="NP_037366.1"
                     /db_xref="CCDS:CCDS12517.1"
                     /db_xref="GeneID:27335"
                     /db_xref="HGNC:HGNC:24656"
                     /db_xref="MIM:609596"
                     /translation="MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDL
                     EANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQI
                     LYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAE
                     MLGDLSDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
                     "
     exon            141..239
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     exon            240..360
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     exon            361..435
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     exon            436..502
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     exon            503..580
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     exon            581..706
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     exon            707..772
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /inference="alignment:Splign:2.1.0"
     regulatory      751..756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /note="hexamer: AATAAA"
     polyA_site      772
                     /gene="EIF3K"
                     /gene_synonym="ARG134; EIF3-p28; EIF3S12; HSPC029; M9;
                     MSTP001; PLAC-24; PLAC24; PRO1474; PTD001"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcctgt tcccgtcctt gaggacgccg tgccgggtca gtgttagcct ccagccctgg
       61 ttgtggaagg cgacagaagt catggcgatg tttgagcaga tgagagccaa cgtgggcaag
      121 ttgctcaagg gtatcgacag gtacaatcct gagaacctgg ccaccctgga gcgctatgta
      181 gagacgcagg ccaaggaaaa tgcctatgat ctggaagcca acctggctgt cctgaagctg
      241 taccagttca acccagcctt ctttcagacc acggtcaccg cccagatcct gctgaaggcc
      301 ctcaccaact tgccgcacac agacttcacc ctgtgcaagt gcatgatcga ccaggcacat
      361 caagaagaac ggccaatccg acagattttg tacctcgggg acctgctgga gacctgccat
      421 ttccaggcct tctggcaagc cctggatgaa aacatggacc tcttggaagg tataactggc
      481 tttgaagact ctgtccgaaa gtttatctgc catgttgtgg gtatcactta ccagcacatt
      541 gaccgctggc tgctggccga gatgctcggg gatctgtcgg acagccagct aaaggtgtgg
      601 atgagcaaat acggctggag tgccgacgag tcggggcaga tcttcatctg tagccaagaa
      661 gagagcatta aacccaagaa cattgtggag aagattgact ttgacagtgt gtccagcatc
      721 atggcctcct cccagtaact tcaggtgttt aataaagatg tgttgactca gc
//
