LOCUS       NM_003752               2910 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit C
            (EIF3C), transcript variant 1, mRNA.
ACCESSION   NM_003752
VERSION     NM_003752.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2910)
  AUTHORS   Jia,Y., Feng,B., Ji,X., Tian,X., Zhao,L., Zhou,J., Zhang,W., Li,M.,
            Fei,Y. and Wu,X.
  TITLE     Complement factor H attenuates TNF-alpha-induced inflammation by
            upregulating EIF3C in rheumatoid arthritis
  JOURNAL   J Transl Med 21 (1), 846 (2023)
   PUBMED   37996918
  REMARK    GeneRIF: Complement factor H attenuates TNF-alpha-induced
            inflammation by upregulating EIF3C in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2910)
  AUTHORS   Ding,L., Wang,R., Zheng,Q., Shen,D., Wang,H., Lu,Z., Luo,W.,
            Xie,H., Ren,L., Jiang,M., Yu,C., Zhou,Z., Lin,Y., Lu,H., Xue,D.,
            Su,W., Xia,L., Neuhaus,J., Cheng,S. and Li,G.
  TITLE     circPDE5A regulates prostate cancer metastasis via controlling
            WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA
  JOURNAL   J Exp Clin Cancer Res 41 (1), 187 (2022)
   PUBMED   35650605
  REMARK    GeneRIF: circPDE5A regulates prostate cancer metastasis via
            controlling WTAP-dependent N6-methyladenisine methylation of EIF3C
            mRNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2910)
  AUTHORS   Singh,C.R., Glineburg,M.R., Moore,C., Tani,N., Jaiswal,R., Zou,Y.,
            Aube,E., Gillaspie,S., Thornton,M., Cecil,A., Hilgers,M.,
            Takasu,A., Asano,I., Asano,M., Escalante,C.R., Nakamura,A.,
            Todd,P.K. and Asano,K.
  TITLE     Human oncoprotein 5MP suppresses general and repeat-associated
            non-AUG translation via eIF3 by a common mechanism
  JOURNAL   Cell Rep 36 (2), 109376 (2021)
   PUBMED   34260931
  REMARK    GeneRIF: Human oncoprotein 5MP suppresses general and
            repeat-associated non-AUG translation via eIF3 by a common
            mechanism.
REFERENCE   4  (bases 1 to 2910)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2910)
  AUTHORS   Liu,H., Qin,Y., Zhou,N., Ma,D. and Wang,Y.
  TITLE     ZNF280A promotes lung adenocarcinoma development by regulating the
            expression of EIF3C
  JOURNAL   Cell Death Dis 12 (1), 39 (2021)
   PUBMED   33414445
  REMARK    GeneRIF: ZNF280A promotes lung adenocarcinoma development by
            regulating the expression of EIF3C.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2910)
  AUTHORS   Morris-Desbois,C., Bochard,V., Reynaud,C. and Jalinot,P.
  TITLE     Interaction between the Ret finger protein and the Int-6 gene
            product and co-localisation into nuclear bodies
  JOURNAL   J Cell Sci 112 (Pt 19), 3331-3342 (1999)
   PUBMED   10504338
REFERENCE   7  (bases 1 to 2910)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   8  (bases 1 to 2910)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J Biol Chem 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   9  (bases 1 to 2910)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   10 (bases 1 to 2910)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from DC341554.1 and BC001571.1.
            
            On Nov 27, 2019 this sequence version replaced NM_003752.4.
            
            Transcript Variant: This variant (1) is the predominant transcript.
            Variants 1-4 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY762099.1, BC001571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331666.11/ ENSP00000332604.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC341554.1         48-66
            20-2910             BC001571.1         1-2891
FEATURES             Location/Qualifiers
     source          1..2910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2910
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /note="eukaryotic translation initiation factor 3 subunit
                     C"
                     /db_xref="GeneID:8663"
                     /db_xref="HGNC:HGNC:3279"
                     /db_xref="MIM:603916"
     exon            1..55
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            56..186
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2827
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /note="isoform a is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 3, subunit 8
                     (110kD); eukaryotic translation initiation factor 3,
                     subunit 8, 110kDa; cell migration-inducing protein 17;
                     eukaryotic translation initiation factor 3 subunit 8"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit C isoform a"
                     /protein_id="NP_003743.1"
                     /db_xref="CCDS:CCDS10638.1"
                     /db_xref="GeneID:8663"
                     /db_xref="HGNC:HGNC:3279"
                     /db_xref="MIM:603916"
                     /translation="MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEED
                     TKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGV
                     PRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYK
                     QNPEQSADEDAEKNEEDSEGSSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDE
                     DEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKRED
                     KAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLN
                     EILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYNPNLATY
                     MKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVER
                     MDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRIL
                     HTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRT
                     CAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQG
                     LTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELL
                     ECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAA
                     SKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSV
                     YDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLA
                     LQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY"
     exon            187..252
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            253..442
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            443..568
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            569..623
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            624..733
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            734..861
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1021
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1125
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1267
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1393
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1487
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1678
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1903
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2267
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2427
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2493
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2581
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2744
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2910
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2890..2895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /note="hexamer: ACTAAA"
     polyA_site      2910
                     /gene="EIF3C"
                     /gene_synonym="eIF3-p110; EIF3CL; EIF3S8"
                     /note="major polyA site"
ORIGIN      
        1 ctctctcggc gtttccgctg tcagggccct gcggtgtgac tcgcgggctc agctggtccg
       61 gccgtagcac ctccgcgccg tcgccatgtc gcggtttttc accaccggtt cggacagcga
      121 gtccgagtcg tccttgtccg gggaggagct cgtcaccaaa cctgtcggag gcaactatgg
      181 caaacagcca ttgttgctga gcgaggatga agaagatacc aagagagttg tccgcagtgc
      241 caaggacaag aggtttgagg agctgaccaa ccttatccgg accatccgta atgccatgaa
      301 gattcgtgat gtcaccaagt gcctggaaga gtttgagctc ctgggaaaag catatgggaa
      361 ggccaaaagc attgtggaca aagaaggtgt cccccggttc tatatccgca tcctggctga
      421 cctagaggac tatcttaatg agctttggga agataaggaa gggaagaaga agatgaacaa
      481 gaacaatgcc aaggctctga gcaccttgcg tcagaagatc cgaaaataca accgtgattt
      541 cgagtcccat atcacaagct acaagcagaa ccccgagcag tctgcggatg aagatgctga
      601 gaaaaatgag gaggattcag aaggctcttc agatgaggat gaggatgagg acggagtcag
      661 tgctgcaact ttcttgaaga agaaatcaga agctccttct ggggagagtc gcaagttcct
      721 caaaaagatg gatgatgaag atgaggactc agaagattcc gaagatgatg aagactggga
      781 cacaggttcc acatcttccg attccgactc agaggaggaa gaagggaaac aaaccgcgct
      841 ggcctcaaga tttcttaaaa aggcacccac cacagatgag gacaagaagg cagccgagaa
      901 gaaacgggag gacaaagcta agaagaagca cgacaggaaa tccaagcgcc tggatgagga
      961 ggaggaggac aatgaaggcg gggagtggga aagggtccgg ggcggagtgc cgttggttaa
     1021 ggagaagcca aaaatgtttg ccaagggaac tgagatcacc catgctgttg ttatcaagaa
     1081 actgaatgag atcctacagg cacgaggcaa gaagggaact gatcgtgctg cccagattga
     1141 gctgctgcaa ctgctggttc agattgcagc ggaaaacaac ctgggagagg gcgtcattgt
     1201 caagatcaag ttcaatatca tcgcctctct ctatgactac aaccccaacc tggcaaccta
     1261 catgaagcca gagatgtggg ggaagtgcct ggactgcatc aatgagctga tggatatcct
     1321 gtttgcaaat cccaacattt ttgttggaga gaatattctg gaagagagtg agaacctgca
     1381 caacgctgac cagccactgc gtgtccgtgg ctgcatccta actctggtgg aacgaatgga
     1441 tgaagaattt accaaaataa tgcaaaatac tgaccctcac tcccaagagt acgtggagca
     1501 cttgaaggat gaggcccagg tgtgtgccat catcgagcgt gtgcagcgct acctggagga
     1561 gaagggcact accgaggagg tctgccgcat ctacctgctg cgcatcctgc acacctacta
     1621 caagtttgat tacaaggccc atcagcgaca gctgaccccg cctgagggct cctcaaagtc
     1681 tgagcaagac caggcagaaa atgagggcga ggactcggct gtgttgatgg agagactgtg
     1741 caagtacatc tacgccaagg accgcacaga ccggatccgc acatgtgcca tcctctgcca
     1801 catctaccac catgctctgc actcgcgctg gtaccaggcc cgcgacctca tgctcatgag
     1861 ccacttgcag gacaacattc agcatgcaga cccgccagtg cagatccttt acaaccgcac
     1921 catggtgcag ctgggcatct gtgccttccg ccaaggcctg accaaggacg cacacaacgc
     1981 cctgctggac atccagtcga gtggccgagc caaggagctt ctgggccagg gcctgctgct
     2041 gcgcagcctg caggagcgca accaggagca ggagaaggtg gagcggcgcc gtcaggtccc
     2101 cttccacctg cacatcaacc tggagctgct ggagtgtgtc tacctggtgt ctgccatgct
     2161 cctggagatc ccctacatgg ccgcccatga gagcgatgcc cgccgacgca tgatcagcaa
     2221 gcagttccac caccagctgc gcgtgggcga gcgacagccc ctgctgggtc cccctgagtc
     2281 catgcgggaa catgtggtcg ctgcctccaa ggccatgaag atgggtgact ggaagacctg
     2341 tcacagtttt atcatcaatg agaagatgaa tgggaaagtg tgggaccttt tccccgaggc
     2401 tgacaaagtc cgcaccatgc tggttaggaa gatccaggaa gagtcactga ggacctacct
     2461 cttcacctac agcagtgtct atgactccat cagcatggag acgctgtcag acatgtttga
     2521 gctggatctg cccactgtgc actccatcat cagcaaaatg atcattaatg aggagctgat
     2581 ggcctccctg gaccagccaa cacagacagt ggtgatgcac cgcactgagc ccactgccca
     2641 gcagaacctg gctctgcagc tggccgagaa gctgggcagc ctggtggaga acaacgaacg
     2701 ggtgtttgac cacaagcagg gcacctacgg gggctacttc cgagaccaga aggacggcta
     2761 ccgcaaaaac gagggctaca tgcgccgcgg tggctaccgc cagcagcagt ctcagacggc
     2821 ctactgagct ctccactctg tttcccgcct gggccatcca accttgaagt cctaaaccac
     2881 acctcagtca ctaaaggtct gtttaaagtt
//
