LOCUS       NM_005875                987 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 1B (EIF1B),
            mRNA.
ACCESSION   NM_005875
VERSION     NM_005875.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 987)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 987)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   5  (bases 1 to 987)
  AUTHORS   Fields,C. and Adams,M.D.
  TITLE     Expressed sequence tags identify a human isolog of the suil
            translation initiation factor
  JOURNAL   Biochem Biophys Res Commun 198 (1), 288-291 (1994)
   PUBMED   7904817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006996.1 and AA521449.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005875.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006996.1, SRR5189655.8731.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232905.4/ ENSP00000232905.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-853               BC006996.1         10-862
            854-925             AA521449.1         12-83               c
            926-987             BC006996.1         936-997
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..987
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="eukaryotic translation initiation factor 1B"
                     /db_xref="GeneID:10289"
                     /db_xref="HGNC:HGNC:30792"
     exon            1..266
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..577
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="translation factor sui1 homolog; protein
                     translation factor SUI1 homolog GC20"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 1b"
                     /protein_id="NP_005866.1"
                     /db_xref="CCDS:CCDS2690.1"
                     /db_xref="GeneID:10289"
                     /db_xref="HGNC:HGNC:30792"
                     /translation="MSTIQNLQSFDPFADATKGDDLLPAGTEDYIHIRIQQRNGRKTL
                     TTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLLEVGI
                     VKEEQLKVHGF"
     exon            267..430
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /inference="alignment:Splign:2.1.0"
     exon            431..532
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /inference="alignment:Splign:2.1.0"
     exon            533..987
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      906..911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="hexamer: AATAAA"
     polyA_site      925
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="major polyA site"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="hexamer: AGTAAA"
     regulatory      965..970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="hexamer: AATACA"
     polyA_site      968
                     /gene="EIF1B"
                     /gene_synonym="GC20"
                     /note="major polyA site"
     polyA_site      987
                     /gene="EIF1B"
                     /gene_synonym="GC20"
ORIGIN      
        1 gagaagccgc agcgccgcct cttctctcgc gccctcgcct cttcctccgc ctcctccttc
       61 gcctcttcct gcctcctccc ggcttccgcc gccgccactc cagcctaatc ccaaccccag
      121 ggcgaagcgt tttcttattt atttccgttt tctcgccact acagcctcct gacaaggtga
      181 tccgggcggg ccccgcagga attttatccc ctcaccggcc tcacactagt atcgcatgtc
      241 cactatccag aacctccaat ctttcgaccc ctttgctgat gcaactaagg gtgacgactt
      301 actcccggca gggactgagg attacattca tataagaatc cagcaacgga acggcagaaa
      361 gacactgact actgttcagg gcattgcaga tgattatgac aaaaagaaac ttgtgaaagc
      421 tttcaaaaag aaatttgcct gtaatggtac tgtgattgaa catcctgaat acggagaggt
      481 tattcagctt caaggtgacc aaagaaaaaa catctgccag tttctcttgg aggttggcat
      541 tgtaaaggag gaacagctta aggttcatgg attctaaaat gaacctaaat acgtggagaa
      601 tttcttgaat agttttgttc tctaaacccg gtttggctgc cttgtgaaat gattccctgc
      661 agtaaacgga cttttcattt atttaatcat tcaaacttcc attcacatct gcatgattac
      721 agaaaacatg gggtatgtag actagtaaca cataagaaaa ttgcagtaag atggtaacaa
      781 aacctcatat tgtctttaca tgtttccaat ggaaaatgtt ttgagtgttt attgttcagt
      841 ttattacgtt tcacttgatt aaattttttt gttgttgtat taaaccatgt acgttgcagc
      901 ttaacaataa aaaaaaatct atgaatcttt gtgagcaatt atgctcccaa atctaagcaa
      961 gtaaaataca cattttgtct ttcttaa
//
