LOCUS       NM_014335               2040 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens EP300 interacting inhibitor of differentiation 1
            (EID1), mRNA.
ACCESSION   NM_014335
VERSION     NM_014335.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2040)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2040)
  AUTHORS   Sanderson,M.R., Badior,K.E., Fahlman,R.P. and Wevrick,R.
  TITLE     The necdin interactome: evaluating the effects of amino acid
            substitutions and cell stress using proximity-dependent
            biotinylation (BioID) and mass spectrometry
  JOURNAL   Hum Genet 139 (12), 1513-1529 (2020)
   PUBMED   32529326
REFERENCE   3  (bases 1 to 2040)
  AUTHORS   Vargas,D., Shimokawa,N., Kaneko,R., Rosales,W., Parra,A.,
            Castellanos,A., Koibuchi,N. and Lizcano,F.
  TITLE     Regulation of human subcutaneous adipocyte differentiation by EID1
  JOURNAL   J Mol Endocrinol 56 (2), 113-122 (2016)
   PUBMED   26643909
  REMARK    GeneRIF: EID1 can modulate adipose mesenchymal stem cells, inducing
            a brown/beige lineage.
REFERENCE   4  (bases 1 to 2040)
  AUTHORS   Zhang,C., Li,X., Adelmant,G., Dobbins,J., Geisen,C., Oser,M.G.,
            Wucherpfenning,K.W., Marto,J.A. and Kaelin,W.G. Jr.
  TITLE     Peptidic degron in EID1 is recognized by an SCF E3 ligase complex
            containing the orphan F-box protein FBXO21
  JOURNAL   Proc Natl Acad Sci U S A 112 (50), 15372-15377 (2015)
   PUBMED   26631746
  REMARK    GeneRIF: SCF(FBXO21) polyubiquitylates EID1 both in vitro and in
            vivo and is required for the efficient degradation of EID1 in both
            cycling and quiescent cells.
REFERENCE   5  (bases 1 to 2040)
  AUTHORS   Watanabe,K., Yumimoto,K. and Nakayama,K.I.
  TITLE     FBXO21 mediates the ubiquitylation and proteasomal degradation of
            EID1
  JOURNAL   Genes Cells 20 (8), 667-674 (2015)
   PUBMED   26085330
  REMARK    GeneRIF: The results suggest that EID1 is a bona fide substrate of
            FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21)
            might affect the transcriptional repression activity of EID1.
REFERENCE   6  (bases 1 to 2040)
  AUTHORS   Wen,H. and Ao,S.
  TITLE     Identification and characterization of a novel human cDNA encoding
            a 21 kDa pRb-associated protein
  JOURNAL   Gene 263 (1-2), 85-92 (2001)
   PUBMED   11223246
REFERENCE   7  (bases 1 to 2040)
  AUTHORS   MacLellan,W.R., Xiao,G., Abdellatif,M. and Schneider,M.D.
  TITLE     A novel Rb- and p300-binding protein inhibits transactivation by
            MyoD
  JOURNAL   Mol Cell Biol 20 (23), 8903-8915 (2000)
   PUBMED   11073990
REFERENCE   8  (bases 1 to 2040)
  AUTHORS   Miyake,S., Sellers,W.R., Safran,M., Li,X., Zhao,W., Grossman,S.R.,
            Gan,J., DeCaprio,J.A., Adams,P.D. and Kaelin,W.G. Jr.
  TITLE     Cells degrade a novel inhibitor of differentiation with E1A-like
            properties upon exiting the cell cycle
  JOURNAL   Mol Cell Biol 20 (23), 8889-8902 (2000)
   PUBMED   11073989
REFERENCE   9  (bases 1 to 2040)
  AUTHORS   Carim,L., Sumoy,L., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     Identification and expression analysis of C15orf3, a novel gene on
            chromosome 15q21.1-->q21.2
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 330-332 (2000)
   PUBMED   10828624
REFERENCE   10 (bases 1 to 2040)
  AUTHORS   Margottin,F., Bour,S.P., Durand,H., Selig,L., Benichou,S.,
            Richard,V., Thomas,D., Strebel,K. and Benarous,R.
  TITLE     A novel human WD protein, h-beta TrCp, that interacts with HIV-1
            Vpu connects CD4 to the ER degradation pathway through an F-box
            motif
  JOURNAL   Mol Cell 1 (4), 565-574 (1998)
   PUBMED   9660940
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF349444.1 and AI360508.1.
            
            On May 17, 2019 this sequence version replaced NM_014335.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660809.27026.1, SRR1660803.31373.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530028.3/ ENSP00000431162.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1672              AF349444.1         12-1683
            1673-2040           AI360508.1         16-383              c
FEATURES             Location/Qualifiers
     source          1..2040
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..2040
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /note="EP300 interacting inhibitor of differentiation 1"
                     /db_xref="GeneID:23741"
                     /db_xref="HGNC:HGNC:1191"
                     /db_xref="MIM:605894"
     exon            1..2040
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..607
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /note="CREBBP/EP300 inhibitory protein 1; CREBBP/EP300
                     inhibitor 1; retinoblastoma protein-associated protein;
                     NB4 apoptosis related protein; Rb- and p300-binding
                     protein EID-1; 21 kDa pRb-associated protein; E1A-like
                     inhibitor of differentiation 1"
                     /codon_start=1
                     /product="EP300-interacting inhibitor of differentiation
                     1"
                     /protein_id="NP_055150.1"
                     /db_xref="CCDS:CCDS53941.1"
                     /db_xref="GeneID:23741"
                     /db_xref="HGNC:HGNC:1191"
                     /db_xref="MIM:605894"
                     /translation="MSEMAELSELYEESSDLQMDVMPGEGDLPQMEVGSGSRELSLRP
                     SRSGAQQLEEEGPMEEEEAQPMAAPEGKRSLANGPNAGEQPGQVAGADFESEDEGEEF
                     DDWEDDYDYPEEEQLSGAGYRVSAALEEADKMFLRTREPALDGGFQMHYEKTPFDQLA
                     FIEELFSLMVVNRLTEELGCDEIIDRE"
     regulatory      1650..1655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /note="hexamer: AATAAA"
     polyA_site      1672
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /note="major polyA site"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /note="hexamer: ATTAAA"
     polyA_site      1817
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
                     /note="hexamer: AGTAAA"
     polyA_site      2040
                     /gene="EID1"
                     /gene_synonym="C15orf3; CRI1; EID-1; IRO45620; PNAS-22;
                     PTD014; RBP21"
ORIGIN      
        1 gtcttgctgg aagctttttc ctagaggttg agcggtttgc acaatgtcgg aaatggctga
       61 gttgtccgag ctgtatgaag agagcagtga cctgcagatg gatgtgatgc ctggcgaggg
      121 tgaccttccg cagatggagg taggcagcgg gagccgggag ctatccctgc gtccctcccg
      181 cagcggggcc caacagctcg aggaggaagg cccaatggag gaggaggagg cccagccaat
      241 ggcggcgcca gaggggaaac ggagccttgc taacgggccc aacgctgggg agcagccagg
      301 ccaggtggcg ggcgcagact tcgagagcga ggacgagggc gaggaatttg atgactggga
      361 ggacgactac gactatcccg aagaggagca gctcagtggt gccggctaca gagtatcagc
      421 cgctcttgaa gaagccgaca agatgtttct gagaacaaga gaaccagccc tggatggcgg
      481 gtttcagatg cattatgaga agaccccgtt tgatcagtta gcttttatcg aagagctttt
      541 ttcactgatg gttgtcaatc gtctgaccga agaactcggc tgtgatgaga ttattgatag
      601 agagtagtta gatgctgtta aaagaggagg aaactacttg aggagggacc caactttccg
      661 ctatcttttg ggttcattcc aaatagtttt gtgccattga aaaacttgac cttcaaaaaa
      721 atttgttttt cagaatagaa cacaatagga cagtgactgc acagttgtga aaaaggaaga
      781 gaatcattaa agaaaaagaa aaaagatttt aagaccgttg aaatcaatta tcaagaacgt
      841 cctaaaacac ctatggcttt gactttgtta ttgatccaga ttattttcct tgcattgggg
      901 aaaatatctt tcatatttgt ttgctgtaaa gatggttttg caagaataag tcatgaccaa
      961 gacaaactgc caatacaaaa gcccactgat actaattata taatgagaaa aaaatgtatc
     1021 caactaggac acatatcttt tgagttattt ggactgaaag cttaagaaaa cttggaaaat
     1081 tctattttgt gatctagtca agccacagtt atcaaaggct acattttcag tgtaagataa
     1141 atggatgagt aaactcaaat atgtatcacg tgtgctttgt atcttaagat gtgtttccaa
     1201 gagcatctga aattttgttt gtacatgtat cttgatcatt tataaagcca ctgtgatcta
     1261 taaatcaaga aaatccattg tcataaccat ttttaaaagt caaaaattaa gacatcctta
     1321 attaaaaagt ttcaaatcta gacactaaat gtgtgtgaat gtacaaagaa aacaaaccat
     1381 tgcttatgct gttatatact agagaaattt tgttttgctt gctgttttaa cttgacagat
     1441 gaaggacttt agttgaactt catattgtaa gaactgttaa taaaagttgt caagtaaaaa
     1501 gcgctatatc taaaaagact ttatgaacag ttattctatc aacttttaaa ggttttaaac
     1561 ctgcccagaa attaccttgg tatctgaagt ttccctctgt ctcctcctct aattaagctt
     1621 gttatttgtc atgcaccagc attggagata ataaaatttc ttgttctgtg tattttgttt
     1681 ggctaatagt attgcataca tactttctct gtatactact ttctattgta tgtgttaacc
     1741 agtattaagg gaaaatgatc cagcttcagc tatctaattc acaaattaat ttctggaaat
     1801 taaactttgt aaattaagtt tttgcctata agaatttgct ggtctgggaa aacctgccct
     1861 atcaatgagt atgttgccgt ggttacctta ctaagatgct gaagttctag gagagtaatg
     1921 attacatcag aaggctaggt tcagcaaaat aagtgtatca gcaggtttta tcatgatcag
     1981 taaaaatgtt ccaaatgctt ctgctccatt atagcagtaa agaacgaata tccaatgcaa
//
