LOCUS       NM_003750               6659 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3 subunit A
            (EIF3A), mRNA.
ACCESSION   NM_003750
VERSION     NM_003750.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6659)
  AUTHORS   Volegova,M.P., Hermosillo,C. and Cate,J.H.D.
  TITLE     The Helix-Loop-Helix motif of human EIF3A regulates translation of
            proliferative cellular mRNAs
  JOURNAL   PLoS One 18 (9), e0292080 (2023)
   PUBMED   37768948
  REMARK    GeneRIF: The Helix-Loop-Helix motif of human EIF3A regulates
            translation of proliferative cellular mRNAs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6659)
  AUTHORS   Duan,H., Zhang,S., Zarai,Y., Ollinger,R., Wu,Y., Sun,L., Hu,C.,
            He,Y., Tian,G., Rad,R., Kong,X., Cheng,Y., Tuller,T. and Wolf,D.A.
  TITLE     eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant
            regulator of ribosome content
  JOURNAL   EMBO J 42 (12), e112362 (2023)
   PUBMED   37155573
  REMARK    GeneRIF: eIF3 mRNA selectivity profiling reveals eIF3k as a
            cancer-relevant regulator of ribosome content.
REFERENCE   3  (bases 1 to 6659)
  AUTHORS   Zhao,Y., Zhao,H., Zhang,D., Quan,Q., Ge,Y., Li,L. and Guo,L.
  TITLE     YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to
            Regulate Translational Processes in Oxaliplatin-Resistant
            Colorectal Cancer
  JOURNAL   ACS Chem Biol 17 (7), 1778-1788 (2022)
   PUBMED   35708211
  REMARK    GeneRIF: YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs
            to Regulate Translational Processes in Oxaliplatin-Resistant
            Colorectal Cancer.
REFERENCE   4  (bases 1 to 6659)
  AUTHORS   Ma,S., Dong,Z., Huang,Y., Liu,J.Y. and Zhang,J.T.
  TITLE     Translation initiation factor eIF3a regulates glucose metabolism
            and cell proliferation via promoting small GTPase Rheb synthesis
            and AMPK activation
  JOURNAL   J Biol Chem 298 (7), 102044 (2022)
   PUBMED   35595099
  REMARK    GeneRIF: Translation initiation factor eIF3a regulates glucose
            metabolism and cell proliferation via promoting small GTPase Rheb
            synthesis and AMPK activation.
REFERENCE   5  (bases 1 to 6659)
  AUTHORS   Ma,S., Dong,Z., Huang,Y., Liu,J.Y. and Zhang,J.T.
  TITLE     eIF3a regulation of mTOR signaling and translational control via
            HuR in cellular response to DNA damage
  JOURNAL   Oncogene 41 (17), 2431-2443 (2022)
   PUBMED   35279705
  REMARK    GeneRIF: eIF3a regulation of mTOR signaling and translational
            control via HuR in cellular response to DNA damage.
REFERENCE   6  (bases 1 to 6659)
  AUTHORS   Johnson,K.R., Merrick,W.C., Zoll,W.L. and Zhu,Y.
  TITLE     Identification of cDNA clones for the large subunit of eukaryotic
            translation initiation factor 3. Comparison of homologues from
            human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces
            cerevisiae
  JOURNAL   J Biol Chem 272 (11), 7106-7113 (1997)
   PUBMED   9054404
REFERENCE   7  (bases 1 to 6659)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J Biol Chem 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   8  (bases 1 to 6659)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J Biol Chem 272 (2), 1101-1109 (1997)
   PUBMED   8995409
REFERENCE   9  (bases 1 to 6659)
  AUTHORS   Methot,N., Song,M.S. and Sonenberg,N.
  TITLE     A region rich in aspartic acid, arginine, tyrosine, and glycine
            (DRYG) mediates eukaryotic initiation factor 4B (eIF4B)
            self-association and interaction with eIF3
  JOURNAL   Mol Cell Biol 16 (10), 5328-5334 (1996)
   PUBMED   8816444
REFERENCE   10 (bases 1 to 6659)
  AUTHORS   Kanner,S.B., Reynolds,A.B., Vines,R.R. and Parsons,J.T.
  TITLE     Monoclonal antibodies to individual tyrosine-phosphorylated protein
            substrates of oncogene-encoded tyrosine kinases
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3328-3332 (1990)
   PUBMED   2110361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL355598.26 and AL157788.16.
            
            On Nov 22, 2018 this sequence version replaced NM_003750.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50929.1, U58046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369144.8/ ENSP00000358140.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AL355598.26        47785-47974         c
            191-381             AL355598.26        40904-41094         c
            382-518             AL355598.26        40598-40734         c
            519-682             AL355598.26        40047-40210         c
            683-882             AL355598.26        38043-38242         c
            883-1091            AL355598.26        36603-36811         c
            1092-1263           AL355598.26        32556-32727         c
            1264-1368           AL355598.26        28381-28485         c
            1369-1467           AL355598.26        27903-28001         c
            1468-1584           AL355598.26        26759-26875         c
            1585-1770           AL355598.26        26369-26554         c
            1771-2118           AL355598.26        25113-25460         c
            2119-2223           AL355598.26        24093-24197         c
            2224-2337           AL355598.26        23897-24010         c
            2338-2460           AL355598.26        18356-18478         c
            2461-2614           AL355598.26        17678-17831         c
            2615-2799           AL355598.26        16958-17142         c
            2800-2888           AL355598.26        11211-11299         c
            2889-3667           AL355598.26        9151-9929           c
            3668-3869           AL355598.26        5395-5596           c
            3870-4060           AL355598.26        4276-4466           c
            4061-5485           AL355598.26        2001-3425           c
            5486-6659           AL157788.16        117931-119104       c
FEATURES             Location/Qualifiers
     source          1..6659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..6659
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /note="eukaryotic translation initiation factor 3 subunit
                     A"
                     /db_xref="GeneID:8661"
                     /db_xref="HGNC:HGNC:3271"
                     /db_xref="MIM:602039"
     exon            1..190
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..4290
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /note="eukaryotic translation initiation factor 3, subunit
                     10 (theta, 170kD); eukaryotic translation initiation
                     factor 3, subunit 10 theta, 150/170kDa; eukaryotic
                     translation initiation factor 3, subunit 10 (theta,
                     150/170kD); cytoplasmic protein p167; EIF3, p180 subunit;
                     centrosomin homolog; eukaryotic translation initiation
                     factor 3, subunit 10, 170kD; eIF3 p167; eIF3 p180; eIF3
                     p185; eIF-3-theta; eukaryotic translation initiation
                     factor 3 subunit 10"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit A"
                     /protein_id="NP_003741.1"
                     /db_xref="CCDS:CCDS7608.1"
                     /db_xref="GeneID:8661"
                     /db_xref="HGNC:HGNC:3271"
                     /db_xref="MIM:602039"
                     /translation="MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQ
                     KIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTE
                     AAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQC
                     LDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAI
                     NLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYY
                     NKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQDEMQRMSTRVLLATLSIPITPE
                     RTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYN
                     WLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVSQIYQSI
                     EFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPIG
                     PHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQ
                     RILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERI
                     LQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKK
                     ELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLER
                     EKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQR
                     KEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVER
                     KKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPP
                     EKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGP
                     EEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWR
                     TADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDDRG
                     PRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRNMDDD
                     RLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEEREWD
                     REKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDS
                     SRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDR
                     VEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDEDGWT
                     TVRR"
     exon            191..381
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            382..518
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            519..682
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            683..882
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1091
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1263
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1368
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1467
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1584
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1770
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..2118
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2223
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2337
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2460
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2614
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2799
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2888
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3667
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3869
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4060
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..6659
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5267..5272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /note="hexamer: AATAAA"
     polyA_site      5288
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /note="major polyA site"
     regulatory      6637..6642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /note="hexamer: AATAAA"
     polyA_site      6659
                     /gene="EIF3A"
                     /gene_synonym="EIF3; eIF3-p170; eIF3-theta; EIF3S10; P167;
                     p180; p185; TIF32"
                     /note="major polyA site"
ORIGIN      
        1 cctttccgtc tctggccggc tgggcgcggg cgactgctgg cgaggcgcgt gggaccttac
       61 gctggttccc cttcgtctcc tctcccggcc cgggccacta gagagttcgc tgacgccggg
      121 tgagctgagc ctgccgccaa gatgccggcc tattttcaga ggccggaaaa tgccctcaaa
      181 cgcgccaacg aatttcttga ggttggcaaa aagcagcctg ctctggatgt tctttatgat
      241 gttatgaaaa gtaaaaaaca tagaacatgg caaaagatac acgaaccaat tatgttgaaa
      301 tacttggaac tttgcgtgga tcttcgcaag agccacttgg caaaggaggg gttataccag
      361 tataagaaca tttgtcaaca ggtgaacata aaatctctgg aggatgttgt tagggcatat
      421 ttgaaaatgg cagaggaaaa aactgaagct gctaaagaag aatctcagca gatggtctta
      481 gatatagagg atctagataa tattcaaact cctgagagtg ttctcctaag tgctgtaagt
      541 ggtgaagaca ctcaggatcg tactgacaga ttacttttaa ctccatgggt taaattcctg
      601 tgggagtctt acaggcagtg tttggacctt cttagaaaca attctagagt agagcgcctg
      661 taccatgata ttgcccagca agctttcaaa ttctgcctcc aatacacgcg taaggctgaa
      721 ttccgtaaac tgtgtgacaa tttgagaatg cacttatcgc agattcagcg ccaccataac
      781 caaagtacgg caatcaatct taataatcca gagagccagt ccatgcattt ggaaaccaga
      841 cttgttcagc tggacagtgc tatcagcatg gaattgtggc aggaagcatt caaagctgtg
      901 gaagatattc acgggctatt ctccttgtct aaaaaaccac ctaaacctca gttgatggca
      961 aattactata acaaagtctc aactgtgttt tggaaatctg gaaatgctct ttttcatgca
     1021 tctacactcc atcgtcttta ccatctctct agagaaatga gaaagaatct cacacaagat
     1081 gagatgcaaa gaatgtctac tagagtcctt ttagccactc tttccatccc tattactcct
     1141 gagcgtacgg atattgctcg acttctggat atggatggca ttatagttga aaaacagcgt
     1201 cgccttgcaa cactactagg tcttcaagcc ccaccgacac gaattggcct tattaatgat
     1261 atggtcagat ttaatgtact acaatatgtt gtcccagaag tgaaagacct ttacaattgg
     1321 cttgaagtag aatttaaccc attaaaactc tgtgagcgag tcacaaaggt tctaaattgg
     1381 gttagggaac aacctgaaaa ggaaccggaa ttgcagcagt atgtgccaca actgcaaaac
     1441 aacaccatcc tccgccttct gcagcaggtg tcacagattt atcagagcat tgagttttct
     1501 cgtttgactt ctttggttcc ttttgttgat gctttccaac tggaacgggc catagtagat
     1561 gcagccaggc attgcgactt gcaggttcgt attgatcaca cttctcggac cctgagtttt
     1621 ggatctgatt tgaattatgc tactcgagaa gatgctccga ttggtcctca tttgcaaagc
     1681 atgccttcag agcagataag aaaccagctg acagccatgt cctcagtact tgcaaaagca
     1741 cttgaagtca ttaaaccagc tcatatactg caagagaaag aagaacagca tcagttggct
     1801 gtcactgcat accttaaaaa ttcacgaaaa gagcaccagc ggatcctggc tcgccgccag
     1861 acaattgagg agagaaaaga gcgccttgag agtctgaata ttcagcgtga gaaagaagaa
     1921 ttggaacaga gggaagctga actccagaaa gtgcggaagg ctgaggaaga gaggctgcgc
     1981 caggaagcaa aggagagaga gaaggagcgt atcttacagg aacatgaaca aatcaaaaag
     2041 aaaactgtcc gagagcgttt ggagcagatc aagaaaacag aactgggtgc caaagcattc
     2101 aaagatattg atattgaaga ccttgaggaa ttggatccag attttatcat ggctaaacag
     2161 gttgaacaac tggagaaaga aaagaaagaa cttcaagaac gcctaaagaa tcaagaaaag
     2221 aagattgact attttgaaag agccaaacgt ttggaagaaa ttcctttgat aaagagcgct
     2281 tacgaggaac agagaattaa agacatggat ctgtgggagc aacaagagga agaaagaatt
     2341 actacaatgc agctagaacg tgaaaaggct cttgaacata agaatcgaat gtcacgaatg
     2401 cttgaagaca gagatttatt cgtaatgcga ctcaaagctg cacggcagtc tgtttatgag
     2461 gaaaaactta aacagtttga agagcgatta gcagaagaaa ggcataatcg attggaagaa
     2521 cggaaaaggc agcgtaaaga agaacgcagg ataacatact atagagaaaa agaagaggag
     2581 gagcagagaa gggcagaaga acaaatgcta aaagagcggg aagagagaga gcgcgccgaa
     2641 cgagcaaaac gcgaggaaga gctacgagag tatcaggagc gggtgaagaa attagaagaa
     2701 gtggaaagga aaaaacgcca aagggagttg gaaattgaag aacgagaacg gcgtagagag
     2761 gaagagagaa gacttggcga tagttccctt tctagaaagg actctcgttg gggagataga
     2821 gattcagaag gcacctggag aaaaggacct gaagcagatt ctgagtggag aagaggcccg
     2881 ccagagaagg agtggagacg tggagaaggg cgagatgagg acaggtctca tagaagagat
     2941 gaagagcggc cccggcgtct gggggatgat gaagatagag agccctctct tagaccagac
     3001 gatgatcggg ttccccggcg tggcatggat gatgacagag gccctagacg tggtcctgag
     3061 gaagataggt tctctcgtcg tggggcagac gatgaccggc cttcctggcg taacacagat
     3121 gatgacaggc ctcccagacg aattgccgat gaagacaggg gaaactggcg tcatgcggat
     3181 gatgacagac cacctagacg aggactggat gaggacagag gaagctggcg aacagctgat
     3241 gaggacagag gaccaagacg tgggatggat gatgaccggg ggccgaggcg aggaggcgct
     3301 gatgatgagc gatcatcctg gcgtaatgct gatgatgacc ggggtcccag gcgagggttg
     3361 gatgatgatc ggggtcccag gcgaggcatg gatgatgacc ggggtcccag gcgaggcatg
     3421 gatgatgacc ggggtcccag gcgaggcatg gatgatgacc ggggtcccag gcgagggttg
     3481 gatgatgatc gaggaccttg gaggaacgcc gatgatgaca gaattcccag gcgtggtgca
     3541 gaggatgaca ggggcccttg gagaaacatg gatgatgatc gcctttcaag acgtgctgat
     3601 gatgatcggt ttcccagacg gggtgatgac tcaagacctg gtccttggag accattagtc
     3661 aagccaggtg gatggagaga gaaagaaaaa gccagagagg agagctgggg tccacctcga
     3721 gaatcaaggc catcagaaga acgtgaatgg gacagagaaa aagaaaggga cagagataat
     3781 caagatcggg aggagaatga caaggaccct gagagagaaa gggacagaga gagagatgtg
     3841 gatcgagagg atcgcttcag aagacctagg gatgaaggtg gctggagaag aggaccagct
     3901 gaggaatctt caagctggag agactcaagt cgccgggacg atagggatag ggatgaccgt
     3961 cgccgtgaga gggatgaccg gcgtgatcta agagaaagac gagatctaag agacgacagg
     4021 gaccgaagag gacctccact cagatcagaa cgtgaagaag taagttcttg gagacgtgct
     4081 gatgacagga aagatgaccg ggtggaagag cgggaccctc ctcgtcgagt tcctccccca
     4141 gctctttcaa gagaccgaga aagagaccga gaccgagaaa gagaaggtga aaaagagaag
     4201 gcctcatgga gagctgagaa agatagggaa tctctccgtc gtactaaaaa tgagactgat
     4261 gaagatggat ggaccacagt acgacgttaa gtctcaagat aatggattta aactggtgtc
     4321 ttaaataggt ttgatcacat tcaaggatta ttatacttgt gcttcaacca atctaaattg
     4381 gattctttaa tgttgtttca ccataacaca aaaagcatga acttgtatta atcctatata
     4441 atagattgat catgcaccat atccacagga ggttggaaaa accatgccat tttctggaat
     4501 ttaagggtgt tgcattattt catcaatcat ttgttgacaa aaaagaaaaa ctaaaaaata
     4561 aatttaaaat gtgacccttc aggtattgag taacaccttt atcttggtat agaactgata
     4621 cttttttttt gattttgaaa tatctgataa taatttggaa tgaagtaagg ttctgttaaa
     4681 atatatttga agacccttta aagcagtgaa tctgaaacaa ttttcacacc cttaagtggt
     4741 tgatacgtac ctattttagg tattttgagg tatttaccat aaactaaatt tagaaatttt
     4801 ttagattcac ttgaagtaaa cattacaaac attggatacg gtggggtttt ctttagattt
     4861 tacttgagag aaggtgagta caaagcaatt tgcagttgtt gtaatgacaa gattactgcg
     4921 caagtgtgaa tccaaacagt atagctttta aattttaaag catttggtaa attatcgctg
     4981 agtttttttc tgttgccaat agcaaactgc ttttccatta atggagaatt catgcctttc
     5041 aagcatttta aatatgacaa tatttataaa tgtatggttt ggaggaatcg tttaaattct
     5101 ctttcctaat tttctttctt ttgaagatag attctttcaa caagtaattt gtagtaatga
     5161 ctgtgttgac ttcaattttg gagcgcagta gctatgttaa agatgaacta tttggtctca
     5221 ttgaagccaa cacagaactt gctgctgtgt tttttcttca gtgataaata aaatacttac
     5281 agaatttgtt ttagtgttga tttgtggtta tagtattttg tttataatgg taagtttgca
     5341 tattcagttg agtttttttt acttgaattt ttatcagtgc cattaaatgt ctgtgtttag
     5401 tatcaatgaa aatgaaccta aatataacaa agaaagcata tgtggctagg atgtccccct
     5461 aacatgtctt cctttgttaa tgcaggaatt ccttagtttc cttgtaacgc tgtcctctga
     5521 gtttgtgtgt gcatgtgcgt gtttgaagta ccaccttggg ttttcacctg aaattagaaa
     5581 aatcgtagtt aatttgagaa aatgttacaa attcatcatg gctgtaggca cttatttctg
     5641 ttattgagta gtggtgagaa ttcctattgg tacagctgta gggccagaag agggagtatt
     5701 gatgcttttt aacttaacca gatgcagcta tttttgtttg atgttaccaa tgatagaaat
     5761 cattttaaac accttagtat ctggtatttc aaatacgtag aagtctttaa aggtctttcg
     5821 tggggagaag gacttttctt tcataacaag agaatttcag atcagtgatt acaagtgggg
     5881 cagtaacttg ctaagagttt gcttcctgga gagtagatct gtatgtgtga catcacaggt
     5941 aagccccaag aatttattta atcagatttg ttcagacgag ttactgctgc ctacgttaga
     6001 gttagatttc aaggcgagtc agcaaaccca tcctttctgc tcagtctccc gtactgttct
     6061 cccaagttct ttgttctggg agtcagaacc caagtgcaag aggagggcag aagagtctga
     6121 tgctgttact ttgcgatcct gctcttggtt tccactgtcc aggccataca actctgtcta
     6181 ctcccattag tatttaccaa caggtgttaa aggaaagctg aacaagcagc ctactcaccg
     6241 atctgctagg tggtcttcca tgttcatggt ggcttctgca gtttcattga gagtaacatt
     6301 gctgttaata cagatagatc cagtagtaga gacatcatcg gtccaaaaga ctttgcatct
     6361 cattagttgt ccatagtgac taccaggagg tggctggcat ctataacgtg tgggacgttt
     6421 ttatgtaaag aactgcctgt gttttttttt ttttttaacc aaagacactg accatagatt
     6481 gacttatact tttataagtc taattgaaat acttggggta ctatgaaagg actgttcctt
     6541 gagtggctac gattagaaaa tcaggactaa caaacttttc tttgtctgga agcatatata
     6601 tttgtgatat aattttaata tgtataattt tggtttaata aatcaaatct atgacaaaa
//
