LOCUS       NM_005801               2338 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens eukaryotic translation initiation factor 1 (EIF1),
            mRNA.
ACCESSION   NM_005801
VERSION     NM_005801.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Ly,J., Xiang,K., Su,K.C., Sissoko,G.B., Bartel,D.P. and
            Cheeseman,I.M.
  TITLE     Nuclear release of eIF1 restricts start-codon selection during
            mitosis
  JOURNAL   Nature 635 (8038), 490-498 (2024)
   PUBMED   39443796
  REMARK    GeneRIF: Nuclear release of eIF1 restricts start-codon selection
            during mitosis.
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Sehrawat,U., Haimov,O., Weiss,B., Tamarkin-Ben Harush,A.,
            Ashkenazi,S., Plotnikov,A., Noiman,T., Leshkowitz,D., Stelzer,G.
            and Dikstein,R.
  TITLE     Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR
            stress-response genes independent of eIF2alpha-phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 119 (30), e2120339119 (2022)
   PUBMED   35857873
  REMARK    GeneRIF: Inhibitors of eIF4G1-eIF1 uncover its regulatory role of
            ER/UPR stress-response genes independent of
            eIF2alpha-phosphorylation.
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Moens,T.G., Niccoli,T., Wilson,K.M., Atilano,M.L., Birsa,N.,
            Gittings,L.M., Holbling,B.V., Dyson,M.C., Thoeng,A., Neeves,J.,
            Glaria,I., Yu,L., Bussmann,J., Storkebaum,E., Pardo,M.,
            Choudhary,J.S., Fratta,P., Partridge,L. and Isaacs,A.M.
  TITLE     C9orf72 arginine-rich dipeptide proteins interact with ribosomal
            proteins in vivo to induce a toxic translational arrest that is
            rescued by eIF1A
  JOURNAL   Acta Neuropathol 137 (3), 487-500 (2019)
   PUBMED   30604225
  REMARK    GeneRIF: These data directly implicate translational repression in
            C9orf72 repeat-induced neurodegeneration and identify eIF1A as a
            novel modifier of C9orf72 repeat toxicity.
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Lin,K.Y., Nag,N., Pestova,T.V. and Marintchev,A.
  TITLE     Human eIF5 and eIF1A Compete for Binding to eIF5B
  JOURNAL   Biochemistry 57 (40), 5910-5920 (2018)
   PUBMED   30211544
  REMARK    GeneRIF: results indicate that in humans, eIF5B displacing eIF2
            from Met-tRNAi upon subunit joining may be coupled to eIF1A
            displacing eIF5 from eIF5B, allowing the eIF5:eIF2-GDP complex to
            leave the ribosome.
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Haimov,O., Sehrawat,U., Tamarkin-Ben Harush,A., Bahat,A.,
            Uzonyi,A., Will,A., Hiraishi,H., Asano,K. and Dikstein,R.
  TITLE     Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1)
            with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent
            Translation
  JOURNAL   Mol Cell Biol 38 (18), e00139-18 (2018)
   PUBMED   29987188
  REMARK    GeneRIF: We report that eIF4G1 exists in two complexes, either with
            eIF4E or with eIF1. Using an eIF1 mutant impaired in eIF4G1
            binding, we demonstrate that eIF1-eIF4G1 interaction is important
            for leaky scanning and for avoiding m7G-cap-proximal initiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2338)
  AUTHORS   Fletcher,C.M., Pestova,T.V., Hellen,C.U. and Wagner,G.
  TITLE     Structure and interactions of the translation initiation factor
            eIF1
  JOURNAL   EMBO J 18 (9), 2631-2637 (1999)
   PUBMED   10228174
REFERENCE   7  (bases 1 to 2338)
  AUTHORS   Lian,Z., Pan,J., Liu,J., Zhang,S., Zhu,M., Arbuthnot,P., Kew,M. and
            Feitelson,M.A.
  TITLE     The translation initiation factor, hu-Sui1 may be a target of
            hepatitis B X antigen in hepatocarcinogenesis
  JOURNAL   Oncogene 18 (9), 1677-1687 (1999)
   PUBMED   10208429
REFERENCE   8  (bases 1 to 2338)
  AUTHORS   Song,F. and Glenny,A.M.
  TITLE     Antimicrobial prophylaxis in colorectal surgery: a systematic
            review of randomized controlled trials
  JOURNAL   Br J Surg 85 (9), 1232-1241 (1998)
   PUBMED   9752867
  REMARK    Review article
            Erratum:[Br J Surg 1999 Feb;86(2):280]
REFERENCE   9  (bases 1 to 2338)
  AUTHORS   Pestova,T.V., Borukhov,S.I. and Hellen,C.U.
  TITLE     Eukaryotic ribosomes require initiation factors 1 and 1A to locate
            initiation codons
  JOURNAL   Nature 394 (6696), 854-859 (1998)
   PUBMED   9732867
REFERENCE   10 (bases 1 to 2338)
  AUTHORS   Fields,C. and Adams,M.D.
  TITLE     Expressed sequence tags identify a human isolog of the suil
            translation initiation factor
  JOURNAL   Biochem Biophys Res Commun 198 (1), 288-291 (1994)
   PUBMED   7904817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BU165055.1, BC005118.1, AA159721.1 and AC130686.15.
            
            On Nov 22, 2018 this sequence version replaced NM_005801.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.81464.1,
                                           SRR3476690.990899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000469257.2/ ENSP00000419449.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BU165055.1         28-37
            11-1314             BC005118.1         1-1304
            1315-1316           AA159721.1         16-17               c
            1317-2338           AC130686.15        20691-21712         c
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2338
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="eukaryotic translation initiation factor 1"
                     /db_xref="GeneID:10209"
                     /db_xref="HGNC:HGNC:3249"
                     /db_xref="MIM:619901"
     exon            1..185
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..496
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="sui1iso1; protein translation factor SUI1 homolog"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 1"
                     /protein_id="NP_005792.1"
                     /db_xref="CCDS:CCDS11403.1"
                     /db_xref="GeneID:10209"
                     /db_xref="HGNC:HGNC:3249"
                     /db_xref="MIM:619901"
                     /translation="MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTL
                     TTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLVEIGL
                     AKDDQLKVHGF"
     exon            186..349
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..451
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..2338
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      651..656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="hexamer: AATAAA"
     polyA_site      669
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="major polyA site"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="hexamer: AATAAA"
     polyA_site      1314
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="major polyA site"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
                     /note="hexamer: AATAAA"
     polyA_site      2338
                     /gene="EIF1"
                     /gene_synonym="A121; EIF-1; EIF1A; ISO1; SUI1"
ORIGIN      
        1 gccccagtca ctgagccgcc gccgaggatt cagcagcctc ccccttgagc cccctcgctt
       61 cccgacgttc cgttcccccc tgcccgcctt ctcccgccac cgccgccgcc gccttccgca
      121 ggccgtttcc accgaggaaa aggaatcgta tcgtatgtcc gctatccaga acctccactc
      181 tttcgacccc tttgctgatg caagtaaggg tgatgacctg cttcctgctg gcactgagga
      241 ttatatccat ataagaattc aacagagaaa cggcaggaag acccttacta ctgtccaagg
      301 gatcgctgat gattacgata aaaagaaact agtgaaggcg tttaagaaaa agtttgcctg
      361 caatggtact gtaattgagc atccggaata tggagaagta attcagctac agggtgacca
      421 acgcaagaac atatgccagt tcctcgtaga gattggactg gctaaggacg atcagctgaa
      481 ggttcatggg ttttaagtgc ttgtggctca ctgaagctta agtgaggatt tccttgcaat
      541 gagtagaatt tcccttctct cccttgtcac aggtttaaaa acctcacagc ttgtataatg
      601 taaccatttg gggtccgctt ttaacttgga ctagtgtaac tccttcatgc aataaactga
      661 aaagagccat gctgtctagt cttgaagtcc ctcatttaaa cagaggtcaa gcaataggcg
      721 cctggcagtg tcaagcctga aaccaagcaa taccgtcatg tttcagccaa gcccagagcc
      781 ctaagattac aaacaactat ggccggaacc tcctcagctc tccctctgca gagttcccta
      841 ccctaagaga atgttaccac ctgaacagtc ctcggtgaat ctgagaggag aggatggggt
      901 aaggcagaag caccagctgt actactagaa gggagctttt ggtggtagat cccctggtgt
      961 ctccaacctg actaggtgga cagagctcaa agaggccctc ttaccgctag cgaggtgata
     1021 ggacatctgg cttgccacaa aggtctgttc gaccagacat atcctagcta agggatgtcc
     1081 aaacatcaga atgtgaggcc aaccttctat cagagttaaa cttttgacaa gggaacaaat
     1141 ctcaaactga tccatcagtc atgtagctag ctgtagagct tgcaacttaa tagcagcagc
     1201 tgcccaatgc catgtgaagt aacaaactgg tttttggttt ttttttcccc ttcagtttta
     1261 atgttatgtg taatgtattt aaacccttat ttaaataaaa cttgttttca gaaatacctg
     1321 acttgcagat tatttatata tagtcgatct tgtgcatata aaggaaccat agaaatgggc
     1381 agtggaggat tcgtccacac ccacagcttc tcaacgggcc tgaatttggc caagaaaaac
     1441 ctttatgagc ttgtccctct ctggtcaact ggttttttgt tcgtttgttt tttgagacag
     1501 gtttgccctt gttgcccagg ctggagtgca gtggcacaat ctcggctcac tgcaacctcc
     1561 acctcaggtt caagcaattg tcgtgcctca gcctccctag tagctgggat tacaggcacc
     1621 atgcccagct aacttttgta tttttagtag agacagggtt tctccatgtt ggccaggctg
     1681 gtcttgaaca cctggcctca agtgatctgc ctgtcttggc ctcccaaagt gctgggatta
     1741 caggcatgag ccaccatgcc cagcaggtca actgtttttg caagcattta gccagagtca
     1801 tgctgtgctg ttaatcagtg tcctggagaa tgggttgctt ggaaatcttg gcgccccctc
     1861 agtagtaaca gccttggttt aagggcgcag agtggagagt aaatgcaagg gctataacaa
     1921 gggcattcat gctgtgggtt aagatccaca aatcgctagg aatgtgtata ctctgggtag
     1981 taagtttgta gtattagaag gtttaatgac aagtatttga agagctgaag ttaagtgttg
     2041 ggaggccatc ccttatgaag gacaatgaat ggcaagtaaa agaccaagtt ctgttcctgg
     2101 gtccattaat ttagttaaaa aggcaaagtt ctttcagcac acatatctgc atgcagtcac
     2161 gtgctgccta aggatgcttc attcaacaat gagcctcaca gccgtgctac acaataagat
     2221 tataatactg tatttttact gtacctttta acattgtgtt acaatggcct acaagaagct
     2281 tgtgtggatg gctttgaatg tggcccaaca cgaactaata aattttgcta aaacatga
//
