LOCUS       NM_153232               1455 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens EP300 interacting inhibitor of differentiation 2
            (EID2), mRNA.
ACCESSION   NM_153232
VERSION     NM_153232.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Sasajima,Y., Tanaka,H., Miyake,S. and Yuasa,Y.
  TITLE     A novel EID family member, EID-3, inhibits differentiation and
            forms a homodimer or heterodimer with EID-2
  JOURNAL   Biochem Biophys Res Commun 333 (3), 969-975 (2005)
   PUBMED   15970276
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Lee,H.J., Lee,J.K., Miyake,S. and Kim,S.J.
  TITLE     A novel E1A-like inhibitor of differentiation (EID) family member,
            EID-2, suppresses transforming growth factor (TGF)-beta signaling
            by blocking TGF-beta-induced formation of Smad3-Smad4 complexes
  JOURNAL   J Biol Chem 279 (4), 2666-2672 (2004)
   PUBMED   14612439
  REMARK    GeneRIF: EID-2 may function as an endogenous suppressor of TGF-beta
            signaling
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Ji,A., Dao,D., Chen,J. and MacLellan,W.R.
  TITLE     EID-2, a novel member of the EID family of p300-binding proteins
            inhibits transactivation by MyoD
  JOURNAL   Gene 318, 35-43 (2003)
   PUBMED   14585496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030137.2 and AC011500.7.
            
            On May 17, 2019 this sequence version replaced NM_153232.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR279825.5101.1, BC030137.2
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390658.4/ ENSP00000375073.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1356              BC030137.2         24-1379
            1357-1455           AC011500.7         143531-143629       c
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1455
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /note="EP300 interacting inhibitor of differentiation 2"
                     /db_xref="GeneID:163126"
                     /db_xref="HGNC:HGNC:28292"
                     /db_xref="MIM:609773"
     exon            1..1455
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..793
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /note="E1A like inhibitor of differentiation 2;
                     CREBBP/EP300 inhibitory protein 2; CREBBP/EP300 inhibitor
                     2; EID-1-like inhibitor of differentiation 2"
                     /codon_start=1
                     /product="EP300-interacting inhibitor of differentiation
                     2"
                     /protein_id="NP_694964.3"
                     /db_xref="CCDS:CCDS12540.2"
                     /db_xref="GeneID:163126"
                     /db_xref="HGNC:HGNC:28292"
                     /db_xref="MIM:609773"
                     /translation="MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGE
                     GAMAAARGGPVPAAREGRMAAARAAPAAAARGAPVAAAALARAAAAGRESPAAAAARE
                     ARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYLRLRHPLSVLGINYQQFLRHY
                     LENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTFTIALTASE
                     VINPLIEELGCDKFINRE"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /note="hexamer: GATAAA"
     polyA_site      1356
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /note="major polyA site"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /note="hexamer: ATTAAA"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
                     /note="hexamer: AATATA"
     polyA_site      1450
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
     polyA_site      1455
                     /gene="EID2"
                     /gene_synonym="CRI2; EID-2"
ORIGIN      
        1 gcactggggt gtccgccggg catcgctctg tccagttatt ccagtttctc tgggagcagc
       61 cgagttgacc ccacggtctg agatgtccaa gctgcccgca gacagcagtg tcccgcagac
      121 aggcgcggcg aatggtgaca gagacgtccc gcaggcggag gtaggccgcg ggaggcggga
      181 gccggccccg gcacagcctg aggaggccgg ggaaggcgcg atggcggcgg ccaggggagg
      241 cccggtgccg gcggccaggg aaggtcggat ggcggcggcc agggcagccc cggcggcggc
      301 agccagggga gccccggtgg cagcggcggc gttggccagg gcagccgcgg cgggcaggga
      361 aagcccggcg gcggcggcgg ccagggaagc ccggatggcg gaggtcgccc gcttgctggg
      421 ggagccagtg gacgaagagg gtcccgaggg caggcccagg tccagacacg ggaacggagg
      481 cctggctgcg ttgccctatc tccgtctccg ccacccactt agcgttttag gcatcaatta
      541 ccagcagttt ctccgccact atctggaaaa ttacccgatt gctcccggca gaatacaaga
      601 gcttgaagaa cgccgcaggc gattcgtgga agcctgcaga gcaagggaag cagcgtttga
      661 tgccgaatat cagcgaaatc ctcacagggt ggacctcgat attttaacct ttacgatagc
      721 tctgactgcc tctgaagtta tcaaccctct gatagaagaa cttggttgcg ataagtttat
      781 caatagagaa tagttatgtg gtgacactac ttcaagagaa cctctgcatt ccagtcatac
      841 caatcctgca acttgatttt cagaagtcaa gagtatatcg cgataagaca gtgcacaggt
      901 ggaggggaaa aaaaggggga gggggaagct tatcttgaaa aagcatcaca gaagtagaaa
      961 aaaatgtcga aagcattata actgtaacgt tctttgagtt tgtgattgat ccacattttt
     1021 ccccctgcat tatggaaaat gtctctcagc attgctttat tacaaagtaa aggatggttt
     1081 tataaaattg agactgatga aacatcaata ctagagccca tgaggatgaa agaaattatc
     1141 aaatagtgct gaacagaata agatgttaac gctgagttat taggactgga aggctatgaa
     1201 aagaacttga aattgtcgga atatgtgctc tcttcatgtc atattcaata gaagtttcta
     1261 gtttaagatt gattttgtgt tttcttaggc atttcaagtg acaagcaaag taaatgtata
     1321 tattatgtga taaatcatgt tttcaagaac gtcaaatttc tggacttttt tctttcaatt
     1381 tttaattttt aaagtttttt tggtattaaa aaatctattc acaagccaaa aaatatataa
     1441 aatatacagc gaaaa
//
