LOCUS       NM_024757               5095 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens euchromatic histone lysine methyltransferase 1
            (EHMT1), transcript variant 1, mRNA.
ACCESSION   NM_024757 XM_942568 XM_946117 XM_946119 XM_946122 XM_946124
            XM_946126 XM_946128 XM_946130 XM_946133
VERSION     NM_024757.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5095)
  AUTHORS   Souza,B.K., Freire,N.H., Monteiro,T.S., Herlinger,A.L., Jaeger,M.,
            Dalmolin,M.G.S., de Farias,C.B., Gregianin,L., Brunetto,A.T.,
            Brunetto,A.L., Thiele,C.J. and Roesler,R.
  TITLE     Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated
            with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing
            Sarcoma
  JOURNAL   Int J Mol Sci 24 (20), 15242 (2023)
   PUBMED   37894922
  REMARK    GeneRIF: Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are
            Associated with Cell Viability and Poorer Prognosis in
            Neuroblastoma and Ewing Sarcoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5095)
  AUTHORS   Besschetnova,A., Han,W., Liu,M., Gao,Y., Li,M., Wang,Z., Labaf,M.,
            Patalano,S., Venkataramani,K., Muriph,R.E., Macoska,J.A.,
            Siegfried,K.R., Evans,J., Balk,S.P., Gao,S., Han,D. and Cai,C.
  TITLE     Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional
            Activity and Promotes Prostate Cancer Progression
  JOURNAL   Cancer Res Commun 3 (8), 1716-1730 (2023)
   PUBMED   37663929
  REMARK    GeneRIF: Demethylation of EHMT1/GLP Protein Reprograms Its
            Transcriptional Activity and Promotes Prostate Cancer Progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5095)
  AUTHORS   Iglesias-Ortega,L., Megias-Fernandez,C., Dominguez-Gimenez,P.,
            Jimeno-Gonzalez,S. and Rivero,S.
  TITLE     Cell consequences of loss of function of the epigenetic factor
            EHMT1
  JOURNAL   Cell Signal 108, 110734 (2023)
   PUBMED   37257768
  REMARK    GeneRIF: Cell consequences of loss of function of the epigenetic
            factor EHMT1.
REFERENCE   4  (bases 1 to 5095)
  AUTHORS   Nachiyappan,A., Gupta,N. and Taneja,R.
  TITLE     EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging
            evidence and mechanisms
  JOURNAL   FEBS J 289 (5), 1329-1351 (2022)
   PUBMED   34954891
  REMARK    GeneRIF: EHMT1/EHMT2 in EMT, cancer stemness and drug resistance:
            emerging evidence and mechanisms.
            Review article
REFERENCE   5  (bases 1 to 5095)
  AUTHORS   Kleefstra,T., Brunner,H.G., Amiel,J., Oudakker,A.R., Nillesen,W.M.,
            Magee,A., Genevieve,D., Cormier-Daire,V., van Esch,H., Fryns,J.P.,
            Hamel,B.C., Sistermans,E.A., de Vries,B.B. and van Bokhoven,H.
  TITLE     Loss-of-function mutations in euchromatin histone methyl
            transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome
  JOURNAL   Am J Hum Genet 79 (2), 370-377 (2006)
   PUBMED   16826528
  REMARK    GeneRIF: Haploinsufficiency of EHMT1 is causative for 9q
            subtelomeric deletion syndrome.
REFERENCE   6  (bases 1 to 5095)
  AUTHORS   Cebrian,A., Pharoah,P.D., Ahmed,S., Ropero,S., Fraga,M.F.,
            Smith,P.L., Conroy,D., Luben,R., Perkins,B., Easton,D.F.,
            Dunning,A.M., Esteller,M. and Ponder,B.A.
  TITLE     Genetic variants in epigenetic genes and breast cancer risk
  JOURNAL   Carcinogenesis 27 (8), 1661-1669 (2006)
   PUBMED   16501248
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5095)
  AUTHORS   Ueda,J., Tachibana,M., Ikura,T. and Shinkai,Y.
  TITLE     Zinc finger protein Wiz links G9a/GLP histone methyltransferases to
            the co-repressor molecule CtBP
  JOURNAL   J Biol Chem 281 (29), 20120-20128 (2006)
   PUBMED   16702210
REFERENCE   8  (bases 1 to 5095)
  AUTHORS   Kleefstra,T., Smidt,M., Banning,M.J., Oudakker,A.R., Van Esch,H.,
            de Brouwer,A.P., Nillesen,W., Sistermans,E.A., Hamel,B.C., de
            Bruijn,D., Fryns,J.P., Yntema,H.G., Brunner,H.G., de Vries,B.B. and
            van Bokhoven,H.
  TITLE     Disruption of the gene Euchromatin Histone Methyl Transferase1
            (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion
            syndrome
  JOURNAL   J Med Genet 42 (4), 299-306 (2005)
   PUBMED   15805155
  REMARK    GeneRIF: This indicates that haploinsufficiency of Eu-HMTase1 is
            responsible for the 9q submicroscopic subtelomeric deletion
            syndrome
REFERENCE   9  (bases 1 to 5095)
  AUTHORS   Ogawa,H., Ishiguro,K., Gaubatz,S., Livingston,D.M. and Nakatani,Y.
  TITLE     A complex with chromatin modifiers that occupies E2F- and
            Myc-responsive genes in G0 cells
  JOURNAL   Science 296 (5570), 1132-1136 (2002)
   PUBMED   12004135
REFERENCE   10 (bases 1 to 5095)
  AUTHORS   Kleefstra,T. and de Leeuw,N.
  TITLE     Kleefstra Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20945554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047504.1, AB028932.1,
            BC011608.2 and CA426038.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024757.4.
            
            Summary: The protein encoded by this gene is a histone
            methyltransferase that methylates the lysine-9 position of histone
            H3. This action marks the genomic region packaged with these
            methylated histones for transcriptional repression. This protein
            may be involved in the silencing of MYC- and E2F-responsive genes
            and therefore could play a role in the G0/G1 cell cycle transition.
            Defects in this gene are a cause of chromosome 9q subtelomeric
            deletion syndrome (9q-syndrome, also known as Kleefstra syndrome).
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.42755.1,
                                           SRR1803613.6578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000460843.6/ ENSP00000417980.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1686              BC047504.1         14-1699
            1687-3921           AB028932.1         520-2754
            3922-4891           BC011608.2         2152-3121
            4892-5095           CA426038.1         16-219              c
FEATURES             Location/Qualifiers
     source          1..5095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..5095
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /note="euchromatic histone lysine methyltransferase 1"
                     /db_xref="GeneID:79813"
                     /db_xref="HGNC:HGNC:24650"
                     /db_xref="MIM:607001"
     exon            1..45
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..3921
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /EC_number="2.1.1.367"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone-lysine N-methyltransferase EHMT1; histone-lysine
                     N-methyltransferase, H3 lysine-9 specific 5; histone H3-K9
                     methyltransferase 5; euchromatic histone-lysine
                     N-methyltransferase 1; H3-K9-HMTase 5; lysine
                     N-methyltransferase 1D; G9a-like protein 1; EHMT1 intronic
                     transcript 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase EHMT1 isoform
                     1"
                     /protein_id="NP_079033.4"
                     /db_xref="CCDS:CCDS7050.2"
                     /db_xref="GeneID:79813"
                     /db_xref="HGNC:HGNC:24650"
                     /db_xref="MIM:607001"
                     /translation="MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAG
                     EAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSE
                     AAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAG
                     KGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAAS
                     KDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTAC
                     LPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGA
                     SSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMD
                     GESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRK
                     KPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDV
                     LETDGLQEVPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPS
                     NKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNA
                     SYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSED
                     DKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPK
                     QLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN
                     IDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ
                     YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAA
                     FSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEG
                     ETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVD
                     SEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDG
                     RLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDI
                     PPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCE
                     PNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPK
                     CRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL"
     exon            46..109
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            110..666
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            667..847
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1005
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1194
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1272
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1393
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1525
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1671
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1815
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2042
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2216
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2299
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2406
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2529
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2631
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2736
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2891
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3059
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3204
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3282
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3398
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3485
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3564
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3740
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..5095
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4687..4692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /note="hexamer: AATAAA"
     polyA_site      4709
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /note="major polyA site"
     regulatory      5071..5076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /note="hexamer: AATAAA"
     polyA_site      5095
                     /gene="EHMT1"
                     /gene_synonym="EHMT1-IT1; Eu-HMTase1; EUHMTASE1; FP13812;
                     GLP; GLP1; KLEFS1; KMT1D"
                     /note="major polyA site"
ORIGIN      
        1 ggggccacgc tgcgggcccg ggccatggcc gccgccgatg ccgaggcagt tccggcgagg
       61 ggggagcctc agcaggattg ctgtgtgaaa accgagctgc tgggagaaga gacacctatg
      121 gctgccgatg aaggctcagc agagaaacag gcaggagagg cccacatggc tgcggacggt
      181 gagaccaatg ggtcttgtga aaacagcgat gccagcagtc atgcaaatgc tgcaaagcac
      241 actcaggaca gcgcaagggt caacccccag gatggcacca acacactaac tcggatagcg
      301 gaaaatgggg tttcagaaag agactcagaa gcggcgaagc aaaaccacgt cactgccgac
      361 gactttgtgc agacttctgt catcggcagc aacggataca tcttaaataa gccggcccta
      421 caggcacagc ccttgaggac taccagcact ctggcctctt cgctgcctgg ccatgctgca
      481 aaaacccttc ctggaggggc tggcaaaggc aggactccaa gcgcttttcc ccagacgcca
      541 gccgccccac cagccaccct tggggagggg agtgctgaca cagaggacag gaagctcccg
      601 gcccctggcg ccgacgtcaa ggtccacagg gcacgcaaga ccatgccgaa gtccgtcgtg
      661 ggcctgcatg cagccagtaa agatcccaga gaagttcgag aagctagaga tcataaggaa
      721 ccaaaagagg agatcaacaa aaacatttct gactttggac gacagcagct tttacccccc
      781 ttcccatccc ttcatcagtc gctacctcag aaccagtgct acatggccac cacaaaatca
      841 cagacagctt gcttgccttt tgttttagca gctgcagtat ctcggaagaa aaaacgaaga
      901 atgggaacct atagcctggt tcctaagaaa aagaccaaag tattaaaaca gaggacggtg
      961 attgagatgt ttaagagcat aactcattcc actgtgggtt ccaaggggga gaaggacctg
     1021 ggcgccagca gcctgcacgt gaatggggag agcctggaga tggactcgga tgaggacgac
     1081 tcagaggagc tcgaggagga cgacggccat ggtgcagagc aggcggccgc gttccccaca
     1141 gaggacagca ggacttccaa ggagagcatg tcggaggctg atcgcgccca gaagatggac
     1201 ggggagtccg aggaggagca ggagtccgtg gacaccgggg aggaggagga aggcggtgac
     1261 gagtctgacc tgagttcgga atccagcatt aagaagaaat ttctcaagag gaaaggaaag
     1321 accgacagtc cctggatcaa gccagccagg aaaaggaggc ggagaagtag aaagaagccc
     1381 agcggtgccc tcggttctga gtcgtataag tcatctgcag gaagcgctga gcagacggca
     1441 ccaggagaca gcacagggta catggaagtt tctctggact ccctggatct ccgagtcaaa
     1501 ggaattctgt cttcacaagc agaagggttg gccaacggtc cagatgtgct ggagacagac
     1561 ggcctccagg aagtgcctct ctgcagctgc cggatggaaa caccgaagag tcgagagatc
     1621 accacactgg ccaacaacca gtgcatggct acagagagcg tggaccatga attgggccgg
     1681 tgcacaaaca gcgtggtcaa gtatgagctg atgcgcccct ccaacaaggc cccgctcctc
     1741 gtgctgtgtg aagaccaccg gggccgcatg gtgaagcacc agtgctgtcc tggctgtggc
     1801 tacttctgca cagcgggtaa ttttatggag tgtcagcccg agagcagcat ctctcaccgt
     1861 ttccacaaag actgtgcctc tcgagtcaat aacgccagct attgtcccca ctgtggggag
     1921 gagagctcca aggccaaaga ggtgacgata gctaaagcag acaccacctc gaccgtgaca
     1981 ccagtccccg ggcaggagaa gggctcggcc ctggagggca gggccgacac cacaacgggc
     2041 agtgctgccg ggccaccact ctcggaggac gacaagctgc agggtgcagc ctcccacgtg
     2101 cccgagggct ttgatccaac gggacctgct gggcttggga ggccaactcc cggcctttcc
     2161 cagggaccag ggaaggaaac cttggagagc gctctcatcg ccctcgactc ggaaaaaccc
     2221 aagaagcttc gcttccaccc aaagcagctg tacttctccg ccaggcaagg ggagcttcag
     2281 aaggtgctcc tcatgctggt ggacggaatt gaccccaact tcaaaatgga gcaccagaat
     2341 aagcgctctc cactgcacgc cgcggcagag gctggacacg tggacatctg ccacatgctg
     2401 gttcaggcgg gcgctaatat tgacacctgc tcagaagacc agaggacccc gttgatggaa
     2461 gcagccgaaa acaaccatct ggaagcagtg aagtacctca tcaaggctgg ggccctggtg
     2521 gatcccaagg acgcagaggg ctctacgtgt ttgcacctgg ctgccaagaa aggccactac
     2581 gaagtggtcc agtacctgct ttcaaatgga cagatggacg tcaactgtca ggatgacgga
     2641 ggctggacac ccatgatctg ggccacagag tacaagcacg tggacctcgt gaagctgctg
     2701 ctgtccaagg gctctgacat caacatccga gacaacgagg agaacatttg cctgcactgg
     2761 gcggcgttct ccggctgcgt ggacatagcc gagatcctgc tggctgccaa gtgcgacctc
     2821 cacgccgtga acatccacgg agactcgcca ctgcacattg ccgcccggga gaaccgctac
     2881 gactgtgtcg tcctctttct ttctcgggat tcagatgtca ccttaaagaa caaggaagga
     2941 gagacgcccc tgcagtgtgc gagcctcaac tctcaggtgt ggagcgctct gcagatgagc
     3001 aaggctctgc aggactcggc ccccgacagg cccagccccg tggagaggat agtgagcagg
     3061 gacatcgctc gaggctacga gcgcatcccc atcccctgtg tcaacgccgt ggacagcgag
     3121 ccatgcccca gcaactacaa gtacgtctct cagaactgcg tgacgtcccc catgaacatc
     3181 gacagaaata tcactcatct gcagtactgc gtgtgcatcg acgactgctc ctccagcaac
     3241 tgcatgtgcg gccagctcag catgcgctgc tggtacgaca aggatggccg gctcctgcca
     3301 gagttcaaca tggcggagcc tcccttgatc ttcgaatgca accacgcgtg ctcctgctgg
     3361 aggaactgcc gaaatcgcgt cgtacagaat ggtctcaggg caaggctgca gctctaccgg
     3421 acgcgggaca tgggctgggg cgtgcggtcc ctgcaggaca tcccaccagg cacctttgtc
     3481 tgcgagtatg ttggggagct gatttcagac tcagaagccg acgttcgaga ggaagattct
     3541 tacctctttg atctcgacaa taaggacggg gaggtttact gcatcgacgc gcggttctac
     3601 gggaacgtca gccggttcat caaccaccac tgcgagccca acctggtgcc cgtgcgcgtg
     3661 ttcatggccc accaggacct gcggttcccc cggatcgcct tcttcagcac ccgcctgatc
     3721 gaggccggcg agcagctcgg gtttgactat ggagagcgct tctgggacat caaaggcaag
     3781 ctcttcagct gccgctgcgg ctcccccaag tgccggcact cgagcgcggc cctggcccag
     3841 cgtcaggcca gcgcggccca ggaggcccag gaggacggct tgcccgacac cagctccgcg
     3901 gctgccgccg accccctatg agacgccgcc ggccagcggg gcgctcggga gccagggacc
     3961 gccgcgtcgc cgattagagg acgaggagga gagattccgc acgcaaccga aagggtcctt
     4021 cggggctgcg ccgccggctt cctggagggg tcggaggtga ggctgcagcc cctgcgggcg
     4081 ggtgtggatg cctcccagcc accttcccag acctgcggcc tcaccgcggg cccagtgccc
     4141 aggctggagc gcacactttg gtccgcgcgc cagagacgct gggagtccgc actggcatca
     4201 ccttctgagt ttctgatgct gatttgtcgt tgcgaagttt ctcgtttctt cctctgacct
     4261 ccgaggtccc cgctgcacca cggggttgct ctgttctcct gtccggccca gactcttctg
     4321 tgtggcgccg ccgaagccac cgttagcgcg agctgctccg ttcgccctgc ccacggcctg
     4381 cgtggctggg gccgagtccc aggggccgca cggagggcac agtctcctgt caggctcgga
     4441 gaggtcagga gaccgacccc accactaact ttggagaaaa tgtgggtttg ctttttaaag
     4501 gaatcctata tctagtccta tatatcaaac ctctaactga cgtttctttt cgaggaagtg
     4561 gcttggtggg tgcagccccc gccggttccg ttgacgctgg caccttctgt tgatttttta
     4621 agccacatgc tatgatgaat aaactgattt attttctacc attactgaac attaggacaa
     4681 acacaaaata aaaaacaaaa cacagacaac ggtgctgatt ctggtgtggt ttctactcac
     4741 cacgtgaaat aaactatcaa ctgtataaag agaacaaagt gattttagaa taaaatgcag
     4801 gaaaaacttt tttaaagatg ttagtcttgt agcgtgaata aatttgccat caccttttgt
     4861 gtggtggcct ggcaggtcat atactttttt ttggcatata cctttttaaa gactgtaatt
     4921 agtgcagtaa cagtggggtt ttttttgtgc aactcttcta aaaacattca taatgcagtc
     4981 atgtttattt ttttctgtta aaatgttttt gacagtttta agagcagtct tttggctctg
     5041 accatttctt gttctgtttc caatgaaatc aataaaaaaa aagaagtact ttaaa
//
