LOCUS       NM_006893               2011 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 2D (EIF2D),
            transcript variant 1, mRNA.
ACCESSION   NM_006893
VERSION     NM_006893.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Grove,D.J., Russell,P.J. and Kearse,M.G.
  TITLE     To initiate or not to initiate: A critical assessment of eIF2A,
            eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes
  JOURNAL   Wiley Interdiscip Rev RNA 15 (2), e1833 (2024)
   PUBMED   38433101
  REMARK    GeneRIF: To initiate or not to initiate: A critical assessment of
            eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to
            ribosomes.
            Review article
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Kim,H., Aponte-Diaz,D., Sotoudegan,M.S., Shengjuler,D., Arnold,J.J.
            and Cameron,C.E.
  TITLE     The enterovirus genome can be translated in an IRES-independent
            manner that requires the initiation factors eIF2A/eIF2D
  JOURNAL   PLoS Biol 21 (1), e3001693 (2023)
   PUBMED   36689548
  REMARK    GeneRIF: The enterovirus genome can be translated in an
            IRES-independent manner that requires the initiation factors
            eIF2A/eIF2D.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2011)
  AUTHORS   Gilabert-Juan,J., Lopez-Campos,G., Sebastia-Ortega,N.,
            Guara-Ciurana,S., Ruso-Julve,F., Prieto,C., Crespo-Facorro,B.,
            Sanjuan,J. and Molto,M.D.
  TITLE     Time dependent expression of the blood biomarkers EIF2D and TOX in
            patients with schizophrenia
  JOURNAL   Brain Behav Immun 80, 909-915 (2019)
   PUBMED   31078689
  REMARK    GeneRIF: We observed a positive correlation trend between EIF2D
            mRNA levels and years of schizophrenia (SZ) disease (p=0.0794;
            r=0.35). We found a trend of an increase in the expression levels
            of EIF2D (p=0.0634) in patients suffering from the disease more
            than 10years compared with the SZ patients from the other subgroup
            .
REFERENCE   4  (bases 1 to 2011)
  AUTHORS   Basu,K., Maurya,N., Kaur,J., Saxena,R., Gupta,V., Sihota,R. and
            Ghosh,I.
  TITLE     Possible role of differentially expressing novel protein markers
            (ligatin and fibulin-7) in human aqueous humor and trabecular
            meshwork tissue in glaucoma progression
  JOURNAL   Cell Biol Int 43 (7), 820-834 (2019)
   PUBMED   30958601
  REMARK    GeneRIF: this is the first report which confirms the presence of
            ligatin and fibulin-7 in human aqueous humor, quantified their
            differential expression, and indicated the possibility of their
            involvement in the maintenance of the trabecular meshwork structure
            in glaucoma progression.
REFERENCE   5  (bases 1 to 2011)
  AUTHORS   Akulich,K.A., Sinitcyn,P.G., Makeeva,D.S., Andreev,D.E.,
            Terenin,I.M., Anisimova,A.S., Shatsky,I.N. and Dmitriev,S.E.
  TITLE     A novel uORF-based regulatory mechanism controls translation of the
            human MDM2 and eIF2D mRNAs during stress
  JOURNAL   Biochimie 157, 92-101 (2019)
   PUBMED   30419262
  REMARK    GeneRIF: a novel uORF-based regulatory mechanism that is employed
            under conditions of hyperosmotic stress by at least two human
            mRNAs, coding for translation reinitiation/recycling factor eIF2D
            and E3 ubiquitin ligase MDM2. This novel mode of translational
            control selectively downregulates their expression and requires as
            few as one uORF.
REFERENCE   6  (bases 1 to 2011)
  AUTHORS   Sanz,M.A., Gonzalez Almela,E. and Carrasco,L.
  TITLE     Translation of Sindbis Subgenomic mRNA is Independent of eIF2,
            eIF2A and eIF2D
  JOURNAL   Sci Rep 7, 43876 (2017)
   PUBMED   28240315
  REMARK    GeneRIF: Data suggest that neither eIF2A nor eIF2D are involved in
            the translation of this Sindbis virus subgenomic mRNA (sgmRNA)
            bearing non-AUG codons
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2011)
  AUTHORS   Dmitriev,S.E., Terenin,I.M., Andreev,D.E., Ivanov,P.A.,
            Dunaevsky,J.E., Merrick,W.C. and Shatsky,I.N.
  TITLE     GTP-independent tRNA delivery to the ribosomal P-site by a novel
            eukaryotic translation factor
  JOURNAL   J Biol Chem 285 (35), 26779-26787 (2010)
   PUBMED   20566627
REFERENCE   8  (bases 1 to 2011)
  AUTHORS   Skabkin,M.A., Skabkina,O.V., Dhote,V., Komar,A.A., Hellen,C.U. and
            Pestova,T.V.
  TITLE     Activities of Ligatin and MCT-1/DENR in eukaryotic translation
            initiation and ribosomal recycling
  JOURNAL   Genes Dev 24 (16), 1787-1801 (2010)
   PUBMED   20713520
REFERENCE   9  (bases 1 to 2011)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 2011)
  AUTHORS   Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
            Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
            and Chen,W.F.
  TITLE     Large scale identification of human hepatocellular
            carcinoma-associated antigens by autoantibodies
  JOURNAL   J Immunol 169 (2), 1102-1109 (2002)
   PUBMED   12097419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI465059.1 and BC058905.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006893.2.
            
            Summary: This gene encodes a translation initiation factor involved
            in the recruitment and delivery of aminoacyl-tRNAs to the P-site of
            the eukaryotic ribosome in a GTP-independent manner. This gene was
            previously referred to as ligatin, but is now known to localize to
            the cytoplasm and localize and function with translation factors.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.205242.1, AK001852.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271764.7/ ENSP00000271764.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BI465059.1         92-140
            50-2011             BC058905.1         1-1962
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2011
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /note="eukaryotic translation initiation factor 2D"
                     /db_xref="GeneID:1939"
                     /db_xref="HGNC:HGNC:6583"
                     /db_xref="MIM:613709"
     exon            1..179
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1878
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ligatin; hepatocellular carcinoma-associated antigen 56"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 2D
                     isoform 1"
                     /protein_id="NP_008824.2"
                     /db_xref="CCDS:CCDS1465.1"
                     /db_xref="GeneID:1939"
                     /db_xref="HGNC:HGNC:6583"
                     /db_xref="MIM:613709"
                     /translation="MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPG
                     KEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLV
                     LEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSG
                     LKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHM
                     TLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHAL
                     KCRVKKADLPLLTSTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKE
                     LSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMT
                     LLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQH
                     TVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVR
                     NLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQL
                     PRKHIQGLEKALKPGKKK"
     exon            180..370
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            371..454
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            455..545
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            546..653
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            654..907
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1025
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1071
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1175
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1325
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1415
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1511
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1632
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1807
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2011
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /note="hexamer: AATAAA"
     polyA_site      2011
                     /gene="EIF2D"
                     /gene_synonym="HCA56; LGTN"
                     /note="major polyA site"
ORIGIN      
        1 ccttttcgcg gccgggcccc agcatggctg cccccacggc tgagggcctg gcagctgctg
       61 cgccctcgct ttcttgacat tccctggctt ctgtgctctc ttccccaggc caccccagca
      121 gacatgtttg ccaaggcctt tcgggtcaag tccaacacgg ccatcaaggg gtcggacagg
      181 agaaagcttc gagctgatgt gacaactgct ttccccaccc ttggaactga tcaagtctct
      241 gagttagtac ctggaaagga ggagctcaac attgtgaagt tgtatgctca caaaggggat
      301 gcagtgactg tgtacgtgag tggtggtaac cccatcctct ttgaactgga gaaaaatctg
      361 tatccaacag tgtacacgct gtggtcctat cctgatcttc tgccaacctt tacaacatgg
      421 cctctggtgc tcgagaaact ggtaggggga gcagatttga tgctgcctgg actggtgatg
      481 ccccctgctg gtctgcctca ggtacagaag ggcgacctct gtgccatttc tttggtgggg
      541 aacagagccc ctgtagccat tggagttgca gccatgtcca cagctgagat gctcacgtca
      601 ggcctgaagg gaaggggctt ctctgtgctc cacacttacc aggaccactt gtggcggtct
      661 ggaaacaagt cctctccacc ttccattgct ccactggccc tggattcagc agatctcagt
      721 gaagagaagg ggtctgtcca gatggactcc accctgcagg gagacatgag gcacatgacc
      781 ctggaggggg aagaggagaa tggggaggtt caccaggcac gtgaagacaa gtctctctca
      841 gaagccccag aagacaccag caccaggggc ctgaaccaag actccacaga tagcaaaacg
      901 cttcaagaac aaatggatga gctgttacag caatgcttct tacatgcctt gaagtgccga
      961 gtcaaaaagg ctgacctccc tttactcacc agcactttcc ttggcagcca catgttctcc
     1021 tgctgccccg aaggacgaca actggacata aagaagtcaa gctacaaaaa gctctctaag
     1081 ttcctgcagc aaatgcagca ggagcagatt atacaggtga aggagctgag caaaggggtg
     1141 gagagcattg tggctgtgga ctggaaacac ccgaggatta catctttcgt catacccgag
     1201 ccctccccga cctcccagac tatccaggag ggtagcaggg aacagcccta tcaccctcca
     1261 gatataaaac ccctctactg tgtcccagcc agcatgaccc tgctcttcca ggagtctggc
     1321 cacaagaagg ggagctttct ggagggcagt gaggtccgaa cgatcgtcat taactacgcc
     1381 aagaaaaatg acctggttga tgcagacaac aaaaatcttg tgagattgga tcccatccta
     1441 tgtgactgca tcttagagaa aaatgaacag catacagtca tgaagcttcc atgggacagt
     1501 cttctgacca ggtgtttgga aaaattacag cctgcctatc aagtgaccct tcccggacaa
     1561 gagcccattg tgaagaaagg gagaatctgt ccaattgaca tcaccctagc acaaagagcg
     1621 tctaataaaa aggtgaccgt ggtccggaac ttggaggcct atggtctgga cccatactca
     1681 gtggctgcca tccttcagca gcgatgccag gctagcacca ccgtcaatcc tgcccctggg
     1741 gccaaggaca gccttcaggt gcagatccag ggaaaccagg tccaccacct cggctggcta
     1801 ttgcttgaag agtatcagct ccctcgaaaa cacatccaag gtctagaaaa ggccctcaaa
     1861 cctggcaaga agaagtgaca gactcttttg tctcacgtgg tggatccggt ggaaatccaa
     1921 gctctgggct ggtaattttt atgagcattt tcagcttttg caaatacaaa atataattct
     1981 ttacaaaaat aaatttttat tctaatctaa a
//
