LOCUS       NM_001037283            3096 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit B
            (EIF3B), transcript variant 2, mRNA.
ACCESSION   NM_001037283
VERSION     NM_001037283.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Huang,R., Nie,W., Mi,L., Yao,C. and Zhu,H.
  TITLE     EIF3B stabilizes PCNA by counteracting SYVN1-mediated
            ubiquitination to serve as a promotor in cholangiocarcinoma
  JOURNAL   Aging (Albany NY) 16 (8), 7311-7330 (2024)
   PUBMED   38687509
  REMARK    GeneRIF: EIF3B stabilizes PCNA by counteracting SYVN1-mediated
            ubiquitination to serve as a promotor in cholangiocarcinoma.
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Fang,P., Han,Y., Qu,Y., Wang,X., Zhang,Y., Zhang,W., Zhang,N.,
            Li,G. and Ma,W.
  TITLE     EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated
            ubiquitination to promote the development and progression of
            malignant melanoma
  JOURNAL   Cancer Sci 113 (12), 4181-4192 (2022)
   PUBMED   36050601
  REMARK    GeneRIF: EIF3B stabilizes PTGS2 expression by counteracting
            MDM2-mediated ubiquitination to promote the development and
            progression of malignant melanoma.
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Song,S., Liu,J., Zhang,M., Gao,X., Sun,W., Liu,P., Wang,Y. and
            Li,J.
  TITLE     Eukaryotic translation initiation factor 3 subunit B could serve as
            a potential prognostic predictor for breast cancer
  JOURNAL   Bioengineered 13 (2), 2762-2776 (2022)
   PUBMED   35040374
  REMARK    GeneRIF: Eukaryotic translation initiation factor 3 subunit B could
            serve as a potential prognostic predictor for breast cancer.
REFERENCE   6  (bases 1 to 3096)
  AUTHORS   Sizova,D.V., Kolupaeva,V.G., Pestova,T.V., Shatsky,I.N. and
            Hellen,C.U.
  TITLE     Specific interaction of eukaryotic translation initiation factor 3
            with the 5' nontranslated regions of hepatitis C virus and
            classical swine fever virus RNAs
  JOURNAL   J Virol 72 (6), 4775-4782 (1998)
   PUBMED   9573242
REFERENCE   7  (bases 1 to 3096)
  AUTHORS   Chaudhuri,J., Chakrabarti,A. and Maitra,U.
  TITLE     Biochemical characterization of mammalian translation initiation
            factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the
            mammalian homologue of Saccharomyces cerevisiae protein Prt1
  JOURNAL   J Biol Chem 272 (49), 30975-30983 (1997)
   PUBMED   9388245
REFERENCE   8  (bases 1 to 3096)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   9  (bases 1 to 3096)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
REFERENCE   10 (bases 1 to 3096)
  AUTHORS   Kirken,R.A., Rui,H., Evans,G.A. and Farrar,W.L.
  TITLE     Characterization of an interleukin-2 (IL-2)-induced tyrosine
            phosphorylated 116-kDa protein associated with the IL-2 receptor
            beta-subunit
  JOURNAL   J Biol Chem 268 (30), 22765-22770 (1993)
   PUBMED   7693677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004971.3, U78525.1 and BQ045103.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001037283.1.
            
            Transcript Variant: This variant (2) represents the longest
            transcript. Variants 1, 2 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.139427.1, U78525.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360876.9/ ENSP00000354125.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC004971.3         9759-9770           c
            13-594              AC004971.3         9177-9758           c
            595-3004            U78525.1           575-2984
            3005-3096           BQ045103.1         14-105              c
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..3096
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="eukaryotic translation initiation factor 3 subunit
                     B"
                     /db_xref="GeneID:8662"
                     /db_xref="HGNC:HGNC:3280"
                     /db_xref="MIM:603917"
     exon            1..594
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2540
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     eukaryotic translation initiation factor 3, subunit 9
                     (eta, 116kD); eukaryotic translation initiation factor 3,
                     subunit 9 eta, 116kDa; prt1 homolog; eukaryotic
                     translation initiation factor 3 subunit 9; protein
                     synthesis 1"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit B isoform 1"
                     /protein_id="NP_001032360.1"
                     /db_xref="CCDS:CCDS5332.1"
                     /db_xref="GeneID:8662"
                     /db_xref="HGNC:HGNC:3280"
                     /db_xref="MIM:603917"
                     /translation="MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPE
                     AAGTEASSEEVGIAEAGPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVP
                     AQGEAPGEQARDERSDSRAQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFV
                     DDVSEEELLGDVLKDRPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKIT
                     NDFYPEEDGKTKGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTIS
                     DEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRTSIFWNDVKDPVSIEERAR
                     WTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYLVTFS
                     PLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYE
                     TPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQEIRVRN
                     LFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETII
                     AFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKIELIKMFDKQQANTIFWSPQGQFVV
                     LAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSHKVDNAYW
                     LWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQIKKDLKKYSKIFEQKDRLSQS
                     KASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRGGVDTDELDSNVDDWEEET
                     IEFFVTEEIIPLGNQE"
     exon            595..787
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..907
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..965
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1094
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1252
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1384
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1451
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1498
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1709
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1782
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1905
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1984
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2123
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2249
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2327
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2436
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2554
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..3096
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="major polyA site"
ORIGIN      
        1 atggctgggc tgtagccgtc gcggcgcgcg gtgcggcctg ggagagtcgg aagcgcggcg
       61 gccgcggagc cctgcgagta ggcagcgttg ggcccatgca ggacgcggag aacgtggcgg
      121 tgcccgaggc ggccgaggag cgcgccgagc ccggccagca gcagccggcc gccgagccgc
      181 cgccagccga ggggctgctg cggcccgcgg ggcccggcgc tccggaggcc gcggggaccg
      241 aggcctccag tgaggaggtg gggatcgcgg aggccgggcc ggagtccgag gtgaggaccg
      301 agccggcggc cgaggcagag gcggcctccg gcccgtccga gtcgccctcg ccgccggccg
      361 ccgaggagct gcccgggtcg catgctgagc cccctgtccc ggcacagggc gaggccccag
      421 gagagcaggc tcgggacgag cgctccgaca gccgggccca ggcggtgtcc gaggacgcgg
      481 gaggaaacga gggcagagcg gccgaggccg aaccccgggc gctggagaac ggcgacgcgg
      541 acgagccctc cttcagcgac cccgaggact tcgtggacga cgtgagcgag gaagaattac
      601 tgggagatgt actcaaagat cggccccagg aagcagatgg aatcgattcg gtgattgtag
      661 tggacaatgt ccctcaggtg ggacccgacc gacttgagaa actcaaaaat gtcatccaca
      721 agatcttttc caagtttggg aaaatcacaa atgattttta tcctgaagag gatgggaaga
      781 caaaagggta tattttcctg gagtacgcgt cccctgccca cgctgtggat gctgtgaaga
      841 acgccgacgg ctacaagctt gacaagcagc acacattccg ggtcaacctc tttacggatt
      901 ttgacaagta tatgacgatc agtgacgagt gggatattcc agagaaacag cctttcaaag
      961 acctggggaa cttacgttac tggcttgaag aggcagaatg cagagatcag tacagtgtga
     1021 tttttgagag tggagaccgc acttccatat tctggaatga cgtaaaagac cctgtctcaa
     1081 ttgaagaaag agcgagatgg acagagacgt atgtgcgttg gtctcctaag ggcacctacc
     1141 tggctacctt tcatcaaaga ggcattgctc tatggggggg agagaaattc aagcaaattc
     1201 agagattcag ccaccaaggg gttcagctta ttgacttctc accttgtgaa aggtacctgg
     1261 tgacctttag ccccctgatg gacacgcagg atgaccctca ggccataatc atctgggaca
     1321 tccttacggg gcacaagaag aggggttttc actgtgagag ctcagcccat tggcctattt
     1381 ttaagtggag ccatgatggc aaattctttg ccagaatgac cctggatacg cttagcatct
     1441 atgaaactcc ttctatgggt cttttggaca agaagagttt gaagatctct gggataaaag
     1501 acttttcttg gtctcctggt ggtaacataa tcgccttctg ggtgcctgaa gacaaagata
     1561 ttccagccag ggtaaccctg atgcagctcc ctaccaggca agagatccga gtgaggaacc
     1621 tgttcaatgt ggtggactgc aagctccatt ggcagaagaa cggagactac ttgtgtgtga
     1681 aagtagatag gactccgaaa ggcacccagg gtgttgtcac aaattttgaa attttccgaa
     1741 tgagggagaa acaggtacct gtggatgtgg tcgagatgaa agaaaccatc atagcctttg
     1801 cctgggaacc aaatggaagt aagtttgctg tgctgcacgg agaggctccg cggatatctg
     1861 tgtctttcta ccacgtcaaa aacaacggga agattgaact catcaagatg ttcgacaagc
     1921 agcaggcgaa caccatcttc tggagccccc aaggacagtt cgtggtgttg gcgggcctga
     1981 ggagtatgaa cggtgcctta gcgtttgtgg acacttcgga ctgcacggtc atgaacatcg
     2041 cagagcacta catggcttcc gacgtcgaat gggatcctac tgggcgctac gtcgtcacct
     2101 ctgtgtcctg gtggagccat aaggtggaca acgcgtactg gctgtggact ttccagggac
     2161 gcctcctgca gaagaacaac aaggaccgct tctgccagct gctgtggcgg ccccggcctc
     2221 ccacactcct gagccaggaa cagatcaagc aaattaaaaa ggatctgaag aaatactcta
     2281 agatctttga acagaaggat cgtttgagtc agtccaaagc ctcaaaggaa ttggtggaga
     2341 gaaggcgcac catgatggaa gatttccgga agtaccggaa aatggcccag gagctctata
     2401 tggagcagaa aaacgagcgc ctggagttgc gaggaggggt ggacactgac gagctggaca
     2461 gcaacgtgga cgactgggaa gaggagacca ttgagttctt cgtcactgaa gaaatcattc
     2521 ccctcgggaa tcaggagtga cctggagcac tgtggggacg gactccgcct gctgttcccg
     2581 cgctgagcta caggactccc gagtgtgagc cgcggttcct ctgttgcagc gcagccgtgt
     2641 gtgctgtgga gccgaggccg tcctgcagga agccgcgtga ctcccgcctc ctccctgtgc
     2701 tctctggctc tggactgtga ctgcgcctgg attctgccat tgcgacacat ttttgtgcct
     2761 ttcagcccct ggtgtctgca gtgggggatt taaggcaccc gcttccactt ctttcttgtt
     2821 tggagttttc tgttggaacc gccggcgttg gctccgaaga cttagcgacg ccactggcgg
     2881 caccttctcc tgcgcccagt gatgtttcca cggtgcctgt acacagccga gcagcatttc
     2941 cgttgaagga cttgcatccc cattgcgggc agtgctggac gtgtcccgga gacccaccgg
     3001 gagggcgccg ccatgccttg tacccccacc gtgcaggttg tggccggttt tctccgcagg
     3061 ttgaacatgg aaataaaagc aaacttgtat gaaaaa
//
