LOCUS       NP_003745                357 aa            linear   PRI 27-APR-2025
DEFINITION  eukaryotic translation initiation factor 3 subunit F [Homo
            sapiens].
ACCESSION   NP_003745
VERSION     NP_003745.1
DBSOURCE    REFSEQ: accession NM_003754.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 357)
  AUTHORS   Pan,Q., Yu,F., Jin,H., Zhang,P., Huang,X., Peng,J., Xie,X., Li,X.,
            Ma,N., Wei,Y., Wen,W., Zhang,J., Zhang,B., Yu,H., Xiao,Y.,
            Liu,R.Y., Liu,Q., Meng,X. and Lee,M.H.
  TITLE     eIF3f Mediates SGOC Pathway Reprogramming by Enhancing
            Deubiquitinating Activity in Colorectal Cancer
  JOURNAL   Adv Sci (Weinh) 10 (27), e2300759 (2023)
   PUBMED   37544925
  REMARK    GeneRIF: eIF3f Mediates SGOC Pathway Reprogramming by Enhancing
            Deubiquitinating Activity in Colorectal Cancer.
REFERENCE   2  (residues 1 to 357)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 357)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 357)
  AUTHORS   Huffmeier,U., Kraus,C., Reuter,M.S., Uebe,S., Abbott,M.A.,
            Ahmed,S.A., Rawson,K.L., Barr,E., Li,H., Bruel,A.L., Faivre,L.,
            Tran Mau-Them,F., Botti,C., Brooks,S., Burns,K., Ward,D.I.,
            Dutra-Clarke,M., Martinez-Agosto,J.A., Lee,H., Nelson,S.F.,
            Zacher,P., Abou Jamra,R., Klockner,C., McGaughran,J., Kohlhase,J.,
            Schuhmann,S., Moran,E., Pappas,J., Raas-Rothschild,A.,
            Sacoto,M.J.G., Henderson,L.B., Palculict,T.B., Mullegama,S.V.,
            Zghal Elloumi,H., Reich,A., Schrier Vergano,S.A., Wahl,E., Reis,A.
            and Zweier,C.
  CONSRTM   UCLA California Center for Rare Disease
  TITLE     EIF3F-related neurodevelopmental disorder: refining the phenotypic
            and expanding the molecular spectrum
  JOURNAL   Orphanet J Rare Dis 16 (1), 136 (2021)
   PUBMED   33736665
  REMARK    GeneRIF: EIF3F-related neurodevelopmental disorder: refining the
            phenotypic and expanding the molecular spectrum.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 357)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (residues 1 to 357)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J Biol Chem 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   7  (residues 1 to 357)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
REFERENCE   8  (residues 1 to 357)
  AUTHORS   Asano,K., Vornlocher,H.P., Richter-Cook,N.J., Merrick,W.C.,
            Hinnebusch,A.G. and Hershey,J.W.
  TITLE     Structure of cDNAs encoding human eukaryotic initiation factor 3
            subunits. Possible roles in RNA binding and macromolecular assembly
  JOURNAL   J Biol Chem 272 (43), 27042-27052 (1997)
   PUBMED   9341143
REFERENCE   9  (residues 1 to 357)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   10 (residues 1 to 357)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from CB141463.1, U94855.1, CD050033.1, BC000490.2 and
            AC116456.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.246689.1,
                                           SRR1660805.149226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651655.1/ ENSP00000499218.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     Protein         1..357
                     /product="eukaryotic translation initiation factor 3
                     subunit F"
                     /EC_number="3.4.19.12"
                     /note="eukaryotic translation initiation factor 3, subunit
                     5 (epsilon, 47kD); eukaryotic translation initiation
                     factor 3, subunit 5 epsilon, 47kDa; eIF3-epsilon;
                     eIF-3-epsilon; deubiquitinating enzyme eIF3f"
                     /calculated_mol_wt=37433
     Region          1..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O00303.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03005,
                     ECO:0000269|PubMed:17322308; propagated from
                     UniProtKB/Swiss-Prot (O00303.1)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK11, in vitro.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03005,
                     ECO:0000269|PubMed:12446680; propagated from
                     UniProtKB/Swiss-Prot (O00303.1)"
     Region          92..354
                     /region_name="MPN_eIF3f"
                     /note="Mpr1p, Pad1p N-terminal (MPN) domains without
                     catalytic isopeptidase activity, found in eIF3f; cd08064"
                     /db_xref="CDD:163695"
     Site            238
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (O00303.1)"
     Site            258
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03005,
                     ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O00303.1)"
     CDS             1..357
                     /gene="EIF3F"
                     /gene_synonym="eIF3-p47; EIF3S5; MRT67"
                     /coded_by="NM_003754.3:17..1090"
                     /db_xref="CCDS:CCDS7785.1"
                     /db_xref="GeneID:8665"
                     /db_xref="HGNC:HGNC:3275"
                     /db_xref="MIM:603914"
ORIGIN      
        1 matpavpvsa ppatptpvpa aapasvpapt papaaapvpa aapasssdpa aaaaataapg
       61 qtpasaqapa qtpapalpgp alpgpfpggr vvrlhpvila sivdsyerrn egaarvigtl
      121 lgtvdkhsve vtncfsvphn esedevavdm efaknmyelh kkvspnelil gwyatghdit
      181 ehsvliheyy sreapnpihl tvdtslqngr msikayvstl mgvpgrtmgv mftpltvkya
      241 yydterigvd limktcfspn rviglssdlq qvggasariq dalstvlqya edvlsgkvsa
      301 dntvgrflms lvnqvpkivp ddfetmlnsn indllmvtyl anltqsqial neklvnl
//
