LOCUS       NM_001568               2022 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit E
            (EIF3E), mRNA.
ACCESSION   NM_001568
VERSION     NM_001568.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2022)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2022)
  AUTHORS   Chong,P.S.Y., Chooi,J.Y., Lim,S.L.J., Chung,T.H., Brunmeir,R.,
            Leow,A.C.Y., Toh,S.H.M., Balan,K., Azaman,M.I.B., Wu,Z.,
            Subramaniam,N., Vardy,L.A. and Chng,W.J.
  TITLE     Epigenetic dysregulation of eukaryotic initiation factor 3 subunit
            E (eIF3E) by lysine methyltransferase REIIBP confers a
            pro-inflammatory phenotype in t(4;14) myeloma
  JOURNAL   Haematologica 109 (6), 1893-1908 (2024)
   PUBMED   38124661
  REMARK    GeneRIF: Epigenetic dysregulation of eukaryotic initiation factor 3
            subunit E (eIF3E) by lysine methyltransferase REIIBP confers a
            pro-inflammatory phenotype in t(4;14) myeloma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2022)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2022)
  AUTHORS   Zhang,L., Wang,X., Wu,J., Xiao,R. and Liu,J.
  TITLE     MiR-335-3p inhibits cell proliferation and induces cell cycle
            arrest and apoptosis in acute myeloid leukemia by targeting EIF3E
  JOURNAL   Biosci Biotechnol Biochem 85 (9), 1953-1961 (2021)
   PUBMED   34191006
  REMARK    GeneRIF: MiR-335-3p inhibits cell proliferation and induces cell
            cycle arrest and apoptosis in acute myeloid leukemia by targeting
            EIF3E.
REFERENCE   5  (bases 1 to 2022)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2022)
  AUTHORS   Miyazaki,S., Imatani,A., Ballard,L., Marchetti,A., Buttitta,F.,
            Albertsen,H., Nevanlinna,H.A., Gallahan,D. and Callahan,R.
  TITLE     The chromosome location of the human homolog of the mouse mammary
            tumor-associated gene INT6 and its status in human breast
            carcinomas
  JOURNAL   Genomics 46 (1), 155-158 (1997)
   PUBMED   9403073
REFERENCE   7  (bases 1 to 2022)
  AUTHORS   Asano,K., Merrick,W.C. and Hershey,J.W.
  TITLE     The translation initiation factor eIF3-p48 subunit is encoded by
            int-6, a site of frequent integration by the mouse mammary tumor
            virus genome
  JOURNAL   J Biol Chem 272 (38), 23477-23480 (1997)
   PUBMED   9295280
REFERENCE   8  (bases 1 to 2022)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   9  (bases 1 to 2022)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
REFERENCE   10 (bases 1 to 2022)
  AUTHORS   Desbois,C., Rousset,R., Bantignies,F. and Jalinot,P.
  TITLE     Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I
            Tax oncoprotein
  JOURNAL   Science 273 (5277), 951-953 (1996)
   PUBMED   8688078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from U62962.1 and AP001331.1.
            
            On May 17, 2019 this sequence version replaced NM_001568.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021679.1, U94175.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220849.10/ ENSP00000220849.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1495              U62962.1           8-1502
            1496-2022           AP001331.1         130160-130686       c
FEATURES             Location/Qualifiers
     source          1..2022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..2022
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /note="eukaryotic translation initiation factor 3 subunit
                     E"
                     /db_xref="GeneID:3646"
                     /db_xref="HGNC:HGNC:3277"
                     /db_xref="MIM:602210"
     exon            1..105
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1353
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /note="eukaryotic translation initiation factor 3, subunit
                     6 (48kD); eukaryotic translation initiation factor 3,
                     subunit 6 48kDa; murine mammary tumor integration site 6
                     (oncogene homolog); mammary tumor-associated protein INT6;
                     eIF-3 p48; viral integration site protein INT-6 homolog;
                     eukaryotic translation initiation factor 3 subunit 6"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit E"
                     /protein_id="NP_001559.1"
                     /db_xref="CCDS:CCDS6308.1"
                     /db_xref="GeneID:3646"
                     /db_xref="HGNC:HGNC:3277"
                     /db_xref="MIM:602210"
                     /translation="MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDL
                     LSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTR
                     QMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPA
                     TDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWS
                     LFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKD
                     LVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIE
                     NARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVV
                     MGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY"
     exon            106..220
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            221..338
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            339..381
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            382..486
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            487..612
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            613..737
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            738..864
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            865..966
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1076
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1179
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1314
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..2022
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /note="hexamer: AATAAA"
     polyA_site      1495
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /note="major polyA site"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /note="hexamer: TATAAA"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
                     /note="hexamer: ATTACA"
     polyA_site      1907
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
     polyA_site      1914
                     /gene="EIF3E"
                     /gene_synonym="eIF3-p46; EIF3-P48; EIF3S6; INT6"
ORIGIN      
        1 cttttctttg gcaagatggc ggagtacgac ttgactactc gcatcgcgca ctttttggat
       61 cggcatctag tctttccgct tcttgaattt ctctctgtaa aggagatata taatgaaaag
      121 gaattattac aaggtaaatt ggaccttctt agtgatacca acatggtaga ctttgctatg
      181 gatgtataca aaaaccttta ttctgatgat attcctcatg ctttgagaga gaaaagaacc
      241 acagtggttg cacaactgaa acagcttcag gcagaaacag aaccaattgt gaagatgttt
      301 gaagatccag aaactacaag gcaaatgcag tcaaccaggg atggtaggat gctctttgac
      361 tacctggcgg acaagcatgg ttttaggcag gaatatttag atacactcta cagatatgca
      421 aaattccagt acgaatgtgg gaattactca ggagcagcag aatatcttta tttttttaga
      481 gtgctggttc cagcaacaga tagaaatgct ttaagttcac tctggggaaa gctggcctct
      541 gaaatcttaa tgcagaattg ggatgcagcc atggaagacc ttacacggtt aaaagagacc
      601 atagataata attctgtgag ttctccactt cagtctcttc agcagagaac atggctcatt
      661 cactggtctc tgtttgtttt cttcaatcac cccaaaggtc gcgataatat tattgacctc
      721 ttcctttatc agccacaata tcttaatgca attcagacaa tgtgtccaca cattcttcgc
      781 tatttgacta cagcagtcat aacaaacaag gatgttcgaa aacgtcggca ggttctaaaa
      841 gatctagtta aagttattca acaggagtct tacacatata aagacccaat tacagaattt
      901 gttgaatgtt tatatgttaa ctttgacttt gatggggctc agaaaaagct gagggaatgt
      961 gaatcagtgc ttgtgaatga cttcttcttg gtggcttgtc ttgaggattt cattgaaaat
     1021 gcccgtctct tcatatttga gactttctgt cgcatccacc agtgtatcag cattaacatg
     1081 ttggcagata aattgaacat gactccagaa gaagctgaaa ggtggattgt aaatttgatt
     1141 agaaatgcaa gactggatgc caagattgat tctaaattag gtcatgtggt tatgggtaac
     1201 aatgcagtct caccctatca gcaagtgatt gaaaagacca aaagcctttc ctttagaagc
     1261 cagatgttgg ccatgaatat tgagaagaaa cttaatcaga atagcaggtc agaggctcct
     1321 aactgggcaa ctcaagattc tggcttctac tgaagaacca taaagaaaag atgaaaaaaa
     1381 aaactatcaa agaaagatga aataataaaa ctattatata aagggtgact tacattttgg
     1441 aaacaacata ttacgtataa attttgaaga attggaataa aattgattca ttttatcttg
     1501 ctgtcagttt tcttgcatgt gcaagtttgt gtttttttaa ctttcttttt tggaataatt
     1561 atattcagag gaatttgcaa aaatagtaca gagaagtccc tgtaggctga accctgtttc
     1621 cctcaatttt ttcactttgt cttactatgg tacagtatca aaaccaggat gttgacattg
     1681 gtacaatgtg tgtacaaata gctccctacc attttatcac gtgtagattt gtgtaaccat
     1741 cactgcagcc aagatagaga actatcatca tgatctccct catgctacct ttttgtagcc
     1801 atacctactc ccaaccaact ctaaccctag gaaccactaa tctgttcctc atcgctatat
     1861 tttgtcatta tgagaatgtt atataaatgg aattacataa tacacaacct ttgagattag
     1921 cttttttcat tcatcacaat gctcttgaga gccatccaag ttgagagata gatatatata
     1981 tatatatgat cagtagttaa ttcctttttt attgccaaat ag
//
