LOCUS       NM_001357734            2636 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens eukaryotic translation initiation factor 2 subunit
            gamma B (EIF2S3B), transcript variant 1, mRNA.
ACCESSION   NM_001357734
VERSION     NM_001357734.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha
            S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson
            AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ,
            Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB,
            Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC,
            Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA,
            Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C,
            Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson
            LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari
            M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ,
            Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q,
            Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V,
            Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE,
            Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I,
            Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C,
            Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM,
            Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A,
            Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M,
            Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M,
            Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal
            B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM,
            Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua
            P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG,
            Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E,
            Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris
            S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO,
            Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ,
            Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin
            W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB,
            Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle
            RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague
            B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB,
            Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT,
            Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen
            J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock
            G and Gibbs RA.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Marques AC, Dupanloup I, Vinckenbosch N, Reymond A and Kaessmann H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068775.52.
            
            On Jan 15, 2021 this sequence version replaced NM_001357734.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR3218371.335706.1,
                                        ERR3218374.206948.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538173.2/ ENSP00000445077.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2636              AC068775.52        90075-92710
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2636
                     /gene="EIF2S3B"
                     /gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
                     /note="eukaryotic translation initiation factor 2 subunit
                     gamma B"
                     /db_xref="GeneID:255308"
                     /db_xref="HGNC:HGNC:43863"
     exon            1..2636
                     /gene="EIF2S3B"
                     /gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1432
                     /gene="EIF2S3B"
                     /gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative eukaryotic translation initiation factor 2
                     subunit 3-like protein; eukaryotic translation initiation
                     factor 2, subunit 3 gamma, 52kDa; eukaryotic translation
                     initiation factor 2 subunit 3B; eIF-2-gamma2"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2
                     subunit 3B isoform 1"
                     /protein_id="NP_001344663.1"
                     /db_xref="CCDS:CCDS91654.1"
                     /db_xref="GeneID:255308"
                     /db_xref="HGNC:HGNC:43863"
                     /translation="MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINI
                     GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECY
                     RSCGSSMPDEFPTDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIA
                     GNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEG
                     APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKG
                     GVAGGSILKGVLKVGQETEVRPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPG
                     GLIGVGTKIDPTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKA
                     AKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKH
                     WRLIGWGQIRRGVTIKPTVDDD"
     regulatory      2078..2083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF2S3B"
                     /gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
                     /note="hexamer: AATAAA"
     polyA_site      2102
                     /gene="EIF2S3B"
                     /gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
                     /note="major polyA site"
ORIGIN      
        1 ctcttttggc aacatggcgg gcggagaagc tggggtgact ctggggcagc cgcacctttc
       61 gcgtcaggat ctcaccacct tggatgttac caagttgacg ccactttcac acgaagttat
      121 cagcagacaa gccacaatta atataggtac aattggtcat gtagctcatg ggaaatccac
      181 agtcgtcaaa gctatttctg gagttcacac cgtcaggttc aaaaatgaac tagaaagaaa
      241 tattacaatc aagcttggat atgctaatgc taagatttat caacttgatg acccaagttg
      301 ccctcggcca gaatgttatc gatcttgtgg gagcagtatg cctgatgagt ttcctacaga
      361 cattccagga accaaaggga acttcagatt agtcagacat gtttcctttg ttgactgtcc
      421 tggccacgat attttgatgg ctactatgct gaacggtgca gcagtgatgg atgcagctct
      481 tctgttgata gctggtaatg aatcttgccc tcagcctcag acatctgaac acctggctgc
      541 tatagagatc atgaaactga agcatatttt gattctacaa aataaaattg atttggtaaa
      601 agaaaggcag gctaaagaac aatacgagca gatccttgcg tttgtccaag gtacagtagc
      661 agagggagct cccattattc caatttcggc tcagctgaaa tacaatattg aagttgtttg
      721 tgagtacata gtaaagaaaa ttccagtacc cccaagagac tttacttcag agccccggct
      781 tattgttatt agatcttttg atgtcaacaa acctggctgt gaagttgatg accttaaggg
      841 aggtgtagct ggtggtagta tcctaaaagg agtattaaag gtgggccagg agacagaagt
      901 aagacctggt attgtttcca aagatagtga aggaaaactc atgtgtaaat caatcttttc
      961 caaaattgtt tcactttttg cggagcataa tgatctgcaa tatgctgctc caggcggtct
     1021 tattggagtt ggaacaaaaa ttgaccccac tttgtgccgg gctgacagaa tggtggggca
     1081 aatacttggt gcagtcggag ctttacctga gatattcaca gaattggaaa tttcctattt
     1141 cctgcttaga cggcttctag gtgtacgcac tgaaggagac aagaaagcag caaaggttca
     1201 aaagctgtct aagaatgaag tgctcatggt gaacatagga tccctgtcga caggagggag
     1261 agttagtgct gtcaaggccg atttgggcaa aattgttttg accaatccag tgtgcacaga
     1321 ggtaggagaa aaaattgccc ttagccgaag agttgaaaaa cactggcgtt taattggttg
     1381 gggtcagata agaagaggag tgacaatcaa gccaacagta gatgatgact gaagaatacc
     1441 ggttaaataa tacattcgga tggagctgga agttgcaatt tctctttaac aaccaagggg
     1501 tttattttca aagcgatatt ggggaattga tttcacagtt tgttacctta gtaggtaacg
     1561 gtaaggttat tctctctttt tttttttggt tatgaaaact tagggactac aattagtata
     1621 aaaattggca taatgttgga ttgaatctac attttggcag aagttaagca ttcccacata
     1681 atgtcaaaat tatacattat gcagtttttt tgtttgtttt attttgtttt gtttttgagt
     1741 ctggctttgt cacctaggct ggcatgtagt ggcatgatct gcaatctctg cctcccaggt
     1801 tcaagcgatt ctcctgcctc agccccccaa gtagctgaga ttacaggtgt gtgccaccac
     1861 acggggctaa tttttgtatt agtagagacg gggtttcggc atgttggcca ggccagtctc
     1921 tcctgacctc agggtgatca gcccacctcg gcctcacaaa gtgccgggat tacaggcgtg
     1981 agccaccttg cctagcccac atcatgcagt ttgaaatgaa actttgccac aaccagcctt
     2041 tgctgtagca cacacatata tcactgaaac tgttcgaaat aaagtttttt tttgtttttc
     2101 atgattcgtc tttgagtacc tccaggctga aggactgttg taccagtaaa aacttaaagg
     2161 cacaaattat ccttgaagac cttctccctt ttctttggcc ccatatttta tgttgcttta
     2221 tctttgaaat tttgcatgaa aaggatgcaa tgaatgggtt cgaattgcat gaaaaggatg
     2281 cacgaatggg ttcgaatgaa attgtccttt agagcatgat tacttgttcc catgggcaaa
     2341 taattttctc cccttgctct tcctggcctg aaatacggga aactagagtc agaagttatc
     2401 tccctctccc tgtgatgcct tgagatgttt ttctgcattg ttttatgcct gaaatccaat
     2461 agtcttcctc cattggaaaa tactgttata ccaaataatt ctagatgagt aacaaagatc
     2521 cttctaggcc ttcattttat gttttttctt aactgttata tgattgtgac acagattata
     2581 atattactaa tttttggatg tttcaaaagg tcaataagta aaagatgtta gaaagc
//
