LOCUS       NM_003753               1880 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit D
            (EIF3D), transcript variant 1, mRNA.
ACCESSION   NM_003753
VERSION     NM_003753.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Liu,Q., Liu,J., Zheng,D., Zhang,R., Xiang,Y., Xu,F., Zhou,X. and
            Qin,J.
  TITLE     EIF3D promoted cervical carcinoma through Warburg effect by
            interacting with GRP78
  JOURNAL   J Obstet Gynaecol 43 (1), 2130200 (2023)
   PUBMED   36264610
  REMARK    GeneRIF: EIF3D promoted cervical carcinoma through Warburg effect
            by interacting with GRP78.
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Mukhopadhyay,S., Amodeo,M.E. and Lee,A.S.Y.
  TITLE     eIF3d controls the persistent integrated stress response
  JOURNAL   Mol Cell 83 (18), 3303-3313 (2023)
   PUBMED   37683648
  REMARK    GeneRIF: eIF3d controls the persistent integrated stress response.
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   She,R., Luo,J. and Weissman,J.S.
  TITLE     Translational fidelity screens in mammalian cells reveal eIF3 and
            eIF4G2 as regulators of start codon selectivity
  JOURNAL   Nucleic Acids Res 51 (12), 6355-6369 (2023)
   PUBMED   37144468
  REMARK    GeneRIF: Translational fidelity screens in mammalian cells reveal
            eIF3 and eIF4G2 as regulators of start codon selectivity.
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   Alard,A., Katsara,O., Rios-Fuller,T., Parra,C., Ozerdem,U.,
            Ernlund,A. and Schneider,R.J.
  TITLE     Breast cancer cell mesenchymal transition and metastasis directed
            by DAP5/eIF3d-mediated selective mRNA translation
  JOURNAL   Cell Rep 42 (6), 112646 (2023)
   PUBMED   37314929
  REMARK    GeneRIF: Breast cancer cell mesenchymal transition and metastasis
            directed by DAP5/eIF3d-mediated selective mRNA translation.
REFERENCE   5  (bases 1 to 1880)
  AUTHORS   Ma,S., Liu,J.Y. and Zhang,J.T.
  TITLE     eIF3d: A driver of noncanonical cap-dependent translation of
            specific mRNAs and a trigger of biological/pathological processes
  JOURNAL   J Biol Chem 299 (5), 104658 (2023)
   PUBMED   36997088
  REMARK    GeneRIF: eIF3d: A driver of noncanonical cap-dependent translation
            of specific mRNAs and a trigger of biological/pathological
            processes.
            Review article
REFERENCE   6  (bases 1 to 1880)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J Biol Chem 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   7  (bases 1 to 1880)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
REFERENCE   8  (bases 1 to 1880)
  AUTHORS   Asano,K., Vornlocher,H.P., Richter-Cook,N.J., Merrick,W.C.,
            Hinnebusch,A.G. and Hershey,J.W.
  TITLE     Structure of cDNAs encoding human eukaryotic initiation factor 3
            subunits. Possible roles in RNA binding and macromolecular assembly
  JOURNAL   J Biol Chem 272 (43), 27042-27052 (1997)
   PUBMED   9341143
REFERENCE   9  (bases 1 to 1880)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   10 (bases 1 to 1880)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG718662.1 and BC014912.2.
            
            On Nov 22, 2018 this sequence version replaced NM_003753.3.
            
            Summary: Eukaryotic translation initiation factor-3 (eIF3), the
            largest of the eIFs, is a multiprotein complex composed of at least
            ten nonidentical subunits. The complex binds to the 40S ribosome
            and helps maintain the 40S and 60S ribosomal subunits in a
            dissociated state. It is also thought to play a role in the
            formation of the 40S initiation complex by interacting with the
            ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA
            binding. The protein encoded by this gene is the major RNA binding
            subunit of the eIF3 complex. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000469.2, U54558.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216190.13/ ENSP00000216190.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BG718662.1         275-291
            18-1880             BC014912.2         1-1863
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1880
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /note="eukaryotic translation initiation factor 3 subunit
                     D"
                     /db_xref="GeneID:8664"
                     /db_xref="HGNC:HGNC:3278"
                     /db_xref="MIM:603915"
     exon            1..91
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            92..224
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1748
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /note="eukaryotic translation initiation factor 3, subunit
                     7 zeta, 66/67kDa; translation initiation factor eIF3 p66
                     subunit"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit D"
                     /protein_id="NP_003744.1"
                     /db_xref="CCDS:CCDS13930.1"
                     /db_xref="GeneID:8664"
                     /db_xref="HGNC:HGNC:3278"
                     /db_xref="MIM:603915"
                     /translation="MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVAD
                     WTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQ
                     RNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDS
                     SVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLR
                     SIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKL
                     FFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKER
                     YNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFIN
                     IKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLG
                     YVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLI
                     LKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET"
     exon            225..270
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            271..407
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            408..493
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            494..566
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            567..679
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            680..812
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            813..960
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1091
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1177
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1307
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1450
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1734
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1880
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /note="hexamer: AATAAA"
     polyA_site      1880
                     /gene="EIF3D"
                     /gene_synonym="eIF3-p66; eIF3-zeta; EIF3S7"
                     /note="major polyA site"
ORIGIN      
        1 ctcttttcct ggtttctcaa gagtgctgct gctaacgcgg tccccggcac gcaccatctg
       61 ttgccatccc ggccggccga ggccattgca gattttggaa gatggcaaag ttcatgacac
      121 ccgtgatcca ggacaacccc tcaggctggg gtccctgtgc ggttcccgag cagtttcggg
      181 atatgcccta ccagccgttc agcaaaggag atcggctagg aaaggttgca gactggacag
      241 gagccacata ccaagataag aggtacacaa ataagtactc ctctcagttt ggtggtggaa
      301 gtcaatatgc ttatttccat gaggaggatg aaagtagctt ccagctggtg gatacagcgc
      361 gcacacagaa gacggcctac cagcggaatc gaatgagatt tgcccagagg aacctccgca
      421 gagacaaaga tcgtcggaac atgttgcagt tcaacctgca gatcctgcct aagagtgcca
      481 aacagaaaga gagagaacgc attcgactgc agaaaaagtt ccagaaacaa tttggggtta
      541 ggcagaaatg ggatcagaaa tcacagaaac cccgagactc ttcagttgaa gttcgtagtg
      601 attgggaagt gaaagaggaa atggattttc ctcagttgat gaagatgcgc tacttggaag
      661 tatcagagcc acaggacatt gagtgttgtg gggccctaga atactacgac aaagcctttg
      721 accgcatcac cacgaggagt gagaagccac tgcggagcat caagcgcatc ttccacactg
      781 tcaccaccac agacgaccct gtcatccgca agctggcaaa aactcagggg aatgtgtttg
      841 ccactgatgc catcctggcc acgctgatga gctgtacccg ctcagtgtat tcctgggata
      901 ttgtcgtcca gagagttggg tccaaactct tctttgacaa gagagacaac tctgactttg
      961 acctcctgac agtgagtgag actgccaatg agccccctca agatgaaggt aattccttca
     1021 attcaccccg caacctggcc atggaggcaa cctacatcaa ccacaatttc tcccagcagt
     1081 gcttgagaat ggggaaggaa agatacaact tccccaaccc aaacccgttt gtggaggacg
     1141 acatggataa gaatgaaatc gcctctgttg cgtaccgtta ccgcaggtgg aagcttggag
     1201 atgatattga ccttattgtc cgttgtgagc acgatggcgt catgactgga gccaacgggg
     1261 aagtgtcctt catcaacatc aagacactca atgagtggga ttccaggcac tgtaatggcg
     1321 ttgactggcg tcagaagctg gactctcagc gaggggctgt cattgccacg gagctgaaga
     1381 acaacagcta caagttggcc cggtggacct gctgtgcttt gctggctgga tctgagtacc
     1441 tcaagcttgg ttatgtgtct cggtaccacg tgaaagactc ctcacgccac gtcatcctag
     1501 gcacccagca gttcaagcct aatgagtttg ccagccagat caacctgagc gtggagaatg
     1561 cctggggcat tttacgctgc gtcattgaca tctgcatgaa gctggaggag ggcaaatacc
     1621 tcatcctcaa ggaccccaac aagcaggtca tccgtgtcta cagcctccct gatggcacct
     1681 tcagctctga tgaagatgag gaggaagagg aggaggaaga agaggaagaa gaagaggaag
     1741 aaacttaaac cagtgatgtg gagctggagt ttgtccttcc accgagacta cgagggcctt
     1801 tgatgcttag tggaatgtgt gtctaacttg ctctctgaca tttagcagat gaaataaaat
     1861 atatatctgt ttagtctttc
//
