LOCUS       NM_001008394            1467 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens EP300 interacting inhibitor of differentiation 3
            (EID3), mRNA.
ACCESSION   NM_001008394
VERSION     NM_001008394.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Jia,L., Tian,H., Sun,S., Hao,X. and Wen,Y.
  TITLE     EID3 inhibits the osteogenic differentiation of periodontal
            ligament stem cells and mediates the signal transduction of
            TAZ-EID3-AKT/MTOR/ERK
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (3), 119662 (2024)
   PUBMED   38216090
  REMARK    GeneRIF: EID3 inhibits the osteogenic differentiation of
            periodontal ligament stem cells and mediates the signal
            transduction of TAZ-EID3-AKT/MTOR/ERK.
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   Wang,Y., Luo,S., Wang,Y., Yang,S., Huang,Z., Zhu,X., Cai,S.,
            Guo,Q., Zhong,W. and Liu,S.
  TITLE     EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma
            through the Activation of PI3K-AKT Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 5941562 (2022)
   PUBMED   36071872
  REMARK    GeneRIF: EID3 Promotes Cancer Stem Cell-Like Phenotypes in
            Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1467)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1467)
  AUTHORS   Adamus,M., Lelkes,E., Potesil,D., Ganji,S.R., Kolesar,P.,
            Zabrady,K., Zdrahal,Z. and Palecek,J.J.
  TITLE     Molecular Insights into the Architecture of the Human SMC5/6
            Complex
  JOURNAL   J Mol Biol 432 (13), 3820-3837 (2020)
   PUBMED   32389690
REFERENCE   5  (bases 1 to 1467)
  AUTHORS   Wang,Y., Wang,Y., Liu,S., Liu,Y., Xu,H., Liang,J., Zhu,J.,
            Zhang,G., Su,W., Dong,W. and Guo,Q.
  TITLE     Upregulation of EID3 sensitizes breast cancer cells to ionizing
            radiation-induced cellular senescence
  JOURNAL   Biomed Pharmacother 107, 606-614 (2018)
   PUBMED   30114644
  REMARK    GeneRIF: Knockdown of EID3 by specific shRNA attenuated BMS-345541
            -induced radiosensitization in MCF-7 cells.
REFERENCE   6  (bases 1 to 1467)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   7  (bases 1 to 1467)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   8  (bases 1 to 1467)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   9  (bases 1 to 1467)
  AUTHORS   Bavner,A., Matthews,J., Sanyal,S., Gustafsson,J.A. and Treuter,E.
  TITLE     EID3 is a novel EID family member and an inhibitor of CBP-dependent
            co-activation
  JOURNAL   Nucleic Acids Res 33 (11), 3561-3569 (2005)
   PUBMED   15987788
  REMARK    GeneRIF: EID3 acts as an inhibitor of CBP/p300-dependent
            transcription in a tissue-specific manner.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1467)
  AUTHORS   Hu,B., Liao,C., Millson,S.H., Mollapour,M., Prodromou,C.,
            Pearl,L.H., Piper,P.W. and Panaretou,B.
  TITLE     Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex
  JOURNAL   Mol Microbiol 55 (6), 1735-1750 (2005)
   PUBMED   15752197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI461575.1 and BC027612.2.
            
            On May 17, 2019 this sequence version replaced NM_001008394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: HM005376.1, BC027612.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527879.2/ ENSP00000435619.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BI461575.1         13-44
            33-1467             BC027612.2         1-1435
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..1467
                     /gene="EID3"
                     /gene_synonym="NS4EB; NSE4B; NSMCE4B"
                     /note="EP300 interacting inhibitor of differentiation 3"
                     /db_xref="GeneID:493861"
                     /db_xref="HGNC:HGNC:32961"
                     /db_xref="MIM:612986"
     exon            1..1467
                     /gene="EID3"
                     /gene_synonym="NS4EB; NSE4B; NSMCE4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1198
                     /gene="EID3"
                     /gene_synonym="NS4EB; NSE4B; NSMCE4B"
                     /note="E1A-like inhibitor of differentiation 3; non-SMC
                     element 4 homolog B; non-structural maintenance of
                     chromosomes element 4 homolog B; EID-3; EID-1-like
                     inhibitor of differentiation 3; testis tissue
                     sperm-binding protein Li 96mP; NSE4 homolog B"
                     /codon_start=1
                     /product="EP300-interacting inhibitor of differentiation
                     3"
                     /protein_id="NP_001008395.1"
                     /db_xref="CCDS:CCDS53822.1"
                     /db_xref="GeneID:493861"
                     /db_xref="HGNC:HGNC:32961"
                     /db_xref="MIM:612986"
                     /translation="MKMDVSVRAAGCSDDLSSGEADVDPKLLELTADEEKCRSIRRQY
                     RQLMYCVRQNREDIVSSANNSLTEALEEANVLFDGVSRTREAALDARFLVMASDLGKE
                     KAKQLNSDMNFFNQLAFCDFLFLFVGLNWMEGDPDKLSDCDDSIALSFWKAIEKEATS
                     WMVKAETFHFVFGSFKLERSAPKPRLEHQKKVRKMEENGNMPTKLQKLDLSSYPEATE
                     KNVERILGLLQTYFRKYPDTPVSYFEFVIDPNSFSRTVENIFYVSFIVRDGFARIRLD
                     EDRLPILEPMNVNQMGEGNDSSCHGRKQGVISLTLQEWKNIVAAFEISEAMITYSSY"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID3"
                     /gene_synonym="NS4EB; NSE4B; NSMCE4B"
                     /note="hexamer: AACAAG"
     polyA_site      1467
                     /gene="EID3"
                     /gene_synonym="NS4EB; NSE4B; NSMCE4B"
                     /note="major polyA site"
ORIGIN      
        1 atgggcgggc gtcctcggct ctaactgccg ccactttcca cacgctggga gggccgttac
       61 ctcagagata cccgtggccg gcatgttggt tgaaaaagct tcccggaagg gagacgaaga
      121 gaaaggagag gagcagctcg tgatcatccc cggtagcgag tacgcggcga agtaggcggc
      181 ggcggaggga gcgctgatga agatggatgt gtcagtgagg gccgcgggct gctccgacga
      241 cctcagctct ggggaggccg acgtagaccc aaagctcctg gagctcaccg ctgacgagga
      301 gaagtgccgc agcatccgca ggcagtaccg gcagctcatg tactgcgtgc ggcagaaccg
      361 ggaggacatc gtgagctcgg cgaacaactc cttaaccgag gctctggagg aagccaacgt
      421 cctctttgat ggcgtgagcc gaaccagaga agcagccctc gacgcccggt ttcttgttat
      481 ggcttctgat ttgggtaaag aaaaggcaaa gcagttaaac tcagatatga acttctttaa
      541 tcagttagca ttttgtgact ttctgtttct gttcgtgggt ctgaattgga tggaaggcga
      601 tcctgacaag ttgagtgatt gtgatgatag catagctctt tccttctgga aggcaataga
      661 aaaggaagca acatcctgga tggtaaaagc tgagacattc cattttgttt ttggttcatt
      721 caagctagaa cgttctgcac caaagccccg acttgaacac cagaaaaaag ttcgcaagat
      781 ggaagaaaat ggcaacatgc ctacaaagtt gcagaagttg gacctgagta gttatccaga
      841 agcgacagaa aaaaacgtag aaaggatttt gggattgttg caaacctact ttcgaaagta
      901 tcctgatact cctgtgtcct attttgagtt tgtgattgat ccaaactctt tttctcgtac
      961 tgtggagaat atattttatg tttcttttat tgtaagagat ggttttgcaa gaataaggct
     1021 tgatgaagac aggctgccaa tattagagcc gatgaatgtt aaccaaatgg gtgagggaaa
     1081 tgattccagt tgccatggca ggaaacaggg agttatatct ttgactttac aggagtggaa
     1141 aaacattgtg gcagcttttg aaatttctga ggctatgatt acatactcct catactaaag
     1201 atttcttagt atagcatcct ttttgtgttt tttttctgaa gttagatgga gagtaaaatg
     1261 taaactgaag cacatattgt atctcttgta aagtgaaaaa gtattttcaa gaacatcaga
     1321 cattgtttta ctgtgcagca tatttttctt agtaatttat aaggtcatga tcttctgtta
     1381 ttaaaacaaa ttcactggca tatttatggg aacgttttat tgaatgccct ttaagactat
     1441 taataaaaac aagttttgga taccaaa
//
