LOCUS       NM_004681               1339 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 1A Y-linked
            (EIF1AY), transcript variant 1, mRNA.
ACCESSION   NM_004681
VERSION     NM_004681.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Luna,R.E., Arthanari,H., Hiraishi,H., Akabayov,B., Tang,L., Cox,C.,
            Markus,M.A., Luna,L.E., Ikeda,Y., Watanabe,R., Bedoya,E., Yu,C.,
            Alikhan,S., Wagner,G. and Asano,K.
  TITLE     The interaction between eukaryotic initiation factor 1A and eIF5
            retains eIF1 within scanning preinitiation complexes
  JOURNAL   Biochemistry 52 (52), 9510-9518 (2013)
   PUBMED   24319994
  REMARK    GeneRIF: The N-terminal tail of eIF1A mediates the interaction with
            eIF5 and eIF1.
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Tian,Y., Stamova,B., Jickling,G.C., Xu,H., Liu,D., Ander,B.P.,
            Bushnell,C., Zhan,X., Turner,R.J., Davis,R.R., Verro,P.,
            Pevec,W.C., Hedayati,N., Dawson,D.L., Khoury,J., Jauch,E.C.,
            Pancioli,A., Broderick,J.P. and Sharp,F.R.
  TITLE     Y chromosome gene expression in the blood of male patients with
            ischemic stroke compared with male controls
  JOURNAL   Gend Med 9 (2), 68-75 (2012)
   PUBMED   22365286
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   Kichine,E., Roze,V., Di Cristofaro,J., Taulier,D., Navarro,A.,
            Streichemberger,E., Decarpentrie,F., Metzler-Guillemain,C.,
            Levy,N., Chiaroni,J., Paquis-Flucklinger,V., Fellmann,F. and
            Mitchell,M.J.
  TITLE     HSFY genes and the P4 palindrome in the AZFb interval of the human
            Y chromosome are not required for spermatocyte maturation
  JOURNAL   Hum Reprod 27 (2), 615-624 (2012)
   PUBMED   22158087
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Yang,B., Wang,H., Gao,X.K., Chen,B.Q., Zhang,Y.Q., Liu,H.L.,
            Wang,Y., Qin,W.J., Qin,R.L., Shao,G.X. and Shao,C.
  TITLE     Expression and significance of Rap1A in testes of azoospermic
            subjects
  JOURNAL   Asian J Androl 6 (1), 35-40 (2004)
   PUBMED   15064832
  REMARK    Erratum:[Asian J Androl. 2004 Jun;6(2):98]
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Agate,R.J., Choe,M. and Arnold,A.P.
  TITLE     Sex differences in structure and expression of the sex chromosome
            genes CHD1Z and CHD1W in zebra finches
  JOURNAL   Mol Biol Evol 21 (2), 384-396 (2004)
   PUBMED   14660691
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Lau,Y.F. and Zhang,J.
  TITLE     Expression analysis of thirty one Y chromosome genes in human
            prostate cancer
  JOURNAL   Mol Carcinog 27 (4), 308-321 (2000)
   PUBMED   10747295
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG499107.1, BC005248.1,
            AF000987.1 and AC007678.3.
            
            On Nov 22, 2018 this sequence version replaced NM_004681.3.
            
            Summary: This gene is located on the non-recombining region of the
            Y chromosome. It encodes a protein related to eukaryotic
            translation initiation factor 1A (EIF1A), which may function in
            stabilizing the binding of the initiator Met-tRNA to 40S ribosomal
            subunits. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF000987.1, SRR5189655.181521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361365.7/ ENSP00000354722.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BG499107.1         52-104
            54-815              BC005248.1         1-762
            816-868             AF000987.1         852-904
            869-869             AC007678.3         23568-23568
            870-1339            AF000987.1         906-1375
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..1339
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /note="eukaryotic translation initiation factor 1A
                     Y-linked"
                     /db_xref="GeneID:9086"
                     /db_xref="HGNC:HGNC:3252"
                     /db_xref="MIM:400014"
     exon            1..112
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..531
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic translation initiation factor 1A, Y chromosome;
                     eukaryotic translation initiation factor 1A,
                     Y-chromosomal; eukaryotic translation initiation factor
                     4C; eIF1A Y isoform"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 1A,
                     Y-chromosomal isoform 1"
                     /protein_id="NP_004672.2"
                     /db_xref="CCDS:CCDS14795.1"
                     /db_xref="GeneID:9086"
                     /db_xref="HGNC:HGNC:3252"
                     /db_xref="MIM:400014"
                     /translation="MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGN
                     GRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARS
                     LKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI"
     exon            113..196
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     exon            197..300
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     exon            301..351
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     exon            352..433
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     exon            434..525
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1339
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      789..794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /note="hexamer: AATAAA"
     polyA_site      815
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /note="major polyA site"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
                     /note="hexamer: AATAAA"
     polyA_site      1339
                     /gene="EIF1AY"
                     /gene_synonym="eIF-4C"
ORIGIN      
        1 gcgcacccac ctgctgcatc ttagttcagt cggctcttag agtagtaacc gccagaaagg
       61 agtcggaaga ggtctcacga ggctgtcatc accgccatgc ccaagaataa aggtaaagga
      121 ggtaaaaaca ggcgcagggg taaaaatgag aatgaatctg aaaaaagaga gttggtgttt
      181 aaagaggatg gacaagagta tgctcaggta atcaaaatgt tgggaaatgg acgattggaa
      241 gcattgtgtt ttgatggtgt aaagaggtta tgccatatca gagggaaatt gagaaaaaag
      301 gtttggataa atacatcaga cattatattg gttggtctac gggactatca ggataacaaa
      361 gctgatgtaa ttttaaagta caatgcagat gaagctagaa gcctgaaggc atatggcgag
      421 cttccagaac atgctaaaat caatgaaaca gacacatttg gtcctggaga tgatgatgaa
      481 atccagtttg acgatattgg agatgatgat gaagacattg atgatatcta aattgaacca
      541 agtgttttta catgacaagt tctctgagga tggttctaca gttgggattt tggccatcat
      601 caaccaagaa gagaaattca tttagtgtgt agtttctgaa agcaaactga tttattttca
      661 ttgttttaaa gtatttattt ctttaaaagc tgaggacact gaattacctt aagttaaatg
      721 ttaatacttt attgttttga tgtaatggaa cttaaggata aaagaccata atatttgctg
      781 ttaaaataaa taaacgagtg cctttcctac tgtgataacg tcaagtaatt ggatattttg
      841 aatacatttc tgcctgataa tcatgctggg ttctaataag ccctacttcc acctaatctg
      901 tttacagtct tttggtatgt ttcagttact tagatggtct cataaggttt ctgatacaat
      961 ttgaagacag aaatctgcat ttagaatcag aaaacatgga catatttttc atatttatct
     1021 agtcatatgt aattttatgc taacattgat agtttataaa tccttttcat cctttgtgcc
     1081 tcggttatta aggaaaaaaa aatgtccaac atacagtttt taaagtgtgg cagttttgag
     1141 tagtaactta gaatgtataa gattaagagt taaagaaacc gaacaataag tggcaaccaa
     1201 ttatcttaac attggaaata ctggggtgcc attttgtttt caaaagttat tcattgtaat
     1261 ccactgtttt ggctttcatg aacaagtaaa ttacagtgta taaatgaaaa gcaatttcat
     1321 aataaattct ataaactga
//
