LOCUS       NM_001412               4414 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens eukaryotic translation initiation factor 1A X-linked
            (EIF1AX), mRNA.
ACCESSION   NM_001412 XM_942595
VERSION     NM_001412.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4414)
  AUTHORS   Ye,Y., Lv,C., Sun,J., Lin,Z., Liu,Y., Huang,Y., Chen,Y., Li,H.,
            Lian,X., Jiang,X., Zhang,S. and Wang,S.
  TITLE     XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor
            Migration and Invasion in Endometrial Carcinoma
  JOURNAL   Oxid Med Cell Longev 2022, 1361135 (2022)
   PUBMED   36589683
  REMARK    GeneRIF: XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor
            Migration and Invasion in Endometrial Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4414)
  AUTHORS   Elsherbini,N., Kim,D.H., Payne,R.J., Hudson,T., Forest,V.I.,
            Hier,M.P., Payne,A.E. and Pusztaszeri,M.P.
  TITLE     EIF1AX mutation in thyroid tumors: a retrospective analysis of
            cytology, histopathology and co-mutation profiles
  JOURNAL   J Otolaryngol Head Neck Surg 51 (1), 43 (2022)
   PUBMED   36371345
  REMARK    GeneRIF: EIF1AX mutation in thyroid tumors: a retrospective
            analysis of cytology, histopathology and co-mutation profiles.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4414)
  AUTHORS   Lapointe,C.P., Grosely,R., Sokabe,M., Alvarado,C., Wang,J.,
            Montabana,E., Villa,N., Shin,B.S., Dever,T.E., Fraser,C.S.,
            Fernandez,I.S. and Puglisi,J.D.
  TITLE     eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit
            joining
  JOURNAL   Nature 607 (7917), 185-190 (2022)
   PUBMED   35732735
  REMARK    GeneRIF: eIF5B and eIF1A reorient initiator tRNA to allow ribosomal
            subunit joining.
REFERENCE   4  (bases 1 to 4414)
  AUTHORS   Karslioglu French,E., Nikitski,A.V., Yip,L., Nikiforova,M.N.,
            Nikiforov,Y.E. and Carty,S.E.
  TITLE     Clinicopathological features and outcomes of thyroid nodules with
            EIF1AX mutations
  JOURNAL   Endocr Relat Cancer 29 (8), 467-473 (2022)
   PUBMED   35609001
  REMARK    GeneRIF: Clinicopathological features and outcomes of thyroid
            nodules with EIF1AX mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4414)
  AUTHORS   Lv,C., Sun,J., Ye,Y., Lin,Z., Li,H., Liu,Y., Mo,K., Xu,W., Hu,W.,
            Draz,E. and Wang,S.
  TITLE     Long noncoding RNA EIF1AX-AS1 promotes endometrial cancer cell
            apoptosis by affecting EIF1AX mRNA stabilization
  JOURNAL   Cancer Sci 113 (4), 1277-1291 (2022)
   PUBMED   35080085
  REMARK    GeneRIF: Long noncoding RNA EIF1AX-AS1 promotes endometrial cancer
            cell apoptosis by affecting EIF1AX mRNA stabilization.
REFERENCE   6  (bases 1 to 4414)
  AUTHORS   Choi,S.K., Olsen,D.S., Roll-Mecak,A., Martung,A., Remo,K.L.,
            Burley,S.K., Hinnebusch,A.G. and Dever,T.E.
  TITLE     Physical and functional interaction between the eukaryotic
            orthologs of prokaryotic translation initiation factors IF1 and IF2
  JOURNAL   Mol Cell Biol 20 (19), 7183-7191 (2000)
   PUBMED   10982835
REFERENCE   7  (bases 1 to 4414)
  AUTHORS   Battiste,J.L., Pestova,T.V., Hellen,C.U. and Wagner,G.
  TITLE     The eIF1A solution structure reveals a large RNA-binding surface
            important for scanning function
  JOURNAL   Mol Cell 5 (1), 109-119 (2000)
   PUBMED   10678173
REFERENCE   8  (bases 1 to 4414)
  AUTHORS   Pestova,T.V., Borukhov,S.I. and Hellen,C.U.
  TITLE     Eukaryotic ribosomes require initiation factors 1 and 1A to locate
            initiation codons
  JOURNAL   Nature 394 (6696), 854-859 (1998)
   PUBMED   9732867
REFERENCE   9  (bases 1 to 4414)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
REFERENCE   10 (bases 1 to 4414)
  AUTHORS   Dever,T.E., Wei,C.L., Benkowski,L.A., Browning,K., Merrick,W.C. and
            Hershey,J.W.
  TITLE     Determination of the amino acid sequence of rabbit, human, and
            wheat germ protein synthesis factor eIF-4C by cloning and chemical
            sequencing
  JOURNAL   J Biol Chem 269 (5), 3212-3218 (1994)
   PUBMED   8106356
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL732366.7 and L18960.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001412.3.
            
            Summary: This gene encodes an essential eukaryotic translation
            initiation factor. The protein is required for the binding of the
            43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5'
            end of capped RNA. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.256397.1,
                                           SRR1803617.7738.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379607.10/ ENSP00000368927.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL732366.7         167917-168130       c
            215-293             L18960.1           224-302
            294-298             AL732366.7         164831-164835       c
            299-905             L18960.1           308-914
            906-4414            AL732366.7         150817-154325       c
FEATURES             Location/Qualifiers
     source          1..4414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..4414
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /note="eukaryotic translation initiation factor 1A
                     X-linked"
                     /db_xref="GeneID:1964"
                     /db_xref="HGNC:HGNC:3250"
                     /db_xref="MIM:300186"
     exon            1..214
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..633
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /note="eukaryotic translation initiation factor 4C;
                     eukaryotic translation initiation factor 1A, X chromosome;
                     Putative eukaryotic translation initiation factor 1A;
                     eIF1A X isoform"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 1A,
                     X-chromosomal"
                     /protein_id="NP_001403.1"
                     /db_xref="CCDS:CCDS14196.1"
                     /db_xref="GeneID:1964"
                     /db_xref="HGNC:HGNC:3250"
                     /db_xref="MIM:300186"
                     /translation="MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGN
                     GRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARS
                     LKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI"
     exon            215..298
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     exon            299..402
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     exon            403..453
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     exon            454..535
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     exon            536..627
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     exon            628..4414
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /note="hexamer: AATAAA"
     polyA_site      4414
                     /gene="EIF1AX"
                     /gene_synonym="eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C"
                     /note="major polyA site"
ORIGIN      
        1 gccatttgct gccgccgagc gtggacgcag gcggatctct gaagagctgg gtcgccagcc
       61 tctcccgcgc acgttgcctg gcctccagca cctacttggt cccgcgcgct ccctcgtgtc
      121 gcccctcgga gcagcagccg ccgcggtcgc cgctacccgg aaagaagtca gagacgccgc
      181 gaggtcgccg ccaccgccat gcccaagaat aaaggtaaag gaggtaaaaa cagacgcagg
      241 ggtaagaatg agaatgaatc tgaaaaaaga gaactggtat tcaaagagga tggtcaggag
      301 tatgctcagg taatcaaaat gttgggaaat ggacggctag aagcaatgtg tttcgatggt
      361 gtaaagaggt tatgtcacat cagaggaaaa ttgagaaaaa aggtttggat aaatacctcg
      421 gacattattt tggttggtct ccgagactac caggataaca aagctgatgt aattttaaaa
      481 tacaatgcag acgaagctag aagtctgaag gcatacggcg agcttccaga gcatgctaaa
      541 atcaatgaaa ctgatacatt tggtcctgga gatgatgatg aaattcagtt tgatgacatt
      601 ggagatgatg atgaagatat tgatgacatc taaattgaac tcaacatttt acattccatc
      661 ttttctgaag attgtcctac aatttggatt ttgatcatga caaagaagat taaaatttca
      721 ttagcatgaa tgcaatttgt taaagcagac tgatttgttt ctaagatatt tttggttttt
      781 ttaaaactga taataatgct gaattatctt aagtgagatg ttaagcccac tttgttcttt
      841 taatgtaatg gagcttatgg gtagaagacc atgtctacta attacaaaaa aaaaaaaaaa
      901 ccatgcattg ctgcttttcc taccacttcc agtaagaaaa tgggtgtttt gaagaaatca
      961 tttgccttgt cctcacggaa tctgattaag ccctggcctc ttgattgtat agagtcattg
     1021 tgtatattcc agttacctag atattccctt gagattttga tacaatttga gggaggcaga
     1081 agtctgcagt tgaagaaaaa aaataagtct gtttgtcata tttaagtagc ctgtggctat
     1141 ttttatactg attttgatat catgttcttt tcatagtcgt attttgccac cgtaaacata
     1201 aaaaaaaaaa aaaagatttc caaaatgccg ttttcagaac ctgggtttta atagcagtat
     1261 tgaatttgta agcttagtag ttgcagaaat tgaacactag gtggcactca gttatcttaa
     1321 caggggaagt actgatacaa ttgttgactt ttcttttact atgtgtaaga aataccccaa
     1381 acatgaaaag attgttttga tcatatgcat gtatgtagaa tatttttgca gagcagaaag
     1441 attatgttag aagtgtgatt tttattttca gaagtcatat acatgtaagc tacaattttg
     1501 agtgctttat aaacacttaa gatatatata taaattttaa tttcatagca acttgtaaaa
     1561 aataaaatac ttgttgaaaa gcctttttca acatatccct aagctaaggg aagaggaagg
     1621 aataacaact cagtgaaaag atggtctcca gtttctgaat gaaaaagcta cagctgagaa
     1681 ataaaataaa atgtcatgct gcagaatatg ttataccctt attttgtgtt aaggatatat
     1741 tttattatgt gaatggtttt gtttttgttt tttgtttttg ttttttgctt gtattgggaa
     1801 ttagctttac tggtaacttc cttatttagt ttttagtggt caactctaat aaaatgaaac
     1861 tagggctgag ctagttagcc ctcactagcc aaactgaaac tctatgcaac attaaaagaa
     1921 gagatccatc atgtagcttg tgacactttt attttattag tcaccgggga acttttcagt
     1981 gatgaaaata cacagggtaa taaaccttca catggcttca aaaggaaaac aagcaaatct
     2041 tctctaatct actcttacta taatttccta agtgtacacc aaactctgga tttaaaaatc
     2101 tgaagtacta tagaacatta agttgaagaa tggaaattaa gagtacgtat tcatggttta
     2161 tatttcttat tctatggagt tcgtgaacac atctaggtgg aatgcatctg agactaaggg
     2221 ctggttttta atcctcataa gaaaccagcc ttgaagaatt aacaattctc ttcattggta
     2281 ttctaaacct cctaagatat ttaggcttct gtacataaaa gtgtttttgc taaatttaca
     2341 gtatatatag atcctttcat attattttac taagaatgtt tgaactttgc atatttgata
     2401 tagttcctgg taggaatagc acagctcaaa cattagtttt tctacttacc tcctctaaca
     2461 cgtggtttgt ctggagagtt tctaaaaatt cagctataac cccagttcat gtatttactg
     2521 gtgattgttc ttgctgaggt agtaacagcc caatcttggg ctgttaaatc ctaggaaatc
     2581 tcgaatcata gtgattaaaa tagttggggt aaagttgtag cttatatgca atactacttg
     2641 gaggaattct tctactaatt tgtatttaat gtggaaattg tatagtttca ttgatttaat
     2701 cataaataat ggaaatggtc tccaagaagt tttatttttc atttttttgc ttatacactc
     2761 tgattcctat aatacagtgc tataagctat gcacagaaaa taaaatgttt gaaatccaag
     2821 aataatggtt cttactgcta agagggagta atagttatta ctaatgattt tgattgggtt
     2881 gcatttttgt tgcaatgttt attccacttg cagttagaat atgaatatgt tttatcacta
     2941 gtgtggctaa ataaccaaac atttgtgtaa aaaaaaaaaa aagccaagat ttcattgttt
     3001 gttgaatatt tcttaagcat ctggccccta aagagaccgc ttcttaccaa gcctgtaaac
     3061 tatgcatgat ggaaattctt gtattttatt taggaatggc tgttggttta ctcaccacat
     3121 ctgtggaatc atggctataa atgtttgctt acaaactctt tgtgacttgt aatttaactt
     3181 aatctcatct aatgtaaata ttagattatg atgttcagta acatcttcca taggtataaa
     3241 ctgctgtcat tattgatttc agagtaactc tgagtaatca aataggtaaa agcatgtttt
     3301 gagtaaaata gctagattta tactttactt gtatacagac ttaacaacaa ccggtattga
     3361 ctggattgac agctaaagta tcagaatgaa agcaaggttt ttttgatgtt acctgactgt
     3421 cataaagatg aaaatgattt gtattggtat gaaatgctta tctttattct acttcgtaag
     3481 ggtaagtttt atttatactc tttggactcc catgaacttt tgcacactgc tttgtgtttt
     3541 tggtttaccc taaactacca tcctttttat ctttgctttt tttcttccta ttcagaaaag
     3601 agcaaaatgt gaaaagacac aagactctca ggtatagaat gaactgagca atttggagaa
     3661 tgtattggac tttgtcctct cttattcccc cctcctagcc ctgcaagttg ctaggtactt
     3721 gtgaggcagt gtactggaga ggggagagca tggatcctgg ggtcaaaggg cctttgcccc
     3781 cacccttact tggccctcta cctgcaggtg accactggca cattctcctg cttgtctcag
     3841 cttcaggttc ttcacctcta agatggggat gatgaaaaca gtacctgtca tgcagaattg
     3901 ttgggaggat tgataattta gatgtttata catgtaatgt acttagatca gtgtctgctc
     3961 ttttcacttg atatccagta ctatgtaaga tagaaggtgc atgtcttctg tattctgtat
     4021 ttcccatttc ttttgcgtgc agtctttgat tcgtacaata gaaggaacac gtagaatgta
     4081 tatttgtaca ttcatgtcaa catagtattt gaaattgcta ccaaactcat ttaatttggc
     4141 ataagactaa cagatgaagt ctctcatttg cttgaagata ttttacaaaa taccaactgt
     4201 tctatatttc tttagaaaaa gattatagtt attaatattg atacctctga taatatttta
     4261 ttcttaaatc ttcagtgatt ccttttacta tagattcatg acagctaatt agtactaact
     4321 gatttagagg tttcctttcc catcatatgg aatgatgtaa agaaatcaga tacaaactac
     4381 tgcaattaga aaataaaata tgaacaactt tcaa
//
