LOCUS       NM_001362792            2799 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit B
            (EIF3B), transcript variant 4, mRNA.
ACCESSION   NM_001362792
VERSION     NM_001362792.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2799)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2799)
  AUTHORS   Huang,R., Nie,W., Mi,L., Yao,C. and Zhu,H.
  TITLE     EIF3B stabilizes PCNA by counteracting SYVN1-mediated
            ubiquitination to serve as a promotor in cholangiocarcinoma
  JOURNAL   Aging (Albany NY) 16 (8), 7311-7330 (2024)
   PUBMED   38687509
  REMARK    GeneRIF: EIF3B stabilizes PCNA by counteracting SYVN1-mediated
            ubiquitination to serve as a promotor in cholangiocarcinoma.
REFERENCE   3  (bases 1 to 2799)
  AUTHORS   Fang,P., Han,Y., Qu,Y., Wang,X., Zhang,Y., Zhang,W., Zhang,N.,
            Li,G. and Ma,W.
  TITLE     EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated
            ubiquitination to promote the development and progression of
            malignant melanoma
  JOURNAL   Cancer Sci 113 (12), 4181-4192 (2022)
   PUBMED   36050601
  REMARK    GeneRIF: EIF3B stabilizes PTGS2 expression by counteracting
            MDM2-mediated ubiquitination to promote the development and
            progression of malignant melanoma.
REFERENCE   4  (bases 1 to 2799)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2799)
  AUTHORS   Song,S., Liu,J., Zhang,M., Gao,X., Sun,W., Liu,P., Wang,Y. and
            Li,J.
  TITLE     Eukaryotic translation initiation factor 3 subunit B could serve as
            a potential prognostic predictor for breast cancer
  JOURNAL   Bioengineered 13 (2), 2762-2776 (2022)
   PUBMED   35040374
  REMARK    GeneRIF: Eukaryotic translation initiation factor 3 subunit B could
            serve as a potential prognostic predictor for breast cancer.
REFERENCE   6  (bases 1 to 2799)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
REFERENCE   7  (bases 1 to 2799)
  AUTHORS   Chaudhuri,J., Chakrabarti,A. and Maitra,U.
  TITLE     Biochemical characterization of mammalian translation initiation
            factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the
            mammalian homologue of Saccharomyces cerevisiae protein Prt1
  JOURNAL   J Biol Chem 272 (49), 30975-30983 (1997)
   PUBMED   9388245
REFERENCE   8  (bases 1 to 2799)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   9  (bases 1 to 2799)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
REFERENCE   10 (bases 1 to 2799)
  AUTHORS   Kirken,R.A., Rui,H., Evans,G.A. and Farrar,W.L.
  TITLE     Characterization of an interleukin-2 (IL-2)-induced tyrosine
            phosphorylated 116-kDa protein associated with the IL-2 receptor
            beta-subunit
  JOURNAL   J Biol Chem 268 (30), 22765-22770 (1993)
   PUBMED   7693677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA781713.1, AC004971.3, AC004840.4 and BQ045103.1.
            
            On May 31, 2019 this sequence version replaced NM_001362792.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.46050.1,
                                           SRR1803613.181484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               DA781713.1         1-517
            518-610             AC004971.3         1833-1925           c
            611-668             AC004971.3         1470-1527           c
            669-797             AC004971.3         837-965             c
            798-822             AC004971.3         201-225             c
            823-955             AC004840.4         149265-149397       c
            956-1087            AC004840.4         147346-147477       c
            1088-1154           AC004840.4         147203-147269       c
            1155-1201           AC004840.4         146749-146795       c
            1202-1412           AC004840.4         144112-144322       c
            1413-1485           AC004840.4         141945-142017       c
            1486-1608           AC004840.4         140999-141121       c
            1609-1687           AC004840.4         139188-139266       c
            1688-1826           AC004840.4         138267-138405       c
            1827-1952           AC004840.4         136719-136844       c
            1953-2030           AC004840.4         135028-135105       c
            2031-2139           AC004840.4         134552-134660       c
            2140-2257           AC004840.4         134283-134400       c
            2258-2788           AC004840.4         133060-133590       c
            2789-2799           BQ045103.1         14-24               c
FEATURES             Location/Qualifiers
     source          1..2799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..2799
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="eukaryotic translation initiation factor 3 subunit
                     B"
                     /db_xref="GeneID:8662"
                     /db_xref="HGNC:HGNC:3280"
                     /db_xref="MIM:603917"
     exon            1..110
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..297
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..490
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..610
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..668
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..2243
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="isoform 2 is encoded by transcript variant 4;
                     eukaryotic translation initiation factor 3, subunit 9
                     (eta, 116kD); eukaryotic translation initiation factor 3,
                     subunit 9 eta, 116kDa; prt1 homolog; eukaryotic
                     translation initiation factor 3 subunit 9; protein
                     synthesis 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit B isoform 2"
                     /protein_id="NP_001349721.1"
                     /db_xref="GeneID:8662"
                     /db_xref="HGNC:HGNC:3280"
                     /db_xref="MIM:603917"
                     /translation="MTISDEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRT
                     SIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQ
                     GVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWS
                     HDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIP
                     ARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFR
                     MREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKIELIKMF
                     DKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGR
                     YVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQIKK
                     DLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRG
                     GVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE"
     exon            669..797
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..955
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1087
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1154
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1201
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1412
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1485
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1608
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1687
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1826
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1952
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2030
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2139
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2257
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2799
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="hexamer: AATAAA"
     polyA_site      2799
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="major polyA site"
ORIGIN      
        1 gtgacccgcg ctgtcccgcg ctgaaggcgg cggcctcgga tggactgaac cactgtgaaa
       61 gcccgaatgg ggggaaacag gcagtgacgg ccgctaggga aggactgggg ggcgaggccc
      121 caggagagca ggctcgggac gagcgctccg acagccgggc ccaggcggtg tccgaggacg
      181 cgggaggaaa cgagggcaga gcggccgagg ccgaaccccg ggcgctggag aacggcgacg
      241 cggacgagcc ctccttcagc gaccccgagg acttcgtgga cgacgtgagc gaggaagaat
      301 tactgggaga tgtactcaaa gatcggcccc aggaagcaga tggaatcgat tcggtgattg
      361 tagtggacaa tgtccctcag gtgggacccg accgacttga gaaactcaaa aatgtcatcc
      421 acaagatctt ttccaagttt gggaaaatca caaatgattt ttatcctgaa gaggatggga
      481 agacaaaagg gtatattttc ctggagtacg cgtcccctgc ccacgctgtg gatgctgtga
      541 agaacgccga cggctacaag cttgacaagc agcacacatt ccgggtcaac ctctttacgg
      601 attttgacaa gtatatgacg atcagtgacg agtgggatat tccagagaaa cagcctttca
      661 aagacctggg gaacttacgt tactggcttg aagaggcaga atgcagagat cagtacagtg
      721 tgatttttga gagtggagac cgcacttcca tattctggaa tgacgtaaaa gaccctgtct
      781 caattgaaga aagagcgaga tggacagaga cgtatgtgcg ttggtctcct aagggcacct
      841 acctggctac ctttcatcaa agaggcattg ctctatgggg gggagagaaa ttcaagcaaa
      901 ttcagagatt cagccaccaa ggggttcagc ttattgactt ctcaccttgt gaaaggtacc
      961 tggtgacctt tagccccctg atggacacgc aggatgaccc tcaggccata atcatctggg
     1021 acatccttac ggggcacaag aagaggggtt ttcactgtga gagctcagcc cattggccta
     1081 tttttaagtg gagccatgat ggcaaattct ttgccagaat gaccctggat acgcttagca
     1141 tctatgaaac tccttctatg ggtcttttgg acaagaagag tttgaagatc tctgggataa
     1201 aagacttttc ttggtctcct ggtggtaaca taatcgcctt ctgggtgcct gaagacaaag
     1261 atattccagc cagggtaacc ctgatgcagc tccctaccag gcaagagatc cgagtgagga
     1321 acctgttcaa tgtggtggac tgcaagctcc attggcagaa gaacggagac tacttgtgtg
     1381 tgaaagtaga taggactccg aaaggcaccc agggtgttgt cacaaatttt gaaattttcc
     1441 gaatgaggga gaaacaggta cctgtggatg tggtcgagat gaaagaaacc atcatagcct
     1501 ttgcctggga accaaatgga agtaagtttg ctgtgctgca cggagaggct ccgcggatat
     1561 ctgtgtcttt ctaccacgtc aaaaacaacg ggaagattga actcatcaag atgttcgaca
     1621 agcagcaggc gaacaccatc ttctggagcc cccaaggaca gttcgtggtg ttggcgggcc
     1681 tgaggagtat gaacggtgcc ttagcgtttg tggacacttc ggactgcacg gtcatgaaca
     1741 tcgcagagca ctacatggct tccgacgtcg aatgggatcc tactgggcgc tacgtcgtca
     1801 cctctgtgtc ctggtggagc cataaggtgg acaacgcgta ctggctgtgg actttccagg
     1861 gacgcctcct gcagaagaac aacaaggacc gcttctgcca gctgctgtgg cggccccggc
     1921 ctcccacact cctgagccag gaacagatca agcaaattaa aaaggatctg aagaaatact
     1981 ctaagatctt tgaacagaag gatcgtttga gtcagtccaa agcctcaaag gaattggtgg
     2041 agagaaggcg caccatgatg gaagatttcc ggaagtaccg gaaaatggcc caggagctct
     2101 atatggagca gaaaaacgag cgcctggagt tgcgaggagg ggtggacact gacgagctgg
     2161 acagcaacgt ggacgactgg gaagaggaga ccattgagtt cttcgtcact gaagaaatca
     2221 ttcccctcgg gaatcaggag tgacctggag cactgtgggg acggactccg cctgctgttc
     2281 ccgcgctgag ctacaggact cccgagtgtg agccgcggtt cctctgttgc agcgcagccg
     2341 tgtgtgctgt ggagccgagg ccgtcctgca ggaagccgcg tgactcccgc ctcctccctg
     2401 tgctctctgg ctctggactg tgactgcgcc tggattctgc cattgcgaca catttttgtg
     2461 cctttcagcc cctggtgtct gcagtggggg atttaaggca cccgcttcca cttctttctt
     2521 gtttggagtt ttctgttgga accgccggcg ttggctccga agacttagcg acgccactgg
     2581 cggcaccttc tcctgcgccc agtgatgttt ccacggtgcc tgtacacagc cgagcagcat
     2641 ttccgttgaa ggacttgcat ccccattgcg ggcagtgctg gacgtgtccc ggagacccac
     2701 cgggagggcg ccgccatgcc ttgtaccccc accgtgcagg ttgtggccgg ttttctccgc
     2761 aggttgaaca tggaaataaa agcaaacttg tatgaaaaa
//
