LOCUS       NM_004879               2191 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens EI24 autophagy associated transmembrane protein
            (EI24), transcript variant 1, mRNA.
ACCESSION   NM_004879
VERSION     NM_004879.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Zhou,W., Yang,W., Yang,J., Zhu,H., Duan,L., Wang,X., Li,Y., Niu,L.,
            Xiao,S., Zhang,R., Yang,J. and Hong,L.
  TITLE     miR-483 promotes the development of colorectal cancer by inhibiting
            the expression level of EI24
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34109432
  REMARK    GeneRIF: miR483 promotes the development of colorectal cancer by
            inhibiting the expression level of EI24.
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Wang,M., Li,P., Wan,R. and Liu,X.
  TITLE     Integrated analysis of the prognostic value of TP53 dependent
            etoposide-induced gene 24 in non-small cell lung cancer
  JOURNAL   Biomed Pharmacother 112, 108590 (2019)
   PUBMED   30784913
  REMARK    GeneRIF: EI24 is a prognostic biomarker and impacts poor outcome in
            non-small cell lung cancer.
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Li,Z., Meng,Q., Pan,A., Wu,X., Cui,J., Wang,Y. and Li,L.
  TITLE     MicroRNA-455-3p promotes invasion and migration in triple negative
            breast cancer by targeting tumor suppressor EI24
  JOURNAL   Oncotarget 8 (12), 19455-19466 (2017)
   PUBMED   28038450
  REMARK    GeneRIF: Low EI24 expression is associated with triple negative
            breast cancer.
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   Devkota,S., Jeong,H., Kim,Y., Ali,M., Roh,J.I., Hwang,D. and
            Lee,H.W.
  TITLE     Functional characterization of EI24-induced autophagy in the
            degradation of RING-domain E3 ligases
  JOURNAL   Autophagy 12 (11), 2038-2053 (2016)
   PUBMED   27541728
  REMARK    GeneRIF: EI24 is an essential player in ubiquitin-proteasome
            system-autophagy crosstalk via degradation of RING E3 ligases.
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Burns,T.F., Bernhard,E.J. and El-Deiry,W.S.
  TITLE     Tissue specific expression of p53 target genes suggests a key role
            for KILLER/DR5 in p53-dependent apoptosis in vivo
  JOURNAL   Oncogene 20 (34), 4601-4612 (2001)
   PUBMED   11498783
REFERENCE   7  (bases 1 to 2191)
  AUTHORS   Gu,Z., Flemington,C., Chittenden,T. and Zambetti,G.P.
  TITLE     ei24, a p53 response gene involved in growth suppression and
            apoptosis
  JOURNAL   Mol Cell Biol 20 (1), 233-241 (2000)
   PUBMED   10594026
REFERENCE   8  (bases 1 to 2191)
  AUTHORS   Gu,Z., Gilbert,D.J., Valentine,V.A., Jenkins,N.A., Copeland,N.G.
            and Zambetti,G.P.
  TITLE     The p53-inducible gene EI24/PIG8 localizes to human chromosome
            11q23 and the proximal region of mouse chromosome 9
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 230-233 (2000)
   PUBMED   10965130
REFERENCE   9  (bases 1 to 2191)
  AUTHORS   Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B.
  TITLE     A model for p53-induced apoptosis
  JOURNAL   Nature 389 (6648), 300-305 (1997)
   PUBMED   9305847
REFERENCE   10 (bases 1 to 2191)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA680745.1, BG566671.1,
            BC002390.2 and DB520736.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004879.4.
            
            Summary: This gene encodes a putative tumor suppressor and has
            higher expression in p53-expressing cells than in control cells and
            is an immediate-early induction target of p53-mediated apoptosis.
            The encoded protein may suppress cell growth by inducing apoptotic
            cell death through the caspase 9 and mitochondrial pathways. This
            gene is located on human chromosome 11q24, a region frequently
            altered in cancers. Alternative splicing results in multiple
            transcript variants. Pseudogenes of this gene have been defined on
            chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.799775.1,
                                           SRR3476690.701996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278903.11/ ENSP00000278903.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA680745.1         91-140
            51-51               BG566671.1         116-116
            52-1769             BC002390.2         8-1725
            1770-2191           DB520736.1         8-429
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2191
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /note="EI24 autophagy associated transmembrane protein"
                     /db_xref="GeneID:9538"
                     /db_xref="HGNC:HGNC:13276"
                     /db_xref="MIM:605170"
     exon            1..97
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            98..209
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1190
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     protein p53 inducible protein 8; ectopic P-granules
                     autophagy protein 4 homolog; etoposide-induced protein 2.4
                     homolog; p53-induced gene 8 protein; etoposide induced
                     2.4"
                     /codon_start=1
                     /product="etoposide-induced protein 2.4 homolog isoform 1"
                     /protein_id="NP_004870.3"
                     /db_xref="CCDS:CCDS73410.1"
                     /db_xref="GeneID:9538"
                     /db_xref="HGNC:HGNC:13276"
                     /db_xref="MIM:605170"
                     /translation="MADSVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQRRRR
                     ASSVLAQRRAQSIERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTA
                     RIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRK
                     PHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFE
                     YRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIIS
                     ANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTSAEKFPSPHPSPAKL
                     KATAGH"
     exon            210..355
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            356..416
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            417..483
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            484..608
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            609..728
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            729..840
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            841..952
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1027
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..2191
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /note="hexamer: ATTAAA"
     polyA_site      2191
                     /gene="EI24"
                     /gene_synonym="EPG4; PIG8; TP53I8"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgggcg cagcggcccc ggccctggaa gcgccccggc ggagctggcc tgcggtgggc
       61 taggggcagg gccggagccg cggcggcgga gctgtggatc cttcatgatg agagatttgg
      121 ggacacttct ctctcctgtg tgtagttgat agtttggtgg tgaagagatg gctgacagtg
      181 tcaaaacctt tctccaggac cttgccagag gaatcaaaga ctccatctgg ggtatttgta
      241 ccatctcaaa gctagatgct cgaatccagc aaaagagaga ggagcagcgt cgaagaaggg
      301 caagtagtgt cttggcacag agaagagccc agagtataga gcggaagcaa gagagtgagc
      361 cacgtattgt tagtagaatt ttccagtgtt gtgcttggaa tggtggagtg ttctggttca
      421 gtctcctctt gttttatcga gtatttattc ctgtgcttca gtcggtaaca gcccgaatta
      481 tcggtgaccc atcactacat ggagatgttt ggtcgtggct ggaattcttc ctcacgtcaa
      541 ttttcagtgc tctttgggtg ctccccttgt ttgtgcttag caaagtggtg aatgccattt
      601 ggtttcagga tatagctgac ctggcatttg aggtatcagg gaggaagcct cacccattcc
      661 ctagtgtcag caaaataatt gctgacatgc tcttcaacct tttgctgcag gctcttttcc
      721 tcattcaggg aatgtttgtg agtctctttc ccatccatct tgtcggtcag ctggttagtc
      781 tcctgcatat gtcccttctc tactcactgt actgctttga atatcgttgg ttcaataaag
      841 gaattgaaat gcaccagcgg ttgtctaaca tagaaaggaa ttggccttac tactttgggt
      901 ttggtttgcc cttggctttt ctcacagcaa tgcagtcctc atatattatc agtggctgcc
      961 ttttctctat cctctttcct ttattcatta tcagcgccaa tgaagcaaag acccctggca
     1021 aagcatatct cttccagttg cgcctcttct ccttggtggt cttcttaagc aacagactct
     1081 tccacaagac agtctacctg cagtcggccc tgagcagctc tacttctgca gagaagttcc
     1141 cttcaccgca tccgtcgcct gccaaactga aggctactgc aggtcactga gttgcctgcc
     1201 atccaaaggg gatgggcggg attggaagaa gctgtggcag ctcttttccc tgttcacctc
     1261 ccgcctgcca gggaaggcag gacccgctct gccaagggcc ctctgcgtat tcccttctct
     1321 ctgaggaatt gaaatttttg tctctggtgc acgtaaggca gaatgttccc tgacaccagt
     1381 gtgtggattt ttaacatcac cgtgagtctg aaaggaccac aggtttttct gcagctattt
     1441 tctagcattt gccagtccct gtgcctggac tgattggaac actttgtttt tctccctgtg
     1501 ccatttaccc ttccaccttt ccatcctgcc ttctaccacc cttggatgaa tggattttgt
     1561 aattctagct gttgtatttt gtgaatttgt taattttgtt gtttttctgt gaaacacata
     1621 cattggatat gggaggtaaa ggagtgtccc agttgctcct ggtcactccc tttatagcca
     1681 ttactgtctt gtttcttgta actcaggtta ggttttggtc tctcttgctc cactgcaaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaag cctgaagaga tgagatagga ggaaagacct
     1801 cacagccaga tctgctgggt tttgaggagt gattttcttt cttccccttg aaggggaaaa
     1861 agctattttc attggtacat ttaaagtccc ccaactatgg ggaggtacca attctggaca
     1921 agtgccacta caacaacact aaacctgaac ttttcaactc cgttggtggt gggaggcagc
     1981 gggcagaaat ttactgttgg ccactgccag gtctatttca tatttcaaag gaatattggg
     2041 tgctgcatat aggaactgaa ggggtcaatg tattaaacct gtgattggtt gttttcctgt
     2101 cattttgaga gactaaatgt ggggggcaga tgtcaaaata cctgtacaat tttaaaatgt
     2161 cacaattaaa catgagctgg tttcccacaa a
//
