LOCUS       NM_152361               1866 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens EP300 interacting inhibitor of differentiation 2B
            (EID2B), mRNA.
ACCESSION   NM_152361
VERSION     NM_152361.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Sasajima,Y., Tanaka,H., Miyake,S. and Yuasa,Y.
  TITLE     A novel EID family member, EID-3, inhibits differentiation and
            forms a homodimer or heterodimer with EID-2
  JOURNAL   Biochem Biophys Res Commun 333 (3), 969-975 (2005)
   PUBMED   15970276
  REMARK    GeneRIF: EID-3 inhibits MyoD- and GRalpha-dependent transcription
            and blocked muscle differentiation in cultured cells. It also
            associates with class I HDACs.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009725.1, AC011500.7 and BQ182601.1.
            
            On May 17, 2019 this sequence version replaced NM_152361.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660803.314406.1,
                                        SRR3476690.568827.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326282.5/ ENSP00000317564.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               BC009725.1         4-187
            185-185             AC011500.7         137492-137492       c
            186-1314            BC009725.1         189-1317
            1315-1320           BQ182601.1         17-22               c
            1321-1866           AC011500.7         135811-136356       c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1866
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
                     /note="EP300 interacting inhibitor of differentiation 2B"
                     /db_xref="GeneID:126272"
                     /db_xref="HGNC:HGNC:26796"
                     /db_xref="MIM:617355"
     exon            1..1866
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..536
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
                     /note="EID-2-like inhibitor of differentiation-3"
                     /codon_start=1
                     /product="EP300-interacting inhibitor of differentiation
                     2B"
                     /protein_id="NP_689574.1"
                     /db_xref="CCDS:CCDS12539.1"
                     /db_xref="GeneID:126272"
                     /db_xref="HGNC:HGNC:26796"
                     /db_xref="MIM:617355"
                     /translation="MAEPTGLLEMSELPGDSSVPQVGTASGVSDVLRGAVGGGVRVQE
                     AREGPVAEAARSMARMPGPVPGPIPSSVPGLASAPDPHQQLAFLEINRQLLFREYLDG
                     SSMIPVRLLRDFEERRRLFVEGCKAREAAFDADPPQMDFAAVAFTVALTASEALSPLA
                     D"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
                     /note="hexamer: AATAAA"
     polyA_site      1314
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
                     /note="major polyA site"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="EID2B"
                     /gene_synonym="EID-2B; EID-3"
ORIGIN      
        1 atacagcagt gcagtgccgt tattccagtc tccgtagaaa cgctgggact atggcggagc
       61 cgactgggct gttggagatg tccgagctcc ccggagatag cagtgtccca caggtgggca
      121 ccgcgagtgg cgtcagcgac gtactgcggg gggcagtcgg cggcggggtt cgggtgcagg
      181 aggctcggga aggcccagtg gccgaagctg cgcggtccat ggcgcggatg ccgggccctg
      241 tgcccgggcc catccccagc agcgtcccgg gcctggcctc cgcgccagac ccccatcagc
      301 agctcgcttt cttagaaatt aaccggcagc tgttgttccg cgagtatctg gatggtagct
      361 ccatgattcc ggtcagatta ctacgggatt tcgaggaacg ccgcaggctg tttgtggaag
      421 gctgcaaggc gagggaagca gcctttgacg cggatccccc gcagatggac ttcgctgctg
      481 tcgcgtttac ggtagcgctg actgcctccg aggccctcag tcctctggcc gactgagtcg
      541 gctgtgatga tgacattggt ggcaaggaat agccaagtga cccttttggg atcaaaagaa
      601 caggcaggct gtgccagttt agttaactca gtcattaggg ggaatgcaaa ctggaaggga
      661 atacggcaat gtgcaattga aggaggaagc acactccgaa atggaaacag acaagactgt
      721 tgaatcttgt tttctttctt cttttttagt attatttaaa tagagaaggg agtctcgcat
      781 ccctaggctg gtcccgaacg cttggacccg agcgatcctc ccgcttcggc ctcccaaagt
      841 gctgggatta ctttacaggc gtgagccacc gcgcccggcc gaatcttgtt ttcaaacagg
      901 tcccaagaca cttctgactt agcactttgt tagcaatgca ttttcctgca tttgtgaaga
      961 atccttcatg actttcacca taaaggatgg ttttgcaaag atatgagaaa aaaaaaatgc
     1021 caataacaga acccatagaa atgaacctaa gtgatgaaag aaaacaaaga aatagagttg
     1081 tcaggaatcc aggtgtacct gagttactag gattggaagg ctattgagag gactttgaaa
     1141 tttcacaatt tgtggtcatg tcaacaaatc ctagtgtaag attcatattt gtgttttctg
     1201 aggtacttta gatgaacagt aaatattcaa tagaaaaaac cacgtattat atgatcagtg
     1261 ttttcaagtc tatgtgaaat tgggtaggtg tggaataaac ttgttttttg ttaattttaa
     1321 gctttttatt ttattctaga atatgtattc tattcacaag actcaacaaa aaaaagtatc
     1381 ggccgggcgc actggcttac gcctgtaatc ccagcacttt gggaggccac ggcgggtgga
     1441 tcacctgagg tcaggaattc aagaccaccc tggccaacat ggtgaaaccc catctctacg
     1501 aaaaataaaa aattaactgg gtgtggtggc acgcgcttgt agtcccagct actcgggagg
     1561 ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtaagcc gagatcacgc
     1621 cactgcactc cagcctggtc aacagagtgg gactccgtct caaaaaaaag aaaaaaagta
     1681 tcaaaagatg ctgtgagaaa tctctcttgt tgctgtcctt tgccaaactc agaactattc
     1741 catgcaggtg ccattgcttg tggcttggag ttttgttgtt gttttcttgg ttttgcttgt
     1801 tttttgcttt ttcactgtac gcctttcagg ttttctaatg catatgcaaa taaacatcaa
     1861 tctaaa
//
