LOCUS       NM_003754               6920 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit F
            (EIF3F), mRNA.
ACCESSION   NM_003754
VERSION     NM_003754.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6920)
  AUTHORS   Pan,Q., Yu,F., Jin,H., Zhang,P., Huang,X., Peng,J., Xie,X., Li,X.,
            Ma,N., Wei,Y., Wen,W., Zhang,J., Zhang,B., Yu,H., Xiao,Y.,
            Liu,R.Y., Liu,Q., Meng,X. and Lee,M.H.
  TITLE     eIF3f Mediates SGOC Pathway Reprogramming by Enhancing
            Deubiquitinating Activity in Colorectal Cancer
  JOURNAL   Adv Sci (Weinh) 10 (27), e2300759 (2023)
   PUBMED   37544925
  REMARK    GeneRIF: eIF3f Mediates SGOC Pathway Reprogramming by Enhancing
            Deubiquitinating Activity in Colorectal Cancer.
REFERENCE   2  (bases 1 to 6920)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6920)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6920)
  AUTHORS   Huffmeier,U., Kraus,C., Reuter,M.S., Uebe,S., Abbott,M.A.,
            Ahmed,S.A., Rawson,K.L., Barr,E., Li,H., Bruel,A.L., Faivre,L.,
            Tran Mau-Them,F., Botti,C., Brooks,S., Burns,K., Ward,D.I.,
            Dutra-Clarke,M., Martinez-Agosto,J.A., Lee,H., Nelson,S.F.,
            Zacher,P., Abou Jamra,R., Klockner,C., McGaughran,J., Kohlhase,J.,
            Schuhmann,S., Moran,E., Pappas,J., Raas-Rothschild,A.,
            Sacoto,M.J.G., Henderson,L.B., Palculict,T.B., Mullegama,S.V.,
            Zghal Elloumi,H., Reich,A., Schrier Vergano,S.A., Wahl,E., Reis,A.
            and Zweier,C.
  CONSRTM   UCLA California Center for Rare Disease
  TITLE     EIF3F-related neurodevelopmental disorder: refining the phenotypic
            and expanding the molecular spectrum
  JOURNAL   Orphanet J Rare Dis 16 (1), 136 (2021)
   PUBMED   33736665
  REMARK    GeneRIF: EIF3F-related neurodevelopmental disorder: refining the
            phenotypic and expanding the molecular spectrum.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6920)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6920)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J Biol Chem 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   7  (bases 1 to 6920)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
REFERENCE   8  (bases 1 to 6920)
  AUTHORS   Asano,K., Vornlocher,H.P., Richter-Cook,N.J., Merrick,W.C.,
            Hinnebusch,A.G. and Hershey,J.W.
  TITLE     Structure of cDNAs encoding human eukaryotic initiation factor 3
            subunits. Possible roles in RNA binding and macromolecular assembly
  JOURNAL   J Biol Chem 272 (43), 27042-27052 (1997)
   PUBMED   9341143
REFERENCE   9  (bases 1 to 6920)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   10 (bases 1 to 6920)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from CB141463.1, U94855.1, CD050033.1, BC000490.2 and
            AC116456.12.
            
            On Nov 23, 2018 this sequence version replaced NM_003754.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.246689.1,
                                           SRR1660805.149226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651655.1/ ENSP00000499218.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CB141463.1         18-27
            11-576              U94855.1           1-566
            577-577             CD050033.1         594-594
            578-1235            U94855.1           568-1225
            1236-1239           BC000490.2         1226-1229
            1240-6920           AC116456.12        23614-29294
FEATURES             Location/Qualifiers
     source          1..6920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6920
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="eukaryotic translation initiation factor 3 subunit
                     F"
                     /db_xref="GeneID:8665"
                     /db_xref="HGNC:HGNC:3275"
                     /db_xref="MIM:603914"
     exon            1..380
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1090
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /EC_number="3.4.19.12"
                     /note="eukaryotic translation initiation factor 3, subunit
                     5 (epsilon, 47kD); eukaryotic translation initiation
                     factor 3, subunit 5 epsilon, 47kDa; eIF3-epsilon;
                     eIF-3-epsilon; deubiquitinating enzyme eIF3f"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit F"
                     /protein_id="NP_003745.1"
                     /db_xref="CCDS:CCDS7785.1"
                     /db_xref="GeneID:8665"
                     /db_xref="HGNC:HGNC:3275"
                     /db_xref="MIM:603914"
                     /translation="MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPA
                     SSSDPAAAAAATAAPGQTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASI
                     VDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELH
                     KKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVS
                     TLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGAS
                     ARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDL
                     LMVTYLANLTQSQIALNEKLVNL"
     exon            381..451
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     exon            452..531
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     exon            532..669
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     exon            670..761
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     exon            762..898
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1012
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..6920
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1414
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="major polyA site"
     regulatory      3207..3212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="hexamer: TATAAA"
     polyA_site      3230
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="major polyA site"
     regulatory      5770..5775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="hexamer: AGTAAA"
     polyA_site      5791
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
     regulatory      6904..6909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="hexamer: TATAAA"
     polyA_site      6920
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /note="major polyA site"
ORIGIN      
        1 cttctttctc gacaagatgg ccacaccggc ggtaccagta agtgctcctc cggccacgcc
       61 aaccccagtc ccggcggcgg ccccagcctc agttccagcg ccaacgccag caccggctgc
      121 ggctccggtt cccgctgcgg ctccagcctc atcctcagac cctgcggcag cagcggctgc
      181 aactgcggct cctggccaga ccccggcctc agcgcaagct ccagcgcaga ccccagcgcc
      241 cgctctgcct ggtcctgctc ttccagggcc cttccccggc ggccgcgtgg tcaggctgca
      301 cccagtcatt ttggcctcca ttgtggacag ctacgagaga cgcaacgagg gtgctgcccg
      361 agttatcggg accctgttgg gaactgtcga caaacactca gtggaggtca ccaattgctt
      421 ttcagtgccg cacaatgagt cagaagatga agtggctgtt gacatggaat ttgctaagaa
      481 tatgtatgaa ctgcataaaa aagtttctcc aaatgagctc atcctgggct ggtacgctac
      541 gggccatgac atcacagagc actctgtgct gatccacgag tactacagcc gagaggcccc
      601 caaccccatc cacctcactg tggacacaag tctccagaac ggccgcatga gcatcaaagc
      661 ctacgtcagc actttaatgg gagtccctgg gaggaccatg ggagtgatgt tcacgcctct
      721 gacagtgaaa tacgcgtact acgacactga acgcatcgga gttgacctga tcatgaagac
      781 ctgctttagc cccaacagag tgattggact ctcaagtgac ttgcagcaag taggaggggc
      841 atcagctcgc atccaggatg ccctgagtac agtgttgcaa tatgcagagg atgtactgtc
      901 tggaaaggtg tcagctgaca atactgtggg ccgcttcctg atgagcctgg ttaaccaagt
      961 accgaaaata gttcccgatg actttgagac catgctcaac agcaacatca atgacctttt
     1021 gatggtgacc tacctggcca acctcacaca gtcacagatt gcactcaatg aaaaacttgt
     1081 aaacctgtga atggacccca agcagtacac ttgctggtct aggtattaac cccaggactc
     1141 agaagtgaag gagaaatggg ttttttgtgg tcttgagtca cactgagata gtcagttgtg
     1201 tgtgactcta ataaacggag cctacctttt gtaaattaat ttcatcttat gtgagtttat
     1261 tgccgggtgg aagggaggaa aatgttttag atcacacaga aactaggaag tgaatattgt
     1321 aggtagagaa gttggttatg tgtttggcat gttactgttt taccaaactg ttcttttggt
     1381 tttcaatatg gaaaggtgtc cattggcaaa acaacctttt cttgaggatt catgtgattt
     1441 ctacaggaaa tgaaaataag aatccatgga gaaaaaatag ctaagaaaat tggatgctta
     1501 atctgaacta aaagagtaga gtgtgtagtc actatcttaa aatacattaa tagtaagatg
     1561 gagctctttg ccactttggt tcggggaggc agaattaaga tctgtgggtt aaagattaaa
     1621 gaggtttccc caaaacttca gaaaattctt aggtgctatc tgtaactcga ggatagagcc
     1681 ttgagttata ctgaggtctg ccagtggctc aatttaagca aagactagat ggcatttccc
     1741 agaggccttg taggctagag tacttgcctg tgtaacttca gacatccatt tcctctggta
     1801 tcctggagtt ccgcctcgcc actgtgtgtc ttagaaataa gtcattattc aagaactcag
     1861 gaaattatac gttggagtga aaaggtgagt gaaggcaatg gggaatcaaa aaggcctgga
     1921 tcctagttct gaggtatgtg tagccttagg aaagataaat tataagagtc ataagatatg
     1981 gatcataaac atacatagtc cattagggta ttatgaggat tccatgaatt aataaatgtc
     2041 aggttaatca acacttgtgg agaatatcac ctggtatgta gtaagcacag ataagtggta
     2101 gatactatga tgcctaaagg tgaatagttt gaaagtaata agcaacatga accccagcct
     2161 ggaactcagt tctgagatat gtacctcagg aaatataagt tatgggagtc ataaagtgtg
     2221 gatagtaatg atagataatt tcttacaggt agggaaatgt aaacagatct tatcggcaaa
     2281 atgataatga caggccaaat tgttaaaggt aggttaaaag tagacagcat ggtgggaagg
     2341 ttaatcagag tcaaaatgtt tcagtgttct tacatttttg ggagtagcca gttaatatca
     2401 acttagtctt tttaagtatg catgataaaa ttccgaggtt aattgctaga agtatatata
     2461 atctctcaat gaatagtgat gagagatggt gggataatag ggaagaaaca aaattttaaa
     2521 tttgagaaat aagcatagaa aaggtggata aaacaaaaga tggcaaaaca agtccaaata
     2581 gatcagtaat tacaataaat gtataagtat taaactagcc caaggaaaaa ttgaatatta
     2641 aaacaaaccc caatcatatg ctgtttacag gagacacatc taaaacaagg acataaagtt
     2701 gtcctgcagc tgtgagtaac aatataggtg aatgttaata ataatgttga atgaaaaaag
     2761 ctggtgtcag aagacatgta cattatgata ctccagaagt tcaaaaacaa gtgaaacttg
     2821 tttagacatg cggttggctg tctgtatatg tgggttccac atctatggac tcaaccaact
     2881 acaggttgaa aatattgagg gggaaaattg tgtctggact aaacctgtac agacattttt
     2941 ccttgtcatt tttccctaaa caatacaaag tattagatgg tgtttatact gtattcggta
     3001 ttataagtaa tctagagatg acttaaaagt atatgagaag gtatgcacag gttatatcca
     3061 aatacttcat attagggact tgagcatcag aggattttta tatccaagga aggttctgga
     3121 accaatcctc cacggatact aaacggtgac tgtgtgtgta tatatatatg tatagtctgt
     3181 tctcattatc tatagtagtt atgttttata aagtcaccat gaacactgaa ttagagagta
     3241 ctgaaccatt attcccaagg gaaatacagg gttgggttcc tatgaacctc tgggcacagt
     3301 ttcatcaacc catcagtaca taaacttgtt acatgtgttt ctgtttgaag acaccttagt
     3361 atatatggtt gacccattaa cactgaactt agcccacgac acttattcct gaatgaagct
     3421 tacctcagtt tctccaggcg gcacatcaca gtcttcttgc acttaggaac acttggcact
     3481 gtgcgtgggg gtcactttaa gcagcaaaat ccacaaaaat gcaaaagaca tggcactaaa
     3541 tagactgaaa aggatacttg tttataagaa ctgaaacaag aaggccttgt tccacctcag
     3601 ctgggaacat ggagagcagg caattcaaat tttttcacat gctgcatgtc cgcaaatggc
     3661 tgcaaaagcc cagcaagtac tgatactgga gttagaaata aattttagca agaggtaaat
     3721 tcacacatac ggagtctgca aaaaatgaga attgactatt atgtgtgtgt atattatata
     3781 tatgataaaa aacaaaagaa tgataaaaat tcccaataat gtttactttg gtggtgagaa
     3841 gaggatggca agtaaaataa gtctgtattg ttatcagcaa ttatctagtt tgaggttgga
     3901 cagtggtttc atcataggta ttgattatat tataaatagc ccaacctgaa ctcatgacca
     3961 tagtgtggtg ttattactta gcgttattct agacttatta gccattgtat ttaaacaaga
     4021 ggaaatagag acattgaaga taaagtggag ccaggcacag tggctcatgc ctgtaatccc
     4081 agcactttgg caggctgaga tgggttaatc aagaccagaa gttcaagacc agcgtggcca
     4141 acatggcaaa accccgtctc tactaaaaaa aaacaaaaaa tacaaaaatt agccaggcgt
     4201 ggtggcacgc acctgtagtc ccagctactt gggaagctga ggcaggagaa tctcgaaccc
     4261 aggaggtagg ggttgcagtg agctgagatc gcaccactgc accccagcct gggtgacagc
     4321 aagatccttt ctcaagaaaa aaagtgaaaa ggaggagggt ttttaaaaaa ttagtactac
     4381 ccagttgata cggtggaaga aaacttgaaa atgctaatga gaaacatgag atgtaatcac
     4441 ttgaaggcat atcatgttct tgaataagaa gactcaacat tattttaaca ggtgttaatt
     4501 ttccctgtta aactacatat ttgtcataat tacaataaaa tacaaagagc tattttggaa
     4561 ctgggcaagc tgtttctaaa tgtatatgga aaaataaaaa tgtctccaaa aaatccctgc
     4621 agagggaaac tagcccttcc agatataaaa tatattatag aactgtgtaa ttaaagcaat
     4681 atggtactgg tccataaaag aacataaaac caaatagttc agtagactca aaatgcaagc
     4741 gttggtgagg gtatggagaa aagggaaccc ttttacactt ggtgtgaatg taaattagta
     4801 cagacattgt ggaaaacagt ttgtagagct tcctcaataa aaacacatat gatccagcaa
     4861 tcccactact gggtatatat ccaaaggaaa tgaaatcagt atgttgaaga gatacttcca
     4921 cgttcactga agcattgttc acaatcgcca agacatcaac ctaagtgtcc atcaacagaa
     4981 gatagatagg gctgagcgcg gtggcccacg cctgtaatcc cagcactttg ggaggccaag
     5041 gcaggtggat catttgaggt cagaagttct tgaccagcct ggccaacatg atgaaacccc
     5101 gtctctacaa aagatacaaa aattagccag gcatcttgga gggcgcctgt aatcccacct
     5161 actcgggctg aagtgagaat ggcttgaacc caggaagtgg agatttcagt gagctgagat
     5221 tccgccactg cagtccagcc tgagcgacaa gagtgagaag agtgagactt catctcaaaa
     5281 aaaaaaaagg tacatctaca caatggaata ttattaacct taaaagaagg aaataactga
     5341 tttacaacaa catggatgga cctggaggac actatgctag tgaaataagc catgatctca
     5401 cttggatatg gaatcacaaa attgaactca caagcagagt gtagaaaggt ggtttcatgg
     5461 actggaggga ggggataaat ggggagatgt tggtcaaggg tacaaagttt cagttaaaca
     5521 ggagtagtac gttccggaga cctgttgtgc agcagggtga ctagttaatg tatacttgaa
     5581 aattgctagg agtagatctc accaggagaa atgaatatgt gaggtgatgg atgtaactag
     5641 cttgattgtg gtaatcaatt tcgcaatgtg tacatatatc aaaacatcac attgtacaaa
     5701 atacatacag tttttgtcaa tttaaagata tcagaattct agaatatgat aaagttgtgt
     5761 tttcaagcaa gtaaagatag attacttaag agcgaatgag tggtaatttg gaaacaatgt
     5821 tggattccta cttcgttacc tgcaccaaaa taagttgctc atggaataaa aacttgtctg
     5881 aaaaaaaaac cataaatatg agggaaaaaa cacagcaatg tgtttttaat gatttatgag
     5941 tgaggaagaa ctttctaaga actgagaatc caggagttat tttaaaagac tgacaaattt
     6001 agcaacattt ttaaaatctg agtgtcaaat tacacacata cacaaatagt caatacaaat
     6061 ataaaactgg gaaaatattt gcagttcata tcaaaaaaag ggctaatatt cttgtcccag
     6121 aattcctaca gttttttaag gccagtaatt tgatacatta gtgtgtaaag gatatgacca
     6181 gacagctcac acacagacac acaaatgtga aaagatgctt gatctcactg ataaagcata
     6241 aattaaaacg atgtcatttt taaaaatcag attcgcaaat tttaaaagtt gctaacactg
     6301 gaatggccag agtaagagga aacgtgacac aggcacagat tgctggtaga catataagtt
     6361 ggtacagccc tctctatgta attttgtgtt tgtcaaaatt acaaatatgc atgcccttaa
     6421 cccaggaatt ccactcctca ttatatatcc tacaaataaa ctggtctcgt tatgacacaa
     6481 tgtaatgaat acatagataa gtactgaaat acttggttat catagcgtaa agatggtaat
     6541 caacccaaat gactattacc agaatagaaa ttaaacaaag tatgatatat ccataaaaca
     6601 caatactatg cagctgttaa gcagaatgag acagtcctct atatatcaat atggataaag
     6661 agtaagtgaa aaaagccagg agagaatgtt gtctataata tgctgttgtt gtgtacggga
     6721 aaataaataa tataaatacc tagaatattt gtgaaggtac agccaagaaa ctactatcac
     6781 tgattgtctt aaggtactag atggggcaca ggacaggacg aaagatttac ttcttattgt
     6841 ttcttctgta taacttttga attttatgct gttaatgtaa tttttcaaaa aaatatataa
     6901 aaatataaaa acatgaaaaa
//
