LOCUS       NM_001317857            2913 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit C
            like (EIF3CL), transcript variant 1, mRNA.
ACCESSION   NM_001317857 XM_005255535
VERSION     NM_001317857.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Zhou,M., Sandercock,A.M., Fraser,C.S., Ridlova,G., Stephens,E.,
            Schenauer,M.R., Yokoi-Fong,T., Barsky,D., Leary,J.A., Hershey,J.W.,
            Doudna,J.A. and Robinson,C.V.
  TITLE     Mass spectrometry reveals modularity and a complete subunit
            interaction map of the eukaryotic translation factor eIF3
  JOURNAL   Proc Natl Acad Sci U S A 105 (47), 18139-18144 (2008)
   PUBMED   18599441
REFERENCE   5  (bases 1 to 2913)
  AUTHORS   Masutani,M., Sonenberg,N., Yokoyama,S. and Imataka,H.
  TITLE     Reconstitution reveals the functional core of mammalian eIF3
  JOURNAL   EMBO J 26 (14), 3373-3383 (2007)
   PUBMED   17581632
REFERENCE   6  (bases 1 to 2913)
  AUTHORS   Kolupaeva,V.G., Unbehaun,A., Lomakin,I.B., Hellen,C.U. and
            Pestova,T.V.
  TITLE     Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits
            and its role in ribosomal dissociation and anti-association
  JOURNAL   RNA 11 (4), 470-486 (2005)
   PUBMED   15703437
REFERENCE   7  (bases 1 to 2913)
  AUTHORS   Mayeur,G.L., Fraser,C.S., Peiretti,F., Block,K.L. and Hershey,J.W.
  TITLE     Characterization of eIF3k: a newly discovered subunit of mammalian
            translation initiation factor elF3
  JOURNAL   Eur J Biochem 270 (20), 4133-4139 (2003)
   PUBMED   14519125
REFERENCE   8  (bases 1 to 2913)
  AUTHORS   Morris-Desbois,C., Bochard,V., Reynaud,C. and Jalinot,P.
  TITLE     Interaction between the Ret finger protein and the Int-6 gene
            product and co-localisation into nuclear bodies
  JOURNAL   J Cell Sci 112 (Pt 19), 3331-3342 (1999)
   PUBMED   10504338
REFERENCE   9  (bases 1 to 2913)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   10 (bases 1 to 2913)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC410988.1 and AC138894.2.
            
            On Nov 27, 2019 this sequence version replaced NM_001317857.1.
            
            Summary: The protein encoded by this gene is a core subunit of the
            eukaryotic translation initiation factor 3 (eIF3) complex. The
            encoded protein is nearly identical to another protein, eIF3c, from
            a related gene. The eIF3 complex binds the 40S ribosome and mRNAs
            to enable translation initiation. Several transcript variants
            encoding the same protein have been found for this gene. [provided
            by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. All three variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.904669.1,
                                           DRR138522.278981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380876.5/ ENSP00000370258.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DC410988.1         45-99
            56-186              AC138894.2         126336-126466
            187-252             AC138894.2         128380-128445
            253-442             AC138894.2         128588-128777
            443-568             AC138894.2         129000-129125
            569-623             AC138894.2         129315-129369
            624-733             AC138894.2         129498-129607
            734-861             AC138894.2         129986-130113
            862-1024            AC138894.2         137842-138004
            1025-1128           AC138894.2         138129-138232
            1129-1270           AC138894.2         139003-139144
            1271-1396           AC138894.2         139339-139464
            1397-1490           AC138894.2         139600-139693
            1491-1681           AC138894.2         141286-141476
            1682-1906           AC138894.2         141702-141926
            1907-2270           AC138894.2         146503-146866
            2271-2430           AC138894.2         149193-149352
            2431-2496           AC138894.2         149451-149516
            2497-2584           AC138894.2         149605-149692
            2585-2747           AC138894.2         149846-150008
            2748-2913           AC138894.2         150104-150269
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..2913
                     /gene="EIF3CL"
                     /note="eukaryotic translation initiation factor 3 subunit
                     C like"
                     /db_xref="GeneID:728689"
                     /db_xref="HGNC:HGNC:26347"
     exon            1..55
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            56..186
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2830
                     /gene="EIF3CL"
                     /note="eukaryotic translation initiation factor 3, subunit
                     8, 110kDa-like; eIF3 p110; eukaryotic translation
                     initiation factor 3 subunit 8"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit C-like protein"
                     /protein_id="NP_001304786.1"
                     /db_xref="CCDS:CCDS42136.1"
                     /db_xref="GeneID:728689"
                     /db_xref="HGNC:HGNC:26347"
                     /translation="MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEED
                     TKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGV
                     PRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYK
                     QNPEQSADEDAEKNEEDSEGSSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDE
                     DEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKRED
                     KAKKKHDRKSKRLDEEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKL
                     NEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYNPNLAT
                     YMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVE
                     RMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRI
                     LHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIR
                     TCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQ
                     GLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLEL
                     LECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVA
                     ASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSS
                     VYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNL
                     ALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY
                     "
     exon            187..252
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            253..442
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            443..568
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            569..623
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            624..733
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            734..861
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1024
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1128
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1270
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1396
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1490
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1681
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1906
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2270
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2430
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2496
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2584
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2747
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2913
                     /gene="EIF3CL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2893..2898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3CL"
                     /note="hexamer: ACTAAA"
     polyA_site      2913
                     /gene="EIF3CL"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcggc gtttccgctg tcagggccct gcggtgtgac tcgcgggctc agctggtccg
       61 gccgtagcac ctccgcgccg tcgccatgtc gcggtttttc accaccggtt cggacagcga
      121 gtccgagtcg tccttgtccg gggaggagct cgtcaccaaa cctgtcggag gcaactatgg
      181 caaacagcca ttgttgctga gcgaggatga agaagatacc aagagagttg tccgcagtgc
      241 caaggacaag aggtttgagg agctgaccaa ccttatccgg accatccgta atgccatgaa
      301 gattcgtgat gtcaccaagt gcctggaaga gtttgagctc ctgggaaaag catatgggaa
      361 ggccaaaagc attgtggaca aagaaggtgt cccccggttc tatatccgca tcctggctga
      421 cctagaggac tatcttaatg agctttggga agataaggaa gggaagaaga agatgaacaa
      481 gaacaatgcc aaggctctga gcaccttgcg tcagaagatc cgaaaataca accgtgattt
      541 cgagtcccat atcacaagct acaagcagaa ccccgagcag tctgcggatg aagatgctga
      601 gaaaaatgag gaggattcag aaggctcttc agatgaggat gaggatgagg acggagtcag
      661 tgctgcaact ttcttgaaga agaaatcaga agctccttct ggggagagtc gcaagttcct
      721 caaaaagatg gatgatgaag atgaggactc agaagattcc gaagatgatg aagactggga
      781 cacaggttcc acatcttccg attccgactc agaggaggaa gaagggaaac aaaccgcgct
      841 ggcctcaaga tttcttaaaa aggcacccac cacagatgag gacaagaagg cagccgagaa
      901 gaaacgggag gacaaagcta agaagaagca cgacaggaaa tccaagcgcc tggatgagga
      961 ggaggaggag gacaatgaag gcggggagtg ggaaagggtc cggggcggag tgccgttggt
     1021 taaggagaag ccaaaaatgt ttgccaaggg aactgagatc acccatgctg ttgttatcaa
     1081 gaaactgaat gagatcctac aggcacgagg caagaaggga actgatcgtg ctgcccagat
     1141 tgagctgctg caactgctgg ttcagattgc agcggaaaac aacctgggag agggcgtcat
     1201 tgtcaagatc aagttcaata tcatcgcctc tctctatgac tacaacccca acctggcaac
     1261 ctacatgaag ccagagatgt gggggaagtg cctggactgc atcaatgagc tgatggatat
     1321 cctgtttgca aatcccaaca tttttgttgg agagaatatt ctggaagaga gtgagaacct
     1381 gcacaacgct gaccagccac tgcgtgtccg tggctgcatc ctaactctgg tggaacgaat
     1441 ggatgaagaa tttaccaaaa taatgcaaaa tactgaccct cactcccaag agtacgtgga
     1501 gcacttgaag gatgaggccc aggtgtgtgc catcatcgag cgtgtgcagc gctacctgga
     1561 ggagaagggc actaccgagg aggtctgccg catctacctg ctgcgcatcc tgcacaccta
     1621 ctacaagttt gattacaagg cccatcagcg acagctgacc ccgcctgagg gctcctcaaa
     1681 gtctgagcaa gaccaggcag aaaatgaggg cgaggactcg gctgtgttga tggagagact
     1741 gtgcaagtac atctacgcca aggaccgcac agaccggatc cgcacatgtg ccatcctctg
     1801 ccacatctac caccatgctc tgcactcgcg ctggtaccag gcccgcgacc tcatgctcat
     1861 gagccacttg caggacaaca ttcagcatgc agacccgcca gtgcagatcc tttacaaccg
     1921 caccatggtg cagctgggca tctgtgcctt ccgccaaggc ctgaccaagg acgcacacaa
     1981 cgccctgctg gacatccagt cgagtggccg agccaaggag cttctgggcc agggcctgct
     2041 gctgcgcagc ctgcaggagc gcaaccagga gcaggagaag gtggagcggc gccgtcaggt
     2101 ccccttccac ctgcacatca acctggagct gctggagtgt gtctacctgg tgtctgccat
     2161 gctcctggag atcccctaca tggccgccca tgagagcgat gcccgccgac gcatgatcag
     2221 caagcagttc caccaccagc tgcgcgtggg cgagcgacag cccctgctgg gtccccctga
     2281 gtccatgcgg gaacatgtgg tcgctgcctc caaggccatg aagatgggtg actggaagac
     2341 ctgtcacagt tttatcatca atgagaagat gaatgggaaa gtgtgggacc ttttccccga
     2401 ggctgacaaa gtccgcacca tgctggttag gaagatccag gaagagtcac tgaggaccta
     2461 cctcttcacc tacagcagtg tctatgactc catcagcatg gagacgctgt cagacatgtt
     2521 tgagctggat ctgcccactg tgcactccat catcagcaaa atgatcatta atgaggagct
     2581 gatggcctcc ctggaccagc caacacagac agtggtgatg caccgcactg agcccactgc
     2641 ccagcagaac ctggctctgc agctggccga gaagctgggc agcctggtgg agaacaacga
     2701 acgggtgttt gaccacaagc agggcaccta cgggggctac ttccgagacc agaaggacgg
     2761 ctaccgcaaa aacgagggct acatgcgccg cggtggctac cgccagcagc agtctcagac
     2821 ggcctactga gctctccact ctgtttcccg cctgggccat ccaaccttga agtcctaaac
     2881 cacacctcag tcactaaagg tctgtttaaa gtt
//
