LOCUS       NM_006709               3979 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens euchromatic histone lysine methyltransferase 2
            (EHMT2), transcript variant 2, mRNA.
ACCESSION   NM_006709
VERSION     NM_006709.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3979)
  AUTHORS   Sun,L., Liu,R., Wu,Z.J., Liu,Z.Y., Wan,A.H., Yan,S., Liu,C.,
            Liang,H., Xiao,M., You,N., Lou,Y., Deng,Y., Bu,X., Chen,D.,
            Huang,J., Zhang,X., Kuang,D.M. and Wan,G.
  TITLE     Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in
            Microsatellite Stability Colorectal Cancer
  JOURNAL   Gastroenterology 166 (3), 466-482 (2024)
   PUBMED   38065340
  REMARK    GeneRIF: Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity
            in Microsatellite Stability Colorectal Cancer.
REFERENCE   2  (bases 1 to 3979)
  AUTHORS   Muneer,A., Wang,L., Xie,L., Zhang,F., Wu,B., Mei,L., Lenarcic,E.M.,
            Feng,E.H., Song,J., Xiong,Y., Yu,X., Wang,C., Jain,K., Strahl,B.D.,
            Cook,J.G., Wan,Y.Y., Moorman,N.J., Song,H., Jin,J. and Chen,X.
  TITLE     Non-canonical function of histone methyltransferase G9a in the
            translational regulation of chronic inflammation
  JOURNAL   Cell Chem Biol 30 (12), 1525-1541 (2023)
   PUBMED   37858336
  REMARK    GeneRIF: Non-canonical function of histone methyltransferase G9a in
            the translational regulation of chronic inflammation.
REFERENCE   3  (bases 1 to 3979)
  AUTHORS   Souza,B.K., Freire,N.H., Monteiro,T.S., Herlinger,A.L., Jaeger,M.,
            Dalmolin,M.G.S., de Farias,C.B., Gregianin,L., Brunetto,A.T.,
            Brunetto,A.L., Thiele,C.J. and Roesler,R.
  TITLE     Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated
            with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing
            Sarcoma
  JOURNAL   Int J Mol Sci 24 (20), 15242 (2023)
   PUBMED   37894922
  REMARK    GeneRIF: Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are
            Associated with Cell Viability and Poorer Prognosis in
            Neuroblastoma and Ewing Sarcoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3979)
  AUTHORS   Fang,Z., Wang,Y., Huang,B., Chen,X., Jiang,R. and Yin,M.
  TITLE     Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis
            via targeting EDAR-NF-kappaB signaling in keratinocyte
  JOURNAL   Cell Death Dis 14 (9), 627 (2023)
   PUBMED   37739945
  REMARK    GeneRIF: Depletion of G9A attenuates imiquimod-induced psoriatic
            dermatitis via targeting EDAR-NF-kappaB signaling in keratinocyte.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3979)
  AUTHORS   Yang,Y., Zhou,Z., Wang,L., Gao,P. and Wu,Z.
  TITLE     G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and
            the cell cycle leading to improvement in kidney fibrosis
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (9), 130417 (2023)
   PUBMED   37356504
  REMARK    GeneRIF: G9a and DNMT1 inhibition modulates CDKN1A promoter
            methylation and the cell cycle leading to improvement in kidney
            fibrosis.
REFERENCE   6  (bases 1 to 3979)
  AUTHORS   Ogawa,H., Ishiguro,K., Gaubatz,S., Livingston,D.M. and Nakatani,Y.
  TITLE     A complex with chromatin modifiers that occupies E2F- and
            Myc-responsive genes in G0 cells
  JOURNAL   Science 296 (5570), 1132-1136 (2002)
   PUBMED   12004135
REFERENCE   7  (bases 1 to 3979)
  AUTHORS   Brown,S.E., Campbell,R.D. and Sanderson,C.M.
  TITLE     Novel NG36/G9a gene products encoded within the human and mouse MHC
            class III regions
  JOURNAL   Mamm Genome 12 (12), 916-924 (2001)
   PUBMED   11707778
REFERENCE   8  (bases 1 to 3979)
  AUTHORS   Tachibana,M., Sugimoto,K., Fukushima,T. and Shinkai,Y.
  TITLE     Set domain-containing protein, G9a, is a novel lysine-preferring
            mammalian histone methyltransferase with hyperactivity and specific
            selectivity to lysines 9 and 27 of histone H3
  JOURNAL   J Biol Chem 276 (27), 25309-25317 (2001)
   PUBMED   11316813
REFERENCE   9  (bases 1 to 3979)
  AUTHORS   Milner,C.M. and Campbell,R.D.
  TITLE     The G9a gene in the human major histocompatibility complex encodes
            a novel protein containing ankyrin-like repeats
  JOURNAL   Biochem J 290 (Pt 3) (Pt 3), 811-818 (1993)
   PUBMED   8457211
  REMARK    Erratum:[Biochem J 1993 Jun 15;292(Pt 3):952]
REFERENCE   10 (bases 1 to 3979)
  AUTHORS   Spies,T., Bresnahan,M. and Strominger,J.L.
  TITLE     Human major histocompatibility complex contains a minimum of 19
            genes between the complement cluster and HLA-B
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 8955-8958 (1989)
   PUBMED   2813433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY067184.1, BC009351.1,
            CN397400.1 and X69838.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006709.4.
            
            Summary: This gene encodes a methyltransferase that methylates
            lysine residues of histone H3. Methylation of H3 at lysine 9 by
            this protein results in recruitment of additional epigenetic
            regulators and repression of transcription. This gene was initially
            thought to be two different genes, NG36 and G9a, adjacent to each
            other in the HLA locus. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2, also known as NG36/G9a) uses
            an alternate 5' UTR and 5' coding region, contains an alternate
            in-frame exon in the 5' coding region, and lacks an alternate
            in-frame exon compared to variant 3. It encodes isoform a, which is
            shorter and has a distinct N-terminus, compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009351.1, AJ315532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375537.9/ ENSP00000364687.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                HY067184.1         10-44
            36-180              BC009351.1         12-156
            181-732             CN397400.1         24-575
            733-3975            BC009351.1         709-3951
            3976-3979           X69838.1           3374-3377
FEATURES             Location/Qualifiers
     source          1..3979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3979
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /note="euchromatic histone lysine methyltransferase 2"
                     /db_xref="GeneID:10919"
                     /db_xref="HGNC:HGNC:14129"
                     /db_xref="MIM:604599"
     exon            1..63
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..3654
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /EC_number="2.1.1.367"
                     /note="isoform a is encoded by transcript variant 2; G9A
                     histone methyltransferase; ankyrin repeat-containing
                     protein; HLA-B associated transcript 8; histone H3-K9
                     methyltransferase 3; euchromatic histone-lysine
                     N-methyltransferase 2; H3-K9-HMTase 3; lysine
                     N-methyltransferase 1C; histone-lysine
                     N-methyltransferase, H3 lysine-9 specific 3;
                     histone-lysine N-methyltransferase EHMT2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EHMT2 isoform
                     a"
                     /protein_id="NP_006700.3"
                     /db_xref="CCDS:CCDS4725.1"
                     /db_xref="GeneID:10919"
                     /db_xref="HGNC:HGNC:14129"
                     /db_xref="MIM:604599"
                     /translation="MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDT
                     PRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
                     RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGA
                     AAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLG
                     KVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDS
                     YSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRS
                     GSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSL
                     ELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATE
                     SVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLE
                     CHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPP
                     PLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLP
                     LGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQ
                     QSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR
                     GGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI
                     EVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLH
                     IAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNR
                     AIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQ
                     HCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNR
                     VVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFD
                     LDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRT
                     GEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGS
                     LPPVNT"
     exon            64..130
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            131..349
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            350..603
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            604..688
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            689..729
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            730..885
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1020
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1135
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1237
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1386
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1530
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1766
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1949
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2032
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2139
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2262
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2364
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2469
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2624
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2792
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2937
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3015
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3131
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3218
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3297
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3473
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3979
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3955..3960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /note="hexamer: AATAAA"
     polyA_site      3979
                     /gene="EHMT2"
                     /gene_synonym="BAT8; C6orf30; G9A; GAT8; KMT1C; NG36"
                     /note="major polyA site"
ORIGIN      
        1 cggcccccag cgcaagcggc gatggcggcg gcggcgggag ctgcagcggc ggcggccgcc
       61 gagggggagg cccccgctga gatgggggcg ctgctgctgg agaaggaaac cagaggagcc
      121 accgagagag ttcatggctc tttgggggac acccctcgta gtgaagaaac cctgcccaag
      181 gccacccccg actccctgga gcctgctggc ccctcatctc cagcctctgt cactgtcact
      241 gttggtgatg agggggctga cacccctgta ggggctacac cactcattgg ggatgaatct
      301 gagaatcttg agggagatgg ggacctccgt gggggccgga tcctgctggg ccatgccaca
      361 aagtcattcc cctcttcccc cagcaagggg ggttcctgtc ctagccgggc caagatgtca
      421 atgacagggg cgggaaaatc acctccatct gtccagagtt tggctatgag gctactgagt
      481 atgccaggag cccagggagc tgcagcagca gggtctgaac cccctccagc caccacgagc
      541 ccagagggac agcccaaggt ccaccgagcc cgcaaaacca tgtccaaacc aggaaatgga
      601 cagcccccgg tccctgagaa gcggccccct gaaatacagc atttccgcat gagtgatgat
      661 gtccactcac tgggaaaggt gacctcagat ctggccaaaa ggaggaagct gaactcagga
      721 ggtggcctgt cagaggagtt aggttctgcc cggcgttcag gagaagtgac cctgacgaaa
      781 ggggaccccg ggtccctgga ggagtgggag acggtggtgg gtgatgactt cagtctctac
      841 tatgattcct actctgtgga tgagcgcgtg gactccgaca gcaagtctga agttgaagct
      901 ctaactgaac aactaagtga agaggaggag gaggaagagg aggaagaaga agaagaggaa
      961 gaggaggagg aagaggaaga agaagaggaa gatgaggagt cagggaatca gtcagatagg
     1021 agtggttcca gtggccggcg caaggccaag aagaaatggc gaaaagacag cccatgggtg
     1081 aagccgtctc ggaaacggcg caagcgggag cctccgcggg ccaaggagcc acgaggagtg
     1141 aatggtgtgg gctcctcagg ccccagtgag tacatggagg tccctctggg gtccctggag
     1201 ctgcccagcg aggggaccct ctcccccaac cacgctgggg tgtccaatga cacatcttcg
     1261 ctggagacag agcgagggtt tgaggagttg cccctgtgca gctgccgcat ggaggcaccc
     1321 aagattgacc gcatcagcga gagggcgggg cacaagtgca tggccactga gagtgtggac
     1381 ggagagctgt caggctgcaa tgccgccatc ctcaagcggg agaccatgag gccatccagc
     1441 cgtgtggccc tgatggtgct ctgtgagacc caccgcgccc gcatggtcaa acaccactgc
     1501 tgcccgggct gcggctactt ctgcacggcg ggcaccttcc tggagtgcca ccctgacttc
     1561 cgtgtggccc accgcttcca caaggcctgt gtgtctcagc tgaatgggat ggtcttctgt
     1621 ccccactgtg gggaggatgc ttctgaagct caagaggtga ccatcccccg gggtgacggg
     1681 gtgaccccac cggccggcac tgcagctcct gcacccccac ccctgtccca ggatgtcccc
     1741 gggagagcag acacttctca gcccagtgcc cggatgcgag ggcatgggga accccggcgc
     1801 ccgccctgcg atcccctggc tgacaccatt gacagctcag ggccctccct gaccctgccc
     1861 aatgggggct gcctttcagc cgtggggctg ccactggggc caggccggga ggccctggaa
     1921 aaggccctgg tcatccagga gtcagagagg cggaagaagc tccgtttcca ccctcggcag
     1981 ttgtacctgt ccgtgaagca gggcgagctg cagaaggtga tcctgatgct gttggacaac
     2041 ctggacccca acttccagag cgaccagcag agcaagcgca cgcccctgca tgcagccgcc
     2101 cagaagggct ccgtggagat ctgccatgtg ctgctgcagg ctggagccaa cataaatgca
     2161 gtggacaaac agcagcggac gccactgatg gaggccgtgg tgaacaacca cctggaggta
     2221 gcccgttaca tggtgcagcg tggtggctgt gtctatagca aggaggagga cggttccacc
     2281 tgcctccacc acgcagccaa aatcgggaac ttggagatgg tcagcctgct gctgagcaca
     2341 ggacaggtgg acgtcaacgc ccaggacagt ggggggtgga cgcccatcat ctgggctgca
     2401 gagcacaagc acatcgaggt gatccgcatg ctactgacgc ggggcgccga cgtcaccctc
     2461 actgacaacg aggagaacat ctgcctgcac tgggcctcct tcacgggcag cgccgccatc
     2521 gccgaagtcc ttctgaatgc gcgctgtgac ctccatgctg tcaactacca tggggacacc
     2581 cccctgcaca tcgcagctcg ggagagctac catgactgcg tgctgttatt cctgtcacgt
     2641 ggggccaacc ctgagctgcg gaacaaagag ggggacacag catgggacct gactcccgag
     2701 cgctccgacg tgtggtttgc gcttcaactc aaccgcaagc tccgacttgg ggtgggaaat
     2761 cgggccatcc gcacagagaa gatcatctgc cgggacgtgg ctcggggcta tgagaacgtg
     2821 cccattccct gtgtcaacgg tgtggatggg gagccctgcc ctgaggatta caagtacatc
     2881 tcagagaact gcgagacgtc caccatgaac atcgatcgca acatcaccca cctgcagcac
     2941 tgcacgtgtg tggacgactg ctctagctcc aactgcctgt gcggccagct cagcatccgg
     3001 tgctggtatg acaaggatgg gcgattgctc caggaattta acaagattga gcctccgctg
     3061 attttcgagt gtaaccaggc gtgctcatgc tggagaaact gcaagaaccg ggtcgtacag
     3121 agtggcatca aggtgcggct acagctctac cgaacagcca agatgggctg gggggtccgc
     3181 gccctgcaga ccatcccaca ggggaccttc atctgcgagt atgtcgggga gctgatctct
     3241 gatgctgagg ctgatgtgag agaggatgat tcttacctct tcgacttaga caacaaggat
     3301 ggagaggtgt actgcataga tgcccgttac tatggcaaca tcagccgctt catcaaccac
     3361 ctgtgtgacc ccaacatcat tcccgtccgg gtcttcatgc tgcaccaaga cctgcgattt
     3421 ccacgcatcg ccttcttcag ttcccgagac atccggactg gggaggagct agggtttgac
     3481 tatggcgacc gcttctggga catcaaaagc aaatatttca cctgccaatg tggctctgag
     3541 aagtgcaagc actcagccga agccattgcc ctggagcaga gccgtctggc ccgcctggac
     3601 ccacaccctg agctgctgcc cgagctcggc tccctgcccc ctgtcaacac atgagaacgg
     3661 accacaccct ctctccccag catggatggc cacagctcag ccgcctcctc tgccaccagc
     3721 tgctcgcagc ccatgcctgg gggtgctgcc atcttctctc cccaccaccc tttcacacat
     3781 tcctgaccag agatcccagc caggccctgg aggtctgaca gcccctccct cccagagctg
     3841 gttcctccct gggagggcaa cttcagggct ggccaccccc cgtgttcccc atcctcagtt
     3901 gaagtttgat gaattgaagt cgggcctcta tgccaactgg ttccttttgt tctcaataaa
     3961 tgttgggttt ggtaataaa
//
