LOCUS       NM_001242481            2916 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 1A domain
            containing (EIF1AD), transcript variant 1, mRNA.
ACCESSION   NM_001242481
VERSION     NM_001242481.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2916)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2916)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2916)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2916)
  AUTHORS   Yu,J. and Marintchev,A.
  TITLE     Comparative sequence and structure analysis of eIF1A and eIF1AD
  JOURNAL   BMC Struct Biol 18 (1), 11 (2018)
   PUBMED   30180896
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2916)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2916)
  AUTHORS   Smirnova,E.V., Rakitina,T.V., Bogatova,O.V., Ivanova,D.L.,
            Vorobyeva,E.E., Lipkin,A.V., Kostanyan,I.A. and Lipkin,V.M.
  TITLE     Novel protein haponin regulates cellular response to oxidative
            stress
  JOURNAL   Dokl Biochem Biophys 440, 225-227 (2011)
   PUBMED   22095125
  REMARK    GeneRIF: Novel protein haponin regulates cellular response to
            oxidative stress.
REFERENCE   7  (bases 1 to 2916)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 2916)
  AUTHORS   Vonarshenko,A.V., Radchenko,V.V., Gapon,M.V., Rodionov,I.L.,
            Babichenko,I.I., Kakuev,D.L., Artamonov,I.D., Garkovenko,A.V.,
            D'iachkova,L.G., Lipkin,V.M. and Kostanian,I.A.
  TITLE     [Identification and expression of haponin, a new protein from HL-60
            cells]
  JOURNAL   Bioorg Khim 33 (6), 653-656 (2007)
   PUBMED   18173130
REFERENCE   9  (bases 1 to 2916)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP328412.1, BE791453.1, AI831454.1, BE669813.1 and AP006287.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001242481.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.178571.1,
                                           SRR1660803.45698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152719, SAMEA2153031
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533544.6/ ENSP00000434056.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               BP328412.1         10-127
            119-468             BE791453.1         42-391
            469-666             AI831454.1         325-522
            667-847             BE669813.1         360-540
            848-2916            AP006287.2         111796-113864       c
FEATURES             Location/Qualifiers
     source          1..2916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2916
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /note="eukaryotic translation initiation factor 1A domain
                     containing"
                     /db_xref="GeneID:84285"
                     /db_xref="HGNC:HGNC:28147"
                     /db_xref="MIM:618473"
     exon            1..248
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /inference="alignment:Splign:2.1.0"
     exon            249..451
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..862
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /note="eukaryotic translation initiation factor 1A
                     domain-containing protein"
                     /codon_start=1
                     /product="probable RNA-binding protein EIF1AD"
                     /protein_id="NP_001229410.1"
                     /db_xref="CCDS:CCDS8124.1"
                     /db_xref="GeneID:84285"
                     /db_xref="HGNC:HGNC:28147"
                     /db_xref="MIM:618473"
                     /translation="MSQATKRKHVVKEVLGEHIVPSDQQQIVRVLRTPGNNLHEVETA
                     QGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKEGFW
                     PEAFSEVAEKHNNRNRQTQPELPAEPQLSGEESSSEDDSDLFVNTNRRQYHESEEESE
                     EEEAA"
     exon            452..560
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /inference="alignment:Splign:2.1.0"
     exon            561..669
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /inference="alignment:Splign:2.1.0"
     exon            670..717
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /inference="alignment:Splign:2.1.0"
     exon            718..2916
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /note="hexamer: TATAAA"
     regulatory      2893..2898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /note="hexamer: AATAAA"
     polyA_site      2894
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
     polyA_site      2916
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /note="major polyA site"
ORIGIN      
        1 agtacggttt tcggagggat cagactcaga ctcacgtcgc actcctcgca gttggactgg
       61 tgggaactgg gaacactgga gacctgattt ctaactgacg ctaccgtcgc ggccgccggc
      121 aagttccttt actgtgtttt cttggttcag ccttgaagtg agtcgtggac gatcctctct
      181 cagcgtccag cctagacggc ggtgttgctc cggcagcgtt cctgggagcc gagggccaga
      241 gactaagtta aaaggcccct ccccatcttc agaacagtcc tgggttctga gcctgccatc
      301 caaggaactc aggaggagga gttgacagtc tcttcgttcc taaccagtgt gggacgactt
      361 cagcatgtct caggccacca agaggaagca tgtggtgaag gaggtgctag gggagcacat
      421 agtgccctcc gaccagcagc agattgtcag ggtactcagg accccaggga acaatctgca
      481 tgaggtggag acagcccaag ggcagcgctt cctggtgagc atgccctcca aataccgcaa
      541 gaacatctgg atcaagagag gggactttct cattgttgac cccattgaag agggagaaaa
      601 ggtgaaggct gaaatctcgt ttgtgctctg caaggaccac gtgcgctctc tgcagaagga
      661 ggggttttgg cctgaggcct tctctgaagt ggctgagaaa cacaacaaca ggaacagaca
      721 aactcaacca gaactcccag ctgagccaca gttatcagga gaggagtcca gctcagaaga
      781 tgattctgac ctgtttgtta acacaaaccg cagacagtat catgagagtg aggaggagag
      841 tgaagaggag gaggcagcct gagactccag gacccaattc tccacttgct cagggactgg
      901 cccctggctc ttctgggctt ggacattccc agggtgctct gcacatcttc acccctgcat
      961 gaggacaaag cagggctcct ctctgaactg atcttttgat tcagagaatt aaacccctgg
     1021 tgggttggtg acttgttctg gtgtctgagt ggctctctcg ggggagggag attgtgatga
     1081 agtgaaaaac tgctccctat ttattagaga ccttgtgggt gggtgggctg aatggggagg
     1141 aaatgggaaa tggctggagt ctttcccagg tggtttgttc tttcttattg ggcacttaga
     1201 aagtgccagg ccgtgctctg ggccttcttg catgtgttta acagctggga gcactcctgc
     1261 ttccttgcct gcttgcagtt cataccaatt taagcattca ggatgacagc cctaggacct
     1321 aacacccacc tgcctctaag agacgctcag gagcccatgg tgcctcgtgc tgttctcccc
     1381 gcctttctag tcaccctgtg tacgggagtg ctcacctcca gctactgtgt ccatccccac
     1441 atacgacctc atctctccca ctctgcacca tctatcactt ccagaaggtg gctggcaaat
     1501 ctctctatcc ttaactttgt tttgaatggt ccatccatct cctgacttta tttgaaacct
     1561 gattattccc tgaggacatt gattgtctta taacctttta aatagaggct gcttttccac
     1621 cctcaccctt cattcttcta accagccctg acattctcat gagtaacctt ctgccttcac
     1681 ttccctcttg tgtagcatca attccgtagt ccaccctaca cccctctgtc tccctccatt
     1741 ctgttccgct agtaaaaccc taaccctggg taaacccaat cattcacctc tgtgcccaaa
     1801 cccaagtcac catcattagg tgagaaaaca gccagcctgg ccaccagttg taccttacgt
     1861 ttatcattac aaacctcaga tggacactaa gcactgccca gcagatctac tctgggatgt
     1921 ctgtttcaaa acttctgtct tatctatcaa ttcccccttg tggtagttac cacaacacat
     1981 gcctcattaa gaaacagcaa ccatcagagg gaatgcctgc ctccctgtta ccagctctgc
     2041 agatgtgcac atatcttcct gtcgtaagcc aatgggactt aaaccttacc tcttgtgttt
     2101 tggagactat cttttttttt tttttttttt ttttgagaga gtgtctccct gtgttgctca
     2161 ggctggagtg cagtggtgtg atctcggctc actgtaacct tcacctactg ggttcaagta
     2221 actctcctgc ctcagcctcc cgagtagctt ggactacagg cgtgcaccac cacacctggc
     2281 taactttttg tatttttagt agagacgggg ttttgccatg ttgcccgggc tggtctcgaa
     2341 ctcctgacct taaatgagcc tcctgcctca gcctcccaaa ctgctgggat tacaggcgtg
     2401 tgccaccatg cctggctaat ttttatattt tcagtagaga cgaggttttg ccatgttggc
     2461 caggctggtc tcgaactcct gacctcaagt ggtccaccca ccttggcctc ctagagtgct
     2521 gggattacag gtgtgagcca ctgtgcccgg cctcttttgc tttcttaaag actttggtcg
     2581 ggtatttgtg ttgttgagta ttgtgtctgg gtgtgggtat ttgattcttt ttttgttttg
     2641 tgtttttggc tgtcctgtct attggatgtg atatgttatg gatgtgatgt gttagtgtcg
     2701 agcgtgctgt agaatctccc atttctgaaa caggcgtgaa aacctgtact gattcccacg
     2761 tcctccagct accacttcat ttgtctgttt ctcatttact ttctcttata gcgtggcttt
     2821 aaacatatat acatttgtat atatgtatat atgaatataa tgtataaaat gtatgtagat
     2881 gtatatacaa aaaataaacg agatgggtta aagata
//
